4nm1 - Revision history

OCA at 12:34, 1 March 2024

OCA — Fri, 01 Mar 2024 12:34:09 GMT

←Older revision		Revision as of 12:34, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4nm1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NM1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NM1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4nm1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NM1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NM1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGM:8-BROMO-2-DEOXYGUANOSINE-5-MONOPHOSPHATE'>BGM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.415Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGM:8-BROMO-2-DEOXYGUANOSINE-5-MONOPHOSPHATE'>BGM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nm1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nm1 OCA], [https://pdbe.org/4nm1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nm1 RCSB], [https://www.ebi.ac.uk/pdbsum/4nm1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nm1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nm1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nm1 OCA], [https://pdbe.org/4nm1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nm1 RCSB], [https://www.ebi.ac.uk/pdbsum/4nm1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nm1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/DPOLB_HUMAN DPOLB_HUMAN] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.<ref>PMID:9207062</ref> <ref>PMID:9572863</ref> <ref>PMID:11805079</ref> <ref>PMID:21362556</ref>		[https://www.uniprot.org/uniprot/DPOLB_HUMAN DPOLB_HUMAN] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.<ref>PMID:9207062</ref> <ref>PMID:9572863</ref> <ref>PMID:11805079</ref> <ref>PMID:21362556</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	8-Halogenated guanine (haloG), a major DNA adduct formed by reactive halogen species during inflammation, is a promutagenic lesion that promotes misincorporation of G opposite the lesion by various DNA polymerases. Currently, the structural basis for such misincorporation is unknown. To gain insights into the mechanism of misincorporation across haloG by polymerase, we determined seven X-ray structures of human DNA polymerase beta (polbeta) bound to DNA bearing 8-bromoguanine (BrG). We determined two pre-catalytic ternary-complex structures of polbeta with an incoming nonhydrolyzable dGTP or dCTP analog paired with templating BrG. We also determined five binary-complex structures of polbeta in complex with DNA containing BrG:C/T at post-insertion and post-extension sites. In the BrG:dGTP ternary structure, BrG adopts syn conformation and forms Hoogsteen base pairing with the incoming dGTP analog. In the BrG:dCTP ternary structure, BrG adopts anti conformation and forms Watson-Crick base pairing with the incoming dCTP analog. In addition, our polbeta binary post-extension structures show Hoogsteen BrG:G base pair and Watson-Crick BrG:C base pair. Taken together, the first structures of haloG-containing DNA bound to a protein indicate that both BrG:G and BrG:C base pairs are accommodated in the active site of polbeta. Our structures suggest that Hoogsteen-type base pairing between G and C8-modified G could be accommodated in the active site of a DNA polymerase, promoting G to C mutation.

-	~~Structural basis for promutagenicity of 8-halogenated guanine.,Koag MC, Min K, Lee S J Biol Chem. 2014 Jan 14. PMID:24425881<ref>PMID:24425881</ref>~~	+	==See Also==
-		+	*[[DNA polymerase 3D structures\|DNA polymerase 3D structures]]
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class~~=~~"pdbe-citations 4nm1" style~~=~~"background-color:#fffaf0;"></div>~~	+
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:34, 11 January 2023

OCA — Wed, 11 Jan 2023 08:34:15 GMT

←Older revision		Revision as of 08:34, 11 January 2023
Line 1:		Line 1:

