4nyk - Revision history

OCA at 08:46, 18 January 2023

OCA — Wed, 18 Jan 2023 08:46:22 GMT

←Older revision		Revision as of 08:46, 18 January 2023
Line 1:		Line 1:

	==Structure of a membrane protein==		==Structure of a membrane protein==
-	<StructureSection load='4nyk' size='340' side='right' caption='[[4nyk]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='4nyk' size='340' side='right'caption='[[4nyk]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4nyk]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Chick Chick~~]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3hgc 3hgc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NYK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4NYK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4nyk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3hgc 3hgc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NYK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NYK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hgc\|3hgc]], [[2qts\|2qts]], [[4ntw\|4ntw]], [[4ntx\|4ntx]], [[4nty\|4nty]], [[4fz0\|4fz0]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nyk OCA], [https://pdbe.org/4nyk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nyk RCSB], [https://www.ebi.ac.uk/pdbsum/4nyk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nyk ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ASIC1, ACCN2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4nyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nyk OCA], [~~http~~://pdbe.org/4nyk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4nyk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4nyk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4nyk ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ASIC1_CHICK ASIC1_CHICK]] Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride (By similarity).<ref>PMID:16002453</ref>	+	[https://www.uniprot.org/uniprot/ASIC1_CHICK ASIC1_CHICK] Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride (By similarity).<ref>PMID:16002453</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 20:

	==See Also==		==See Also==
-	*[[Ion channels\|Ion channels]]	+	*[[Ion channels 3D structures\|Ion channels 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Chick~~]]	+	[[Category: Gallus gallus]]
-	[[Category: Baconguis, I]]	+	[[Category: Large Structures]]
-	[[Category: Bohlen~~, C J~~]]	+	[[Category: Baconguis I]]
-	[[Category: Goehring, A]]	+	[[Category: Bohlen CJ]]
-	[[Category: Gouaux, E]]	+	[[Category: Goehring A]]
-	[[Category: Julius, D]]	+	[[Category: Gouaux E]]
-	~~[[Category: Ion channel]]~~	+	[[Category: Julius D]]
-	~~[[Category: Transport protein~~]]	+

OCA at 10:30, 4 August 2016

OCA — Thu, 04 Aug 2016 10:30:42 GMT

←Older revision		Revision as of 10:30, 4 August 2016
Line 1:		Line 1:
		+
	==Structure of a membrane protein==		==Structure of a membrane protein==
	<StructureSection load='4nyk' size='340' side='right' caption='[[4nyk]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4nyk' size='340' side='right' caption='[[4nyk]], [[Resolution\|resolution]] 3.00Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hgc\|3hgc]], [[2qts\|2qts]], [[4ntw\|4ntw]], [[4ntx\|4ntx]], [[4nty\|4nty]], [[4fz0\|4fz0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hgc\|3hgc]], [[2qts\|2qts]], [[4ntw\|4ntw]], [[4ntx\|4ntx]], [[4nty\|4nty]], [[4fz0\|4fz0]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ASIC1, ACCN2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ASIC1, ACCN2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nyk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nyk RCSB], [http://www.ebi.ac.uk/pdbsum/4nyk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nyk OCA], [http://pdbe.org/4nyk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nyk RCSB], [http://www.ebi.ac.uk/pdbsum/4nyk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nyk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4nyk" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ion channels\|Ion channels]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:21, 25 December 2014

OCA — Thu, 25 Dec 2014 08:21:34 GMT

←Older revision		Revision as of 08:21, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4nyk\| PDB~~=4nyk \| ~~SCENE~~= }}	+	==Structure of a membrane protein==
-	===~~Structure of~~ a ~~membrane protein~~===	+	<StructureSection load='4nyk' size='340' side='right' caption='[[4nyk]], [[Resolution\|resolution]] 3.00Å' scene=''>
-	~~{{ABSTRACT_PUBMED_19641589}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4nyk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3hgc 3hgc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NYK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NYK FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hgc\|3hgc]], [[2qts\|2qts]], [[4ntw\|4ntw]], [[4ntx\|4ntx]], [[4nty\|4nty]], [[4fz0\|4fz0]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ASIC1, ACCN2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nyk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nyk RCSB], [http://www.ebi.ac.uk/pdbsum/4nyk PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/ASIC1_CHICK ASIC1_CHICK]] Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride (By similarity).<ref>PMID:16002453</ref>		[[http://www.uniprot.org/uniprot/ASIC1_CHICK ASIC1_CHICK]] Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride (By similarity).<ref>PMID:16002453</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Acid-sensing ion channels are proton-activated, sodium-selective channels composed of three subunits, and are members of the superfamily of epithelial sodium channels, mechanosensitive and FMRF-amide peptide-gated ion channels. These ubiquitous eukaryotic ion channels have essential roles in biological activities as diverse as sodium homeostasis, taste and pain. Despite their crucial roles in biology and their unusual trimeric subunit stoichiometry, there is little knowledge of the structural and chemical principles underlying their ion channel architecture and ion-binding sites. Here we present the structure of a functional acid-sensing ion channel in a desensitized state at 3 A resolution, the location and composition of the approximately 8 A 'thick' desensitization gate, and the trigonal antiprism coordination of caesium ions bound in the extracellular vestibule. Comparison of the acid-sensing ion channel structure with the ATP-gated P2X(4) receptor reveals similarity in pore architecture and aqueous vestibules, suggesting that there are unanticipated yet common structural and mechanistic principles.

