4o70 - Revision history

OCA at 17:07, 20 September 2023

OCA — Wed, 20 Sep 2023 17:07:54 GMT

←Older revision		Revision as of 17:07, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4o70]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O70 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O70 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4o70]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O70 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O70 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1QK:3-[({3-ETHYL-5-[(2S)-2-(2-HYDROXYETHYL)PIPERIDIN-1-YL]PYRAZOLO[1,5-A]PYRIMIDIN-7-YL}AMINO)METHYL]-1-HYDROXYPYRIDINIUM'>1QK</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.55Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1QK:3-[({3-ETHYL-5-[(2S)-2-(2-HYDROXYETHYL)PIPERIDIN-1-YL]PYRAZOLO[1,5-A]PYRIMIDIN-7-YL}AMINO)METHYL]-1-HYDROXYPYRIDINIUM'>1QK</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o70 OCA], [https://pdbe.org/4o70 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o70 RCSB], [https://www.ebi.ac.uk/pdbsum/4o70 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o70 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o70 OCA], [https://pdbe.org/4o70 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o70 RCSB], [https://www.ebi.ac.uk/pdbsum/4o70 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o70 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 08:58, 18 January 2023

OCA — Wed, 18 Jan 2023 08:58:39 GMT

←Older revision		Revision as of 08:58, 18 January 2023
Line 1:		Line 1:

	==Crystal structure of the first bromodomain of human BRD4 in complex with DINACICLIB==		==Crystal structure of the first bromodomain of human BRD4 in complex with DINACICLIB==
-	<StructureSection load='4o70' size='340' side='right' caption='[[4o70]], [[Resolution\|resolution]] 1.55Å' scene=''>	+	<StructureSection load='4o70' size='340' side='right'caption='[[4o70]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4o70]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O70 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4O70 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4o70]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O70 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O70 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1QK:3-[({3-ETHYL-5-[(2S)-2-(2-HYDROXYETHYL)PIPERIDIN-1-YL]PYRAZOLO[1,5-A]PYRIMIDIN-7-YL}AMINO)METHYL]-1-HYDROXYPYRIDINIUM'>1QK</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1QK:3-[({3-ETHYL-5-[(2S)-2-(2-HYDROXYETHYL)PIPERIDIN-1-YL]PYRAZOLO[1,5-A]PYRIMIDIN-7-YL}AMINO)METHYL]-1-HYDROXYPYRIDINIUM'>1QK</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4o71\|4o71]], [[4o72\|4o72]], [[4o73\|4o73]], [[4o74\|4o74]], [[4o75\|4o75]], [[4o76\|4o76]], [[4o77\|4o77]], [[4o78\|4o78]], [[4o7a\|4o7a]], [[4o7b\|4o7b]], [[4o7c\|4o7c]], [[4o7e\|4o7e]], [[4o7f\|4o7f]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o70 OCA], [https://pdbe.org/4o70 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o70 RCSB], [https://www.ebi.ac.uk/pdbsum/4o70 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o70 ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4o70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o70 OCA], [~~http~~://pdbe.org/4o70 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4o70 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4o70 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4o70 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>	+	[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).	+	[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 22:

	==See Also==		==See Also==
-	*[[Bromodomain-containing protein\|Bromodomain-containing protein]]	+	*[[Bromodomain-containing protein 3D structures\|Bromodomain-containing protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: Ember~~, S W~~]]	+	[[Category: Large Structures]]
-	[[Category: Schonbrunn, E]]	+	[[Category: Ember SW]]
-	[[Category: Watts, C]]	+	[[Category: Schonbrunn E]]
-	[[Category: Zhu, J Y]]	+	[[Category: Watts C]]
-	~~[[Category: Bromodomain]]~~	+	[[Category: Zhu J-Y]]
-	~~[[Category: Cap]]~~	+
-	~~[[Category: Cell cycle]]~~	+
-	~~[[Category: Hunk1]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Mcap]]~~	+
-	~~[[Category: Mitotic chromosome associated protein]]~~	+
-	~~[[Category: Protein binding-inhibitor complex]]~~	+
-	~~[[Category: Transcription-inhibitor complex~~]]	+

