4npt - Revision history

OCA at 17:01, 20 September 2023

OCA — Wed, 20 Sep 2023 17:01:30 GMT

←Older revision		Revision as of 17:01, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4npt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NPT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NPT FirstGlance]. <br>		<table><tr><td colspan='2'>[[4npt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NPT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NPT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=017:(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE'>017</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.66Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=017:(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE'>017</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4npt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4npt OCA], [https://pdbe.org/4npt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4npt RCSB], [https://www.ebi.ac.uk/pdbsum/4npt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4npt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4npt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4npt OCA], [https://pdbe.org/4npt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4npt RCSB], [https://www.ebi.ac.uk/pdbsum/4npt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4npt ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:41, 11 January 2023

OCA — Wed, 11 Jan 2023 08:41:06 GMT

←Older revision		Revision as of 08:41, 11 January 2023
Line 3:		Line 3:
	<StructureSection load='4npt' size='340' side='right'caption='[[4npt]], [[Resolution\|resolution]] 1.66Å' scene=''>		<StructureSection load='4npt' size='340' side='right'caption='[[4npt]], [[Resolution\|resolution]] 1.66Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4npt]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~9hiv1 9hiv1~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NPT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4NPT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4npt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NPT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NPT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=017:(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE'>017</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=017:(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE'>017</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4npu\|4npu]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4npt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4npt OCA], [https://pdbe.org/4npt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4npt RCSB], [https://www.ebi.ac.uk/pdbsum/4npt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4npt ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4npt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4npt OCA], [~~http~~://pdbe.org/4npt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4npt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4npt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4npt ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/O38896_9HIV1 O38896_9HIV1]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human immunodeficiency virus 1]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Weber~~, I T~~]]	+	[[Category: Weber IT]]
-	[[Category: Zhang, Y]]	+	[[Category: Zhang Y]]
-	~~[[Category: Darunavir]]~~	+
-	~~[[Category: Drug resistance]]~~	+
-	~~[[Category: Hiv-1 protease]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Multiple mutant]]~~	+
-	~~[[Category: P51~~]]	+

OCA at 08:07, 10 April 2019

OCA — Wed, 10 Apr 2019 08:07:38 GMT

←Older revision		Revision as of 08:07, 10 April 2019
Line 1:		Line 1:

	==Crystal Structure of HIV-1 Protease Multiple Mutant P51 Complexed with Darunavir==		==Crystal Structure of HIV-1 Protease Multiple Mutant P51 Complexed with Darunavir==
-	<StructureSection load='4npt' size='340' side='right' caption='[[4npt]], [[Resolution\|resolution]] 1.66Å' scene=''>	+	<StructureSection load='4npt' size='340' side='right'caption='[[4npt]], [[Resolution\|resolution]] 1.66Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4npt]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NPT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NPT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4npt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NPT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NPT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=017:(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE'>017</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=017:(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE'>017</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4npu\|4npu]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4npu\|4npu]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4npt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4npt OCA], [http://pdbe.org/4npt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4npt RCSB], [http://www.ebi.ac.uk/pdbsum/4npt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4npt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4npt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4npt OCA], [http://pdbe.org/4npt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4npt RCSB], [http://www.ebi.ac.uk/pdbsum/4npt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4npt ProSAT]</span></td></tr>
	</table>		</table>
Line 17:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4npt" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4npt" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Immunodeficiency virus protease 3D structures\|Immunodeficiency virus protease 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Weber, I T]]		[[Category: Weber, I T]]
	[[Category: Zhang, Y]]		[[Category: Zhang, Y]]

OCA at 16:46, 11 August 2016

OCA — Thu, 11 Aug 2016 16:46:57 GMT

←Older revision		Revision as of 16:46, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of HIV-1 Protease Multiple Mutant P51 Complexed with Darunavir==		==Crystal Structure of HIV-1 Protease Multiple Mutant P51 Complexed with Darunavir==
	<StructureSection load='4npt' size='340' side='right' caption='[[4npt]], [[Resolution\|resolution]] 1.66Å' scene=''>		<StructureSection load='4npt' size='340' side='right' caption='[[4npt]], [[Resolution\|resolution]] 1.66Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=017:(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE'>017</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=017:(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE'>017</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4npu\|4npu]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4npu\|4npu]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4npt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4npt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4npt RCSB], [http://www.ebi.ac.uk/pdbsum/4npt PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4npt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4npt OCA], [http://pdbe.org/4npt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4npt RCSB], [http://www.ebi.ac.uk/pdbsum/4npt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4npt ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4npt" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:00, 20 January 2015

OCA — Tue, 20 Jan 2015 11:00:25 GMT

←Older revision		Revision as of 11:00, 20 January 2015
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Weber, I T.]]	+	[[Category: Weber, I T]]
-	[[Category: Zhang, Y.]]	+	[[Category: Zhang, Y]]
	[[Category: Darunavir]]		[[Category: Darunavir]]
	[[Category: Drug resistance]]		[[Category: Drug resistance]]

OCA at 07:32, 8 October 2014

OCA — Wed, 08 Oct 2014 07:32:24 GMT

←Older revision		Revision as of 07:32, 8 October 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal Structure of HIV-1 Protease Multiple Mutant P51 Complexed with Darunavir==
		+	<StructureSection load='4npt' size='340' side='right' caption='[[4npt]], [[Resolution\|resolution]] 1.66Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4npt]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NPT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NPT FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=017:(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE'>017</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4npu\|4npu]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4npt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4npt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4npt RCSB], [http://www.ebi.ac.uk/pdbsum/4npt PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The molecular basis for high resistance to clinical inhibitors of HIV-1 protease (PR) was examined for the variant designated PRP51 that was selected for resistance to darunavir (DRV). High resolution crystal structures of PRP51 with the active site D25N mutation revealed a ligand-free form and an inhibitor-bound form showing a unique binding site and orientation for DRV. This inactivating mutation is known to increase the dimer dissociation constant and decrease DRV affinity of PR. The PRP51-D25N dimers were in the open conformation with widely separated flaps, as reported for other highly resistant variants. PRP51-D25N dimer bound two DRV molecules and showed larger separation of 8.7 A between the closest atoms of the two flaps compared with 4.4 A for the ligand-free structure of this mutant. The ligand-free structure, however, lacked van der Waals contacts between Ile50 and Pro81' from the other subunit in the dimer, unlike the majority of PR structures. DRV is bound inside the active site cavity; however, the inhibitor is oriented almost perpendicular to its typical position and exhibits only 2 direct hydrogen bond and two water-mediated interactions with atoms of PRP51-D25N compared with 11 hydrogen bond interactions seen for DRV bound in the typical position in wild-type enzyme. The atypical location of DRV may provide opportunities for design of novel inhibitors targeting the open conformation of PR drug-resistant mutants.

-	~~The entry 4npt is ON HOLD until Paper Publication~~	+	Structures of darunavir-resistant HIV-1 protease mutant reveal atypical binding of darunavir to wide open flaps.,Zhang Y, Chang YC, Louis JM, Wang YF, Harrison RW, Weber IT ACS Chem Biol. 2014 Jun 20;9(6):1351-8. doi: 10.1021/cb4008875. Epub 2014 Apr 28. PMID:24738918<ref>PMID:24738918</ref>

-	~~Authors: Zhang~~, Y., Weber, I.T.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal Structure of HIV~~-1 ~~Protease~~ Multiple ~~Mutant~~ P51 ~~Complexed with Darunavir~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Weber, I T.]]
		+	[[Category: Zhang, Y.]]
		+	[[Category: Darunavir]]
		+	[[Category: Drug resistance]]
		+	[[Category: Hiv-1 protease]]
		+	[[Category: Hydrolase]]
		+	[[Category: Multiple mutant]]
		+	[[Category: P51]]

OCA at 07:00, 29 January 2014

OCA — Wed, 29 Jan 2014 07:00:54 GMT

←Older revision		Revision as of 07:00, 29 January 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4npt is ON HOLD	+	The entry 4npt is ON HOLD until Paper Publication

	Authors: Zhang, Y., Weber, I.T.		Authors: Zhang, Y., Weber, I.T.

	Description: Crystal Structure of HIV-1 Protease Multiple Mutant P51 Complexed with Darunavir		Description: Crystal Structure of HIV-1 Protease Multiple Mutant P51 Complexed with Darunavir

OCA: Protected "4npt" [edit=sysop:move=sysop]

OCA — Wed, 04 Dec 2013 06:51:40 GMT

Protected "4npt" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:51, 4 December 2013

OCA: New page: '''Unreleased structure''' The entry 4npt is ON HOLD Authors: Zhang, Y., Weber, I.T. Description: Crystal Structure of HIV-1 Protease Multiple Mutant P51 Complexed with Darunavir

OCA — Wed, 04 Dec 2013 06:51:38 GMT

New page: '''Unreleased structure''' The entry 4npt is ON HOLD Authors: Zhang, Y., Weber, I.T. Description: Crystal Structure of HIV-1 Protease Multiple Mutant P51 Complexed with Darunavir

New page

'''Unreleased structure'''

The entry 4npt is ON HOLD

Authors: Zhang, Y., Weber, I.T.

Description: Crystal Structure of HIV-1 Protease Multiple Mutant P51 Complexed with Darunavir