4nwy - Revision history

OCA at 11:48, 5 August 2016

OCA — Fri, 05 Aug 2016 11:48:11 GMT

←Older revision		Revision as of 11:48, 5 August 2016
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		+
	==Crystal structure of the b' domain of human protein disulfide isomerase-like protein of the testis (PDILT)==		==Crystal structure of the b' domain of human protein disulfide isomerase-like protein of the testis (PDILT)==
	<StructureSection load='4nwy' size='340' side='right' caption='[[4nwy]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4nwy' size='340' side='right' caption='[[4nwy]], [[Resolution\|resolution]] 2.00Å' scene=''>
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDILT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDILT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_disulfide-isomerase Protein disulfide-isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.4.1 5.3.4.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_disulfide-isomerase Protein disulfide-isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.4.1 5.3.4.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nwy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nwy RCSB], [http://www.ebi.ac.uk/pdbsum/4nwy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nwy OCA], [http://pdbe.org/4nwy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nwy RCSB], [http://www.ebi.ac.uk/pdbsum/4nwy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nwy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4nwy" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:34, 25 December 2014

OCA — Thu, 25 Dec 2014 18:34:06 GMT

←Older revision		Revision as of 18:34, 25 December 2014
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-	~~{{STRUCTURE_4nwy\| PDB=4nwy \| SCENE= }}~~	+	==Crystal structure of the b' domain of human protein disulfide isomerase-like protein of the testis (PDILT)==
-	===Crystal structure of the b' domain of human protein disulfide isomerase-like protein of the testis (PDILT)===	+	<StructureSection load='4nwy' size='340' side='right' caption='[[4nwy]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24662985}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4nwy]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NWY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NWY FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PDILT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_disulfide-isomerase Protein disulfide-isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.4.1 5.3.4.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nwy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nwy RCSB], [http://www.ebi.ac.uk/pdbsum/4nwy PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/PDILT_HUMAN PDILT_HUMAN]] Probable redox-inactive chaperone involved in spermatogenesis.<ref>PMID:17507649</ref>		[[http://www.uniprot.org/uniprot/PDILT_HUMAN PDILT_HUMAN]] Probable redox-inactive chaperone involved in spermatogenesis.<ref>PMID:17507649</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Protein Disulfide Isomerase-Like protein of the Testis (PDILT) is a testis-specific member of the PDI family. PDILT displays similar domain architecture to PDIA1, the founding member of this protein family, but lacks catalytic cysteines needed for oxidoreduction reactions. This suggests special importance of chaperone activity of PDILT, but how it recognizes misfolded protein substrates is unknown. Here, we report the high-resolution crystal structure of the b' domain of human PDILT. The structure reveals a conserved hydrophobic pocket, which is likely a principal substrate-binding site in PDILT. In the crystal, this pocket is occupied by side chains of tyrosine and tryptophan residues from another PDILT molecule, suggesting a preference for binding exposed aromatic residues in protein substrates. The lack of interaction of the b' domain with the P-domains of calreticulin-3 and calmegin hints at a novel way of interaction between testis-specific lectin chaperones and PDILT. Further studies of this recently discovered PDI member would help to understand the important role that PDILT plays in the differentiation and maturation of spermatozoids.

-	~~==About this~~ Structure==	+	Structure of the substrate-binding b' domain of the Protein disulfide isomerase-like protein of the testis.,Bastos-Aristizabal S, Kozlov G, Gehring K Sci Rep. 2014 Mar 25;4:4464. doi: 10.1038/srep04464. PMID:24662985<ref>PMID:24662985</ref>
-	~~[[4nwy]] is a~~ 4 ~~chain structure~~. ~~Full crystallographic information is available from [http~~:~~//oca~~.~~weizmann.ac.il~~/~~oca-bin/ocashort?id=4NWY OCA]~~.	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024662985</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Human]]
	[[Category: Protein disulfide-isomerase]]		[[Category: Protein disulfide-isomerase]]
-	[[Category: Bastos-Aristizabal, S.]]	+	[[Category: Bastos-Aristizabal, S]]
-	[[Category: Gehring, K.]]	+	[[Category: Gehring, K]]
-	[[Category: Kozlov, G.]]	+	[[Category: Kozlov, G]]
	[[Category: Endoplasmic reticulum]]		[[Category: Endoplasmic reticulum]]
	[[Category: Isomerase]]		[[Category: Isomerase]]
	[[Category: Substrate-binding domain]]		[[Category: Substrate-binding domain]]
	[[Category: Thioredoxin-like fold]]		[[Category: Thioredoxin-like fold]]

OCA at 09:03, 2 April 2014

OCA — Wed, 02 Apr 2014 09:03:14 GMT

←Older revision		Revision as of 09:03, 2 April 2014
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-	~~'''Unreleased~~ structure'''	+	{{STRUCTURE_4nwy\| PDB=4nwy \| SCENE= }}
		+	===Crystal structure of the b' domain of human protein disulfide isomerase-like protein of the testis (PDILT)===
		+	{{ABSTRACT_PUBMED_24662985}}

-	~~The entry 4nwy is ON HOLD~~ ~~until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/PDILT_HUMAN PDILT_HUMAN]] Probable redox-inactive chaperone involved in spermatogenesis.<ref>PMID:17507649</ref>

-	~~Authors~~: ~~Bastos-Aristizabal, S~~.~~, Kozlov, G~~.~~, Gehring, K~~.	+	==About this Structure==
		+	[[4nwy]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NWY OCA].

-	~~Description~~: ~~Crystal structure of the b' domain of human protein~~ disulfide isomerase-like ~~protein of the testis (PDILT)~~	+	==Reference==
		+	<ref group="xtra">PMID:024662985</ref><references group="xtra"/><references/>
		+	[[Category: Protein disulfide-isomerase]]
		+	[[Category: Bastos-Aristizabal, S.]]
		+	[[Category: Gehring, K.]]
		+	[[Category: Kozlov, G.]]
		+	[[Category: Endoplasmic reticulum]]
		+	[[Category: Isomerase]]
		+	[[Category: Substrate-binding domain]]
		+	[[Category: Thioredoxin-like fold]]

OCA at 09:19, 8 January 2014

OCA — Wed, 08 Jan 2014 09:19:30 GMT

←Older revision		Revision as of 09:19, 8 January 2014
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4nwy is ON HOLD	+	The entry 4nwy is ON HOLD until Paper Publication

	Authors: Bastos-Aristizabal, S., Kozlov, G., Gehring, K.		Authors: Bastos-Aristizabal, S., Kozlov, G., Gehring, K.

	Description: Crystal structure of the b' domain of human protein disulfide isomerase-like protein of the testis (PDILT)		Description: Crystal structure of the b' domain of human protein disulfide isomerase-like protein of the testis (PDILT)

OCA: Protected "4nwy" [edit=sysop:move=sysop]

OCA — Wed, 18 Dec 2013 09:24:52 GMT

Protected "4nwy" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:24, 18 December 2013

OCA: New page: '''Unreleased structure''' The entry 4nwy is ON HOLD Authors: Bastos-Aristizabal, S., Kozlov, G., Gehring, K. Description: Crystal structure of the b' domain of human protein disulfide...

OCA — Wed, 18 Dec 2013 09:24:51 GMT

New page: '''Unreleased structure''' The entry 4nwy is ON HOLD Authors: Bastos-Aristizabal, S., Kozlov, G., Gehring, K. Description: Crystal structure of the b' domain of human protein disulfide...

New page

'''Unreleased structure'''

The entry 4nwy is ON HOLD

Authors: Bastos-Aristizabal, S., Kozlov, G., Gehring, K.

Description: Crystal structure of the b' domain of human protein disulfide isomerase-like protein of the testis (PDILT)