4ofp - Revision history

OCA at 17:12, 20 September 2023

OCA — Wed, 20 Sep 2023 17:12:28 GMT

←Older revision		Revision as of 17:12, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ofp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OFP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OFP FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ofp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OFP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OFP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ofp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ofp OCA], [https://pdbe.org/4ofp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ofp RCSB], [https://www.ebi.ac.uk/pdbsum/4ofp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ofp ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ofp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ofp OCA], [https://pdbe.org/4ofp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ofp RCSB], [https://www.ebi.ac.uk/pdbsum/4ofp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ofp ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:22, 25 January 2023

OCA — Wed, 25 Jan 2023 07:22:34 GMT

←Older revision		Revision as of 07:22, 25 January 2023
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	==Crystal Structure of SYG-2 D3-D4==		==Crystal Structure of SYG-2 D3-D4==
-	<StructureSection load='4ofp' size='340' side='right' caption='[[4ofp]], [[Resolution\|resolution]] 3.00Å' scene=''>	+	<StructureSection load='4ofp' size='340' side='right'caption='[[4ofp]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ofp]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Caeel Caeel~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OFP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4OFP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ofp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OFP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OFP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4of0\|4of0]], [[4of3\|4of3]], [[4of6\|4of6]], [[4of7\|4of7]], [[4of8\|4of8]], [[4ofd\|4ofd]], [[4ofi\|4ofi]], [[4ofk\|4ofk]], [[4ofy\|4ofy]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ofp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ofp OCA], [https://pdbe.org/4ofp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ofp RCSB], [https://www.ebi.ac.uk/pdbsum/4ofp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ofp ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C26G2.1, CELE_C26G2.1, syg-2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ofp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ofp OCA], [~~http~~://pdbe.org/4ofp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ofp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ofp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ofp ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SYG2_CAEEL SYG2_CAEEL] Cell adhesion protein (PubMed:15035988). Determines synapse formation (PubMed:15035988, PubMed:21858180, PubMed:24485456). Required for correct localization of syg-1 at synaptic sites (PubMed:15035988).<ref>PMID:15035988</ref> <ref>PMID:21858180</ref> <ref>PMID:24485456</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Caeel~~]]	+	[[Category: Caenorhabditis elegans]]
-	[[Category: ~~Garcia, K C~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Ozkan, E~~]]	+	[[Category: Garcia KC]]
-	[[Category: ~~Cell adhesion]]~~	+	[[Category: Ozkan E]]
-	~~[[Category: Extracellular]]~~	+
-	~~[[Category: Immunoglobulin superfamily]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: N-linked glycosylation]]~~	+
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Signaling protein]]~~	+
-	~~[[Category: Synaptogenesis~~]]	+

OCA at 15:13, 4 August 2016

OCA — Thu, 04 Aug 2016 15:13:08 GMT

←Older revision		Revision as of 15:13, 4 August 2016
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		+
	==Crystal Structure of SYG-2 D3-D4==		==Crystal Structure of SYG-2 D3-D4==
	<StructureSection load='4ofp' size='340' side='right' caption='[[4ofp]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='4ofp' size='340' side='right' caption='[[4ofp]], [[Resolution\|resolution]] 3.00Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4of0\|4of0]], [[4of3\|4of3]], [[4of6\|4of6]], [[4of7\|4of7]], [[4of8\|4of8]], [[4ofd\|4ofd]], [[4ofi\|4ofi]], [[4ofk\|4ofk]], [[4ofy\|4ofy]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4of0\|4of0]], [[4of3\|4of3]], [[4of6\|4of6]], [[4of7\|4of7]], [[4of8\|4of8]], [[4ofd\|4ofd]], [[4ofi\|4ofi]], [[4ofk\|4ofk]], [[4ofy\|4ofy]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C26G2.1, CELE_C26G2.1, syg-2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C26G2.1, CELE_C26G2.1, syg-2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ofp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ofp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ofp RCSB], [http://www.ebi.ac.uk/pdbsum/4ofp PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ofp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ofp OCA], [http://pdbe.org/4ofp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ofp RCSB], [http://www.ebi.ac.uk/pdbsum/4ofp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ofp ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ofp" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 04:39, 22 December 2014

OCA — Mon, 22 Dec 2014 04:39:00 GMT

←Older revision		Revision as of 04:39, 22 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4ofp~~\| ~~PDB~~=4ofp \| ~~SCENE~~= }}	+	==Crystal Structure of SYG-2 D3-D4==
-	===~~Crystal Structure of SYG~~-2 D3-D4===	+	<StructureSection load='4ofp' size='340' side='right' caption='[[4ofp]], [[Resolution\|resolution]] 3.00Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24485456}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4ofp]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OFP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OFP FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4of0\|4of0]], [[4of3\|4of3]], [[4of6\|4of6]], [[4of7\|4of7]], [[4of8\|4of8]], [[4ofd\|4ofd]], [[4ofi\|4ofi]], [[4ofk\|4ofk]], [[4ofy\|4ofy]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">C26G2.1, CELE_C26G2.1, syg-2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ofp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ofp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ofp RCSB], [http://www.ebi.ac.uk/pdbsum/4ofp PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	SYG-1 and SYG-2 are multipurpose cell adhesion molecules (CAMs) that have evolved across all major animal taxa to participate in diverse physiological functions, ranging from synapse formation to formation of the kidney filtration barrier. In the crystal structures of several SYG-1 and SYG-2 orthologs and their complexes, we find that SYG-1 orthologs homodimerize through a common, bispecific interface that similarly mediates an unusual orthogonal docking geometry in the heterophilic SYG-1/SYG-2 complex. C. elegans SYG-1's specification of proper synapse formation in vivo closely correlates with the heterophilic complex affinity, which appears to be tuned for optimal function. Furthermore, replacement of the interacting domains of SYG-1 and SYG-2 with those from CAM complexes that assume alternative docking geometries or the introduction of segmental flexibility compromised synaptic function. These results suggest that SYG extracellular complexes do not simply act as "molecular velcro" and that their distinct structural features are important in instructing synaptogenesis. PAPERFLICK:

-	~~==About this Structure==~~	+	Extracellular Architecture of the SYG-1/SYG-2 Adhesion Complex Instructs Synaptogenesis.,Ozkan E, Chia PH, Wang RR, Goriatcheva N, Borek D, Otwinowski Z, Walz T, Shen K, Garcia KC Cell. 2014 Jan 30;156(3):482-94. doi: 10.1016/j.cell.2014.01.004. PMID:24485456<ref>PMID:24485456</ref>
-	~~[[4ofp]] is a 4 chain structure~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.ac.~~il/oca-bin/ocashort?id=4OFP OCA]~~.	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024485456</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
-	[[Category: Garcia, K C.]]	+	== References ==
-	[[Category: Ozkan, E.]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Caeel]]
		+	[[Category: Garcia, K C]]
		+	[[Category: Ozkan, E]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
	[[Category: Extracellular]]		[[Category: Extracellular]]

OCA at 17:26, 19 February 2014

OCA — Wed, 19 Feb 2014 17:26:17 GMT

←Older revision		Revision as of 17:26, 19 February 2014
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-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4ofp\| PDB=4ofp \| SCENE= }}
		+	===Crystal Structure of SYG-2 D3-D4===
		+	{{ABSTRACT_PUBMED_24485456}}

-	~~The entry~~ 4ofp is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
		+	[[4ofp]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OFP OCA].

-	~~Authors~~: ~~Ozkan, E.,~~ Garcia, K.C.	+	==Reference==
-		+	<ref group="xtra">PMID:024485456</ref><references group="xtra"/><references/>
-	~~Description~~: ~~Crystal Structure of SYG~~-~~2 D3-D4~~	+	[[Category: Garcia, K C.]]
		+	[[Category: Ozkan, E.]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Extracellular]]
		+	[[Category: Immunoglobulin superfamily]]
		+	[[Category: Membrane]]
		+	[[Category: N-linked glycosylation]]
		+	[[Category: Protein binding]]
		+	[[Category: Signaling protein]]
		+	[[Category: Synaptogenesis]]

OCA at 10:28, 5 February 2014

OCA — Wed, 05 Feb 2014 10:28:13 GMT

←Older revision		Revision as of 10:28, 5 February 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4ofp is ON HOLD	+	The entry 4ofp is ON HOLD until Paper Publication

	Authors: Ozkan, E., Garcia, K.C.		Authors: Ozkan, E., Garcia, K.C.

	Description: Crystal Structure of SYG-2 D3-D4		Description: Crystal Structure of SYG-2 D3-D4

OCA: Protected "4ofp" [edit=sysop:move=sysop]

OCA — Wed, 22 Jan 2014 06:48:34 GMT

Protected "4ofp" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:48, 22 January 2014

OCA: New page: '''Unreleased structure''' The entry 4ofp is ON HOLD Authors: Ozkan, E., Garcia, K.C. Description: Crystal Structure of SYG-2 D3-D4

OCA — Wed, 22 Jan 2014 06:48:33 GMT

New page: '''Unreleased structure''' The entry 4ofp is ON HOLD Authors: Ozkan, E., Garcia, K.C. Description: Crystal Structure of SYG-2 D3-D4

New page

'''Unreleased structure'''

The entry 4ofp is ON HOLD

Authors: Ozkan, E., Garcia, K.C.

Description: Crystal Structure of SYG-2 D3-D4