4nzl - Revision history

OCA at 17:05, 20 September 2023

OCA — Wed, 20 Sep 2023 17:05:13 GMT

←Older revision		Revision as of 17:05, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4nzl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_Mu50 Staphylococcus aureus subsp. aureus Mu50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NZL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NZL FirstGlance]. <br>		<table><tr><td colspan='2'>[[4nzl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_Mu50 Staphylococcus aureus subsp. aureus Mu50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NZL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NZL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.85Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nzl OCA], [https://pdbe.org/4nzl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nzl RCSB], [https://www.ebi.ac.uk/pdbsum/4nzl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nzl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nzl OCA], [https://pdbe.org/4nzl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nzl RCSB], [https://www.ebi.ac.uk/pdbsum/4nzl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nzl ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:48, 18 January 2023

OCA — Wed, 18 Jan 2023 08:48:02 GMT

←Older revision		Revision as of 08:48, 18 January 2023
Line 1:		Line 1:

	==Extracellular proteins of Staphylococcus aureus inhibit the neutrophil serine proteases==		==Extracellular proteins of Staphylococcus aureus inhibit the neutrophil serine proteases==
-	<StructureSection load='4nzl' size='340' side='right' caption='[[4nzl]], [[Resolution\|resolution]] 1.85Å' scene=''>	+	<StructureSection load='4nzl' size='340' side='right'caption='[[4nzl]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4nzl]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [~~http~~://en.wikipedia.org/wiki/~~Staam Staam~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NZL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4NZL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4nzl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_Mu50 Staphylococcus aureus subsp. aureus Mu50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NZL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NZL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SAV2205 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=158878 STAAM])</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nzl OCA], [https://pdbe.org/4nzl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nzl RCSB], [https://www.ebi.ac.uk/pdbsum/4nzl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nzl ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leukocyte_elastase Leukocyte elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.37 3.4.21.37] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4nzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nzl OCA], [~~http~~://pdbe.org/4nzl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4nzl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4nzl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4nzl ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/ELNE_HUMAN ELNE_HUMAN]] Defects in ELANE are a cause of cyclic haematopoiesis (CH) [MIM:[~~http~~://omim.org/entry/162800 162800]]; also known as cyclic neutropenia. CH is an autosomal dominant disease in which blood-cell production from the bone marrow oscillates with 21-day periodicity. Circulating neutrophils vary between almost normal numbers and zero. During intervals of neutropenia, affected individuals are at risk for opportunistic infection. Monocytes, platelets, lymphocytes and reticulocytes also cycle with the same frequency.<ref>PMID:14673143</ref> <ref>PMID:10581030</ref> Defects in ELANE are the cause of neutropenia severe congenital autosomal dominant type 1 (SCN1) [MIM:[~~http~~://omim.org/entry/202700 202700]]. SCN1 is a disorder of hematopoiesis characterized by a maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections.<ref>PMID:20220065</ref>	+	[https://www.uniprot.org/uniprot/ELNE_HUMAN ELNE_HUMAN] Defects in ELANE are a cause of cyclic haematopoiesis (CH) [MIM:[https://omim.org/entry/162800 162800]; also known as cyclic neutropenia. CH is an autosomal dominant disease in which blood-cell production from the bone marrow oscillates with 21-day periodicity. Circulating neutrophils vary between almost normal numbers and zero. During intervals of neutropenia, affected individuals are at risk for opportunistic infection. Monocytes, platelets, lymphocytes and reticulocytes also cycle with the same frequency.<ref>PMID:14673143</ref> <ref>PMID:10581030</ref> Defects in ELANE are the cause of neutropenia severe congenital autosomal dominant type 1 (SCN1) [MIM:[https://omim.org/entry/202700 202700]. SCN1 is a disorder of hematopoiesis characterized by a maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections.<ref>PMID:20220065</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ELNE_HUMAN ELNE_HUMAN]] Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis.<ref>PMID:15140022</ref>	+	[https://www.uniprot.org/uniprot/ELNE_HUMAN ELNE_HUMAN] Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis.<ref>PMID:15140022</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4nzl" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4nzl" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Elastase 3D structures\|Elastase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: ~~Leukocyte elastase~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Staam~~]]	+	[[Category: Staphylococcus aureus subsp. aureus Mu50]]
-	[[Category: Bischoff, M]]	+	[[Category: Bischoff M]]
-	[[Category: Geisbrecht~~, B V~~]]	+	[[Category: Geisbrecht BV]]
-	[[Category: Herrmann, M]]	+	[[Category: Herrmann M]]
-	~~[[Category: Kessel, K P.M van]]~~	+	[[Category: McWhorter WJ]]
-	~~[[Category: Koeckritz-Blickwede, M von~~]]	+	[[Category: Milder F]]
-	[[Category: McWhorter~~, W J~~]]	+	[[Category: Ramyar KX]]
-	[[Category: Milder, F]]	+	[[Category: Rooijakkers SHM]]
-	[[Category: Ramyar~~, K X~~]]	+	[[Category: Ruyken M]]
-	[[Category: Rooijakkers~~, S H.M~~]]	+	[[Category: Scheepmaker L]]
-	[[Category: Ruyken, M]]	+	[[Category: Stapels DAC]]
-	[[Category: Scheepmaker, L]]	+	[[Category: Van Kessel KPM]]
-	[[Category: Stapels~~, D A.C~~]]	+	[[Category: Von Koeckritz-Blickwede M]]
-	[[Category: ~~Azurophilic granule~~]]	+
-	[[Category: ~~Hydrolase~~-~~hydrolase inhibitor complex]]~~	+
-	~~[[Category: Innate immunity]]~~	+
-	~~[[Category: Primarily beta]]~~	+
-	~~[[Category: Protease inhibitor]]~~	+
-	~~[[Category: Serine protease~~]]	+

