4nwg - Revision history

OCA at 12:36, 1 March 2024

OCA — Fri, 01 Mar 2024 12:36:04 GMT

←Older revision		Revision as of 12:36, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4nwg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NWG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NWG FirstGlance]. <br>		<table><tr><td colspan='2'>[[4nwg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NWG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NWG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.45Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nwg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nwg OCA], [https://pdbe.org/4nwg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nwg RCSB], [https://www.ebi.ac.uk/pdbsum/4nwg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nwg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nwg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nwg OCA], [https://pdbe.org/4nwg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nwg RCSB], [https://www.ebi.ac.uk/pdbsum/4nwg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nwg ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:43, 18 January 2023

OCA — Wed, 18 Jan 2023 08:43:44 GMT

←Older revision		Revision as of 08:43, 18 January 2023
Line 3:		Line 3:
	<StructureSection load='4nwg' size='340' side='right'caption='[[4nwg]], [[Resolution\|resolution]] 2.45Å' scene=''>		<StructureSection load='4nwg' size='340' side='right'caption='[[4nwg]], [[Resolution\|resolution]] 2.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4nwg]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NWG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4NWG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4nwg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NWG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NWG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4nwf\|4nwf]], [[4nxd\|4nxd]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nwg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nwg OCA], [https://pdbe.org/4nwg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nwg RCSB], [https://www.ebi.ac.uk/pdbsum/4nwg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nwg ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PTPN11, PTP2C, SHPTP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4nwg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nwg OCA], [~~http~~://pdbe.org/4nwg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4nwg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4nwg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4nwg ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/PTN11_HUMAN PTN11_HUMAN]] Defects in PTPN11 are the cause of LEOPARD syndrome type 1 (LEOPARD1) [MIM:[~~http~~://omim.org/entry/151100 151100]]. It is an autosomal dominant disorder allelic with Noonan syndrome. The acronym LEOPARD stands for lentigines, electrocardiographic conduction abnormalities, ocular hypertelorism, pulmonic stenosis, abnormalities of genitalia, retardation of growth, and deafness.<ref>PMID:12058348</ref> <ref>PMID:14961557</ref> <ref>PMID:15389709</ref> <ref>PMID:15520399</ref> <ref>PMID:15121796</ref> <ref>PMID:15690106</ref> <ref>PMID:16679933</ref> Defects in PTPN11 are the cause of Noonan syndrome type 1 (NS1) [MIM:[~~http~~://omim.org/entry/163950 163950]]. Noonan syndrome (NS) is a disorder characterized by dysmorphic facial features, short stature, hypertelorism, cardiac anomalies, deafness, motor delay, and a bleeding diathesis. Some patients with Noonan syndrome type 1 develop multiple giant cell lesions of the jaw or other bony or soft tissues, which are classified as pigmented villomoduolar synovitis (PVNS) when occurring in the jaw or joints. Note=Mutations in PTPN11 account for more than 50% of the cases. Rarely, NS is associated with juvenile myelomonocytic leukemia (JMML). NS1 inheritance is autosomal dominant.<ref>PMID:11704759</ref> <ref>PMID:11992261</ref> <ref>PMID:12325025</ref> <ref>PMID:12161469</ref> <ref>PMID:12529711</ref> <ref>PMID:12634870</ref> <ref>PMID:12739139</ref> <ref>PMID:12960218</ref> <ref>PMID:12717436</ref> <ref>PMID:15384080</ref> <ref>PMID:15948193</ref> <ref>PMID:19020799</ref> Defects in PTPN11 are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:[~~http~~://omim.org/entry/607785 607785]]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. It is characterized by leukocytosis with tissue infiltration and in vitro hypersensitivity of myeloid progenitors to granulocyte-macrophage colony stimulating factor.<ref>PMID:12717436</ref> Defects in PTPN11 are a cause of metachondromatosis (MC) [MIM:[~~http~~://omim.org/entry/156250 156250]]. It is a skeletal disorder with radiologic fetarures of both multiple exostoses and Ollier disease, characterized by the presence of multiple enchondromas and osteochondroma-like lesions.<ref>PMID:20577567</ref>	+	[https://www.uniprot.org/uniprot/PTN11_HUMAN PTN11_HUMAN] Defects in PTPN11 are the cause of LEOPARD syndrome type 1 (LEOPARD1) [MIM:[https://omim.org/entry/151100 151100]. It is an autosomal dominant disorder allelic with Noonan syndrome. The acronym LEOPARD stands for lentigines, electrocardiographic conduction abnormalities, ocular hypertelorism, pulmonic stenosis, abnormalities of genitalia, retardation of growth, and deafness.<ref>PMID:12058348</ref> <ref>PMID:14961557</ref> <ref>PMID:15389709</ref> <ref>PMID:15520399</ref> <ref>PMID:15121796</ref> <ref>PMID:15690106</ref> <ref>PMID:16679933</ref> Defects in PTPN11 are the cause of Noonan syndrome type 1 (NS1) [MIM:[https://omim.org/entry/163950 163950]. Noonan syndrome (NS) is a disorder characterized by dysmorphic facial features, short stature, hypertelorism, cardiac anomalies, deafness, motor delay, and a bleeding diathesis. Some patients with Noonan syndrome type 1 develop multiple giant cell lesions of the jaw or other bony or soft tissues, which are classified as pigmented villomoduolar synovitis (PVNS) when occurring in the jaw or joints. Note=Mutations in PTPN11 account for more than 50% of the cases. Rarely, NS is associated with juvenile myelomonocytic leukemia (JMML). NS1 inheritance is autosomal dominant.<ref>PMID:11704759</ref> <ref>PMID:11992261</ref> <ref>PMID:12325025</ref> <ref>PMID:12161469</ref> <ref>PMID:12529711</ref> <ref>PMID:12634870</ref> <ref>PMID:12739139</ref> <ref>PMID:12960218</ref> <ref>PMID:12717436</ref> <ref>PMID:15384080</ref> <ref>PMID:15948193</ref> <ref>PMID:19020799</ref> Defects in PTPN11 are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:[https://omim.org/entry/607785 607785]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. It is characterized by leukocytosis with tissue infiltration and in vitro hypersensitivity of myeloid progenitors to granulocyte-macrophage colony stimulating factor.<ref>PMID:12717436</ref> Defects in PTPN11 are a cause of metachondromatosis (MC) [MIM:[https://omim.org/entry/156250 156250]. It is a skeletal disorder with radiologic fetarures of both multiple exostoses and Ollier disease, characterized by the presence of multiple enchondromas and osteochondroma-like lesions.<ref>PMID:20577567</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PTN11_HUMAN PTN11_HUMAN]] Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.<ref>PMID:10655584</ref> <ref>PMID:18829466</ref> <ref>PMID:18559669</ref>	+	[https://www.uniprot.org/uniprot/PTN11_HUMAN PTN11_HUMAN] Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.<ref>PMID:10655584</ref> <ref>PMID:18829466</ref> <ref>PMID:18559669</ref>

	==See Also==		==See Also==
-	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]	+	*[[Tyrosine phosphatase 3D structures\|Tyrosine phosphatase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Protein-tyrosine-phosphatase]]~~	+	[[Category: Battalie K]]
-	[[Category: Battalie, K]]	+	[[Category: Chirgadze NY]]
-	[[Category: Chirgadze~~, N Y~~]]	+	[[Category: Hutchinson A]]
-	[[Category: Hutchinson, A]]	+	[[Category: Kisselman G]]
-	[[Category: Kisselman, G]]	+	[[Category: Lam K]]
-	[[Category: Lam, K]]	+	[[Category: Lin A]]
-	[[Category: Lin, A]]	+	[[Category: Qiu W]]
-	[[Category: Qiu, W]]	+	[[Category: Romanov V]]
-	[[Category: Romanov, V]]	+	[[Category: Ruzanov M]]
-	[[Category: Ruzanov, M]]	+	[[Category: Thompson C]]
-	[[Category: Thompson, C]]	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 09:06, 10 April 2019

OCA — Wed, 10 Apr 2019 09:06:19 GMT

←Older revision		Revision as of 09:06, 10 April 2019
Line 1:		Line 1:

	==Crystal structure of the tyrosine phosphatase SHP-2 with E139D mutation==		==Crystal structure of the tyrosine phosphatase SHP-2 with E139D mutation==
-	<StructureSection load='4nwg' size='340' side='right' caption='[[4nwg]], [[Resolution\|resolution]] 2.45Å' scene=''>	+	<StructureSection load='4nwg' size='340' side='right'caption='[[4nwg]], [[Resolution\|resolution]] 2.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4nwg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NWG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NWG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4nwg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NWG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NWG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4nwf\|4nwf]], [[4nxd\|4nxd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4nwf\|4nwf]], [[4nxd\|4nxd]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PTPN11, PTP2C, SHPTP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nwg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nwg OCA], [http://pdbe.org/4nwg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nwg RCSB], [http://www.ebi.ac.uk/pdbsum/4nwg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nwg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nwg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nwg OCA], [http://pdbe.org/4nwg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nwg RCSB], [http://www.ebi.ac.uk/pdbsum/4nwg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nwg ProSAT]</span></td></tr>
Line 20:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Protein-tyrosine-phosphatase]]		[[Category: Protein-tyrosine-phosphatase]]
	[[Category: Battalie, K]]		[[Category: Battalie, K]]

OCA at 17:07, 2 January 2017

OCA — Mon, 02 Jan 2017 17:07:43 GMT

←Older revision		Revision as of 17:07, 2 January 2017
Line 1:		Line 1:
		+
	==Crystal structure of the tyrosine phosphatase SHP-2 with E139D mutation==		==Crystal structure of the tyrosine phosphatase SHP-2 with E139D mutation==
	<StructureSection load='4nwg' size='340' side='right' caption='[[4nwg]], [[Resolution\|resolution]] 2.45Å' scene=''>		<StructureSection load='4nwg' size='340' side='right' caption='[[4nwg]], [[Resolution\|resolution]] 2.45Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4nwf\|4nwf]], [[4nxd\|4nxd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4nwf\|4nwf]], [[4nxd\|4nxd]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nwg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nwg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nwg RCSB], [http://www.ebi.ac.uk/pdbsum/4nwg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nwg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nwg OCA], [http://pdbe.org/4nwg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nwg RCSB], [http://www.ebi.ac.uk/pdbsum/4nwg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nwg ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 12:		Line 13:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/PTN11_HUMAN PTN11_HUMAN]] Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.<ref>PMID:10655584</ref> <ref>PMID:18829466</ref> <ref>PMID:18559669</ref>		[[http://www.uniprot.org/uniprot/PTN11_HUMAN PTN11_HUMAN]] Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.<ref>PMID:10655584</ref> <ref>PMID:18829466</ref> <ref>PMID:18559669</ref>
		+
		+	==See Also==
		+	*[[Tyrosine phosphatase\|Tyrosine phosphatase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:21, 10 December 2014

OCA — Wed, 10 Dec 2014 16:21:29 GMT

←Older revision		Revision as of 16:21, 10 December 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of the tyrosine phosphatase SHP-2 with E139D mutation==
-		+	<StructureSection load='4nwg' size='340' side='right' caption='[[4nwg]], [[Resolution\|resolution]] 2.45Å' scene=''>
-	~~The entry~~ 4nwg is ~~ON HOLD until Dec 06 2015~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4nwg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NWG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NWG FirstGlance]. <br>
-	~~Authors~~: ~~Qiu~~, W., ~~Lin~~, A., ~~Hutchinson~~, A., ~~Romanov~~, V., ~~Ruzanov~~, M., ~~Thompson~~, C., ~~Lam~~, K., ~~Kisselman~~, G., ~~Battalie~~, K., ~~Chirgadze~~, N.Y.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4nwf\|4nwf]], [[4nxd\|4nxd]]</td></tr>
-	~~Description~~: ~~Crystal structure~~ of the tyrosine ~~phosphatase SHP~~-~~2 with E139D mutation~~	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nwg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nwg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nwg RCSB], [http://www.ebi.ac.uk/pdbsum/4nwg PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/PTN11_HUMAN PTN11_HUMAN]] Defects in PTPN11 are the cause of LEOPARD syndrome type 1 (LEOPARD1) [MIM:[http://omim.org/entry/151100 151100]]. It is an autosomal dominant disorder allelic with Noonan syndrome. The acronym LEOPARD stands for lentigines, electrocardiographic conduction abnormalities, ocular hypertelorism, pulmonic stenosis, abnormalities of genitalia, retardation of growth, and deafness.<ref>PMID:12058348</ref> <ref>PMID:14961557</ref> <ref>PMID:15389709</ref> <ref>PMID:15520399</ref> <ref>PMID:15121796</ref> <ref>PMID:15690106</ref> <ref>PMID:16679933</ref> Defects in PTPN11 are the cause of Noonan syndrome type 1 (NS1) [MIM:[http://omim.org/entry/163950 163950]]. Noonan syndrome (NS) is a disorder characterized by dysmorphic facial features, short stature, hypertelorism, cardiac anomalies, deafness, motor delay, and a bleeding diathesis. Some patients with Noonan syndrome type 1 develop multiple giant cell lesions of the jaw or other bony or soft tissues, which are classified as pigmented villomoduolar synovitis (PVNS) when occurring in the jaw or joints. Note=Mutations in PTPN11 account for more than 50% of the cases. Rarely, NS is associated with juvenile myelomonocytic leukemia (JMML). NS1 inheritance is autosomal dominant.<ref>PMID:11704759</ref> <ref>PMID:11992261</ref> <ref>PMID:12325025</ref> <ref>PMID:12161469</ref> <ref>PMID:12529711</ref> <ref>PMID:12634870</ref> <ref>PMID:12739139</ref> <ref>PMID:12960218</ref> <ref>PMID:12717436</ref> <ref>PMID:15384080</ref> <ref>PMID:15948193</ref> <ref>PMID:19020799</ref> Defects in PTPN11 are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:[http://omim.org/entry/607785 607785]]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. It is characterized by leukocytosis with tissue infiltration and in vitro hypersensitivity of myeloid progenitors to granulocyte-macrophage colony stimulating factor.<ref>PMID:12717436</ref> Defects in PTPN11 are a cause of metachondromatosis (MC) [MIM:[http://omim.org/entry/156250 156250]]. It is a skeletal disorder with radiologic fetarures of both multiple exostoses and Ollier disease, characterized by the presence of multiple enchondromas and osteochondroma-like lesions.<ref>PMID:20577567</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PTN11_HUMAN PTN11_HUMAN]] Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.<ref>PMID:10655584</ref> <ref>PMID:18829466</ref> <ref>PMID:18559669</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Protein-tyrosine-phosphatase]]
		+	[[Category: Battalie, K]]
		+	[[Category: Chirgadze, N Y]]
		+	[[Category: Hutchinson, A]]
		+	[[Category: Kisselman, G]]
		+	[[Category: Lam, K]]
		+	[[Category: Lin, A]]
		+	[[Category: Qiu, W]]
		+	[[Category: Romanov, V]]
		+	[[Category: Ruzanov, M]]
		+	[[Category: Thompson, C]]
		+	[[Category: Hydrolase]]

OCA at 12:09, 12 March 2014

OCA — Wed, 12 Mar 2014 12:09:10 GMT

←Older revision		Revision as of 12:09, 12 March 2014
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4nwg is ON HOLD	+	The entry 4nwg is ON HOLD until Dec 06 2015

	Authors: Qiu, W., Lin, A., Hutchinson, A., Romanov, V., Ruzanov, M., Thompson, C., Lam, K., Kisselman, G., Battalie, K., Chirgadze, N.Y.		Authors: Qiu, W., Lin, A., Hutchinson, A., Romanov, V., Ruzanov, M., Thompson, C., Lam, K., Kisselman, G., Battalie, K., Chirgadze, N.Y.

	Description: Crystal structure of the tyrosine phosphatase SHP-2 with E139D mutation		Description: Crystal structure of the tyrosine phosphatase SHP-2 with E139D mutation

OCA at 07:38, 15 January 2014

OCA — Wed, 15 Jan 2014 07:38:23 GMT

←Older revision		Revision as of 07:38, 15 January 2014
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	The entry 4nwg is ON HOLD		The entry 4nwg is ON HOLD

-	Authors: Qiu, W, Lin, A. , Hutchinson, A. , Romanov, V. , Ruzanov, M. , Thompson, C. , Lam, K. , Kisselman, G. , Battalie, K. , Chirgadze, N. Y.	+	Authors: Qiu, W., Lin, A., Hutchinson, A., Romanov, V., Ruzanov, M., Thompson, C., Lam, K., Kisselman, G., Battalie, K., Chirgadze, N.Y.

	Description: Crystal structure of the tyrosine phosphatase SHP-2 with E139D mutation		Description: Crystal structure of the tyrosine phosphatase SHP-2 with E139D mutation

OCA: Protected "4nwg" [edit=sysop:move=sysop]

OCA — Wed, 18 Dec 2013 09:24:01 GMT

Protected "4nwg" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:24, 18 December 2013

OCA: New page: '''Unreleased structure''' The entry 4nwg is ON HOLD Authors: Qiu, W, Lin, A. , Hutchinson, A. , Romanov, V. , Ruzanov, M. , Thompson, C. , Lam, K. , Kisselman, G. , Battalie, K. , Chir...

OCA — Wed, 18 Dec 2013 09:23:59 GMT

New page: '''Unreleased structure''' The entry 4nwg is ON HOLD Authors: Qiu, W, Lin, A. , Hutchinson, A. , Romanov, V. , Ruzanov, M. , Thompson, C. , Lam, K. , Kisselman, G. , Battalie, K. , Chir...

New page

'''Unreleased structure'''

The entry 4nwg is ON HOLD

Authors: Qiu, W, Lin, A. , Hutchinson, A. , Romanov, V. , Ruzanov, M. , Thompson, C. , Lam, K. , Kisselman, G. , Battalie, K. , Chirgadze, N. Y.

Description: Crystal structure of the tyrosine phosphatase SHP-2 with E139D mutation