	==Structure of human DNA polymerase beta complexed with a nicked DNA containing a 8BrG-C at N-1 position and G-C at N position==		==Structure of human DNA polymerase beta complexed with a nicked DNA containing a 8BrG-C at N-1 position and G-C at N position==
-	<StructureSection load='4nm1' size='340' side='right' caption='[[4nm1]], [[Resolution\|resolution]] 2.42Å' scene=''>	+	<StructureSection load='4nm1' size='340' side='right'caption='[[4nm1]], [[Resolution\|resolution]] 2.42Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4nm1]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NM1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4NM1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4nm1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NM1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NM1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:~~MAGNESIUM+ION~~'>MG</scene>, <scene name='pdbligand=NA:~~SODIUM~~+ION'>NA</scene>, <scene name='pdbligand=~~PO4~~:~~PHOSPHATE~~+ION'>~~PO4~~</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGM:8-BROMO-2-DEOXYGUANOSINE-5-MONOPHOSPHATE'>BGM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=~~BGM~~:~~8-BROMO-2-DEOXYGUANOSINE-5-MONOPHOSPHATE~~'>~~BGM~~</scene>~~</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nm1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nm1 OCA], [https://pdbe.org/4nm1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nm1 RCSB], [https://www.ebi.ac.uk/pdbsum/4nm1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nm1 ProSAT]</span></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bpx\|1bpx]], [[3isb\|3isb]], [[4nlk\|4nlk]], [[4nln\|4nln]], [[4nlz\|4nlz]], [[4nm2\|4nm2]]</td></tr>	+
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">POLB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4nm1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nm1 OCA], [~~http~~://pdbe.org/4nm1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4nm1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4nm1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4nm1 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/DPOLB_HUMAN DPOLB_HUMAN]] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.<ref>PMID:9207062</ref> <ref>PMID:9572863</ref> <ref>PMID:11805079</ref> <ref>PMID:21362556</ref>	+	[https://www.uniprot.org/uniprot/DPOLB_HUMAN DPOLB_HUMAN] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.<ref>PMID:9207062</ref> <ref>PMID:9572863</ref> <ref>PMID:11805079</ref> <ref>PMID:21362556</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4nm1" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4nm1" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[DNA polymerase\|DNA polymerase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: Koag, M C]]	+	[[Category: Large Structures]]
-	[[Category: Lee, S]]	+	[[Category: Koag M-C]]
-	[[Category: Min, K]]	+	[[Category: Lee S]]
-	[[Category: Monzingo~~, A F]]~~	+	[[Category: Min K]]
-	~~[[Category: Dna binding]]~~	+	[[Category: Monzingo AF]]
-	~~[[Category: Helix-turn-helix motif]]~~	+
-	~~[[Category: Lyase-dna complex]]~~	+
-	~~[[Category: Nucleotidyl transferase]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Polymerase fold]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 20:02, 4 August 2016

OCA — Thu, 04 Aug 2016 20:02:42 GMT

←Older revision		Revision as of 20:02, 4 August 2016
Line 1:		Line 1:
		+
	==Structure of human DNA polymerase beta complexed with a nicked DNA containing a 8BrG-C at N-1 position and G-C at N position==		==Structure of human DNA polymerase beta complexed with a nicked DNA containing a 8BrG-C at N-1 position and G-C at N position==
	<StructureSection load='4nm1' size='340' side='right' caption='[[4nm1]], [[Resolution\|resolution]] 2.42Å' scene=''>		<StructureSection load='4nm1' size='340' side='right' caption='[[4nm1]], [[Resolution\|resolution]] 2.42Å' scene=''>
Line 7:		Line 8:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bpx\|1bpx]], [[3isb\|3isb]], [[4nlk\|4nlk]], [[4nln\|4nln]], [[4nlz\|4nlz]], [[4nm2\|4nm2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bpx\|1bpx]], [[3isb\|3isb]], [[4nlk\|4nlk]], [[4nln\|4nln]], [[4nlz\|4nlz]], [[4nm2\|4nm2]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">POLB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">POLB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nm1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nm1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nm1 RCSB], [http://www.ebi.ac.uk/pdbsum/4nm1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nm1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nm1 OCA], [http://pdbe.org/4nm1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nm1 RCSB], [http://www.ebi.ac.uk/pdbsum/4nm1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nm1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4nm1" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 12:40, 25 December 2014

