4o5u - Revision history

OCA at 08:56, 18 January 2023

OCA — Wed, 18 Jan 2023 08:56:58 GMT

←Older revision		Revision as of 08:56, 18 January 2023
Line 3:		Line 3:
	<StructureSection load='4o5u' size='340' side='right'caption='[[4o5u]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='4o5u' size='340' side='right'caption='[[4o5u]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4o5u]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Escherichia_coli~~ Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O5U OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4O5U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4o5u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O5U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O5U FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fl2\|1fl2]], [[4o5r\|4o5r]], [[4o5q\|4o5q]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o5u OCA], [https://pdbe.org/4o5u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o5u RCSB], [https://www.ebi.ac.uk/pdbsum/4o5u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o5u ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4o5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o5u OCA], [~~http~~://pdbe.org/4o5u PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4o5u RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4o5u PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4o5u ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/AHPF_ECOLI AHPF_ECOLI]] Serves to protect the cell against DNA damage by alkyl hydroperoxides. It can use either NADH or NADPH as electron donor for direct reduction of redox dyes or of alkyl hydroperoxides when combined with the AhpC protein.	+	[https://www.uniprot.org/uniprot/AHPF_ECOLI AHPF_ECOLI] Serves to protect the cell against DNA damage by alkyl hydroperoxides. It can use either NADH or NADPH as electron donor for direct reduction of redox dyes or of alkyl hydroperoxides when combined with the AhpC protein.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 20:

	==See Also==		==See Also==
-	*[[Thioredoxin ~~Reductase~~\|Thioredoxin ~~Reductase~~]]	+	*[[Thioredoxin reductase 3D structures\|Thioredoxin reductase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Escherichia coli]]	+	[[Category: Escherichia coli K-12]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dip~~, P V~~]]	+	[[Category: Dip PV]]
-	[[Category: Eisenhaber, B]]	+	[[Category: Eisenhaber B]]
-	[[Category: Eisenhaber, F]]	+	[[Category: Eisenhaber F]]
-	[[Category: Gruber, G]]	+	[[Category: Gruber G]]
-	[[Category: Kamariah, N]]	+	[[Category: Kamariah N]]
-	[[Category: Manimekalai~~, M S.S]]~~	+	[[Category: Manimekalai MSS]]
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 08:45, 10 April 2019

OCA — Wed, 10 Apr 2019 08:45:49 GMT

←Older revision		Revision as of 08:45, 10 April 2019
Line 1:		Line 1:

	==Crystal structure of Alkylhydroperoxide Reductase subunit F from E. coli at 2.65 Ang resolution==		==Crystal structure of Alkylhydroperoxide Reductase subunit F from E. coli at 2.65 Ang resolution==
-	<StructureSection load='4o5u' size='340' side='right' caption='[[4o5u]], [[Resolution\|resolution]] 2.65Å' scene=''>	+	<StructureSection load='4o5u' size='340' side='right'caption='[[4o5u]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4o5u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O5U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O5U FirstGlance]. <br>		<table><tr><td colspan='2'>[[4o5u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O5U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O5U FirstGlance]. <br>
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
		+	[[Category: Large Structures]]
	[[Category: Dip, P V]]		[[Category: Dip, P V]]
	[[Category: Eisenhaber, B]]		[[Category: Eisenhaber, B]]

OCA at 16:54, 2 January 2017

OCA — Mon, 02 Jan 2017 16:54:39 GMT

←Older revision		Revision as of 16:54, 2 January 2017
Line 1:		Line 1:
		+
	==Crystal structure of Alkylhydroperoxide Reductase subunit F from E. coli at 2.65 Ang resolution==		==Crystal structure of Alkylhydroperoxide Reductase subunit F from E. coli at 2.65 Ang resolution==
	<StructureSection load='4o5u' size='340' side='right' caption='[[4o5u]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='4o5u' size='340' side='right' caption='[[4o5u]], [[Resolution\|resolution]] 2.65Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fl2\|1fl2]], [[4o5r\|4o5r]], [[4o5q\|4o5q]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fl2\|1fl2]], [[4o5r\|4o5r]], [[4o5q\|4o5q]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o5u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o5u RCSB], [http://www.ebi.ac.uk/pdbsum/4o5u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o5u OCA], [http://pdbe.org/4o5u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4o5u RCSB], [http://www.ebi.ac.uk/pdbsum/4o5u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4o5u ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4o5u" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Thioredoxin Reductase\|Thioredoxin Reductase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:54, 25 February 2015

OCA — Wed, 25 Feb 2015 07:54:56 GMT

←Older revision		Revision as of 07:54, 25 February 2015
Line 9:		Line 9:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/AHPF_ECOLI AHPF_ECOLI]] Serves to protect the cell against DNA damage by alkyl hydroperoxides. It can use either NADH or NADPH as electron donor for direct reduction of redox dyes or of alkyl hydroperoxides when combined with the AhpC protein.		[[http://www.uniprot.org/uniprot/AHPF_ECOLI AHPF_ECOLI]] Serves to protect the cell against DNA damage by alkyl hydroperoxides. It can use either NADH or NADPH as electron donor for direct reduction of redox dyes or of alkyl hydroperoxides when combined with the AhpC protein.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Hydroperoxides are reactive oxygen species (ROS) that are toxic to all cells and must be converted into the corresponding alcohols to alleviate oxidative stress. In Escherichia coli, the enzyme primarily responsible for this reaction is alkylhydroperoxide reductase (AhpR). Here, the crystal structures of both of the subunits of EcAhpR, EcAhpF (57 kDa) and EcAhpC (21 kDa), have been solved. The EcAhpF structures (2.0 and 2.65 A resolution) reveal an open and elongated conformation, while that of EcAhpC (3.3 A resolution) forms a decameric ring. Solution X-ray scattering analysis of EcAhpF unravels the flexibility of its N-terminal domain, and its binding to EcAhpC was demonstrated by isothermal titration calorimetry. These studies suggest a novel overall mechanistic model of AhpR as a hydroperoxide scavenger, in which the dimeric, extended AhpF prefers complex formation with the AhpC ring to accelerate the catalytic activity and thus to increase the chance of rescuing the cell from ROS.
		+
		+	Structure, mechanism and ensemble formation of the alkylhydroperoxide reductase subunits AhpC and AhpF from Escherichia coli.,Dip PV, Kamariah N, Subramanian Manimekalai MS, Nartey W, Balakrishna AM, Eisenhaber F, Eisenhaber B, Gruber G Acta Crystallogr D Biol Crystallogr. 2014 Nov;70(Pt 11):2848-62. doi:, 10.1107/S1399004714019233. Epub 2014 Oct 16. PMID:25372677<ref>PMID:25372677</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 16:22, 25 December 2014

OCA — Thu, 25 Dec 2014 16:22:01 GMT

←Older revision		Revision as of 16:22, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o5u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o5u RCSB], [http://www.ebi.ac.uk/pdbsum/4o5u PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o5u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o5u RCSB], [http://www.ebi.ac.uk/pdbsum/4o5u PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/AHPF_ECOLI AHPF_ECOLI]] Serves to protect the cell against DNA damage by alkyl hydroperoxides. It can use either NADH or NADPH as electron donor for direct reduction of redox dyes or of alkyl hydroperoxides when combined with the AhpC protein.
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 07:43, 12 November 2014

OCA — Wed, 12 Nov 2014 07:43:16 GMT

←Older revision		Revision as of 07:43, 12 November 2014
Line 10:		Line 10:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Dip, P V.]]	+	[[Category: Dip, P V]]
-	[[Category: Eisenhaber, B.]]	+	[[Category: Eisenhaber, B]]
-	[[Category: Eisenhaber, F.]]	+	[[Category: Eisenhaber, F]]
-	[[Category: Gruber, G.]]	+	[[Category: Gruber, G]]
-	[[Category: Kamariah, N.]]	+	[[Category: Kamariah, N]]
-	[[Category: Manimekalai, M S.S.]]	+	[[Category: Manimekalai, M S.S]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 08:55, 5 November 2014

OCA — Wed, 05 Nov 2014 08:55:26 GMT

←Older revision		Revision as of 08:55, 5 November 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of Alkylhydroperoxide Reductase subunit F from E. coli at 2.65 Ang resolution==
-		+	<StructureSection load='4o5u' size='340' side='right' caption='[[4o5u]], [[Resolution\|resolution]] 2.65Å' scene=''>
-	~~The entry~~ 4o5u is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4o5u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O5U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O5U FirstGlance]. <br>
-	~~Authors~~: ~~Kamariah~~, N., ~~Dip~~, P.V., ~~Manimekalai, M~~.S.S., ~~Gruber, G~~., Eisenhaber, F., ~~Eisenhaber, B~~.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1fl2\|1fl2]], [[4o5r\|4o5r]], [[4o5q\|4o5q]]</td></tr>
-	~~Description~~: ~~Crystal structure of Alkylhydroperoxide Reductase subunit F from E~~. ~~coli at 2~~.~~65 Ang resolution~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o5u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o5u RCSB], [http://www.ebi.ac.uk/pdbsum/4o5u PDBsum]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Escherichia coli]]
		+	[[Category: Dip, P V.]]
		+	[[Category: Eisenhaber, B.]]
		+	[[Category: Eisenhaber, F.]]
		+	[[Category: Gruber, G.]]
		+	[[Category: Kamariah, N.]]
		+	[[Category: Manimekalai, M S.S.]]
		+	[[Category: Oxidoreductase]]

OCA at 09:23, 8 January 2014

OCA — Wed, 08 Jan 2014 09:23:30 GMT

←Older revision		Revision as of 09:23, 8 January 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4o5u is ON HOLD	+	The entry 4o5u is ON HOLD until Paper Publication

	Authors: Kamariah, N., Dip, P.V., Manimekalai, M.S.S., Gruber, G., Eisenhaber, F., Eisenhaber, B.		Authors: Kamariah, N., Dip, P.V., Manimekalai, M.S.S., Gruber, G., Eisenhaber, F., Eisenhaber, B.

	Description: Crystal structure of Alkylhydroperoxide Reductase subunit F from E. coli at 2.65 Ang resolution		Description: Crystal structure of Alkylhydroperoxide Reductase subunit F from E. coli at 2.65 Ang resolution

OCA: Protected "4o5u" [edit=sysop:move=sysop]

OCA — Wed, 25 Dec 2013 09:35:19 GMT

Protected "4o5u" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:35, 25 December 2013

OCA: New page: '''Unreleased structure''' The entry 4o5u is ON HOLD Authors: Kamariah, N., Dip, P.V., Manimekalai, M.S.S., Gruber, G., Eisenhaber, F., Eisenhaber, B. Description: Crystal structure of...

OCA — Wed, 25 Dec 2013 09:35:19 GMT

New page: '''Unreleased structure''' The entry 4o5u is ON HOLD Authors: Kamariah, N., Dip, P.V., Manimekalai, M.S.S., Gruber, G., Eisenhaber, F., Eisenhaber, B. Description: Crystal structure of...

New page

'''Unreleased structure'''

The entry 4o5u is ON HOLD

Authors: Kamariah, N., Dip, P.V., Manimekalai, M.S.S., Gruber, G., Eisenhaber, F., Eisenhaber, B.

Description: Crystal structure of Alkylhydroperoxide Reductase subunit F from E. coli at 2.65 Ang resolution