OCA at 15:54, 11 August 2016

OCA — Thu, 11 Aug 2016 15:54:21 GMT

←Older revision		Revision as of 15:54, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the first bromodomain of human BRD4 in complex with DINACICLIB==		==Crystal structure of the first bromodomain of human BRD4 in complex with DINACICLIB==
	<StructureSection load='4o70' size='340' side='right' caption='[[4o70]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='4o70' size='340' side='right' caption='[[4o70]], [[Resolution\|resolution]] 1.55Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4o71\|4o71]], [[4o72\|4o72]], [[4o73\|4o73]], [[4o74\|4o74]], [[4o75\|4o75]], [[4o76\|4o76]], [[4o77\|4o77]], [[4o78\|4o78]], [[4o7a\|4o7a]], [[4o7b\|4o7b]], [[4o7c\|4o7c]], [[4o7e\|4o7e]], [[4o7f\|4o7f]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4o71\|4o71]], [[4o72\|4o72]], [[4o73\|4o73]], [[4o74\|4o74]], [[4o75\|4o75]], [[4o76\|4o76]], [[4o77\|4o77]], [[4o78\|4o78]], [[4o7a\|4o7a]], [[4o7b\|4o7b]], [[4o7c\|4o7c]], [[4o7e\|4o7e]], [[4o7f\|4o7f]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o70 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o70 RCSB], [http://www.ebi.ac.uk/pdbsum/4o70 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o70 OCA], [http://pdbe.org/4o70 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4o70 RCSB], [http://www.ebi.ac.uk/pdbsum/4o70 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4o70 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 21:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4o70" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Bromodomain-containing protein\|Bromodomain-containing protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:27, 5 January 2015

OCA — Mon, 05 Jan 2015 08:27:45 GMT

←Older revision		Revision as of 08:27, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4o70]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O70 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O70 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4o70]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O70 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O70 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1QK:3-[({3-ETHYL-5-[(2S)-2-(2-HYDROXYETHYL)PIPERIDIN-1-YL]PYRAZOLO[1,5-A]PYRIMIDIN-7-YL}AMINO)METHYL]-1-HYDROXYPYRIDINIUM'>1QK</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1QK:3-[({3-ETHYL-5-[(2S)-2-(2-HYDROXYETHYL)PIPERIDIN-1-YL]PYRAZOLO[1,5-A]PYRIMIDIN-7-YL}AMINO)METHYL]-1-HYDROXYPYRIDINIUM'>1QK</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4o71\|4o71]], [[4o72\|4o72]], [[4o73\|4o73]], [[4o74\|4o74]], [[4o75\|4o75]], [[4o76\|4o76]], [[4o77\|4o77]], [[4o78\|4o78]], [[4o7a\|4o7a]], [[4o7b\|4o7b]], [[4o7c\|4o7c]], [[4o7e\|4o7e]], [[4o7f\|4o7f]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4o71\|4o71]], [[4o72\|4o72]], [[4o73\|4o73]], [[4o74\|4o74]], [[4o75\|4o75]], [[4o76\|4o76]], [[4o77\|4o77]], [[4o78\|4o78]], [[4o7a\|4o7a]], [[4o7b\|4o7b]], [[4o7c\|4o7c]], [[4o7e\|4o7e]], [[4o7f\|4o7f]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o70 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o70 RCSB], [http://www.ebi.ac.uk/pdbsum/4o70 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o70 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o70 RCSB], [http://www.ebi.ac.uk/pdbsum/4o70 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>		[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
Line 18:		Line 18:
	Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors.,Ember SW, Zhu JY, Olesen SH, Martin MP, Becker A, Berndt N, Georg GI, Schonbrunn E ACS Chem Biol. 2014 Mar 13. PMID:24568369<ref>PMID:24568369</ref>		Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors.,Ember SW, Zhu JY, Olesen SH, Martin MP, Becker A, Berndt N, Georg GI, Schonbrunn E ACS Chem Biol. 2014 Mar 13. PMID:24568369<ref>PMID:24568369</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
-	[[Category: Ember, S W.]]	+	[[Category: Ember, S W]]
-	[[Category: Schonbrunn, E.]]	+	[[Category: Schonbrunn, E]]
-	[[Category: Watts, C.]]	+	[[Category: Watts, C]]
-	[[Category: Zhu, J Y.]]	+	[[Category: Zhu, J Y]]
	[[Category: Bromodomain]]		[[Category: Bromodomain]]
	[[Category: Cap]]		[[Category: Cap]]

