4oq5 - Revision history

OCA at 12:41, 1 March 2024

OCA — Fri, 01 Mar 2024 12:41:32 GMT

←Older revision		Revision as of 12:41, 1 March 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4oq5]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OQ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OQ5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4oq5]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OQ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OQ5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2UU:4-(4-METHYLNAPHTHALEN-1-YL)-2-{[(4-PHENOXYPHENYL)SULFONYL]AMINO}BENZOIC+ACID'>2UU</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.86Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2UU:4-(4-METHYLNAPHTHALEN-1-YL)-2-{[(4-PHENOXYPHENYL)SULFONYL]AMINO}BENZOIC+ACID'>2UU</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oq5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oq5 OCA], [https://pdbe.org/4oq5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oq5 RCSB], [https://www.ebi.ac.uk/pdbsum/4oq5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oq5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oq5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oq5 OCA], [https://pdbe.org/4oq5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oq5 RCSB], [https://www.ebi.ac.uk/pdbsum/4oq5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oq5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref>		[https://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Apoptosis is regulated by the BCL-2 family of proteins, which is comprised of both pro-death and pro-survival members. Evasion of apoptosis is a hallmark of malignant cells. One way in which cancer cells achieve this evasion is thru overexpression of the pro-survival members of the BCL-2 family. Overexpression of MCL-1, a pro-survival protein, has been shown to be a resistance factor for Navitoclax, a potent inhibitor of BCL-2 and BCL-XL. Here we describe the use of fragment screening methods and structural biology to drive the discovery of novel MCL-1 inhibitors from two distinct structural classes. Specifically, cores derived from a biphenyl sulfonamide and salicylic acid were uncovered in an NMR-based fragment screen and elaborated using high throughput analog synthesis. This culminated in the discovery of selective and potent inhibitors of MCL-1 that may serve as promising leads for medicinal chemistry optimization efforts.
-
-	Fragment-based discovery of potent inhibitors of the anti-apoptotic MCL-1 protein.,Petros AM, Swann SL, Song D, Swinger K, Park C, Zhang H, Wendt MD, Kunzer AR, Souers AJ, Sun C Bioorg Med Chem Lett. 2014 Mar 15;24(6):1484-8. doi: 10.1016/j.bmcl.2014.02.010. , Epub 2014 Feb 14. PMID:24582986<ref>PMID:24582986</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 4oq5" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 07:39, 25 January 2023

OCA — Wed, 25 Jan 2023 07:39:28 GMT

←Older revision		Revision as of 07:39, 25 January 2023
Line 1:		Line 1:

	==Crystal Structure of Human MCL-1 Bound to Inhibitor 4-(4-methylnaphthalen-1-yl)-2-{[(4-phenoxyphenyl)sulfonyl]amino}benzoic acid==		==Crystal Structure of Human MCL-1 Bound to Inhibitor 4-(4-methylnaphthalen-1-yl)-2-{[(4-phenoxyphenyl)sulfonyl]amino}benzoic acid==
-	<StructureSection load='4oq5' size='340' side='right' caption='[[4oq5]], [[Resolution\|resolution]] 2.86Å' scene=''>	+	<StructureSection load='4oq5' size='340' side='right'caption='[[4oq5]], [[Resolution\|resolution]] 2.86Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4oq5]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OQ5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4OQ5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4oq5]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OQ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OQ5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2UU:4-(4-METHYLNAPHTHALEN-1-YL)-2-{[(4-PHENOXYPHENYL)SULFONYL]AMINO}BENZOIC+ACID'>2UU</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2UU:4-(4-METHYLNAPHTHALEN-1-YL)-2-{[(4-PHENOXYPHENYL)SULFONYL]AMINO}BENZOIC+ACID'>2UU</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4oq6\|4oq6]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oq5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oq5 OCA], [https://pdbe.org/4oq5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oq5 RCSB], [https://www.ebi.ac.uk/pdbsum/4oq5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oq5 ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MCL1, BCL2L3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4oq5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oq5 OCA], [~~http~~://pdbe.org/4oq5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4oq5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4oq5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4oq5 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref>	+	[https://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4oq5" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4oq5" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[B-cell lymphoma proteins 3D structures\|B-cell lymphoma proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: Kunzer~~, A R~~]]	+	[[Category: Large Structures]]
-	[[Category: Park, C]]	+	[[Category: Kunzer AR]]
-	[[Category: Petros~~, A M~~]]	+	[[Category: Park C]]
-	[[Category: Song, D]]	+	[[Category: Petros AM]]
-	[[Category: Souers~~, A J~~]]	+	[[Category: Song D]]
-	[[Category: Sun, C]]	+	[[Category: Souers AJ]]
-	[[Category: Swann~~, S L~~]]	+	[[Category: Sun C]]
-	[[Category: Swinger, K]]	+	[[Category: Swann SL]]
-	[[Category: Wendt~~, M D~~]]	+	[[Category: Swinger K]]
-	[[Category: Zhang, H]]	+	[[Category: Wendt MD]]
-	~~[[Category: Apoptosis-inhibitor complex~~]]	+	[[Category: Zhang H]]