OCA — Thu, 25 Dec 2014 12:40:19 GMT

←Older revision		Revision as of 12:40, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4nm1\| PDB=4nm1 \| SCENE= }}~~	+	==Structure of human DNA polymerase beta complexed with a nicked DNA containing a 8BrG-C at N-1 position and G-C at N position==
-	===Structure of human DNA polymerase beta complexed with a nicked DNA containing a 8BrG-C at N-1 position and G-C at N position===	+	<StructureSection load='4nm1' size='340' side='right' caption='[[4nm1]], [[Resolution\|resolution]] 2.42Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24425881}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4nm1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NM1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NM1 FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGM:8-BROMO-2-DEOXYGUANOSINE-5-MONOPHOSPHATE'>BGM</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bpx\|1bpx]], [[3isb\|3isb]], [[4nlk\|4nlk]], [[4nln\|4nln]], [[4nlz\|4nlz]], [[4nm2\|4nm2]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">POLB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nm1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nm1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nm1 RCSB], [http://www.ebi.ac.uk/pdbsum/4nm1 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/DPOLB_HUMAN DPOLB_HUMAN]] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.<ref>PMID:9207062</ref> <ref>PMID:9572863</ref> <ref>PMID:11805079</ref> <ref>PMID:21362556</ref>		[[http://www.uniprot.org/uniprot/DPOLB_HUMAN DPOLB_HUMAN]] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.<ref>PMID:9207062</ref> <ref>PMID:9572863</ref> <ref>PMID:11805079</ref> <ref>PMID:21362556</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	8-Halogenated guanine (haloG), a major DNA adduct formed by reactive halogen species during inflammation, is a promutagenic lesion that promotes misincorporation of G opposite the lesion by various DNA polymerases. Currently, the structural basis for such misincorporation is unknown. To gain insights into the mechanism of misincorporation across haloG by polymerase, we determined seven X-ray structures of human DNA polymerase beta (polbeta) bound to DNA bearing 8-bromoguanine (BrG). We determined two pre-catalytic ternary-complex structures of polbeta with an incoming nonhydrolyzable dGTP or dCTP analog paired with templating BrG. We also determined five binary-complex structures of polbeta in complex with DNA containing BrG:C/T at post-insertion and post-extension sites. In the BrG:dGTP ternary structure, BrG adopts syn conformation and forms Hoogsteen base pairing with the incoming dGTP analog. In the BrG:dCTP ternary structure, BrG adopts anti conformation and forms Watson-Crick base pairing with the incoming dCTP analog. In addition, our polbeta binary post-extension structures show Hoogsteen BrG:G base pair and Watson-Crick BrG:C base pair. Taken together, the first structures of haloG-containing DNA bound to a protein indicate that both BrG:G and BrG:C base pairs are accommodated in the active site of polbeta. Our structures suggest that Hoogsteen-type base pairing between G and C8-modified G could be accommodated in the active site of a DNA polymerase, promoting G to C mutation.

-	~~==About this Structure==~~	+	Structural basis for promutagenicity of 8-halogenated guanine.,Koag MC, Min K, Lee S J Biol Chem. 2014 Jan 14. PMID:24425881<ref>PMID:24425881</ref>
-	~~[[4nm1]] is a 4 chain structure~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4NM1 OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[DNA polymerase\|DNA polymerase]]		*[[DNA polymerase\|DNA polymerase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:024425881</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
-	[[Category: Koag, M C.]]	+	</StructureSection>
-	[[Category: Lee, S.]]	+	[[Category: Human]]
-	[[Category: Min, K.]]	+	[[Category: Koag, M C]]
-	[[Category: Monzingo, A F.]]	+	[[Category: Lee, S]]
		+	[[Category: Min, K]]
		+	[[Category: Monzingo, A F]]
	[[Category: Dna binding]]		[[Category: Dna binding]]
	[[Category: Helix-turn-helix motif]]		[[Category: Helix-turn-helix motif]]

OCA at 10:00, 19 March 2014

OCA — Wed, 19 Mar 2014 10:00:32 GMT

←Older revision		Revision as of 10:00, 19 March 2014
Line 8:		Line 8:
	==About this Structure==		==About this Structure==
	[[4nm1]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NM1 OCA].		[[4nm1]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NM1 OCA].
		+
		+	==See Also==
		+	*[[DNA polymerase\|DNA polymerase]]

	==Reference==		==Reference==

OCA at 04:40, 13 February 2014

OCA — Thu, 13 Feb 2014 04:40:41 GMT

←Older revision		Revision as of 04:40, 13 February 2014
Line 1:		Line 1:
	{{STRUCTURE_4nm1\| PDB=4nm1 \| SCENE= }}		{{STRUCTURE_4nm1\| PDB=4nm1 \| SCENE= }}
	===Structure of human DNA polymerase beta complexed with a nicked DNA containing a 8BrG-C at N-1 position and G-C at N position===		===Structure of human DNA polymerase beta complexed with a nicked DNA containing a 8BrG-C at N-1 position and G-C at N position===
		+	{{ABSTRACT_PUBMED_24425881}}

	==Function==		==Function==
Line 9:		Line 10:

	==Reference==		==Reference==
-	<references group="xtra"/><references/>	+	<ref group="xtra">PMID:024425881</ref><references group="xtra"/><references/>
	[[Category: Koag, M C.]]		[[Category: Koag, M C.]]
	[[Category: Lee, S.]]		[[Category: Lee, S.]]

OCA at 07:05, 22 January 2014

OCA — Wed, 22 Jan 2014 07:05:32 GMT

←Older revision		Revision as of 07:05, 22 January 2014
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-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4nm1\| PDB=4nm1 \| SCENE= }}
		+	===Structure of human DNA polymerase beta complexed with a nicked DNA containing a 8BrG-C at N-1 position and G-C at N position===

-	~~The entry 4nm1 is ON HOLD~~ ~~until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/DPOLB_HUMAN DPOLB_HUMAN]] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.<ref>PMID:9207062</ref> <ref>PMID:9572863</ref> <ref>PMID:11805079</ref> <ref>PMID:21362556</ref>

-	~~Authors~~: ~~Koag, M~~.-C.~~, Min, K~~.~~, Monzingo, A.F., Lee, S~~.	+	==About this Structure==
		+	[[4nm1]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NM1 OCA].

-	~~Description~~: ~~Structure of human DNA polymerase beta complexed with a nicked DNA containing a 8BrG-~~C ~~at N~~-~~1 position and G~~-~~C at N position~~	+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Koag, M C.]]
		+	[[Category: Lee, S.]]
		+	[[Category: Min, K.]]
		+	[[Category: Monzingo, A F.]]
		+	[[Category: Dna binding]]
		+	[[Category: Helix-turn-helix motif]]
		+	[[Category: Lyase-dna complex]]
		+	[[Category: Nucleotidyl transferase]]
		+	[[Category: Nucleus]]
		+	[[Category: Polymerase fold]]
		+	[[Category: Transferase]]

OCA at 09:50, 27 November 2013

OCA — Wed, 27 Nov 2013 09:50:50 GMT

←Older revision		Revision as of 09:50, 27 November 2013
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4nm1 is ON HOLD	+	The entry 4nm1 is ON HOLD until Paper Publication

-	Authors: Koag, M-C., Min, K, Monzingo, A.F., Lee, S	+	Authors: Koag, M.-C., Min, K., Monzingo, A.F., Lee, S.

-	Description: Structure of human DNA polymerase complexed with a nicked DNA containing a 8BrG C at N-1 position and G C at N position	+	Description: Structure of human DNA polymerase beta complexed with a nicked DNA containing a 8BrG-C at N-1 position and G-C at N position

OCA: Protected "4nm1" [edit=sysop:move=sysop]

OCA — Wed, 20 Nov 2013 13:02:46 GMT

Protected "4nm1" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:02, 20 November 2013

OCA: New page: '''Unreleased structure''' The entry 4nm1 is ON HOLD Authors: Koag, M-C., Min, K, Monzingo, A.F., Lee, S Description: Structure of human DNA polymerase complexed with a nicked DNA cont...

OCA — Wed, 20 Nov 2013 13:02:45 GMT

New page: '''Unreleased structure''' The entry 4nm1 is ON HOLD Authors: Koag, M-C., Min, K, Monzingo, A.F., Lee, S Description: Structure of human DNA polymerase complexed with a nicked DNA cont...

New page

'''Unreleased structure'''

The entry 4nm1 is ON HOLD

Authors: Koag, M-C., Min, K, Monzingo, A.F., Lee, S

Description: Structure of human DNA polymerase complexed with a nicked DNA containing a 8BrG C at N-1 position and G C at N position