4o1x - Revision history

OCA at 08:52, 18 January 2023

OCA — Wed, 18 Jan 2023 08:52:19 GMT

←Older revision		Revision as of 08:52, 18 January 2023
Line 3:		Line 3:
	<StructureSection load='4o1x' size='340' side='right'caption='[[4o1x]], [[Resolution\|resolution]] 2.32Å' scene=''>		<StructureSection load='4o1x' size='340' side='right'caption='[[4o1x]], [[Resolution\|resolution]] 2.32Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4o1x]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O1X OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4O1X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4o1x]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O1X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O1X FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=~~EDO~~:1,2-~~ETHANEDIOL~~'>~~EDO~~</scene>, <scene name='pdbligand=~~SO4~~:~~SULFATE+ION'>SO4</scene></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SCH:S-METHYL-THIO-CYSTEINE'>SCH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S~~,~~S-(~~2-~~HYDROXYETHYL)THIOCYSTEINE~~'>~~CME~~</scene>, <scene name='pdbligand=SCH:S-METHYL-THIO-CYSTEINE'>SCH</scene>~~</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o1x OCA], [https://pdbe.org/4o1x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o1x RCSB], [https://www.ebi.ac.uk/pdbsum/4o1x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o1x ProSAT]</span></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4o1u\|4o1u]]</td></tr>~~	+
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">OK/SW-cl.29~~, ~~TS, TYMS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~<~~/td></tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45]~~ </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4o1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o1x OCA], [~~http~~://pdbe.org/4o1x PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4o1x RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4o1x PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4o1x ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TYSY_HUMAN TYSY_HUMAN]] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.<ref>PMID:21876188</ref>	+	[https://www.uniprot.org/uniprot/TYSY_HUMAN TYSY_HUMAN] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.<ref>PMID:21876188</ref>

	==See Also==		==See Also==
-	*[[Thymidylate synthase\|Thymidylate synthase]]	+	*[[Thymidylate synthase 3D structures\|Thymidylate synthase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Thymidylate synthase]]~~	+	[[Category: Mangani S]]
-	[[Category: Mangani, S]]	+	[[Category: Pozzi C]]
-	[[Category: Pozzi, C]]	+
-	~~[[Category: Active conformation]]~~	+
-	~~[[Category: Dimer-dimer interface modification]]~~	+
-	~~[[Category: Methyltransferase]]~~	+
-	~~[[Category: Nucleotide biosynthesis]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 08:35, 10 April 2019

OCA — Wed, 10 Apr 2019 08:35:46 GMT

←Older revision		Revision as of 08:35, 10 April 2019
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	==Crystal structure of human thymidylate synthase double mutant C195S-Y202C==		==Crystal structure of human thymidylate synthase double mutant C195S-Y202C==
-	<StructureSection load='4o1x' size='340' side='right' caption='[[4o1x]], [[Resolution\|resolution]] 2.32Å' scene=''>	+	<StructureSection load='4o1x' size='340' side='right'caption='[[4o1x]], [[Resolution\|resolution]] 2.32Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4o1x]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O1X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O1X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4o1x]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O1X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O1X FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=SCH:S-METHYL-THIO-CYSTEINE'>SCH</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=SCH:S-METHYL-THIO-CYSTEINE'>SCH</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4o1u\|4o1u]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4o1u\|4o1u]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">OK/SW-cl.29, TS, TYMS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o1x OCA], [http://pdbe.org/4o1x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4o1x RCSB], [http://www.ebi.ac.uk/pdbsum/4o1x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4o1x ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o1x OCA], [http://pdbe.org/4o1x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4o1x RCSB], [http://www.ebi.ac.uk/pdbsum/4o1x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4o1x ProSAT]</span></td></tr>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Thymidylate synthase]]		[[Category: Thymidylate synthase]]
	[[Category: Mangani, S]]		[[Category: Mangani, S]]

OCA at 07:37, 11 August 2016

OCA — Thu, 11 Aug 2016 07:37:35 GMT

←Older revision		Revision as of 07:37, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of human thymidylate synthase double mutant C195S-Y202C==		==Crystal structure of human thymidylate synthase double mutant C195S-Y202C==
	<StructureSection load='4o1x' size='340' side='right' caption='[[4o1x]], [[Resolution\|resolution]] 2.32Å' scene=''>		<StructureSection load='4o1x' size='340' side='right' caption='[[4o1x]], [[Resolution\|resolution]] 2.32Å' scene=''>
Line 7:		Line 8:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4o1u\|4o1u]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4o1u\|4o1u]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o1x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o1x RCSB], [http://www.ebi.ac.uk/pdbsum/4o1x PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o1x OCA], [http://pdbe.org/4o1x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4o1x RCSB], [http://www.ebi.ac.uk/pdbsum/4o1x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4o1x ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/TYSY_HUMAN TYSY_HUMAN]] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.<ref>PMID:21876188</ref>		[[http://www.uniprot.org/uniprot/TYSY_HUMAN TYSY_HUMAN]] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.<ref>PMID:21876188</ref>
		+
		+	==See Also==
		+	*[[Thymidylate synthase\|Thymidylate synthase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:57, 21 January 2015

OCA — Wed, 21 Jan 2015 16:57:34 GMT

←Older revision		Revision as of 16:57, 21 January 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of human thymidylate synthase double mutant C195S-Y202C==
-		+	<StructureSection load='4o1x' size='340' side='right' caption='[[4o1x]], [[Resolution\|resolution]] 2.32Å' scene=''>
-	~~The entry~~ 4o1x is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4o1x]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O1X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O1X FirstGlance]. <br>
-	~~Authors~~: ~~Pozzi~~, C., ~~Mangani~~, S.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=SCH:S-METHYL-THIO-CYSTEINE'>SCH</scene></td></tr>
-	~~Description~~: ~~Crystal structure of human~~ thymidylate ~~synthase double mutant C195S-Y202C~~	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4o1u\|4o1u]]</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o1x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o1x RCSB], [http://www.ebi.ac.uk/pdbsum/4o1x PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TYSY_HUMAN TYSY_HUMAN]] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.<ref>PMID:21876188</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Thymidylate synthase]]
	[[Category: Mangani, S]]		[[Category: Mangani, S]]
	[[Category: Pozzi, C]]		[[Category: Pozzi, C]]
		+	[[Category: Active conformation]]
		+	[[Category: Dimer-dimer interface modification]]
		+	[[Category: Methyltransferase]]
		+	[[Category: Nucleotide biosynthesis]]
		+	[[Category: Transferase]]

OCA at 14:16, 24 December 2014

OCA — Wed, 24 Dec 2014 14:16:57 GMT

←Older revision		Revision as of 14:16, 24 December 2014
Line 6:		Line 6:

	Description: Crystal structure of human thymidylate synthase double mutant C195S-Y202C		Description: Crystal structure of human thymidylate synthase double mutant C195S-Y202C
		+	[[Category: Unreleased Structures]]
		+	[[Category: Mangani, S]]
		+	[[Category: Pozzi, C]]

OCA at 09:22, 8 January 2014

OCA — Wed, 08 Jan 2014 09:22:16 GMT

←Older revision		Revision as of 09:22, 8 January 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4o1x is ON HOLD	+	The entry 4o1x is ON HOLD until Paper Publication

	Authors: Pozzi, C., Mangani, S.		Authors: Pozzi, C., Mangani, S.

	Description: Crystal structure of human thymidylate synthase double mutant C195S-Y202C		Description: Crystal structure of human thymidylate synthase double mutant C195S-Y202C

OCA: Protected "4o1x" [edit=sysop:move=sysop]

OCA — Wed, 25 Dec 2013 09:30:47 GMT

Protected "4o1x" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:30, 25 December 2013

OCA: New page: '''Unreleased structure''' The entry 4o1x is ON HOLD Authors: Pozzi, C., Mangani, S. Description: Crystal structure of human thymidylate synthase double mutant C195S-Y202C

OCA — Wed, 25 Dec 2013 09:30:47 GMT

New page: '''Unreleased structure''' The entry 4o1x is ON HOLD Authors: Pozzi, C., Mangani, S. Description: Crystal structure of human thymidylate synthase double mutant C195S-Y202C

New page

'''Unreleased structure'''

The entry 4o1x is ON HOLD

Authors: Pozzi, C., Mangani, S.

Description: Crystal structure of human thymidylate synthase double mutant C195S-Y202C