OCA at 14:25, 15 November 2017

OCA — Wed, 15 Nov 2017 14:25:45 GMT

←Older revision		Revision as of 14:25, 15 November 2017
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4oq5" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4oq5" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Bcl-2\|Bcl-2]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 20:53, 5 August 2016

OCA — Fri, 05 Aug 2016 20:53:29 GMT

←Older revision		Revision as of 20:53, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of Human MCL-1 Bound to Inhibitor 4-(4-methylnaphthalen-1-yl)-2-{[(4-phenoxyphenyl)sulfonyl]amino}benzoic acid==		==Crystal Structure of Human MCL-1 Bound to Inhibitor 4-(4-methylnaphthalen-1-yl)-2-{[(4-phenoxyphenyl)sulfonyl]amino}benzoic acid==
	<StructureSection load='4oq5' size='340' side='right' caption='[[4oq5]], [[Resolution\|resolution]] 2.86Å' scene=''>		<StructureSection load='4oq5' size='340' side='right' caption='[[4oq5]], [[Resolution\|resolution]] 2.86Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4oq6\|4oq6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4oq6\|4oq6]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MCL1, BCL2L3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MCL1, BCL2L3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oq5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oq5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oq5 RCSB], [http://www.ebi.ac.uk/pdbsum/4oq5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oq5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oq5 OCA], [http://pdbe.org/4oq5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4oq5 RCSB], [http://www.ebi.ac.uk/pdbsum/4oq5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4oq5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4oq5" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 21:49, 25 December 2014

OCA — Thu, 25 Dec 2014 21:49:41 GMT

←Older revision		Revision as of 21:49, 25 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4oq5\| PDB=4oq5 \| SCENE= }}~~	+	==Crystal Structure of Human MCL-1 Bound to Inhibitor 4-(4-methylnaphthalen-1-yl)-2-{[(4-phenoxyphenyl)sulfonyl]amino}benzoic acid==
-	===Crystal Structure of Human MCL-1 Bound to Inhibitor 4-(4-methylnaphthalen-1-yl)-2-{[(4-phenoxyphenyl)sulfonyl]amino}benzoic acid===	+	<StructureSection load='4oq5' size='340' side='right' caption='[[4oq5]], [[Resolution\|resolution]] 2.86Å' scene=''>
-	{~~{ABSTRACT_PUBMED_24582986}~~}	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4oq5]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OQ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OQ5 FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2UU:4-(4-METHYLNAPHTHALEN-1-YL)-2-{[(4-PHENOXYPHENYL)SULFONYL]AMINO}BENZOIC+ACID'>2UU</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4oq6\|4oq6]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MCL1, BCL2L3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oq5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oq5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oq5 RCSB], [http://www.ebi.ac.uk/pdbsum/4oq5 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref>		[[http://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Apoptosis is regulated by the BCL-2 family of proteins, which is comprised of both pro-death and pro-survival members. Evasion of apoptosis is a hallmark of malignant cells. One way in which cancer cells achieve this evasion is thru overexpression of the pro-survival members of the BCL-2 family. Overexpression of MCL-1, a pro-survival protein, has been shown to be a resistance factor for Navitoclax, a potent inhibitor of BCL-2 and BCL-XL. Here we describe the use of fragment screening methods and structural biology to drive the discovery of novel MCL-1 inhibitors from two distinct structural classes. Specifically, cores derived from a biphenyl sulfonamide and salicylic acid were uncovered in an NMR-based fragment screen and elaborated using high throughput analog synthesis. This culminated in the discovery of selective and potent inhibitors of MCL-1 that may serve as promising leads for medicinal chemistry optimization efforts.
		+
		+	Fragment-based discovery of potent inhibitors of the anti-apoptotic MCL-1 protein.,Petros AM, Swann SL, Song D, Swinger K, Park C, Zhang H, Wendt MD, Kunzer AR, Souers AJ, Sun C Bioorg Med Chem Lett. 2014 Mar 15;24(6):1484-8. doi: 10.1016/j.bmcl.2014.02.010. , Epub 2014 Feb 14. PMID:24582986<ref>PMID:24582986</ref>

