4nni - Revision history

OCA at 08:57, 20 March 2024

OCA — Wed, 20 Mar 2024 08:57:06 GMT

←Older revision		Revision as of 08:57, 20 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4nni]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NNI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NNI FirstGlance]. <br>		<table><tr><td colspan='2'>[[4nni]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NNI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NNI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=VGL:PYRAZINE-2-CARBOXYLIC+ACID'>VGL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.64Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=VGL:PYRAZINE-2-CARBOXYLIC+ACID'>VGL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nni OCA], [https://pdbe.org/4nni PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nni RCSB], [https://www.ebi.ac.uk/pdbsum/4nni PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nni ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nni OCA], [https://pdbe.org/4nni PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nni RCSB], [https://www.ebi.ac.uk/pdbsum/4nni PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nni ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/RS1_MYCTU RS1_MYCTU] Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity).		[https://www.uniprot.org/uniprot/RS1_MYCTU RS1_MYCTU] Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity).
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Pyrazinamide (PZA) is a first-line drug for tuberculosis (TB) treatment and is responsible for shortening the duration of TB therapy. The mode of action of PZA remains elusive. RpsA, the ribosomal protein S1 of Mycobacterium tuberculosis (Mtb), was recently identified as a target of PZA based on its binding activity to pyrazinoic acid (POA), the active form of PZA. POA binding to RpsA led to the inhibition of trans-translation. However, the nature of the RpsA-POA interaction remains unknown. Key questions include why POA exhibits an exquisite specificity to RpsA of Mtb and how RpsA mutations confer PZA resistance. Here, we report the crystal structures of the C-terminal domain of RpsA of Mtb and its complex with POA, as well as the corresponding domains of two RpsA variants that are associated with PZA resistance. Structural analysis reveals that POA binds to RpsA through hydrogen bonds and hydrophobic interactions, mediated mainly by residues (Lys303, Phe307, Phe310 and Arg357) that are essential for tmRNA binding. Conformational changes induced by mutation or sequence variation at the C-terminus of RpsA abolish the POA binding activity. Our findings provide insights into the mode of action of PZA and molecular basis of PZA resistance associated with RpsA mutations.
-
-	Structural basis for targeting the ribosomal protein S1 of Mycobacterium tuberculosis by pyrazinamide.,Yang J, Liu Y, Bi J, Cai Q, Liao X, Li W, Guo C, Zhang Q, Lin T, Zhao Y, Wang H, Liu J, Zhang X, Lin D Mol Microbiol. 2015 Mar;95(5):791-803. doi: 10.1111/mmi.12892. Epub 2015 Jan 16. PMID:25430994<ref>PMID:25430994</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4nni" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Ribosomal protein S1\|Ribosomal protein S1]]		*[[Ribosomal protein S1\|Ribosomal protein S1]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:36, 11 January 2023

OCA — Wed, 11 Jan 2023 08:36:15 GMT

←Older revision		Revision as of 08:36, 11 January 2023
Line 1:		Line 1:

	==Structural basis for targeting the ribosomal protein S1 of Mycobacterium tuberculosis by pyrazinamide==		==Structural basis for targeting the ribosomal protein S1 of Mycobacterium tuberculosis by pyrazinamide==
-	<StructureSection load='4nni' size='340' side='right' caption='[[4nni]], [[Resolution\|resolution]] 2.64Å' scene=''>	+	<StructureSection load='4nni' size='340' side='right'caption='[[4nni]], [[Resolution\|resolution]] 2.64Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4nni]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Myctu Myctu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NNI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4NNI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4nni]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NNI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NNI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=VGL:PYRAZINE-2-CARBOXYLIC+ACID'>VGL</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=VGL:PYRAZINE-2-CARBOXYLIC+ACID'>VGL</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4nng\|4nng]], [[4nnh\|4nnh]], [[4nnk\|4nnk]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nni OCA], [https://pdbe.org/4nni PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nni RCSB], [https://www.ebi.ac.uk/pdbsum/4nni PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nni ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MT1666, MTCY01B2.22, rpsA, Rv1630 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4nni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nni OCA], [~~http~~://pdbe.org/4nni PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4nni RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4nni PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4nni ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/RS1_MYCTU RS1_MYCTU]] Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity).	+	[https://www.uniprot.org/uniprot/RS1_MYCTU RS1_MYCTU] Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4nni" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4nni" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ribosomal protein S1\|Ribosomal protein S1]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Myctu~~]]	+	[[Category: Large Structures]]
-	[[Category: Cai, Q]]	+	[[Category: Mycobacterium tuberculosis H37Rv]]
-	[[Category: Lin, D]]	+	[[Category: Cai Q]]
-	[[Category: Liu, Y]]	+	[[Category: Lin D]]
-	[[Category: Yang, J]]	+	[[Category: Liu Y]]
-	~~[[Category: Beta barrel]]~~	+	[[Category: Yang J]]
-	~~[[Category: Ribosomal protein~~]]	+

OCA at 08:15, 22 November 2017

OCA — Wed, 22 Nov 2017 08:15:36 GMT

←Older revision		Revision as of 08:15, 22 November 2017
Line 1:		Line 1:
		+
	==Structural basis for targeting the ribosomal protein S1 of Mycobacterium tuberculosis by pyrazinamide==		==Structural basis for targeting the ribosomal protein S1 of Mycobacterium tuberculosis by pyrazinamide==
	<StructureSection load='4nni' size='340' side='right' caption='[[4nni]], [[Resolution\|resolution]] 2.64Å' scene=''>		<StructureSection load='4nni' size='340' side='right' caption='[[4nni]], [[Resolution\|resolution]] 2.64Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4nni]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NNI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NNI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4nni]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NNI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NNI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=VGL:PYRAZINE-2-CARBOXYLIC+ACID'>VGL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=VGL:PYRAZINE-2-CARBOXYLIC+ACID'>VGL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4nng\|4nng]], [[4nnh\|4nnh]], [[4nnk\|4nnk]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4nng\|4nng]], [[4nnh\|4nnh]], [[4nnk\|4nnk]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nni OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nni RCSB], [http://www.ebi.ac.uk/pdbsum/4nni PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MT1666, MTCY01B2.22, rpsA, Rv1630 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nni OCA], [http://pdbe.org/4nni PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nni RCSB], [http://www.ebi.ac.uk/pdbsum/4nni PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nni ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
-		+	<div class="pdbe-citations 4nni" style="background-color:#fffaf0;"></div>
-	==~~See Also==~~	+
-	*[[Ribosomal protein S1\|Ribosomal protein S1]]	+
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Myctu]]
	[[Category: Cai, Q]]		[[Category: Cai, Q]]
	[[Category: Lin, D]]		[[Category: Lin, D]]

OCA at 05:07, 9 September 2015

OCA — Wed, 09 Sep 2015 05:07:45 GMT

←Older revision		Revision as of 05:07, 9 September 2015
Line 9:		Line 9:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/RS1_MYCTU RS1_MYCTU]] Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity).		[[http://www.uniprot.org/uniprot/RS1_MYCTU RS1_MYCTU]] Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Pyrazinamide (PZA) is a first-line drug for tuberculosis (TB) treatment and is responsible for shortening the duration of TB therapy. The mode of action of PZA remains elusive. RpsA, the ribosomal protein S1 of Mycobacterium tuberculosis (Mtb), was recently identified as a target of PZA based on its binding activity to pyrazinoic acid (POA), the active form of PZA. POA binding to RpsA led to the inhibition of trans-translation. However, the nature of the RpsA-POA interaction remains unknown. Key questions include why POA exhibits an exquisite specificity to RpsA of Mtb and how RpsA mutations confer PZA resistance. Here, we report the crystal structures of the C-terminal domain of RpsA of Mtb and its complex with POA, as well as the corresponding domains of two RpsA variants that are associated with PZA resistance. Structural analysis reveals that POA binds to RpsA through hydrogen bonds and hydrophobic interactions, mediated mainly by residues (Lys303, Phe307, Phe310 and Arg357) that are essential for tmRNA binding. Conformational changes induced by mutation or sequence variation at the C-terminus of RpsA abolish the POA binding activity. Our findings provide insights into the mode of action of PZA and molecular basis of PZA resistance associated with RpsA mutations.
		+
		+	Structural basis for targeting the ribosomal protein S1 of Mycobacterium tuberculosis by pyrazinamide.,Yang J, Liu Y, Bi J, Cai Q, Liao X, Li W, Guo C, Zhang Q, Lin T, Zhao Y, Wang H, Liu J, Zhang X, Lin D Mol Microbiol. 2015 Mar;95(5):791-803. doi: 10.1111/mmi.12892. Epub 2015 Jan 16. PMID:25430994<ref>PMID:25430994</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+
		+	==See Also==
		+	*[[Ribosomal protein S1\|Ribosomal protein S1]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 11:06, 24 December 2014

OCA — Wed, 24 Dec 2014 11:06:37 GMT

←Older revision		Revision as of 11:06, 24 December 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Structural basis for targeting the ribosomal protein S1 of Mycobacterium tuberculosis by pyrazinamide==
-		+	<StructureSection load='4nni' size='340' side='right' caption='[[4nni]], [[Resolution\|resolution]] 2.64Å' scene=''>
-	~~The entry~~ 4nni is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4nni]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NNI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NNI FirstGlance]. <br>
-	~~Authors~~: ~~Yang~~, J., ~~Liu~~, Y., Cai, Q., Lin, D.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=VGL:PYRAZINE-2-CARBOXYLIC+ACID'>VGL</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4nng\|4nng]], [[4nnh\|4nnh]], [[4nnk\|4nnk]]</td></tr>
-	~~Description~~: ~~The Structure Basis~~: ~~a Novel Target RpsA From Mycobacterium Tuberculosis Recognition of Pyrazinoic Acid for Inhibiting Trans-translation~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nni OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nni RCSB], [http://www.ebi.ac.uk/pdbsum/4nni PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RS1_MYCTU RS1_MYCTU]] Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity).
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Cai, Q]]
		+	[[Category: Lin, D]]
		+	[[Category: Liu, Y]]
		+	[[Category: Yang, J]]
		+	[[Category: Beta barrel]]
		+	[[Category: Ribosomal protein]]

OCA at 06:44, 22 January 2014

OCA — Wed, 22 Jan 2014 06:44:22 GMT

←Older revision		Revision as of 06:44, 22 January 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4nni is ON HOLD	+	The entry 4nni is ON HOLD until Paper Publication

	Authors: Yang, J., Liu, Y., Cai, Q., Lin, D.		Authors: Yang, J., Liu, Y., Cai, Q., Lin, D.

	Description: The Structure Basis: a Novel Target RpsA From Mycobacterium Tuberculosis Recognition of Pyrazinoic Acid for Inhibiting Trans-translation		Description: The Structure Basis: a Novel Target RpsA From Mycobacterium Tuberculosis Recognition of Pyrazinoic Acid for Inhibiting Trans-translation

OCA at 13:05, 11 December 2013

OCA — Wed, 11 Dec 2013 13:05:08 GMT

←Older revision		Revision as of 13:05, 11 December 2013
Line 3:		Line 3:
	The entry 4nni is ON HOLD		The entry 4nni is ON HOLD

-	Authors: ~~Juanjuan~~ Yang, J.Y., ~~Yindi~~ Liu, Y.L., ~~Qixu cai~~, Q.C., ~~Donghai~~ Lin, D.~~L., the nuclear magnetic resonance research center~~	+	Authors: Yang, J., Liu, Y., Cai, Q., Lin, D.

	Description: The Structure Basis: a Novel Target RpsA From Mycobacterium Tuberculosis Recognition of Pyrazinoic Acid for Inhibiting Trans-translation		Description: The Structure Basis: a Novel Target RpsA From Mycobacterium Tuberculosis Recognition of Pyrazinoic Acid for Inhibiting Trans-translation

OCA: Protected "4nni" [edit=sysop:move=sysop]

OCA — Wed, 27 Nov 2013 09:52:21 GMT

Protected "4nni" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:52, 27 November 2013

OCA: New page: '''Unreleased structure''' The entry 4nni is ON HOLD Authors: Juanjuan Yang, J.Y., Yindi Liu, Y.L., Qixu cai, Q.C., Donghai Lin, D.L., the nuclear magnetic resonance research center De...

OCA — Wed, 27 Nov 2013 09:52:20 GMT

New page: '''Unreleased structure''' The entry 4nni is ON HOLD Authors: Juanjuan Yang, J.Y., Yindi Liu, Y.L., Qixu cai, Q.C., Donghai Lin, D.L., the nuclear magnetic resonance research center De...

New page

'''Unreleased structure'''

The entry 4nni is ON HOLD

Authors: Juanjuan Yang, J.Y., Yindi Liu, Y.L., Qixu cai, Q.C., Donghai Lin, D.L., the nuclear magnetic resonance research center

Description: The Structure Basis: a Novel Target RpsA From Mycobacterium Tuberculosis Recognition of Pyrazinoic Acid for Inhibiting Trans-translation