4nuu - Revision history

OCA at 14:07, 13 March 2024

OCA — Wed, 13 Mar 2024 14:07:31 GMT

←Older revision		Revision as of 14:07, 13 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4nuu]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Plasmodium_vivax_Sal-1 Plasmodium vivax Sal-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NUU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NUU FirstGlance]. <br>		<table><tr><td colspan='2'>[[4nuu]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Plasmodium_vivax_Sal-1 Plasmodium vivax Sal-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NUU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NUU FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nuu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nuu OCA], [https://pdbe.org/4nuu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nuu RCSB], [https://www.ebi.ac.uk/pdbsum/4nuu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nuu ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.95Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nuu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nuu OCA], [https://pdbe.org/4nuu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nuu RCSB], [https://www.ebi.ac.uk/pdbsum/4nuu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nuu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/PVDR_PLAVS PVDR_PLAVS] Binds to the human erythrocytes Duffy blood group determinant.		[https://www.uniprot.org/uniprot/PVDR_PLAVS PVDR_PLAVS] Binds to the human erythrocytes Duffy blood group determinant.
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Plasmodium parasites use specialized ligands which bind to red blood cell (RBC) receptors during invasion. Defining the mechanism of receptor recognition is essential for the design of interventions against malaria. Here, we present the structural basis for Duffy antigen (DARC) engagement by P. vivax Duffy binding protein (DBP). We used NMR to map the core region of the DARC ectodomain contacted by the receptor binding domain of DBP (DBP-RII) and solved two distinct crystal structures of DBP-RII bound to this core region of DARC. Isothermal titration calorimetry studies show these structures are part of a multi-step binding pathway, and individual point mutations of residues contacting DARC result in a complete loss of RBC binding by DBP-RII. Two DBP-RII molecules sandwich either one or two DARC ectodomains, creating distinct heterotrimeric and heterotetrameric architectures. The DARC N-terminus forms an amphipathic helix upon DBP-RII binding. The studies reveal a receptor binding pocket in DBP and critical contacts in DARC, reveal novel targets for intervention, and suggest that targeting the critical DARC binding sites will lead to potent disruption of RBC engagement as complex assembly is dependent on DARC binding. These results allow for models to examine inter-species infection barriers, Plasmodium immune evasion mechanisms, P. knowlesi receptor-ligand specificity, and mechanisms of naturally acquired P. vivax immunity. The step-wise binding model identifies a possible mechanism by which signaling pathways could be activated during invasion. It is anticipated that the structural basis of DBP host-cell engagement will enable development of rational therapeutics targeting this interaction.
-
-	Red Blood Cell Invasion by Plasmodium vivax: Structural Basis for DBP Engagement of DARC.,Batchelor JD, Malpede BM, Omattage NS, Dekoster GT, Henzler-Wildman KA, Tolia NH PLoS Pathog. 2014 Jan;10(1):e1003869. doi: 10.1371/journal.ppat.1003869. Epub, 2014 Jan 9. PMID:24415938<ref>PMID:24415938</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4nuu" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Erythrocyte binding antigen\|Erythrocyte binding antigen]]		*[[Erythrocyte binding antigen\|Erythrocyte binding antigen]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:41, 18 January 2023

OCA — Wed, 18 Jan 2023 08:41:07 GMT

←Older revision		Revision as of 08:41, 18 January 2023
Line 1:		Line 1:

	==Heterotrimer structure of Region II from Plasmodium vivax Duffy Binding Protein (PvDBP) bound to the ectodomain of the Duffy Antigen Receptor for Chemokines (DARC)==		==Heterotrimer structure of Region II from Plasmodium vivax Duffy Binding Protein (PvDBP) bound to the ectodomain of the Duffy Antigen Receptor for Chemokines (DARC)==
-	<StructureSection load='4nuu' size='340' side='right' caption='[[4nuu]], [[Resolution\|resolution]] 1.95Å' scene=''>	+	<StructureSection load='4nuu' size='340' side='right'caption='[[4nuu]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4nuu]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~] and [~~http~~://en.wikipedia.org/wiki/~~Plavs Plavs~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NUU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4NUU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4nuu]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Plasmodium_vivax_Sal-1 Plasmodium vivax Sal-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NUU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NUU FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4nuv\|4nuv]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nuu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nuu OCA], [https://pdbe.org/4nuu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nuu RCSB], [https://www.ebi.ac.uk/pdbsum/4nuu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nuu ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PVDR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=126793 PLAVS]), DARC, ACKR1, FY, GPD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4nuu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nuu OCA], [~~http~~://pdbe.org/4nuu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4nuu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4nuu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4nuu ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PVDR_PLAVS PVDR_PLAVS]] Binds to the human erythrocytes Duffy blood group determinant. [[http://www.uniprot.org/uniprot/ACKR1_HUMAN ACKR1_HUMAN]] Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.	+	[https://www.uniprot.org/uniprot/PVDR_PLAVS PVDR_PLAVS] Binds to the human erythrocytes Duffy blood group determinant.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 17:
	</div>		</div>
	<div class="pdbe-citations 4nuu" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4nuu" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Erythrocyte binding antigen\|Erythrocyte binding antigen]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Plavs~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Tolia, N H~~]]	+	[[Category: Plasmodium vivax Sal-1]]
-	[[Category: ~~Adhesion]]~~	+	[[Category: Tolia NH]]
-	~~[[Category: Cell invasion]]~~	+
-	~~[[Category: Chemokine binding]]~~	+
-	~~[[Category: Duffy antigen receptor for chemokine]]~~	+
-	~~[[Category: Gpcr]]~~	+
-	~~[[Category: Invasion]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Red blood cell binding~~]]	+