-	~~==About this Structure==~~	+	Pore architecture and ion sites in acid-sensing ion channels and P2X receptors.,Gonzales EB, Kawate T, Gouaux E Nature. 2009 Jul 30;460(7255):599-604. PMID:19641589<ref>PMID:19641589</ref>
-	~~[[4nyk]] is a 1 chain structure~~. ~~This structure supersedes the now removed PDB entry [http~~:~~//oca.weizmann.ac.il/oca~~-~~bin/send-pdb?obs=1&id=3hgc 3hgc]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=4NYK OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:019641589</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
-	[[Category: Baconguis, I.]]	+	== References ==
-	[[Category: Bohlen, C J.]]	+	<references/>
-	[[Category: Goehring, A.]]	+	__TOC__
-	[[Category: Gouaux, E.]]	+	</StructureSection>
-	[[Category: Julius, D.]]	+	[[Category: Chick]]
		+	[[Category: Baconguis, I]]
		+	[[Category: Bohlen, C J]]
		+	[[Category: Goehring, A]]
		+	[[Category: Gouaux, E]]
		+	[[Category: Julius, D]]
	[[Category: Ion channel]]		[[Category: Ion channel]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA at 04:57, 13 February 2014

OCA — Thu, 13 Feb 2014 04:57:44 GMT

←Older revision		Revision as of 04:57, 13 February 2014
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4nyk\| PDB=4nyk \| SCENE= }}
		+	===Structure of a membrane protein===
		+	{{ABSTRACT_PUBMED_19641589}}

-	~~The entry 4nyk~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/ASIC1_CHICK ASIC1_CHICK]] Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride (By similarity).<ref>PMID:16002453</ref>

-	~~Authors~~: ~~Baconguis, I~~.~~, Bohlen, C~~.J.~~, Goehring, A~~.~~, Julius, D~~.~~, Gouaux, E~~.	+	==About this Structure==
		+	[[4nyk]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3hgc 3hgc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NYK OCA].

-	~~Description~~:	+	==Reference==
		+	<ref group="xtra">PMID:019641589</ref><references group="xtra"/><references/>
		+	[[Category: Baconguis, I.]]
		+	[[Category: Bohlen, C J.]]
		+	[[Category: Goehring, A.]]
		+	[[Category: Gouaux, E.]]
		+	[[Category: Julius, D.]]
		+	[[Category: Ion channel]]
		+	[[Category: Transport protein]]

OCA at 10:22, 5 February 2014

OCA — Wed, 05 Feb 2014 10:22:07 GMT

←Older revision		Revision as of 10:22, 5 February 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4nyk is ON HOLD	+	The entry 4nyk is ON HOLD until Paper Publication

	Authors: Baconguis, I., Bohlen, C.J., Goehring, A., Julius, D., Gouaux, E.		Authors: Baconguis, I., Bohlen, C.J., Goehring, A., Julius, D., Gouaux, E.

	Description:		Description:

OCA at 09:20, 8 January 2014

OCA — Wed, 08 Jan 2014 09:20:14 GMT

←Older revision		Revision as of 09:20, 8 January 2014
Line 5:		Line 5:
	Authors: Baconguis, I., Bohlen, C.J., Goehring, A., Julius, D., Gouaux, E.		Authors: Baconguis, I., Bohlen, C.J., Goehring, A., Julius, D., Gouaux, E.

-	Description: ~~structure of a membrane protein~~	+	Description:

OCA: Protected "4nyk" [edit=sysop:move=sysop]

OCA — Wed, 18 Dec 2013 09:27:34 GMT

Protected "4nyk" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:27, 18 December 2013

OCA: New page: '''Unreleased structure''' The entry 4nyk is ON HOLD Authors: Baconguis, I., Bohlen, C.J., Goehring, A., Julius, D., Gouaux, E. Description: structure of a membrane protein

OCA — Wed, 18 Dec 2013 09:27:32 GMT

New page: '''Unreleased structure''' The entry 4nyk is ON HOLD Authors: Baconguis, I., Bohlen, C.J., Goehring, A., Julius, D., Gouaux, E. Description: structure of a membrane protein

New page

'''Unreleased structure'''

The entry 4nyk is ON HOLD

Authors: Baconguis, I., Bohlen, C.J., Goehring, A., Julius, D., Gouaux, E.

Description: structure of a membrane protein