OCA at 08:19, 22 November 2017

OCA — Wed, 22 Nov 2017 08:19:40 GMT

←Older revision		Revision as of 08:19, 22 November 2017
Line 3:		Line 3:
	<StructureSection load='4nzl' size='340' side='right' caption='[[4nzl]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='4nzl' size='340' side='right' caption='[[4nzl]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4nzl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NZL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NZL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4nzl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Staam Staam]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NZL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NZL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SAV2205 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=158878 STAAM])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leukocyte_elastase Leukocyte elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.37 3.4.21.37] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leukocyte_elastase Leukocyte elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.37 3.4.21.37] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nzl OCA], [http://pdbe.org/4nzl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nzl RCSB], [http://www.ebi.ac.uk/pdbsum/4nzl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nzl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nzl OCA], [http://pdbe.org/4nzl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nzl RCSB], [http://www.ebi.ac.uk/pdbsum/4nzl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nzl ProSAT]</span></td></tr>
Line 21:		Line 22:
	</div>		</div>
	<div class="pdbe-citations 4nzl" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4nzl" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Elastase\|Elastase]]
	== References ==		== References ==
	<references/>		<references/>
Line 30:		Line 28:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Leukocyte elastase]]		[[Category: Leukocyte elastase]]
		+	[[Category: Staam]]
	[[Category: Bischoff, M]]		[[Category: Bischoff, M]]
	[[Category: Geisbrecht, B V]]		[[Category: Geisbrecht, B V]]

OCA at 12:52, 11 August 2016

OCA — Thu, 11 Aug 2016 12:52:13 GMT

←Older revision		Revision as of 12:52, 11 August 2016
Line 1:		Line 1:
		+
	==Extracellular proteins of Staphylococcus aureus inhibit the neutrophil serine proteases==		==Extracellular proteins of Staphylococcus aureus inhibit the neutrophil serine proteases==
	<StructureSection load='4nzl' size='340' side='right' caption='[[4nzl]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='4nzl' size='340' side='right' caption='[[4nzl]], [[Resolution\|resolution]] 1.85Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leukocyte_elastase Leukocyte elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.37 3.4.21.37] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leukocyte_elastase Leukocyte elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.37 3.4.21.37] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nzl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nzl RCSB], [http://www.ebi.ac.uk/pdbsum/4nzl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nzl OCA], [http://pdbe.org/4nzl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nzl RCSB], [http://www.ebi.ac.uk/pdbsum/4nzl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nzl ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4nzl" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Elastase\|Elastase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:30, 20 January 2015

