4nrv - Revision history

OCA at 17:02, 20 September 2023

OCA — Wed, 20 Sep 2023 17:02:46 GMT

←Older revision		Revision as of 17:02, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4nrv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NRV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NRV FirstGlance]. <br>		<table><tr><td colspan='2'>[[4nrv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NRV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NRV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.601Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nrv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nrv OCA], [https://pdbe.org/4nrv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nrv RCSB], [https://www.ebi.ac.uk/pdbsum/4nrv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nrv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nrv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nrv OCA], [https://pdbe.org/4nrv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nrv RCSB], [https://www.ebi.ac.uk/pdbsum/4nrv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nrv ProSAT]</span></td></tr>
	</table>		</table>
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4nrv" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4nrv" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Endonuclease 3D structures\|Endonuclease 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:35, 18 January 2023

OCA — Wed, 18 Jan 2023 08:35:52 GMT

←Older revision		Revision as of 08:35, 18 January 2023
Line 1:		Line 1:

	==Crystal Structure of non-edited human NEIL1==		==Crystal Structure of non-edited human NEIL1==
-	<StructureSection load='4nrv' size='340' side='right' caption='[[4nrv]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='4nrv' size='340' side='right'caption='[[4nrv]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4nrv]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NRV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4NRV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4nrv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NRV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NRV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4nrw\|4nrw]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nrv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nrv OCA], [https://pdbe.org/4nrv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nrv RCSB], [https://www.ebi.ac.uk/pdbsum/4nrv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nrv ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Endonuclease VIII (nei) 1, NEIL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4nrv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nrv OCA], [~~http~~://pdbe.org/4nrv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4nrv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4nrv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4nrv ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/NEIL1_HUMAN NEIL1_HUMAN]] Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches.<ref>PMID:12200441</ref> <ref>PMID:12509226</ref> <ref>PMID:11904416</ref> <ref>PMID:14522990</ref>	+	[https://www.uniprot.org/uniprot/NEIL1_HUMAN NEIL1_HUMAN] Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches.<ref>PMID:12200441</ref> <ref>PMID:12509226</ref> <ref>PMID:11904416</ref> <ref>PMID:14522990</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Doublie, S~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Prakash, A~~]]	+	[[Category: Doublie S]]
-	[[Category: ~~Dna glycosylase]]~~	+	[[Category: Prakash A]]
-	~~[[Category: Helix two-turns helix motif]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Zincless finger domain~~]]	+

OCA at 09:59, 4 August 2016

OCA — Thu, 04 Aug 2016 09:59:45 GMT

←Older revision		Revision as of 09:59, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of non-edited human NEIL1==		==Crystal Structure of non-edited human NEIL1==
	<StructureSection load='4nrv' size='340' side='right' caption='[[4nrv]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='4nrv' size='340' side='right' caption='[[4nrv]], [[Resolution\|resolution]] 2.60Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4nrw\|4nrw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4nrw\|4nrw]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Endonuclease VIII (nei) 1, NEIL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Endonuclease VIII (nei) 1, NEIL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nrv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nrv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nrv RCSB], [http://www.ebi.ac.uk/pdbsum/4nrv PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nrv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nrv OCA], [http://pdbe.org/4nrv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nrv RCSB], [http://www.ebi.ac.uk/pdbsum/4nrv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nrv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4nrv" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:07, 25 December 2014

OCA — Thu, 25 Dec 2014 08:07:15 GMT

←Older revision		Revision as of 08:07, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nrv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nrv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nrv RCSB], [http://www.ebi.ac.uk/pdbsum/4nrv PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nrv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nrv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nrv RCSB], [http://www.ebi.ac.uk/pdbsum/4nrv PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NEIL1_HUMAN NEIL1_HUMAN]] Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches.<ref>PMID:12200441</ref> <ref>PMID:12509226</ref> <ref>PMID:11904416</ref> <ref>PMID:14522990</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 16:37, 21 December 2014

OCA — Sun, 21 Dec 2014 16:37:59 GMT

←Older revision		Revision as of 16:37, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4nrv\| PDB=4nrv \| SCENE= }}~~	+	==Crystal Structure of non-edited human NEIL1==
-	===Crystal Structure of non-edited human NEIL1===	+	<StructureSection load='4nrv' size='340' side='right' caption='[[4nrv]], [[Resolution\|resolution]] 2.60Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24382305}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4nrv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NRV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NRV FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4nrw\|4nrw]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Endonuclease VIII (nei) 1, NEIL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nrv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nrv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nrv RCSB], [http://www.ebi.ac.uk/pdbsum/4nrv PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The repair of free-radical oxidative DNA damage is carried out by lesion-specific DNA glycosylases as the first step of the highly conserved base excision repair (BER) pathway. In humans, three orthologs of the prototypical endonuclease VIII (Nei), the Nei-like NEIL1-3 enzymes are involved in the repair of oxidized DNA lesions. In recent years, several genome and cancer single-nucleotide polymorphic variants of the NEIL1 glycosylase have been identified. In this study we characterized four variants of human NEIL1: S82C, G83D, P208S, and DeltaE28, and tested their ability to excise pyrimidine-derived lesions such as thymine glycol (Tg), 5-hydroxyuracil (5-OHU), and dihydrouracil (DHU) and the purine-derived guanidinohydantoin (Gh), spiroiminodihydantoin 1 (Sp1), and methylated 2,6-diamino-4-hydroxy-5-formamidopyrimidine (MeFapyG). The P208S variant has near wild-type activity on all substrates tested. The S82C and DeltaE28 variants exhibit decreased Tg excision compared to wild-type. G83D displays little to no activity with any of the substrates tested, with the exception of Gh and Sp1. Human NEIL1 is known to undergo editing whereby the lysine at position 242 is recoded into an arginine. The non-edited form of NEIL1 is more efficient at cleaving Tg than the R242 form, but the G83D variant does not cleave Tg regardless of the edited status of NEIL1. The corresponding G86D variant in Mimivirus Nei1 similarly lacks glycosylase activity. A structure of a G86D-DNA complex reveals a rearrangement in the beta4/5 loop comprising Leu84, the highly-conserved void-filling residue, thereby providing a structural rationale for the decreased glycosylase activity of the glycine to aspartate variant.

-	~~==Function==~~	+	Genome and cancer single nucleotide polymorphisms of the human NEIL1 DNA glycosylase: Activity, structure, and the effect of editing.,Prakash A, Carroll BL, Sweasy JB, Wallace SS, Doublie S DNA Repair (Amst). 2014 Feb;14:17-26. doi: 10.1016/j.dnarep.2013.12.003. Epub, 2013 Dec 29. PMID:24382305<ref>PMID:24382305</ref>
-	~~[[http://www.uniprot.org/uniprot/NEIL1_HUMAN NEIL1_HUMAN]] Involved in base excision repair~~ of ~~DNA damaged by oxidation or by mutagenic agents. Acts as~~ DNA glycosylase ~~that recognizes~~ and ~~removes damaged bases~~. ~~Has a preference for oxidized pyrimidines~~, ~~such as thymine glycol~~, ~~formamidopyrimidine~~ (~~Fapy~~) ~~and 5-hydroxyuracil~~. ~~Has marginal activity towards 8~~-~~oxoguanine~~. ~~Has AP (apurinic~~/~~apyrimidinic) lyase activity and introduces nicks in the DNA strand~~. ~~Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates~~. ~~Has DNA glycosylase/lyase activity towards mismatched uracil and thymine~~, ~~in particular in U:C and T:C mismatches~~.~~<ref>~~PMID:~~12200441</ref> <ref>PMID:12509226</ref> <ref>PMID:11904416</ref>~~ <ref>PMID:~~14522990~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4nrv]] is~~ a ~~1 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4NRV OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:024382305</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
-	[[Category: Doublie, S.]]	+	</StructureSection>
-	[[Category: Prakash, A.]]	+	[[Category: Human]]
		+	[[Category: Doublie, S]]
		+	[[Category: Prakash, A]]
	[[Category: Dna glycosylase]]		[[Category: Dna glycosylase]]
	[[Category: Helix two-turns helix motif]]		[[Category: Helix two-turns helix motif]]

OCA at 08:46, 5 February 2014

OCA — Wed, 05 Feb 2014 08:46:40 GMT

←Older revision		Revision as of 08:46, 5 February 2014
Line 1:		Line 1:
	{{STRUCTURE_4nrv\| PDB=4nrv \| SCENE= }}		{{STRUCTURE_4nrv\| PDB=4nrv \| SCENE= }}
	===Crystal Structure of non-edited human NEIL1===		===Crystal Structure of non-edited human NEIL1===
		+	{{ABSTRACT_PUBMED_24382305}}

	==Function==		==Function==
Line 9:		Line 10:

	==Reference==		==Reference==
-	<references group="xtra"/><references/>	+	<ref group="xtra">PMID:024382305</ref><references group="xtra"/><references/>
	[[Category: Doublie, S.]]		[[Category: Doublie, S.]]
	[[Category: Prakash, A.]]		[[Category: Prakash, A.]]

OCA at 12:16, 1 January 2014

OCA — Wed, 01 Jan 2014 12:16:41 GMT

←Older revision		Revision as of 12:16, 1 January 2014
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4nrv\| PDB=4nrv \| SCENE= }}
		+	===Crystal Structure of non-edited human NEIL1===

-	~~The entry 4nrv is ON HOLD~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/NEIL1_HUMAN NEIL1_HUMAN]] Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches.<ref>PMID:12200441</ref> <ref>PMID:12509226</ref> <ref>PMID:11904416</ref> <ref>PMID:14522990</ref>

-	~~Authors~~: ~~Prakash, A~~.~~, Doublie, S~~.	+	==About this Structure==
		+	[[4nrv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NRV OCA].

-	~~Description~~: ~~Crystal Structure of non~~-~~edited human NEIL1~~	+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Doublie, S.]]
		+	[[Category: Prakash, A.]]
		+	[[Category: Dna glycosylase]]
		+	[[Category: Helix two-turns helix motif]]
		+	[[Category: Hydrolase]]
		+	[[Category: Lyase]]
		+	[[Category: Zincless finger domain]]

OCA: Protected "4nrv" [edit=sysop:move=sysop]

OCA — Wed, 04 Dec 2013 06:54:08 GMT

Protected "4nrv" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:54, 4 December 2013

OCA: New page: '''Unreleased structure''' The entry 4nrv is ON HOLD Authors: Prakash, A., Doublie, S. Description: Crystal Structure of non-edited human NEIL1

OCA — Wed, 04 Dec 2013 06:54:07 GMT

New page: '''Unreleased structure''' The entry 4nrv is ON HOLD Authors: Prakash, A., Doublie, S. Description: Crystal Structure of non-edited human NEIL1

New page

'''Unreleased structure'''

The entry 4nrv is ON HOLD

Authors: Prakash, A., Doublie, S.

Description: Crystal Structure of non-edited human NEIL1