4nru - Revision history

OCA at 08:35, 18 January 2023

OCA — Wed, 18 Jan 2023 08:35:43 GMT

←Older revision		Revision as of 08:35, 18 January 2023
Line 3:		Line 3:
	<StructureSection load='4nru' size='340' side='right'caption='[[4nru]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4nru' size='340' side='right'caption='[[4nru]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4nru]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Murine_norovirus_1 Murine norovirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NRU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4NRU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4nru]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Murine_norovirus_1 Murine norovirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NRU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NRU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2NG:4-({4-METHYL-3-[(3-NITROBENZOYL)AMINO]BENZOYL}AMINO)NAPHTHALENE-1,5-DISULFONIC+ACID'>2NG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2NG:4-({4-METHYL-3-[(3-NITROBENZOYL)AMINO]BENZOYL}AMINO)NAPHTHALENE-1,5-DISULFONIC+ACID'>2NG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4nru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nru OCA], [~~http~~://pdbe.org/4nru PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4nru RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4nru PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4nru ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nru OCA], [https://pdbe.org/4nru PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nru RCSB], [https://www.ebi.ac.uk/pdbsum/4nru PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nru ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q80J95_9CALI Q80J95_9CALI]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 20:

	==See Also==		==See Also==
-	*[[RNA polymerase\|RNA polymerase]]	+	*[[RNA polymerase 3D structures\|RNA polymerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 25:		Line 27:
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Murine norovirus 1]]		[[Category: Murine norovirus 1]]
-	[[Category: Bolognesi, M]]	+	[[Category: Bolognesi M]]
-	[[Category: Croci, R]]	+	[[Category: Croci R]]
-	[[Category: Mastrangelo, E]]	+	[[Category: Mastrangelo E]]
-	[[Category: Milani, M]]	+	[[Category: Milani M]]
-	[[Category: Pezzullo, M]]	+	[[Category: Pezzullo M]]
-	[[Category: Tarantino, D]]	+	[[Category: Tarantino D]]
-	~~[[Category: Murine norovirus]]~~	+
-	~~[[Category: Rna dependent rna polymerase]]~~	+
-	~~[[Category: Viral protein-transcription inhibitor complex~~]]	+

OCA at 08:55, 10 April 2019

OCA — Wed, 10 Apr 2019 08:55:31 GMT

←Older revision		Revision as of 08:55, 10 April 2019
Line 1:		Line 1:

	==Murine Norovirus RNA-dependent-RNA-polymerase in complex with Compound 6, a suramin derivative==		==Murine Norovirus RNA-dependent-RNA-polymerase in complex with Compound 6, a suramin derivative==
-	<StructureSection load='4nru' size='340' side='right' caption='[[4nru]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='4nru' size='340' side='right'caption='[[4nru]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4nru]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NRU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NRU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4nru]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Murine_norovirus_1 Murine norovirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NRU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NRU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2NG:4-({4-METHYL-3-[(3-NITROBENZOYL)AMINO]BENZOYL}AMINO)NAPHTHALENE-1,5-DISULFONIC+ACID'>2NG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2NG:4-({4-METHYL-3-[(3-NITROBENZOYL)AMINO]BENZOYL}AMINO)NAPHTHALENE-1,5-DISULFONIC+ACID'>2NG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nru OCA], [http://pdbe.org/4nru PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nru RCSB], [http://www.ebi.ac.uk/pdbsum/4nru PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nru ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nru OCA], [http://pdbe.org/4nru PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nru RCSB], [http://www.ebi.ac.uk/pdbsum/4nru PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nru ProSAT]</span></td></tr>
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Murine norovirus 1]]
	[[Category: Bolognesi, M]]		[[Category: Bolognesi, M]]
	[[Category: Croci, R]]		[[Category: Croci, R]]

OCA at 11:20, 11 August 2016

OCA — Thu, 11 Aug 2016 11:20:22 GMT

←Older revision		Revision as of 11:20, 11 August 2016
Line 1:		Line 1:
		+
	==Murine Norovirus RNA-dependent-RNA-polymerase in complex with Compound 6, a suramin derivative==		==Murine Norovirus RNA-dependent-RNA-polymerase in complex with Compound 6, a suramin derivative==
	<StructureSection load='4nru' size='340' side='right' caption='[[4nru]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4nru' size='340' side='right' caption='[[4nru]], [[Resolution\|resolution]] 2.30Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4nru]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NRU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NRU FirstGlance]. <br>		<table><tr><td colspan='2'>[[4nru]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NRU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NRU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2NG:4-({4-METHYL-3-[(3-NITROBENZOYL)AMINO]BENZOYL}AMINO)NAPHTHALENE-1,5-DISULFONIC+ACID'>2NG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2NG:4-({4-METHYL-3-[(3-NITROBENZOYL)AMINO]BENZOYL}AMINO)NAPHTHALENE-1,5-DISULFONIC+ACID'>2NG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nru OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nru RCSB], [http://www.ebi.ac.uk/pdbsum/4nru PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nru OCA], [http://pdbe.org/4nru PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nru RCSB], [http://www.ebi.ac.uk/pdbsum/4nru PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nru ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4nru" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[RNA polymerase\|RNA polymerase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:13, 25 January 2015

OCA — Sun, 25 Jan 2015 08:13:06 GMT

←Older revision		Revision as of 08:13, 25 January 2015
Line 18:		Line 18:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bolognesi, M.]]	+	[[Category: Bolognesi, M]]
-	[[Category: Croci, R.]]	+	[[Category: Croci, R]]
-	[[Category: Mastrangelo, E.]]	+	[[Category: Mastrangelo, E]]
-	[[Category: Milani, M.]]	+	[[Category: Milani, M]]
-	[[Category: Pezzullo, M.]]	+	[[Category: Pezzullo, M]]
-	[[Category: Tarantino, D.]]	+	[[Category: Tarantino, D]]
	[[Category: Murine norovirus]]		[[Category: Murine norovirus]]
	[[Category: Rna dependent rna polymerase]]		[[Category: Rna dependent rna polymerase]]
	[[Category: Viral protein-transcription inhibitor complex]]		[[Category: Viral protein-transcription inhibitor complex]]

OCA at 10:38, 20 October 2014

OCA — Mon, 20 Oct 2014 10:38:09 GMT

←Older revision		Revision as of 10:38, 20 October 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Murine Norovirus RNA-dependent-RNA-polymerase in complex with Compound 6, a suramin derivative==
		+	<StructureSection load='4nru' size='340' side='right' caption='[[4nru]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4nru]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NRU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NRU FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2NG:4-({4-METHYL-3-[(3-NITROBENZOYL)AMINO]BENZOYL}AMINO)NAPHTHALENE-1,5-DISULFONIC+ACID'>2NG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nru OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nru RCSB], [http://www.ebi.ac.uk/pdbsum/4nru PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Noroviruses (NV) are +ssRNA viruses responsible for severe gastroenteritis; no effective vaccines/antivirals are currently available. We previously identified Suramin (9) as a potent inhibitor of NV-RNA dependent RNA polymerase (NV-RdRp). Despite significant in vitro activities versus several pharmacological targets, Suramin clinical use is hampered by pharmacokinetics/toxicity problems. To improve Suramin access to NV-RdRp in vivo, a Suramin-derivative, 8, devoid of two sulphonate groups, was synthesized, achieving significant anti-human-NV-RdRp activity (IC50 = 28 nM); the compound inhibits also murine NV (mNV) RdRp. The synthesis process led to the isolation/characterization of lower molecular weight intermediates (3-7) hosting only one sulphonate head. The crystal structures of both hNV/mNV-RdRps in complex with 6, were analyzed, providing new knowledge on the interactions that a small fragment can establish with NV-RdRps, and establishing a platform for structure-guided optimization of potency, selectivity and drugability.

-	~~The entry 4nru is ON HOLD until Paper Publication~~	+	Structural bases of norovirus RNA dependent RNA polymerase inhibition by novel suramin-related compounds.,Croci R, Pezzullo M, Tarantino D, Milani M, Tsay SC, Sureshbabu R, Tsai YJ, Mastrangelo E, Rohayem J, Bolognesi M, Hwu JR PLoS One. 2014 Mar 12;9(3):e91765. doi: 10.1371/journal.pone.0091765. eCollection, 2014. PMID:24622391<ref>PMID:24622391</ref>

-	~~Authors~~: ~~Milani~~, M., Croci, R., ~~Pezzullo~~, M., Tarantino, D.~~, Mastrangelo, E., Bolognesi, M.~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: Murine ~~Norovirus RNA-~~dependent~~-RNA-~~polymerase in complex ~~with Compound 6, a suramin derivative~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Bolognesi, M.]]
		+	[[Category: Croci, R.]]
		+	[[Category: Mastrangelo, E.]]
		+	[[Category: Milani, M.]]
		+	[[Category: Pezzullo, M.]]
		+	[[Category: Tarantino, D.]]
		+	[[Category: Murine norovirus]]
		+	[[Category: Rna dependent rna polymerase]]
		+	[[Category: Viral protein-transcription inhibitor complex]]

OCA at 09:17, 8 January 2014

OCA — Wed, 08 Jan 2014 09:17:07 GMT

←Older revision		Revision as of 09:17, 8 January 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4nru is ON HOLD	+	The entry 4nru is ON HOLD until Paper Publication

	Authors: Milani, M., Croci, R., Pezzullo, M., Tarantino, D., Mastrangelo, E., Bolognesi, M.		Authors: Milani, M., Croci, R., Pezzullo, M., Tarantino, D., Mastrangelo, E., Bolognesi, M.

	Description: Murine Norovirus RNA-dependent-RNA-polymerase in complex with Compound 6, a suramin derivative		Description: Murine Norovirus RNA-dependent-RNA-polymerase in complex with Compound 6, a suramin derivative

OCA: Protected "4nru" [edit=sysop:move=sysop]

OCA — Wed, 04 Dec 2013 06:54:06 GMT

Protected "4nru" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:54, 4 December 2013

OCA: New page: '''Unreleased structure''' The entry 4nru is ON HOLD Authors: Milani, M., Croci, R., Pezzullo, M., Tarantino, D., Mastrangelo, E., Bolognesi, M. Description: Murine Norovirus RNA-depen...

OCA — Wed, 04 Dec 2013 06:54:06 GMT

New page: '''Unreleased structure''' The entry 4nru is ON HOLD Authors: Milani, M., Croci, R., Pezzullo, M., Tarantino, D., Mastrangelo, E., Bolognesi, M. Description: Murine Norovirus RNA-depen...

New page

'''Unreleased structure'''

The entry 4nru is ON HOLD

Authors: Milani, M., Croci, R., Pezzullo, M., Tarantino, D., Mastrangelo, E., Bolognesi, M.

Description: Murine Norovirus RNA-dependent-RNA-polymerase in complex with Compound 6, a suramin derivative