4okq - Revision history

OCA at 14:56, 8 November 2023

OCA — Wed, 08 Nov 2023 14:56:43 GMT

←Older revision		Revision as of 14:56, 8 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4okq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_thermodenitrificans_NG80-2 Geobacillus thermodenitrificans NG80-2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OKQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OKQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4okq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_thermodenitrificans_NG80-2 Geobacillus thermodenitrificans NG80-2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OKQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OKQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HIS:HISTIDINE'>HIS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HIS:HISTIDINE'>HIS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4okq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4okq OCA], [https://pdbe.org/4okq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4okq RCSB], [https://www.ebi.ac.uk/pdbsum/4okq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4okq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4okq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4okq OCA], [https://pdbe.org/4okq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4okq RCSB], [https://www.ebi.ac.uk/pdbsum/4okq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4okq ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:30, 25 January 2023

OCA — Wed, 25 Jan 2023 07:30:44 GMT

←Older revision		Revision as of 07:30, 25 January 2023
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	==Crystal structure of the single-stranded RNA binding protein HutP from Geobacillus thermodenitrificans==		==Crystal structure of the single-stranded RNA binding protein HutP from Geobacillus thermodenitrificans==
-	<StructureSection load='4okq' size='340' side='right' caption='[[4okq]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='4okq' size='340' side='right'caption='[[4okq]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4okq]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Geotn Geotn~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OKQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4OKQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4okq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_thermodenitrificans_NG80-2 Geobacillus thermodenitrificans NG80-2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OKQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OKQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIS:HISTIDINE'>HIS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HIS:HISTIDINE'>HIS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ok9\|4ok9]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4okq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4okq OCA], [https://pdbe.org/4okq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4okq RCSB], [https://www.ebi.ac.uk/pdbsum/4okq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4okq ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GTNG_0361, hutP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=420246 GEOTN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4okq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4okq OCA], [~~http~~://pdbe.org/4okq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4okq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4okq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4okq ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/HUTP_GEOTN HUTP_GEOTN]] Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization (By similarity).	+	[https://www.uniprot.org/uniprot/HUTP_GEOTN HUTP_GEOTN] Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Geotn~~]]	+	[[Category: Geobacillus thermodenitrificans NG80-2]]
-	[[Category: ~~Kumarevel, T S~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Ponnuswamy, M N~~]]	+	[[Category: Kumarevel TS]]
-	[[Category: ~~Thiruselvam, V~~]]	+	[[Category: Ponnuswamy MN]]
-	[[Category: ~~Antitermination]]~~	+	[[Category: Thiruselvam V]]
-	~~[[Category: Rna binding protein]]~~	+
-	~~[[Category: Single stranded-rna binding protein~~]]	+

OCA at 00:11, 5 August 2016

OCA — Fri, 05 Aug 2016 00:11:21 GMT

←Older revision		Revision as of 00:11, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the single-stranded RNA binding protein HutP from Geobacillus thermodenitrificans==		==Crystal structure of the single-stranded RNA binding protein HutP from Geobacillus thermodenitrificans==
	<StructureSection load='4okq' size='340' side='right' caption='[[4okq]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='4okq' size='340' side='right' caption='[[4okq]], [[Resolution\|resolution]] 2.50Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ok9\|4ok9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ok9\|4ok9]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GTNG_0361, hutP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=420246 GEOTN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GTNG_0361, hutP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=420246 GEOTN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4okq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4okq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4okq RCSB], [http://www.ebi.ac.uk/pdbsum/4okq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4okq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4okq OCA], [http://pdbe.org/4okq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4okq RCSB], [http://www.ebi.ac.uk/pdbsum/4okq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4okq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4okq" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 21:03, 24 December 2014

OCA — Wed, 24 Dec 2014 21:03:46 GMT

←Older revision		Revision as of 21:03, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4okq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4okq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4okq RCSB], [http://www.ebi.ac.uk/pdbsum/4okq PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4okq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4okq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4okq RCSB], [http://www.ebi.ac.uk/pdbsum/4okq PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HUTP_GEOTN HUTP_GEOTN]] Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 09:31, 17 December 2014

OCA — Wed, 17 Dec 2014 09:31:34 GMT

←Older revision		Revision as of 09:31, 17 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4okq\| PDB=4okq \| SCENE= }}~~	+	==Crystal structure of the single-stranded RNA binding protein HutP from Geobacillus thermodenitrificans==
-	===Crystal structure of the single-stranded RNA binding protein HutP from Geobacillus thermodenitrificans===	+	<StructureSection load='4okq' size='340' side='right' caption='[[4okq]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4okq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Geotn Geotn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OKQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OKQ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIS:HISTIDINE'>HIS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ok9\|4ok9]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GTNG_0361, hutP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=420246 GEOTN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4okq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4okq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4okq RCSB], [http://www.ebi.ac.uk/pdbsum/4okq PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	RNA binding proteins control gene expression by the attenuation/antitermination mechanism. HutP is an RNA binding antitermination protein. It regulates the expression of hut operon when it binds with RNA by modulating the secondary structure of single-stranded hut mRNA. HutP necessitates the presence of l-histidine and divalent metal ion to bind with RNA. Herein, we report the crystal structures of ternary complex (HutP-l-histidine-Mg(2+)) and EDTA (0.5 M) treated ternary complex (HutP-l-histidine-Mg(2+)), solved at 1.9 A and 2.5 A resolutions, respectively, from Geobacillus thermodenitrificans. The addition of 0.5 M EDTA does not affect the overall metal-ion mediated ternary complex structure and however, the metal ions at the non-specific binding sites are chelated, as evidenced from the results of structural features.