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[4oq5]] is~~ a ~~6 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4OQ5 OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:024582986</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Bcl-2\|Bcl-2]]
-	[[Category: Kunzer, A R.]]	+	== References ==
-	[[Category: Park, C.]]	+	<references/>
-	[[Category: Petros, A M.]]	+	__TOC__
-	[[Category: Song, D.]]	+	</StructureSection>
-	[[Category: Souers, A J.]]	+	[[Category: Human]]
-	[[Category: Sun, C.]]	+	[[Category: Kunzer, A R]]
-	[[Category: Swann, S L.]]	+	[[Category: Park, C]]
-	[[Category: Swinger, K.]]	+	[[Category: Petros, A M]]
-	[[Category: Wendt, M D.]]	+	[[Category: Song, D]]
-	[[Category: Zhang, H.]]	+	[[Category: Souers, A J]]
		+	[[Category: Sun, C]]
		+	[[Category: Swann, S L]]
		+	[[Category: Swinger, K]]
		+	[[Category: Wendt, M D]]
		+	[[Category: Zhang, H]]
	[[Category: Apoptosis-inhibitor complex]]		[[Category: Apoptosis-inhibitor complex]]

OCA at 13:47, 12 March 2014

OCA — Wed, 12 Mar 2014 13:47:26 GMT

←Older revision		Revision as of 13:47, 12 March 2014
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4oq5\| PDB=4oq5 \| SCENE= }}
		+	===Crystal Structure of Human MCL-1 Bound to Inhibitor 4-(4-methylnaphthalen-1-yl)-2-{[(4-phenoxyphenyl)sulfonyl]amino}benzoic acid===
		+	{{ABSTRACT_PUBMED_24582986}}

-	~~The entry 4oq5 is ON HOLD~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref>

-	~~Authors~~: ~~Petros, A.M., Swann, S.L., Song, D., Swinger, K., Park, C., Zhang, H., Wendt, M.D., Kunzer, A.R~~.~~, Souers, A~~.J.~~, Sun, C~~.	+	==About this Structure==
		+	[[4oq5]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OQ5 OCA].

-	~~Description~~:	+	==Reference==
		+	<ref group="xtra">PMID:024582986</ref><references group="xtra"/><references/>
		+	[[Category: Kunzer, A R.]]
		+	[[Category: Park, C.]]
		+	[[Category: Petros, A M.]]
		+	[[Category: Song, D.]]
		+	[[Category: Souers, A J.]]
		+	[[Category: Sun, C.]]
		+	[[Category: Swann, S L.]]
		+	[[Category: Swinger, K.]]
		+	[[Category: Wendt, M D.]]
		+	[[Category: Zhang, H.]]
		+	[[Category: Apoptosis-inhibitor complex]]

OCA: Protected "4oq5" [edit=sysop:move=sysop]

OCA — Wed, 19 Feb 2014 16:18:52 GMT

Protected "4oq5" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:18, 19 February 2014

OCA: New page: '''Unreleased structure''' The entry 4oq5 is ON HOLD Authors: Petros, A.M., Swann, S.L., Song, D., Swinger, K., Park, C., Zhang, H., Wendt, M.D., Kunzer, A.R., Souers, A.J., Sun, C. De...

OCA — Wed, 19 Feb 2014 16:18:51 GMT

New page: '''Unreleased structure''' The entry 4oq5 is ON HOLD Authors: Petros, A.M., Swann, S.L., Song, D., Swinger, K., Park, C., Zhang, H., Wendt, M.D., Kunzer, A.R., Souers, A.J., Sun, C. De...

New page

'''Unreleased structure'''

The entry 4oq5 is ON HOLD

Authors: Petros, A.M., Swann, S.L., Song, D., Swinger, K., Park, C., Zhang, H., Wendt, M.D., Kunzer, A.R., Souers, A.J., Sun, C.

Description: