4nog - Revision history

OCA at 17:01, 20 September 2023

OCA — Wed, 20 Sep 2023 17:01:08 GMT

←Older revision		Revision as of 17:01, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4nog]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxoplasma_gondii_ME49 Toxoplasma gondii ME49]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NOG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NOG FirstGlance]. <br>		<table><tr><td colspan='2'>[[4nog]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxoplasma_gondii_ME49 Toxoplasma gondii ME49]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NOG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NOG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nog FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nog OCA], [https://pdbe.org/4nog PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nog RCSB], [https://www.ebi.ac.uk/pdbsum/4nog PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nog ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nog FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nog OCA], [https://pdbe.org/4nog PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nog RCSB], [https://www.ebi.ac.uk/pdbsum/4nog PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nog ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:38, 11 January 2023

OCA — Wed, 11 Jan 2023 08:38:24 GMT

←Older revision		Revision as of 08:38, 11 January 2023
Line 1:		Line 1:

	==Crystal structure of a putative ornithine aminotransferase from Toxoplasma gondii ME49 in complex with pyrodoxal-5'-phosphate==		==Crystal structure of a putative ornithine aminotransferase from Toxoplasma gondii ME49 in complex with pyrodoxal-5'-phosphate==
-	<StructureSection load='4nog' size='340' side='right' caption='[[4nog]], [[Resolution\|resolution]] 1.20Å' scene=''>	+	<StructureSection load='4nog' size='340' side='right'caption='[[4nog]], [[Resolution\|resolution]] 1.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4nog]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Toxgm Toxgm~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NOG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4NOG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4nog]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxoplasma_gondii_ME49 Toxoplasma gondii ME49]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NOG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NOG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TGME49_069110, TGME49_269110 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=508771 TOXGM])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nog FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nog OCA], [https://pdbe.org/4nog PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nog RCSB], [https://www.ebi.ac.uk/pdbsum/4nog PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nog ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ornithine_aminotransferase Ornithine aminotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.13 2.6.1.13] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4nog FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nog OCA], [~~http~~://pdbe.org/4nog PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4nog RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4nog PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4nog ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/S8EY38_TOXGM S8EY38_TOXGM]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Toxoplasma gondii, an Apicomplexan parasite, causes significant morbidity and mortality, including severe disease in immunocompromised hosts and devastating congenital disease, with no effective treatment for the bradyzoite stage. To address this, we used the Tropical Disease Research database, crystallography, molecular modeling, and antisense to identify and characterize a range of potential therapeutic targets for toxoplasmosis. Phosphoglycerate mutase II (PGMII), nucleoside diphosphate kinase (NDK), ribulose phosphate 3-epimerase (RPE), ribose-5-phosphate isomerase (RPI), and ornithine aminotransferase (OAT) were structurally characterized. Crystallography revealed insights into the overall structure, protein oligomeric states and molecular details of active sites important for ligand recognition. Literature and molecular modeling suggested potential inhibitors and druggability. The targets were further studied with vivoPMO to interrupt enzyme synthesis, identifying the targets as potentially important to parasitic replication and, therefore, of therapeutic interest. Targeted vivoPMO resulted in statistically significant perturbation of parasite replication without concomitant host cell toxicity, consistent with a previous CRISPR/Cas9 screen showing PGM, RPE, and RPI contribute to parasite fitness. PGM, RPE, and RPI have the greatest promise for affecting replication in tachyzoites. These targets are shared between other medically important parasites and may have wider therapeutic potential.
		+
		+	CSGID Solves Structures and Identifies Phenotypes for Five Enzymes in Toxoplasma gondii.,Lykins JD, Filippova EV, Halavaty AS, Minasov G, Zhou Y, Dubrovska I, Flores KJ, Shuvalova LA, Ruan J, El Bissati K, Dovgin S, Roberts CW, Woods S, Moulton JD, Moulton H, McPhillie MJ, Muench SP, Fishwick CWG, Sabini E, Shanmugam D, Roos DS, McLeod R, Anderson WF, Ngo HM Front Cell Infect Microbiol. 2018 Oct 5;8:352. doi: 10.3389/fcimb.2018.00352. , eCollection 2018. PMID:30345257<ref>PMID:30345257</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4nog" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ornithine aminotransferase~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Toxgm~~]]	+	[[Category: Toxoplasma gondii ME49]]
-	[[Category: Anderson~~, W F~~]]	+	[[Category: Anderson WF]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
-	[[Category: Dubrovska, I]]	+	[[Category: Dubrovska I]]
-	[[Category: Filippova~~, E V~~]]	+	[[Category: Filippova EV]]
-	[[Category: Flores, K]]	+	[[Category: Flores K]]
-	[[Category: Halavaty, A]]	+	[[Category: Halavaty A]]
-	[[Category: Ngo, H]]	+	[[Category: Ngo H]]
-	[[Category: Roos, D]]	+	[[Category: Roos D]]
-	[[Category: Ruan, J]]	+	[[Category: Ruan J]]
-	[[Category: Shanmugam, D]]	+	[[Category: Shanmugam D]]
-	[[Category: Shuvalova, L]]	+	[[Category: Shuvalova L]]
-	~~[[Category: Csgid]]~~	+
-	~~[[Category: National institute of allergy and infectious disease]]~~	+
-	~~[[Category: Niaid]]~~	+
-	~~[[Category: Toxoplasma]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 08:15, 22 November 2017

OCA — Wed, 22 Nov 2017 08:15:51 GMT

←Older revision		Revision as of 08:15, 22 November 2017
Line 3:		Line 3:
	<StructureSection load='4nog' size='340' side='right' caption='[[4nog]], [[Resolution\|resolution]] 1.20Å' scene=''>		<StructureSection load='4nog' size='340' side='right' caption='[[4nog]], [[Resolution\|resolution]] 1.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4nog]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Toxoplasma_gondii_me49 Toxoplasma gondii me49~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NOG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NOG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4nog]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxgm Toxgm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NOG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NOG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TGME49_069110, TGME49_269110 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=508771 ~~Toxoplasma gondii ME49~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TGME49_069110, TGME49_269110 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=508771 TOXGM])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ornithine_aminotransferase Ornithine aminotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.13 2.6.1.13] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ornithine_aminotransferase Ornithine aminotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.13 2.6.1.13] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nog FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nog OCA], [http://pdbe.org/4nog PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nog RCSB], [http://www.ebi.ac.uk/pdbsum/4nog PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nog ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nog FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nog OCA], [http://pdbe.org/4nog PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nog RCSB], [http://www.ebi.ac.uk/pdbsum/4nog PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nog ProSAT]</span></td></tr>
Line 12:		Line 12:
	</StructureSection>		</StructureSection>
	[[Category: Ornithine aminotransferase]]		[[Category: Ornithine aminotransferase]]
-	[[Category: ~~Toxoplasma gondii me49~~]]	+	[[Category: Toxgm]]
	[[Category: Anderson, W F]]		[[Category: Anderson, W F]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]

OCA at 17:09, 11 August 2016

OCA — Thu, 11 Aug 2016 17:09:36 GMT

←Older revision		Revision as of 17:09, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of a putative ornithine aminotransferase from Toxoplasma gondii ME49 in complex with pyrodoxal-5'-phosphate==		==Crystal structure of a putative ornithine aminotransferase from Toxoplasma gondii ME49 in complex with pyrodoxal-5'-phosphate==
	<StructureSection load='4nog' size='340' side='right' caption='[[4nog]], [[Resolution\|resolution]] 1.20Å' scene=''>		<StructureSection load='4nog' size='340' side='right' caption='[[4nog]], [[Resolution\|resolution]] 1.20Å' scene=''>
Line 6:		Line 7:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TGME49_069110, TGME49_269110 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=508771 Toxoplasma gondii ME49])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TGME49_069110, TGME49_269110 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=508771 Toxoplasma gondii ME49])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ornithine_aminotransferase Ornithine aminotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.13 2.6.1.13] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ornithine_aminotransferase Ornithine aminotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.13 2.6.1.13] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nog FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nog OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nog RCSB], [http://www.ebi.ac.uk/pdbsum/4nog PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nog FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nog OCA], [http://pdbe.org/4nog PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nog RCSB], [http://www.ebi.ac.uk/pdbsum/4nog PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nog ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__

OCA at 12:46, 5 January 2015

OCA — Mon, 05 Jan 2015 12:46:55 GMT

←Older revision		Revision as of 12:46, 5 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_4nog\| PDB=4nog \| SCENE= }}~~	+	==Crystal structure of a putative ornithine aminotransferase from Toxoplasma gondii ME49 in complex with pyrodoxal-5'-phosphate==
-	===Crystal structure of a putative ornithine aminotransferase from Toxoplasma gondii ME49 in complex with pyrodoxal-5'-phosphate===	+	<StructureSection load='4nog' size='340' side='right' caption='[[4nog]], [[Resolution\|resolution]] 1.20Å' scene=''>
-		+	== Structural highlights ==
-	==~~About this Structure~~==	+	<table><tr><td colspan='2'>[[4nog]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii_me49 Toxoplasma gondii me49]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NOG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NOG FirstGlance]. <br>
-	[[4nog]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NOG OCA].	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TGME49_069110, TGME49_269110 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=508771 Toxoplasma gondii ME49])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ornithine_aminotransferase Ornithine aminotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.13 2.6.1.13] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nog FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nog OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nog RCSB], [http://www.ebi.ac.uk/pdbsum/4nog PDBsum]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
	[[Category: Ornithine aminotransferase]]		[[Category: Ornithine aminotransferase]]
-	[[Category: Anderson, W F.]]	+	[[Category: Toxoplasma gondii me49]]
-	[[Category: ~~CSGID, Center for~~ Structural ~~Genomics of Infectious Diseases.~~]]	+	[[Category: Anderson, W F]]
-	[[Category: Dubrovska, I.]]	+	[[Category: Structural genomic]]
-	[[Category: Filippova, E V.]]	+	[[Category: Dubrovska, I]]
-	[[Category: Flores, K.]]	+	[[Category: Filippova, E V]]
-	[[Category: Halavaty, A.]]	+	[[Category: Flores, K]]
-	[[Category: Ngo, H.]]	+	[[Category: Halavaty, A]]
-	[[Category: Roos, D.]]	+	[[Category: Ngo, H]]
-	[[Category: Ruan, J.]]	+	[[Category: Roos, D]]
-	[[Category: Shanmugam, D.]]	+	[[Category: Ruan, J]]
-	[[Category: Shuvalova, L~~.]]~~	+	[[Category: Shanmugam, D]]
-	~~[[Category: Diseases, Center for structural genomics of infectious.]]~~	+	[[Category: Shuvalova, L]]
-	~~[[Category: Center for structural genomics of infectious disease~~]]	+
	[[Category: Csgid]]		[[Category: Csgid]]
	[[Category: National institute of allergy and infectious disease]]		[[Category: National institute of allergy and infectious disease]]
	[[Category: Niaid]]		[[Category: Niaid]]
-	[[Category: Ornithine aminotransferase]]
-	[[Category: Structural genomic]]
	[[Category: Toxoplasma]]		[[Category: Toxoplasma]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 07:35, 4 December 2013

OCA — Wed, 04 Dec 2013 07:35:32 GMT

←Older revision		Revision as of 07:35, 4 December 2013
Line 1:		Line 1:
-	~~'''Unreleased~~ structure'''	+	{{STRUCTURE_4nog\| PDB=4nog \| SCENE= }}
		+	===Crystal structure of a putative ornithine aminotransferase from Toxoplasma gondii ME49 in complex with pyrodoxal-5'-phosphate===

-	~~The entry~~ 4nog is ~~ON HOLD~~	+	==About this Structure==
-		+	[[4nog]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NOG OCA].
-	~~Authors~~: ~~Filippova~~, ~~E.V~~., ~~Halavaty, A~~., ~~Ruan, J~~., ~~Shuvalova, L~~., Flores, K., ~~Dubrovska, I~~., Ngo, H.~~, Shanmugam~~, D., ~~Roos~~, D., ~~Anderson, W.F~~., Center for structural genomics of infectious ~~diseases,~~ Center for ~~Structural Genomics~~ of ~~Infectious Diseases (CSGID)~~	+	[[Category: Ornithine aminotransferase]]
-		+	[[Category: Anderson, W F.]]
-	~~Description~~: ~~Crystal structure~~ of ~~a putative ornithine~~ aminotransferase ~~from~~ Toxoplasma ~~gondii ME49 in complex with pyrodoxal-5'-phosphate~~	+	[[Category: CSGID, Center for Structural Genomics of Infectious Diseases.]]
		+	[[Category: Dubrovska, I.]]
		+	[[Category: Filippova, E V.]]
		+	[[Category: Flores, K.]]
		+	[[Category: Halavaty, A.]]
		+	[[Category: Ngo, H.]]
		+	[[Category: Roos, D.]]
		+	[[Category: Ruan, J.]]
		+	[[Category: Shanmugam, D.]]
		+	[[Category: Shuvalova, L.]]
		+	[[Category: Diseases, Center for structural genomics of infectious.]]
		+	[[Category: Center for structural genomics of infectious disease]]
		+	[[Category: Csgid]]
		+	[[Category: National institute of allergy and infectious disease]]
		+	[[Category: Niaid]]
		+	[[Category: Ornithine aminotransferase]]
		+	[[Category: Structural genomic]]
		+	[[Category: Toxoplasma]]
		+	[[Category: Transferase]]

OCA: Protected "4nog" [edit=sysop:move=sysop]

OCA — Wed, 27 Nov 2013 09:53:29 GMT

Protected "4nog" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:53, 27 November 2013

OCA: New page: '''Unreleased structure''' The entry 4nog is ON HOLD Authors: Filippova, E.V., Halavaty, A., Ruan, J., Shuvalova, L., Flores, K., Dubrovska, I., Ngo, H., Shanmugam, D., Roos, D., Anders...

OCA — Wed, 27 Nov 2013 09:53:28 GMT

New page: '''Unreleased structure''' The entry 4nog is ON HOLD Authors: Filippova, E.V., Halavaty, A., Ruan, J., Shuvalova, L., Flores, K., Dubrovska, I., Ngo, H., Shanmugam, D., Roos, D., Anders...

New page

'''Unreleased structure'''

The entry 4nog is ON HOLD

Authors: Filippova, E.V., Halavaty, A., Ruan, J., Shuvalova, L., Flores, K., Dubrovska, I., Ngo, H., Shanmugam, D., Roos, D., Anderson, W.F., Center for structural genomics of infectious diseases, Center for Structural Genomics of Infectious Diseases (CSGID)

Description: Crystal structure of a putative ornithine aminotransferase from Toxoplasma gondii ME49 in complex with pyrodoxal-5'-phosphate