-	~~==Function==~~	+	Crystal structure of the single-stranded RNA binding protein HutP from Geobacillus thermodenitrificans.,Thiruselvam V, Sivaraman P, Kumarevel T, Ponnuswamy MN Biochem Biophys Res Commun. 2014 Apr 18;446(4):945-51. doi:, 10.1016/j.bbrc.2014.03.036. Epub 2014 Mar 17. PMID:24650662<ref>PMID:24650662</ref>
-	~~[[http://www.uniprot.org/uniprot/HUTP_GEOTN HUTP_GEOTN]] Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence~~ of ~~histidine, thereby suppressing transcription termination and activating~~ the ~~hut operon for histidine utilization~~ (~~By similarity~~).	+

-	==~~About this Structure~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[~~4okq]] is a 2 chain structure. Full crystallographic information is available from [http~~:~~//oca.weizmann.ac.il/oca-bin/ocashort?id=4OKQ OCA~~].	+	</div>
-	[[Category: Kumarevel, T S.]]	+	== References ==
-	[[Category: Ponnuswamy, M N.]]	+	<references/>
-	[[Category: Thiruselvam, V.]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Geotn]]
		+	[[Category: Kumarevel, T S]]
		+	[[Category: Ponnuswamy, M N]]
		+	[[Category: Thiruselvam, V]]
	[[Category: Antitermination]]		[[Category: Antitermination]]
	[[Category: Rna binding protein]]		[[Category: Rna binding protein]]
	[[Category: Single stranded-rna binding protein]]		[[Category: Single stranded-rna binding protein]]

OCA at 09:43, 19 March 2014

OCA — Wed, 19 Mar 2014 09:43:15 GMT

←Older revision		Revision as of 09:43, 19 March 2014
Line 1:		Line 1:
-	~~'''Unreleased~~ structure~~'''~~	+	{{STRUCTURE_4okq\| PDB=4okq \| SCENE= }}
		+	===Crystal structure of the single-stranded RNA binding protein HutP from Geobacillus thermodenitrificans===

-	~~The entry 4okq is ON HOLD until Mar 16 2015~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/HUTP_GEOTN HUTP_GEOTN]] Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization (By similarity).

-	~~Authors~~: ~~Thiruselvam, V~~., Ponnuswamy, M.N., ~~Kumarevel, T.S~~.	+	==About this Structure==
-		+	[[4okq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OKQ OCA].
-	~~Description~~: ~~Crystal structure of the single-~~stranded ~~RNA~~ binding protein ~~HutP from Geobacillus thermodenitrificans~~	+	[[Category: Kumarevel, T S.]]
		+	[[Category: Ponnuswamy, M N.]]
		+	[[Category: Thiruselvam, V.]]
		+	[[Category: Antitermination]]
		+	[[Category: Rna binding protein]]
		+	[[Category: Single stranded-rna binding protein]]

OCA at 10:31, 5 February 2014

OCA — Wed, 05 Feb 2014 10:31:01 GMT

←Older revision		Revision as of 10:31, 5 February 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4okq is ON HOLD	+	The entry 4okq is ON HOLD until Mar 16 2015

	Authors: Thiruselvam, V., Ponnuswamy, M.N., Kumarevel, T.S.		Authors: Thiruselvam, V., Ponnuswamy, M.N., Kumarevel, T.S.

	Description: Crystal structure of the single-stranded RNA binding protein HutP from Geobacillus thermodenitrificans		Description: Crystal structure of the single-stranded RNA binding protein HutP from Geobacillus thermodenitrificans

OCA: Protected "4okq" [edit=sysop:move=sysop]

OCA — Wed, 29 Jan 2014 07:12:20 GMT

Protected "4okq" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:12, 29 January 2014

OCA: New page: '''Unreleased structure''' The entry 4okq is ON HOLD Authors: Thiruselvam, V., Ponnuswamy, M.N., Kumarevel, T.S. Description: Crystal structure of the single-stranded RNA binding prote...

OCA — Wed, 29 Jan 2014 07:12:19 GMT

New page: '''Unreleased structure''' The entry 4okq is ON HOLD Authors: Thiruselvam, V., Ponnuswamy, M.N., Kumarevel, T.S. Description: Crystal structure of the single-stranded RNA binding prote...

New page

'''Unreleased structure'''

The entry 4okq is ON HOLD

Authors: Thiruselvam, V., Ponnuswamy, M.N., Kumarevel, T.S.

Description: Crystal structure of the single-stranded RNA binding protein HutP from Geobacillus thermodenitrificans