OCA at 16:15, 4 August 2016

OCA — Thu, 04 Aug 2016 16:15:37 GMT

←Older revision		Revision as of 16:15, 4 August 2016
Line 1:		Line 1:
		+
	==Heterotrimer structure of Region II from Plasmodium vivax Duffy Binding Protein (PvDBP) bound to the ectodomain of the Duffy Antigen Receptor for Chemokines (DARC)==		==Heterotrimer structure of Region II from Plasmodium vivax Duffy Binding Protein (PvDBP) bound to the ectodomain of the Duffy Antigen Receptor for Chemokines (DARC)==
	<StructureSection load='4nuu' size='340' side='right' caption='[[4nuu]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='4nuu' size='340' side='right' caption='[[4nuu]], [[Resolution\|resolution]] 1.95Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4nuv\|4nuv]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4nuv\|4nuv]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PVDR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=126793 PLAVS]), DARC, ACKR1, FY, GPD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PVDR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=126793 PLAVS]), DARC, ACKR1, FY, GPD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nuu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nuu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nuu RCSB], [http://www.ebi.ac.uk/pdbsum/4nuu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nuu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nuu OCA], [http://pdbe.org/4nuu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nuu RCSB], [http://www.ebi.ac.uk/pdbsum/4nuu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nuu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4nuu" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:55, 25 December 2014

OCA — Thu, 25 Dec 2014 10:55:47 GMT

←Older revision		Revision as of 10:55, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nuu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nuu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nuu RCSB], [http://www.ebi.ac.uk/pdbsum/4nuu PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nuu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nuu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nuu RCSB], [http://www.ebi.ac.uk/pdbsum/4nuu PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PVDR_PLAVS PVDR_PLAVS]] Binds to the human erythrocytes Duffy blood group determinant. [[http://www.uniprot.org/uniprot/ACKR1_HUMAN ACKR1_HUMAN]] Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 18:27, 21 December 2014

OCA — Sun, 21 Dec 2014 18:27:07 GMT

←Older revision		Revision as of 18:27, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4nuu\| PDB=4nuu \| SCENE= }}~~	+	==Heterotrimer structure of Region II from Plasmodium vivax Duffy Binding Protein (PvDBP) bound to the ectodomain of the Duffy Antigen Receptor for Chemokines (DARC)==
-	===Heterotrimer structure of Region II from Plasmodium vivax Duffy Binding Protein (PvDBP) bound to the ectodomain of the Duffy Antigen Receptor for Chemokines (DARC)===	+	<StructureSection load='4nuu' size='340' side='right' caption='[[4nuu]], [[Resolution\|resolution]] 1.95Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24415938}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4nuu]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Plavs Plavs]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NUU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NUU FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4nuv\|4nuv]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PVDR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=126793 PLAVS]), DARC, ACKR1, FY, GPD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nuu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nuu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nuu RCSB], [http://www.ebi.ac.uk/pdbsum/4nuu PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Plasmodium parasites use specialized ligands which bind to red blood cell (RBC) receptors during invasion. Defining the mechanism of receptor recognition is essential for the design of interventions against malaria. Here, we present the structural basis for Duffy antigen (DARC) engagement by P. vivax Duffy binding protein (DBP). We used NMR to map the core region of the DARC ectodomain contacted by the receptor binding domain of DBP (DBP-RII) and solved two distinct crystal structures of DBP-RII bound to this core region of DARC. Isothermal titration calorimetry studies show these structures are part of a multi-step binding pathway, and individual point mutations of residues contacting DARC result in a complete loss of RBC binding by DBP-RII. Two DBP-RII molecules sandwich either one or two DARC ectodomains, creating distinct heterotrimeric and heterotetrameric architectures. The DARC N-terminus forms an amphipathic helix upon DBP-RII binding. The studies reveal a receptor binding pocket in DBP and critical contacts in DARC, reveal novel targets for intervention, and suggest that targeting the critical DARC binding sites will lead to potent disruption of RBC engagement as complex assembly is dependent on DARC binding. These results allow for models to examine inter-species infection barriers, Plasmodium immune evasion mechanisms, P. knowlesi receptor-ligand specificity, and mechanisms of naturally acquired P. vivax immunity. The step-wise binding model identifies a possible mechanism by which signaling pathways could be activated during invasion. It is anticipated that the structural basis of DBP host-cell engagement will enable development of rational therapeutics targeting this interaction.

-	~~==Function==~~	+	Red Blood Cell Invasion by Plasmodium vivax: Structural Basis for DBP Engagement of DARC.,Batchelor JD, Malpede BM, Omattage NS, Dekoster GT, Henzler-Wildman KA, Tolia NH PLoS Pathog. 2014 Jan;10(1):e1003869. doi: 10.1371/journal.ppat.1003869. Epub, 2014 Jan 9. PMID:24415938<ref>PMID:24415938</ref>
-	~~[[http~~:~~//www~~.uniprot.org/uniprot/PVDR_PLAVS PVDR_PLAVS]] Binds to the human erythrocytes Duffy blood group determinant. [[http://www.uniprot.org/uniprot/ACKR1_HUMAN ACKR1_HUMAN]] Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, ~~resulting instead in chemokine sequestration~~, ~~degradation~~, ~~or transcytosis~~. ~~Also known as interceptor~~ (~~internalizing receptor~~) ~~or chemokine-scavenging receptor or chemokine decoy receptor~~. ~~Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines~~. ~~Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8~~/~~CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P~~.~~vivax and P~~.~~knowlesi~~. ~~May regulate chemokine bioavailability and~~, ~~consequently, leukocyte recruitment through two distinct mechanisms~~: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4nuu]] is~~ a ~~3 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4NUU OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:024415938</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
-	[[Category: Tolia, N H.]]	+	</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Plavs]]
		+	[[Category: Tolia, N H]]
	[[Category: Adhesion]]		[[Category: Adhesion]]
	[[Category: Cell invasion]]		[[Category: Cell invasion]]

OCA at 11:06, 5 February 2014

OCA — Wed, 05 Feb 2014 11:06:29 GMT

←Older revision		Revision as of 11:06, 5 February 2014
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4nuu\| PDB=4nuu \| SCENE= }}
		+	===Heterotrimer structure of Region II from Plasmodium vivax Duffy Binding Protein (PvDBP) bound to the ectodomain of the Duffy Antigen Receptor for Chemokines (DARC)===
		+	{{ABSTRACT_PUBMED_24415938}}

-	~~The entry 4nuu~~ is ~~ON HOLD until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/PVDR_PLAVS PVDR_PLAVS]] Binds to the human erythrocytes Duffy blood group determinant. [[http://www.uniprot.org/uniprot/ACKR1_HUMAN ACKR1_HUMAN]] Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.

-	~~Authors~~: ~~Tolia, N~~.H.	+	==About this Structure==
		+	[[4nuu]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NUU OCA].

-	~~Description~~: ~~Heterotrimer structure of Region II from Plasmodium vivax~~ Duffy ~~Binding Protein (PvDBP) bound to the ectodomain of the Duffy Antigen Receptor~~ for ~~Chemokines (DARC)~~	+	==Reference==
		+	<ref group="xtra">PMID:024415938</ref><references group="xtra"/><references/>
		+	[[Category: Tolia, N H.]]
		+	[[Category: Adhesion]]
		+	[[Category: Cell invasion]]
		+	[[Category: Chemokine binding]]
		+	[[Category: Duffy antigen receptor for chemokine]]
		+	[[Category: Gpcr]]
		+	[[Category: Invasion]]
		+	[[Category: Membrane]]
		+	[[Category: Membrane protein]]
		+	[[Category: Protein binding]]
		+	[[Category: Red blood cell binding]]

OCA at 09:23, 18 December 2013

OCA — Wed, 18 Dec 2013 09:23:07 GMT

←Older revision		Revision as of 09:23, 18 December 2013
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4nuu is ON HOLD	+	The entry 4nuu is ON HOLD until Paper Publication

	Authors: Tolia, N.H.		Authors: Tolia, N.H.

	Description: Heterotrimer structure of Region II from Plasmodium vivax Duffy Binding Protein (PvDBP) bound to the ectodomain of the Duffy Antigen Receptor for Chemokines (DARC)		Description: Heterotrimer structure of Region II from Plasmodium vivax Duffy Binding Protein (PvDBP) bound to the ectodomain of the Duffy Antigen Receptor for Chemokines (DARC)

OCA: Protected "4nuu" [edit=sysop:move=sysop]

OCA — Wed, 11 Dec 2013 13:09:16 GMT

Protected "4nuu" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:09, 11 December 2013

OCA: New page: '''Unreleased structure''' The entry 4nuu is ON HOLD Authors: Tolia, N.H. Description: Heterotrimer structure of Region II from Plasmodium vivax Duffy Binding Protein (PvDBP) bound to ...

OCA — Wed, 11 Dec 2013 13:09:14 GMT

New page: '''Unreleased structure''' The entry 4nuu is ON HOLD Authors: Tolia, N.H. Description: Heterotrimer structure of Region II from Plasmodium vivax Duffy Binding Protein (PvDBP) bound to ...

New page

'''Unreleased structure'''

The entry 4nuu is ON HOLD

Authors: Tolia, N.H.

Description: Heterotrimer structure of Region II from Plasmodium vivax Duffy Binding Protein (PvDBP) bound to the ectodomain of the Duffy Antigen Receptor for Chemokines (DARC)