4ooy - Revision history

OCA at 07:37, 25 January 2023

OCA — Wed, 25 Jan 2023 07:37:19 GMT

←Older revision		Revision as of 07:37, 25 January 2023
Line 1:		Line 1:

	==Avibactam and class C beta-lactamases: mechanism of inhibition, conservation of binding pocket and implications for resistance==		==Avibactam and class C beta-lactamases: mechanism of inhibition, conservation of binding pocket and implications for resistance==
-	<StructureSection load='4ooy' size='340' side='right' caption='[[4ooy]], [[Resolution\|resolution]] 1.10Å' scene=''>	+	<StructureSection load='4ooy' size='340' side='right'caption='[[4ooy]], [[Resolution\|resolution]] 1.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ooy]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Pseae Pseae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OOY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4OOY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ooy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OOY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OOY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NXL:(2S,5R)-1-FORMYL-5-[(SULFOOXY)AMINO]PIPERIDINE-2-CARBOXAMIDE'>NXL</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NXL:(2S,5R)-1-FORMYL-5-[(SULFOOXY)AMINO]PIPERIDINE-2-CARBOXAMIDE'>NXL</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hef\|4hef]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ooy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ooy OCA], [https://pdbe.org/4ooy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ooy RCSB], [https://www.ebi.ac.uk/pdbsum/4ooy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ooy ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ampC, PA4110 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ooy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ooy OCA], [~~http~~://pdbe.org/4ooy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ooy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ooy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ooy ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/AMPC_PSEAE AMPC_PSEAE]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4ooy" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4ooy" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta-lactamase 3D structures\|Beta-lactamase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Beta-lactamase~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Pseae~~]]	+	[[Category: Pseudomonas aeruginosa PAO1]]
-	[[Category: Alm~~, R A~~]]	+	[[Category: Alm RA]]
-	[[Category: Lahiri~~, S D~~]]	+	[[Category: Lahiri SD]]
-	[[Category: Olivier~~, N B]]~~	+	[[Category: Olivier NB]]
-	~~[[Category: B-lactamase]]~~	+
-	~~[[Category: Carbamoylation with the inhibitor]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex~~]]	+

OCA at 06:51, 15 February 2018

OCA — Thu, 15 Feb 2018 06:51:08 GMT

←Older revision		Revision as of 06:51, 15 February 2018
Line 3:		Line 3:
	<StructureSection load='4ooy' size='340' side='right' caption='[[4ooy]], [[Resolution\|resolution]] 1.10Å' scene=''>		<StructureSection load='4ooy' size='340' side='right' caption='[[4ooy]], [[Resolution\|resolution]] 1.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ooy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OOY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OOY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ooy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OOY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OOY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NXL:(2S,5R)-1-FORMYL-5-[(SULFOOXY)AMINO]PIPERIDINE-2-CARBOXAMIDE'>NXL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NXL:(2S,5R)-1-FORMYL-5-[(SULFOOXY)AMINO]PIPERIDINE-2-CARBOXAMIDE'>NXL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hef\|4hef]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hef\|4hef]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ampC, PA4110 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ooy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ooy OCA], [http://pdbe.org/4ooy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ooy RCSB], [http://www.ebi.ac.uk/pdbsum/4ooy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ooy ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ooy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ooy OCA], [http://pdbe.org/4ooy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ooy RCSB], [http://www.ebi.ac.uk/pdbsum/4ooy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ooy ProSAT]</span></td></tr>
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4ooy" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4ooy" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Beta-lactamase\|Beta-lactamase]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
		+	[[Category: Pseae]]
	[[Category: Alm, R A]]		[[Category: Alm, R A]]
	[[Category: Lahiri, S D]]		[[Category: Lahiri, S D]]