OCA — Tue, 20 Jan 2015 10:30:52 GMT

←Older revision		Revision as of 10:30, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4nzl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NZL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NZL FirstGlance]. <br>		<table><tr><td colspan='2'>[[4nzl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NZL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NZL FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leukocyte_elastase Leukocyte elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.37 3.4.21.37] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leukocyte_elastase Leukocyte elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.37 3.4.21.37] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nzl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nzl RCSB], [http://www.ebi.ac.uk/pdbsum/4nzl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nzl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nzl RCSB], [http://www.ebi.ac.uk/pdbsum/4nzl PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/ELNE_HUMAN ELNE_HUMAN]] Defects in ELANE are a cause of cyclic haematopoiesis (CH) [MIM:[http://omim.org/entry/162800 162800]]; also known as cyclic neutropenia. CH is an autosomal dominant disease in which blood-cell production from the bone marrow oscillates with 21-day periodicity. Circulating neutrophils vary between almost normal numbers and zero. During intervals of neutropenia, affected individuals are at risk for opportunistic infection. Monocytes, platelets, lymphocytes and reticulocytes also cycle with the same frequency.<ref>PMID:14673143</ref> <ref>PMID:10581030</ref> Defects in ELANE are the cause of neutropenia severe congenital autosomal dominant type 1 (SCN1) [MIM:[http://omim.org/entry/202700 202700]]. SCN1 is a disorder of hematopoiesis characterized by a maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections.<ref>PMID:20220065</ref>		[[http://www.uniprot.org/uniprot/ELNE_HUMAN ELNE_HUMAN]] Defects in ELANE are a cause of cyclic haematopoiesis (CH) [MIM:[http://omim.org/entry/162800 162800]]; also known as cyclic neutropenia. CH is an autosomal dominant disease in which blood-cell production from the bone marrow oscillates with 21-day periodicity. Circulating neutrophils vary between almost normal numbers and zero. During intervals of neutropenia, affected individuals are at risk for opportunistic infection. Monocytes, platelets, lymphocytes and reticulocytes also cycle with the same frequency.<ref>PMID:14673143</ref> <ref>PMID:10581030</ref> Defects in ELANE are the cause of neutropenia severe congenital autosomal dominant type 1 (SCN1) [MIM:[http://omim.org/entry/202700 202700]]. SCN1 is a disorder of hematopoiesis characterized by a maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections.<ref>PMID:20220065</ref>
Line 25:		Line 25:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Leukocyte elastase]]		[[Category: Leukocyte elastase]]
-	[[Category: Bischoff, M.]]	+	[[Category: Bischoff, M]]
-	[[Category: Geisbrecht, B V.]]	+	[[Category: Geisbrecht, B V]]
-	[[Category: Herrmann, M.]]	+	[[Category: Herrmann, M]]
-	[[Category: Kessel, K P.M van.]]	+	[[Category: Kessel, K P.M van]]
-	[[Category: Koeckritz-Blickwede, M von.]]	+	[[Category: Koeckritz-Blickwede, M von]]
-	[[Category: McWhorter, W J.]]	+	[[Category: McWhorter, W J]]
-	[[Category: Milder, F.]]	+	[[Category: Milder, F]]
-	[[Category: Ramyar, K X.]]	+	[[Category: Ramyar, K X]]
-	[[Category: Rooijakkers, S H.M.]]	+	[[Category: Rooijakkers, S H.M]]
-	[[Category: Ruyken, M.]]	+	[[Category: Ruyken, M]]
-	[[Category: Scheepmaker, L.]]	+	[[Category: Scheepmaker, L]]
-	[[Category: Stapels, D A.C.]]	+	[[Category: Stapels, D A.C]]
	[[Category: Azurophilic granule]]		[[Category: Azurophilic granule]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]

OCA at 21:50, 1 October 2014

OCA — Wed, 01 Oct 2014 21:50:44 GMT

←Older revision		Revision as of 21:50, 1 October 2014
Line 11:		Line 11:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/ELNE_HUMAN ELNE_HUMAN]] Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis.<ref>PMID:15140022</ref>		[[http://www.uniprot.org/uniprot/ELNE_HUMAN ELNE_HUMAN]] Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis.<ref>PMID:15140022</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Neutrophils are indispensable for clearing infections with the prominent human pathogen Staphylococcus aureus. Here, we report that S. aureus secretes a family of proteins that potently inhibits the activity of neutrophil serine proteases (NSPs): neutrophil elastase (NE), proteinase 3, and cathepsin G. The NSPs, but not related serine proteases, are specifically blocked by the extracellular adherence protein (Eap) and the functionally orphan Eap homologs EapH1 and EapH2, with inhibitory-constant values in the low-nanomolar range. Eap proteins are together essential for NSP inhibition by S. aureus in vitro and promote staphylococcal infection in vivo. The crystal structure of the EapH1/NE complex showed that Eap molecules constitute a unique class of noncovalent protease inhibitors that occlude the catalytic cleft of NSPs. These findings increase our insights into the complex pathogenesis of S. aureus infections and create opportunities to design novel treatment strategies for inflammatory conditions related to excessive NSP activity.
		+
		+	Staphylococcus aureus secretes a unique class of neutrophil serine protease inhibitors.,Stapels DA, Ramyar KX, Bischoff M, von Kockritz-Blickwede M, Milder FJ, Ruyken M, Eisenbeis J, McWhorter WJ, Herrmann M, van Kessel KP, Geisbrecht BV, Rooijakkers SH Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13187-92. doi:, 10.1073/pnas.1407616111. Epub 2014 Aug 26. PMID:25161283<ref>PMID:25161283</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:31, 20 August 2014

OCA — Wed, 20 Aug 2014 16:31:53 GMT

←Older revision		Revision as of 16:31, 20 August 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Extracellular proteins of Staphylococcus aureus inhibit the neutrophil serine proteases==
-		+	<StructureSection load='4nzl' size='340' side='right' caption='[[4nzl]], [[Resolution\|resolution]] 1.85Å' scene=''>
-	~~The entry~~ 4nzl is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4nzl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NZL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NZL FirstGlance]. <br>
-	~~Authors~~: ~~Stapels~~, D.~~A.C~~., ~~von Koeckritz~~-~~Blickwede, M~~.~~, Ramyar, K~~.X., ~~Bischoff~~, M., ~~Milder, F~~., ~~Ruyken, M~~., ~~Scheepmaker~~, L., ~~McWhorter, W~~.J., Herrmann, M.~~, van~~ Kessel, K.P.M., ~~Geisbrecht~~, B.V., Rooijakkers, S.H.M.	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
-		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leukocyte_elastase Leukocyte elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.37 3.4.21.37] </span></td></tr>
-	~~Description~~: ~~Extracellular proteins of Staphylococcus aureus inhibit the neutrophil serine proteases~~	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nzl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nzl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nzl RCSB], [http://www.ebi.ac.uk/pdbsum/4nzl PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/ELNE_HUMAN ELNE_HUMAN]] Defects in ELANE are a cause of cyclic haematopoiesis (CH) [MIM:[http://omim.org/entry/162800 162800]]; also known as cyclic neutropenia. CH is an autosomal dominant disease in which blood-cell production from the bone marrow oscillates with 21-day periodicity. Circulating neutrophils vary between almost normal numbers and zero. During intervals of neutropenia, affected individuals are at risk for opportunistic infection. Monocytes, platelets, lymphocytes and reticulocytes also cycle with the same frequency.<ref>PMID:14673143</ref> <ref>PMID:10581030</ref> Defects in ELANE are the cause of neutropenia severe congenital autosomal dominant type 1 (SCN1) [MIM:[http://omim.org/entry/202700 202700]]. SCN1 is a disorder of hematopoiesis characterized by a maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections.<ref>PMID:20220065</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ELNE_HUMAN ELNE_HUMAN]] Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis.<ref>PMID:15140022</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Homo sapiens]]
		+	[[Category: Leukocyte elastase]]
		+	[[Category: Bischoff, M.]]
		+	[[Category: Geisbrecht, B V.]]
		+	[[Category: Herrmann, M.]]
		+	[[Category: Kessel, K P.M van.]]
		+	[[Category: Koeckritz-Blickwede, M von.]]
		+	[[Category: McWhorter, W J.]]
		+	[[Category: Milder, F.]]
		+	[[Category: Ramyar, K X.]]
		+	[[Category: Rooijakkers, S H.M.]]
		+	[[Category: Ruyken, M.]]
		+	[[Category: Scheepmaker, L.]]
		+	[[Category: Stapels, D A.C.]]
		+	[[Category: Azurophilic granule]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Innate immunity]]
		+	[[Category: Primarily beta]]
		+	[[Category: Protease inhibitor]]
		+	[[Category: Serine protease]]

