4o6k - Revision history

OCA at 08:58, 18 January 2023

OCA — Wed, 18 Jan 2023 08:58:12 GMT

←Older revision		Revision as of 08:58, 18 January 2023
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	==The crystal structure of zebrafish IL-22==		==The crystal structure of zebrafish IL-22==
-	<StructureSection load='4o6k' size='340' side='right' caption='[[4o6k]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='4o6k' size='340' side='right'caption='[[4o6k]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4o6k]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Brachidanio_rerio Brachidanio~~ rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O6K OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4O6K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4o6k]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O6K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O6K FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">il22, IL-22 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o6k OCA], [https://pdbe.org/4o6k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o6k RCSB], [https://www.ebi.ac.uk/pdbsum/4o6k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o6k ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4o6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o6k OCA], [~~http~~://pdbe.org/4o6k PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4o6k RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4o6k PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4o6k ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q5TLE4_DANRE Q5TLE4_DANRE]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 4o6k" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4o6k" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Interleukin 3D structures\|Interleukin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Brachidanio~~ rerio]]	+	[[Category: Danio rerio]]
-	[[Category: Fretaud, M]]	+	[[Category: Large Structures]]
-	[[Category: Hamming~~, O J~~]]	+	[[Category: Fretaud M]]
-	[[Category: Hartmann, R]]	+	[[Category: Hamming OJ]]
-	[[Category: Levraud~~, J P~~]]	+	[[Category: Hartmann R]]
-	[[Category: Luftalla, G]]	+	[[Category: Levraud JP]]
-	[[Category: Siupka, P]]	+	[[Category: Luftalla G]]
-	~~[[Category: Il-22]]~~	+	[[Category: Siupka P]]
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Interleukin-22]]~~	+
-	~~[[Category: Zil-22~~]]	+

OCA at 07:34, 23 May 2018

OCA — Wed, 23 May 2018 07:34:45 GMT

←Older revision		Revision as of 07:34, 23 May 2018
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	<StructureSection load='4o6k' size='340' side='right' caption='[[4o6k]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4o6k' size='340' side='right' caption='[[4o6k]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4o6k]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O6K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O6K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4o6k]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O6K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O6K FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o6k OCA], [http://pdbe.org/4o6k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4o6k RCSB], [http://www.ebi.ac.uk/pdbsum/4o6k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4o6k ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">il22, IL-22 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o6k OCA], [http://pdbe.org/4o6k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4o6k RCSB], [http://www.ebi.ac.uk/pdbsum/4o6k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4o6k ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Brachidanio rerio]]
	[[Category: Fretaud, M]]		[[Category: Fretaud, M]]
	[[Category: Hamming, O J]]		[[Category: Hamming, O J]]

OCA at 18:18, 11 August 2016

OCA — Thu, 11 Aug 2016 18:18:47 GMT

←Older revision		Revision as of 18:18, 11 August 2016
Line 1:		Line 1:
		+
	==The crystal structure of zebrafish IL-22==		==The crystal structure of zebrafish IL-22==
	<StructureSection load='4o6k' size='340' side='right' caption='[[4o6k]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4o6k' size='340' side='right' caption='[[4o6k]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4o6k]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O6K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O6K FirstGlance]. <br>		<table><tr><td colspan='2'>[[4o6k]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O6K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O6K FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o6k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o6k RCSB], [http://www.ebi.ac.uk/pdbsum/4o6k PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o6k OCA], [http://pdbe.org/4o6k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4o6k RCSB], [http://www.ebi.ac.uk/pdbsum/4o6k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4o6k ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4o6k" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:12, 26 November 2014

OCA — Wed, 26 Nov 2014 06:12:00 GMT

←Older revision		Revision as of 06:12, 26 November 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4o6k]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O6K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O6K FirstGlance]. <br>		<table><tr><td colspan='2'>[[4o6k]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O6K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O6K FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o6k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o6k RCSB], [http://www.ebi.ac.uk/pdbsum/4o6k PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o6k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o6k RCSB], [http://www.ebi.ac.uk/pdbsum/4o6k PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Fretaud, M.]]	+	[[Category: Fretaud, M]]
-	[[Category: Hamming, O J.]]	+	[[Category: Hamming, O J]]
-	[[Category: Hartmann, R.]]	+	[[Category: Hartmann, R]]
-	[[Category: Levraud, J P.]]	+	[[Category: Levraud, J P]]
-	[[Category: Luftalla, G.]]	+	[[Category: Luftalla, G]]
-	[[Category: Siupka, P.]]	+	[[Category: Siupka, P]]
	[[Category: Il-22]]		[[Category: Il-22]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Interleukin-22]]		[[Category: Interleukin-22]]
	[[Category: Zil-22]]		[[Category: Zil-22]]

OCA at 10:00, 10 September 2014

OCA — Wed, 10 Sep 2014 10:00:09 GMT

←Older revision		Revision as of 10:00, 10 September 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==The crystal structure of zebrafish IL-22==
		+	<StructureSection load='4o6k' size='340' side='right' caption='[[4o6k]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4o6k]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O6K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O6K FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o6k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o6k RCSB], [http://www.ebi.ac.uk/pdbsum/4o6k PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The class II cytokine family consists of small alpha-helical signaling proteins including the interleukin-10 (IL-10)/IL-22 family, as well as interferons (IFNs). They regulate the innate immune response and in addition have an important role in protecting epithelial tissues. Teleost fish possess a class II cytokine system surprisingly similar to that of humans, and thus zebrafish offers an attractive model organism for investigating the role of class II cytokines in inflammation. However, the evolution of class II cytokines is critical to understand if we are to take full advantage of zebrafish as a model system. The small size and fast evolution of these cytokines obscure phylogenetic analyses based purely on sequences, but one can overcome this obstacle by using information contained within the structure of those molecules. Here we present the crystal structure of IL-22 from zebrafish (zIL-22) solved at 2.1 A, which displays a typical class II cytokine architecture. We generated a structure-guided alignment of vertebrate class II cytokines and used it for phylogenetic analysis. Our analysis suggests that IL-22 and IL-26 arose early during the evolution of the IL-10-like cytokines. Thus, we propose an evolutionary scenario of class II cytokines in vertebrates, based on genomic and structural data.

-	The ~~entry 4o6k is ON HOLD~~	+	The crystal structure of zebrafish IL-22 reveals an evolutionary, conserved structure highly similar to that of human IL-22.,Siupka P, Hamming OJ, Fretaud M, Luftalla G, Levraud JP, Hartmann R Genes Immun. 2014 Jul-Aug;15(5):293-302. doi: 10.1038/gene.2014.18. Epub 2014 May, 15. PMID:24833303<ref>PMID:24833303</ref>

-	~~Authors: Siupka~~, P., Hamming, O.J., ~~Frtaud, M~~., Luftalla, G., ~~Levraud, J.~~P.~~, Hartmann, R.~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Zebrafish IL~~-22	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Fretaud, M.]]
		+	[[Category: Hamming, O J.]]
		+	[[Category: Hartmann, R.]]
		+	[[Category: Levraud, J P.]]
		+	[[Category: Luftalla, G.]]
		+	[[Category: Siupka, P.]]
		+	[[Category: Il-22]]
		+	[[Category: Immune system]]
		+	[[Category: Interleukin-22]]
		+	[[Category: Zil-22]]

OCA at 06:46, 22 January 2014

OCA — Wed, 22 Jan 2014 06:46:17 GMT

←Older revision		Revision as of 06:46, 22 January 2014
Line 3:		Line 3:
	The entry 4o6k is ON HOLD		The entry 4o6k is ON HOLD

-	Authors: Siupka, P., Hamming, O.J., ~~Fr taud~~, M., Luftalla, G., Levraud, J-P., Hartmann, R.	+	Authors: Siupka, P., Hamming, O.J., Frtaud, M., Luftalla, G., Levraud, J.P., Hartmann, R.

	Description: Zebrafish IL-22		Description: Zebrafish IL-22

OCA: Protected "4o6k" [edit=sysop:move=sysop]

OCA — Wed, 08 Jan 2014 09:24:45 GMT

Protected "4o6k" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:24, 8 January 2014

OCA: New page: '''Unreleased structure''' The entry 4o6k is ON HOLD Authors: Siupka, P., Hamming, O.J., Fr taud, M., Luftalla, G., Levraud, J-P., Hartmann, R. Description: Zebrafish IL-22

OCA — Wed, 08 Jan 2014 09:24:43 GMT

New page: '''Unreleased structure''' The entry 4o6k is ON HOLD Authors: Siupka, P., Hamming, O.J., Fr taud, M., Luftalla, G., Levraud, J-P., Hartmann, R. Description: Zebrafish IL-22

New page

'''Unreleased structure'''

The entry 4o6k is ON HOLD

Authors: Siupka, P., Hamming, O.J., Fr taud, M., Luftalla, G., Levraud, J-P., Hartmann, R.

Description: Zebrafish IL-22