OCA at 17:36, 9 March 2017

OCA — Thu, 09 Mar 2017 17:36:58 GMT

←Older revision		Revision as of 17:36, 9 March 2017
Line 1:		Line 1:
		+
	==Avibactam and class C beta-lactamases: mechanism of inhibition, conservation of binding pocket and implications for resistance==		==Avibactam and class C beta-lactamases: mechanism of inhibition, conservation of binding pocket and implications for resistance==
	<StructureSection load='4ooy' size='340' side='right' caption='[[4ooy]], [[Resolution\|resolution]] 1.10Å' scene=''>		<StructureSection load='4ooy' size='340' side='right' caption='[[4ooy]], [[Resolution\|resolution]] 1.10Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hef\|4hef]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hef\|4hef]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ooy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ooy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ooy RCSB], [http://www.ebi.ac.uk/pdbsum/4ooy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ooy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ooy OCA], [http://pdbe.org/4ooy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ooy RCSB], [http://www.ebi.ac.uk/pdbsum/4ooy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ooy ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ooy" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 06:58, 3 June 2015

OCA — Wed, 03 Jun 2015 06:58:54 GMT

←Older revision		Revision as of 06:58, 3 June 2015
Line 16:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+
		+	==See Also==
		+	*[[Beta-lactamase\|Beta-lactamase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:52, 20 January 2015

OCA — Tue, 20 Jan 2015 09:52:00 GMT

←Older revision		Revision as of 09:52, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ooy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OOY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OOY FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ooy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OOY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OOY FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NXL:(2S,5R)-1-FORMYL-5-[(SULFOOXY)AMINO]PIPERIDINE-2-CARBOXAMIDE'>NXL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NXL:(2S,5R)-1-FORMYL-5-[(SULFOOXY)AMINO]PIPERIDINE-2-CARBOXAMIDE'>NXL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hef\|4hef]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hef\|4hef]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ooy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ooy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ooy RCSB], [http://www.ebi.ac.uk/pdbsum/4ooy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ooy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ooy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ooy RCSB], [http://www.ebi.ac.uk/pdbsum/4ooy PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
-	[[Category: Alm, R A.]]	+	[[Category: Alm, R A]]
-	[[Category: Lahiri, S D.]]	+	[[Category: Lahiri, S D]]
-	[[Category: Olivier, N B.]]	+	[[Category: Olivier, N B]]
	[[Category: B-lactamase]]		[[Category: B-lactamase]]
	[[Category: Carbamoylation with the inhibitor]]		[[Category: Carbamoylation with the inhibitor]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]

OCA at 16:23, 20 August 2014

OCA — Wed, 20 Aug 2014 16:23:56 GMT

←Older revision		Revision as of 16:23, 20 August 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Avibactam and class C beta-lactamases: mechanism of inhibition, conservation of binding pocket and implications for resistance==
		+	<StructureSection load='4ooy' size='340' side='right' caption='[[4ooy]], [[Resolution\|resolution]] 1.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4ooy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OOY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OOY FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NXL:(2S,5R)-1-FORMYL-5-[(SULFOOXY)AMINO]PIPERIDINE-2-CARBOXAMIDE'>NXL</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4hef\|4hef]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ooy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ooy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ooy RCSB], [http://www.ebi.ac.uk/pdbsum/4ooy PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Avibactam is a novel non-beta-lactam beta-lactamase inhibitor that inhibits a wide range of beta-lactamases. These include class A, class C and some class D enzymes, which erode the activity of beta-lactam drugs in multi-drug-resistant pathogens like Pseudomonas aeruginosa and Enterobacteriaceae. Avibactam is currently in clinical development in combination with the beta-lactam antibiotics ceftazidime, ceftaroline fosamil and aztreonam. Avibactam has the potential to be the first beta-lactamase inhibitor that could provide activity against class C-mediated resistance, which represents a growing concern in both hospital- and community-acquired infections. Avibactam has an unusual mechanism of action: it is a covalent inhibitor that acts via ring-opening but, in contrast to other currently used beta-lactamase inhibitors, this reaction is reversible. Here we present a high resolution structure of avibactam bound to a class C beta-lactamase, AmpC, from P. aeruginosa that provided insight into the mechanism of both acylation and recyclization in this enzyme class and highlighted the differences observed between class A and class C inhibition. Furthermore, variants resistant to avibactam were isolated that identified the residues that are important for inhibition. Finally, the structural information was used to predict effective inhibition by sequence analysis and functional studies of class C beta-lactamases from a large and diverse set of contemporary clinical isolates (P. aeruginosa and several Enterobacteriaceae spp.) obtained from recent infections to understand any pre-existing variability in the binding pocket that could affect inhibition by avibactam.

-	~~The entry 4ooy is ON HOLD until Paper Publication~~	+	Avibactam and class C beta-lactamases: mechanism of inhibition, conservation of binding pocket and implications for resistance.,Lahiri SD, Johnstone M, Ross PL, McLaughlin R, Olivier NB, Alm RA Antimicrob Agents Chemother. 2014 Jul 14. pii: AAC.03057-14. PMID:25022578<ref>PMID:25022578</ref>

-	~~Authors~~: Lahiri, S.D., Olivier, N.B.~~, Alm, R.A.~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Avibactam and class C~~ -~~lactamases~~: ~~mechanism of inhibition, conservation of binding pocket and implications for resistance~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Beta-lactamase]]
		+	[[Category: Alm, R A.]]
		+	[[Category: Lahiri, S D.]]
		+	[[Category: Olivier, N B.]]
		+	[[Category: B-lactamase]]
		+	[[Category: Carbamoylation with the inhibitor]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]

OCA at 07:25, 19 March 2014

OCA — Wed, 19 Mar 2014 07:25:30 GMT

←Older revision		Revision as of 07:25, 19 March 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4ooy is ON HOLD	+	The entry 4ooy is ON HOLD until Paper Publication

	Authors: Lahiri, S.D., Olivier, N.B., Alm, R.A.		Authors: Lahiri, S.D., Olivier, N.B., Alm, R.A.

	Description: Avibactam and class C -lactamases: mechanism of inhibition, conservation of binding pocket and implications for resistance		Description: Avibactam and class C -lactamases: mechanism of inhibition, conservation of binding pocket and implications for resistance

OCA at 16:18, 19 February 2014

OCA — Wed, 19 Feb 2014 16:18:06 GMT

←Older revision		Revision as of 16:18, 19 February 2014
Line 3:		Line 3:
	The entry 4ooy is ON HOLD		The entry 4ooy is ON HOLD

-	Authors: Lahiri, SD, Olivier, NB, Alm, RA	+	Authors: Lahiri, S.D., Olivier, N.B., Alm, R.A.

	Description: Avibactam and class C -lactamases: mechanism of inhibition, conservation of binding pocket and implications for resistance		Description: Avibactam and class C -lactamases: mechanism of inhibition, conservation of binding pocket and implications for resistance

OCA: Protected "4ooy" [edit=sysop:move=sysop]

OCA — Thu, 13 Feb 2014 04:52:06 GMT

Protected "4ooy" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:52, 13 February 2014

OCA: New page: '''Unreleased structure''' The entry 4ooy is ON HOLD Authors: Lahiri, SD, Olivier, NB, Alm, RA Description: Avibactam and class C -lactamases: mechanism of inhibition, conservation of ...

OCA — Thu, 13 Feb 2014 04:52:05 GMT

New page: '''Unreleased structure''' The entry 4ooy is ON HOLD Authors: Lahiri, SD, Olivier, NB, Alm, RA Description: Avibactam and class C -lactamases: mechanism of inhibition, conservation of ...

New page

'''Unreleased structure'''

The entry 4ooy is ON HOLD

Authors: Lahiri, SD, Olivier, NB, Alm, RA

Description: Avibactam and class C -lactamases: mechanism of inhibition, conservation of binding pocket and implications for resistance