OCA at 09:39, 16 July 2014

OCA — Wed, 16 Jul 2014 09:39:08 GMT

←Older revision		Revision as of 09:39, 16 July 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4nzl is ON HOLD until ~~sometime in the future~~	+	The entry 4nzl is ON HOLD until Paper Publication

	Authors: Stapels, D.A.C., von Koeckritz-Blickwede, M., Ramyar, K.X., Bischoff, M., Milder, F., Ruyken, M., Scheepmaker, L., McWhorter, W.J., Herrmann, M., van Kessel, K.P.M., Geisbrecht, B.V., Rooijakkers, S.H.M.		Authors: Stapels, D.A.C., von Koeckritz-Blickwede, M., Ramyar, K.X., Bischoff, M., Milder, F., Ruyken, M., Scheepmaker, L., McWhorter, W.J., Herrmann, M., van Kessel, K.P.M., Geisbrecht, B.V., Rooijakkers, S.H.M.

	Description: Extracellular proteins of Staphylococcus aureus inhibit the neutrophil serine proteases		Description: Extracellular proteins of Staphylococcus aureus inhibit the neutrophil serine proteases

OCA at 10:22, 5 February 2014

OCA — Wed, 05 Feb 2014 10:22:16 GMT

←Older revision		Revision as of 10:22, 5 February 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4nzl is ON HOLD	+	The entry 4nzl is ON HOLD until sometime in the future

	Authors: Stapels, D.A.C., von Koeckritz-Blickwede, M., Ramyar, K.X., Bischoff, M., Milder, F., Ruyken, M., Scheepmaker, L., McWhorter, W.J., Herrmann, M., van Kessel, K.P.M., Geisbrecht, B.V., Rooijakkers, S.H.M.		Authors: Stapels, D.A.C., von Koeckritz-Blickwede, M., Ramyar, K.X., Bischoff, M., Milder, F., Ruyken, M., Scheepmaker, L., McWhorter, W.J., Herrmann, M., van Kessel, K.P.M., Geisbrecht, B.V., Rooijakkers, S.H.M.

	Description: Extracellular proteins of Staphylococcus aureus inhibit the neutrophil serine proteases		Description: Extracellular proteins of Staphylococcus aureus inhibit the neutrophil serine proteases

OCA: Protected "4nzl" [edit=sysop:move=sysop]

OCA — Wed, 18 Dec 2013 09:29:19 GMT

Protected "4nzl" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:29, 18 December 2013