4o6x - Revision history

OCA at 17:07, 20 September 2023

OCA — Wed, 20 Sep 2023 17:07:53 GMT

←Older revision		Revision as of 17:07, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4o6x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O6X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O6X FirstGlance]. <br>		<table><tr><td colspan='2'>[[4o6x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O6X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O6X FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o6x OCA], [https://pdbe.org/4o6x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o6x RCSB], [https://www.ebi.ac.uk/pdbsum/4o6x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o6x ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.103Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o6x OCA], [https://pdbe.org/4o6x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o6x RCSB], [https://www.ebi.ac.uk/pdbsum/4o6x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o6x ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==

OCA at 08:58, 18 January 2023

OCA — Wed, 18 Jan 2023 08:58:35 GMT

←Older revision		Revision as of 08:58, 18 January 2023
Line 3:		Line 3:
	<StructureSection load='4o6x' size='340' side='right'caption='[[4o6x]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4o6x' size='340' side='right'caption='[[4o6x]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4o6x]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O6X OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4O6X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4o6x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O6X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O6X FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3psp\|3psp]], [[3pst\|3pst]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o6x OCA], [https://pdbe.org/4o6x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o6x RCSB], [https://www.ebi.ac.uk/pdbsum/4o6x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o6x ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ANK3, Ankyrin G ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4o6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o6x OCA], [~~http~~://pdbe.org/4o6x PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4o6x RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4o6x PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4o6x ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/ANK3_HUMAN ANK3_HUMAN]] Intellectual disability - hypotonia - spasticity - sleep disorder;Schizophrenia. Genetic variations in ANK3 may be associated with autism spectrum disorders susceptibility. The disease is caused by mutations affecting the gene represented in this entry. A homozygous deletion in ANK3 predicted to result in frameshift and premature truncation, has been shown to be the cause of moderate intellectual disability, an ADHD-like phenotype and behavioral problems in a consanguineous family (PubMed:23390136).<ref>PMID:23390136</ref>	+	[https://www.uniprot.org/uniprot/ANK3_HUMAN ANK3_HUMAN] Intellectual disability - hypotonia - spasticity - sleep disorder;Schizophrenia. Genetic variations in ANK3 may be associated with autism spectrum disorders susceptibility. The disease is caused by mutations affecting the gene represented in this entry. A homozygous deletion in ANK3 predicted to result in frameshift and premature truncation, has been shown to be the cause of moderate intellectual disability, an ADHD-like phenotype and behavioral problems in a consanguineous family (PubMed:23390136).<ref>PMID:23390136</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ANK3_HUMAN ANK3_HUMAN]] In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. Isoform 5: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin.	+	[https://www.uniprot.org/uniprot/ANK3_HUMAN ANK3_HUMAN] In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. Isoform 5: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Liu, Y]]	+	[[Category: Liu Y]]
-	[[Category: Wang~~, J H~~]]	+	[[Category: Wang JH]]
-	[[Category: Zhang, Y]]	+	[[Category: Zhang Y]]
-	~~[[Category: Alpha helix]]~~	+
-	~~[[Category: Alpha helix bundle]]~~	+
-	~~[[Category: Death domain]]~~	+
-	~~[[Category: Protein binding~~]]	+

OCA at 08:56, 10 April 2019

OCA — Wed, 10 Apr 2019 08:56:20 GMT

←Older revision		Revision as of 08:56, 10 April 2019
Line 1:		Line 1:

	==Crystal structure of human Ankyrin G death domain==		==Crystal structure of human Ankyrin G death domain==
-	<StructureSection load='4o6x' size='340' side='right' caption='[[4o6x]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='4o6x' size='340' side='right'caption='[[4o6x]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4o6x]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O6X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O6X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4o6x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O6X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O6X FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3psp\|3psp]], [[3pst\|3pst]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3psp\|3psp]], [[3pst\|3pst]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ANK3, Ankyrin G ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o6x OCA], [http://pdbe.org/4o6x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4o6x RCSB], [http://www.ebi.ac.uk/pdbsum/4o6x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4o6x ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o6x OCA], [http://pdbe.org/4o6x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4o6x RCSB], [http://www.ebi.ac.uk/pdbsum/4o6x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4o6x ProSAT]</span></td></tr>
	</table>		</table>
Line 22:		Line 23:

	==See Also==		==See Also==
-	*[[Ankyrin\|Ankyrin]]	+	*[[Ankyrin 3D structures\|Ankyrin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Liu, Y]]		[[Category: Liu, Y]]
	[[Category: Wang, J H]]		[[Category: Wang, J H]]

OCA at 17:02, 2 January 2017

OCA — Mon, 02 Jan 2017 17:02:02 GMT

←Older revision		Revision as of 17:02, 2 January 2017
Line 1:		Line 1:
		+
	==Crystal structure of human Ankyrin G death domain==		==Crystal structure of human Ankyrin G death domain==
	<StructureSection load='4o6x' size='340' side='right' caption='[[4o6x]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4o6x' size='340' side='right' caption='[[4o6x]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4o6x]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O6X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O6X FirstGlance]. <br>		<table><tr><td colspan='2'>[[4o6x]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O6X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O6X FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3psp\|3psp]], [[3pst\|3pst]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3psp\|3psp]], [[3pst\|3pst]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o6x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o6x RCSB], [http://www.ebi.ac.uk/pdbsum/4o6x PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o6x OCA], [http://pdbe.org/4o6x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4o6x RCSB], [http://www.ebi.ac.uk/pdbsum/4o6x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4o6x ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4o6x" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ankyrin\|Ankyrin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:44, 17 December 2014

OCA — Wed, 17 Dec 2014 09:44:54 GMT

←Older revision		Revision as of 09:44, 17 December 2014
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Liu, Y.]]	+	[[Category: Liu, Y]]
-	[[Category: Wang, J H.]]	+	[[Category: Wang, J H]]
-	[[Category: Zhang, Y.]]	+	[[Category: Zhang, Y]]
	[[Category: Alpha helix]]		[[Category: Alpha helix]]
	[[Category: Alpha helix bundle]]		[[Category: Alpha helix bundle]]
	[[Category: Death domain]]		[[Category: Death domain]]
	[[Category: Protein binding]]		[[Category: Protein binding]]

OCA at 11:13, 29 October 2014

OCA — Wed, 29 Oct 2014 11:13:13 GMT

←Older revision		Revision as of 11:13, 29 October 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of human Ankyrin G death domain==
		+	<StructureSection load='4o6x' size='340' side='right' caption='[[4o6x]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4o6x]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O6X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O6X FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3psp\|3psp]], [[3pst\|3pst]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o6x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o6x RCSB], [http://www.ebi.ac.uk/pdbsum/4o6x PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/ANK3_HUMAN ANK3_HUMAN]] Intellectual disability - hypotonia - spasticity - sleep disorder;Schizophrenia. Genetic variations in ANK3 may be associated with autism spectrum disorders susceptibility. The disease is caused by mutations affecting the gene represented in this entry. A homozygous deletion in ANK3 predicted to result in frameshift and premature truncation, has been shown to be the cause of moderate intellectual disability, an ADHD-like phenotype and behavioral problems in a consanguineous family (PubMed:23390136).<ref>PMID:23390136</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ANK3_HUMAN ANK3_HUMAN]] In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. Isoform 5: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Ankyrins (Ank) are a ubiquitously expressed family of multifunctional membrane adapter proteins. Ankyrin G (AnkG) is critical for assembling and maintenance of the axon initial segment. Here we present the 2.1 A crystal structure of human AnkG death domain (hAnkG-DD). The core death domain is composed of six alpha-helices and three 310 -helices. It forms a hydrophobic pocket on the surface of the molecule. The C-terminal tail of the hAnkG-DD curves back to have the aromatic ring of a phenylalanine residue, Phe100 insert into this pocket, which anchors the flexible tail onto the core domain. Related DDs were selected for structure comparison. The major variations are at the C-terminal region, including the alpha6 and the long C-terminal extension. The results of size exclusion chromatography and analytical ultracentrifugation suggest that hAnkG-DD exists as monomer in solution. Our work should help for the future investigation of the structure-function of AnkG.Proteins 2014. (c) 2014 Wiley Periodicals, Inc.

-	~~The entry 4o6x is ON HOLD until Paper Publication~~	+	Crystal structure of human Ankyrin G death domain.,Liu Y, Zhang Y, Wang JH Proteins. 2014 Oct 11. doi: 10.1002/prot.24702. PMID:25307106<ref>PMID:25307106</ref>

-	~~Authors~~: Liu, Y.~~, Zhang, Y.,~~ Wang, J.H.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal structure of human Ankyrin G death~~ domain	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Liu, Y.]]
		+	[[Category: Wang, J H.]]
		+	[[Category: Zhang, Y.]]
		+	[[Category: Alpha helix]]
		+	[[Category: Alpha helix bundle]]
		+	[[Category: Death domain]]
		+	[[Category: Protein binding]]

OCA at 07:04, 29 January 2014

OCA — Wed, 29 Jan 2014 07:04:35 GMT

←Older revision		Revision as of 07:04, 29 January 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4o6x is ON HOLD	+	The entry 4o6x is ON HOLD until Paper Publication

-	Authors: Liu, Y.	+	Authors: Liu, Y., Zhang, Y., Wang, J.H.

	Description: Crystal structure of human Ankyrin G death domain		Description: Crystal structure of human Ankyrin G death domain

OCA: Protected "4o6x" [edit=sysop:move=sysop]

OCA — Wed, 08 Jan 2014 09:25:22 GMT

Protected "4o6x" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:25, 8 January 2014

OCA: New page: '''Unreleased structure''' The entry 4o6x is ON HOLD Authors: Liu, Y. Description: Crystal structure of human Ankyrin G death domain

OCA — Wed, 08 Jan 2014 09:25:20 GMT

New page: '''Unreleased structure''' The entry 4o6x is ON HOLD Authors: Liu, Y. Description: Crystal structure of human Ankyrin G death domain

New page

'''Unreleased structure'''

The entry 4o6x is ON HOLD

Authors: Liu, Y.

Description: Crystal structure of human Ankyrin G death domain