OCA at 12:32, 18 May 2014

OCA — Sun, 18 May 2014 12:32:29 GMT

←Older revision		Revision as of 12:32, 18 May 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4o70\| PDB=4o70 \| SCENE= }}~~	+	==Crystal structure of the first bromodomain of human BRD4 in complex with DINACICLIB==
-	===Crystal structure of the first bromodomain of human BRD4 in complex with DINACICLIB===	+	<StructureSection load='4o70' size='340' side='right' caption='[[4o70]], [[Resolution\|resolution]] 1.55Å' scene=''>
-	{~~{ABSTRACT_PUBMED_24568369}~~}	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4o70]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O70 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O70 FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1QK:3-[({3-ETHYL-5-[(2S)-2-(2-HYDROXYETHYL)PIPERIDIN-1-YL]PYRAZOLO[1,5-A]PYRIMIDIN-7-YL}AMINO)METHYL]-1-HYDROXYPYRIDINIUM'>1QK</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4o71\|4o71]], [[4o72\|4o72]], [[4o73\|4o73]], [[4o74\|4o74]], [[4o75\|4o75]], [[4o76\|4o76]], [[4o77\|4o77]], [[4o78\|4o78]], [[4o7a\|4o7a]], [[4o7b\|4o7b]], [[4o7c\|4o7c]], [[4o7e\|4o7e]], [[4o7f\|4o7f]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o70 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o70 RCSB], [http://www.ebi.ac.uk/pdbsum/4o70 PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>		[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
-		+	== Function ==
-	==Function==	+
	[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).		[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Members of the bromodomain and extra terminal (BET) family of proteins are essential for the recognition of acetylated lysine (KAc) residues in histones and have emerged as promising drug targets in cancer, inflammation, and contraception research. In co-crystallization screening campaigns using the first bromodomain of BRD4 (BRD4-1) against kinase inhibitor libraries, we identified and characterized 14 kinase inhibitors (10 distinct chemical scaffolds) as ligands of the KAc binding site. Among these, the PLK1 inhibitor BI2536 and the JAK2 inhibitor TG101209 displayed strongest inhibitory potential against BRD4 (IC50 = 25 nM and 130 nM, respectively) and high selectivity for BET bromodomains. Comparative structural analysis revealed markedly different binding modes of kinase hinge-binding scaffolds in the KAc binding site, suggesting that BET proteins are potential off-targets of diverse kinase inhibitors. Combined, these findings provide a new structural framework for the rational design of next-generation BET-selective and dual-activity BET-kinase inhibitors.

-	~~==About this Structure==~~	+	Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors.,Ember SW, Zhu JY, Olesen SH, Martin MP, Becker A, Berndt N, Georg GI, Schonbrunn E ACS Chem Biol. 2014 Mar 13. PMID:24568369<ref>PMID:24568369</ref>
-	~~[[4o70]] is a 2 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4O70 OCA].~~	+

-	==~~Reference~~==	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024568369</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Human]]
	[[Category: Ember, S W.]]		[[Category: Ember, S W.]]
	[[Category: Schonbrunn, E.]]		[[Category: Schonbrunn, E.]]

OCA at 08:45, 19 March 2014

OCA — Wed, 19 Mar 2014 08:45:24 GMT

←Older revision		Revision as of 08:45, 19 March 2014
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-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4o70\| PDB=4o70 \| SCENE= }}
		+	===Crystal structure of the first bromodomain of human BRD4 in complex with DINACICLIB===
		+	{{ABSTRACT_PUBMED_24568369}}

-	~~The entry 4o70~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>

-	~~Authors~~: ~~Ember, S~~.W.~~, Zhu, J.-Y., Watts, C., Schonbrunn, E~~.	+	==Function==
		+	[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

-	~~Description~~:	+	==About this Structure==
		+	[[4o70]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O70 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:024568369</ref><references group="xtra"/><references/>
		+	[[Category: Ember, S W.]]
		+	[[Category: Schonbrunn, E.]]
		+	[[Category: Watts, C.]]
		+	[[Category: Zhu, J Y.]]
		+	[[Category: Bromodomain]]
		+	[[Category: Cap]]
		+	[[Category: Cell cycle]]
		+	[[Category: Hunk1]]
		+	[[Category: Inhibitor]]
		+	[[Category: Mcap]]
		+	[[Category: Mitotic chromosome associated protein]]
		+	[[Category: Protein binding-inhibitor complex]]
		+	[[Category: Transcription-inhibitor complex]]

OCA at 06:46, 22 January 2014

OCA — Wed, 22 Jan 2014 06:46:21 GMT

←Older revision		Revision as of 06:46, 22 January 2014
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4o70 is ON HOLD	+	The entry 4o70 is ON HOLD until Paper Publication

	Authors: Ember, S.W., Zhu, J.-Y., Watts, C., Schonbrunn, E.		Authors: Ember, S.W., Zhu, J.-Y., Watts, C., Schonbrunn, E.

	Description:		Description:

OCA: Protected "4o70" [edit=sysop:move=sysop]

OCA — Wed, 08 Jan 2014 09:25:30 GMT

Protected "4o70" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:25, 8 January 2014

OCA: New page: '''Unreleased structure''' The entry 4o70 is ON HOLD Authors: Ember, S.W., Zhu, J.-Y., Watts, C., Schonbrunn, E. Description:

OCA — Wed, 08 Jan 2014 09:25:29 GMT

New page: '''Unreleased structure''' The entry 4o70 is ON HOLD Authors: Ember, S.W., Zhu, J.-Y., Watts, C., Schonbrunn, E. Description:

New page

'''Unreleased structure'''

The entry 4o70 is ON HOLD

Authors: Ember, S.W., Zhu, J.-Y., Watts, C., Schonbrunn, E.

Description: