4orc - Revision history

OCA at 14:58, 8 November 2023

OCA — Wed, 08 Nov 2023 14:58:11 GMT

←Older revision		Revision as of 14:58, 8 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4orc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ORC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ORC FirstGlance]. <br>		<table><tr><td colspan='2'>[[4orc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ORC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ORC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4orc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4orc OCA], [https://pdbe.org/4orc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4orc RCSB], [https://www.ebi.ac.uk/pdbsum/4orc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4orc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4orc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4orc OCA], [https://pdbe.org/4orc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4orc RCSB], [https://www.ebi.ac.uk/pdbsum/4orc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4orc ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:42, 25 January 2023

OCA — Wed, 25 Jan 2023 07:42:11 GMT

←Older revision		Revision as of 07:42, 25 January 2023
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	<StructureSection load='4orc' size='340' side='right'caption='[[4orc]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='4orc' size='340' side='right'caption='[[4orc]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4orc]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ORC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ORC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4orc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ORC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ORC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ora\|4ora]], [[4orb\|4orb]], [[4or9\|4or9]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4orc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4orc OCA], [https://pdbe.org/4orc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4orc RCSB], [https://www.ebi.ac.uk/pdbsum/4orc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4orc ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CALNA2, CALNB, CNA2, PPP3CB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), CNA2, CNB, PPP3R1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4orc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4orc OCA], [~~http~~://pdbe.org/4orc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4orc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4orc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4orc ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PP2BB_HUMAN PP2BB_HUMAN]] Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. ~~[[http~~:/~~/www~~.~~uniprot~~.~~org/uniprot/CANB1_HUMAN CANB1_HUMAN]] Regulatory subunit~~ of ~~calcineurin~~, a ~~calcium~~-~~dependent~~, calmodulin ~~stimulated protein phosphatase~~. ~~Confers calcium sensitivity~~.	+	[https://www.uniprot.org/uniprot/PP2BB_HUMAN PP2BB_HUMAN] Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Ca(2+)/calmodulin-dependent protein phosphatase calcineurin (CN), a heterodimer composed of a catalytic subunit A and an essential regulatory subunit B, plays critical functions in various cellular processes such as cardiac hypertrophy and T cell activation. It is the target of the most widely used immunosuppressants for transplantation, tacrolimus (FK506) and cyclosporin A. However, the structure of a large part of the CNA regulatory region remains to be determined, and there has been considerable debate concerning the regulation of CN activity. Here, we report the crystal structure of full-length CN (beta isoform), which revealed a novel autoinhibitory segment (AIS) in addition to the well-known autoinhibitory domain (AID). The AIS nestles in a hydrophobic intersubunit groove, which overlaps the recognition site for substrates and immunosuppressant-immunophilin complexes. Indeed, disruption of this AIS interaction results in partial stimulation of CN activity. More importantly, our biochemical studies demonstrate that calmodulin does not remove AID from the active site, but only regulates the orientation of AID with respect to the catalytic core, causing incomplete activation of CN. Our findings challenge the current model for CN activation, and provide a better understanding of molecular mechanisms of CN activity regulation.
		+
		+	Cooperative autoinhibition and multi-level activation mechanisms of calcineurin.,Li SJ, Wang J, Ma L, Lu C, Wang J, Wu JW, Wang ZX Cell Res. 2016 Mar;26(3):336-49. doi: 10.1038/cr.2016.14. Epub 2016 Jan 22. PMID:26794871<ref>PMID:26794871</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4orc" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
-	*[[Calcineurin\|Calcineurin]]	+	*[[Calcineurin 3D structures\|Calcineurin 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Phosphoprotein phosphatase]]~~	+	[[Category: Li SJ]]
-	[[Category: Li~~, S J~~]]	+	[[Category: Ma L]]
-	[[Category: Ma, L]]	+	[[Category: Wang J]]
-	[[Category: Wang, J]]	+	[[Category: Wang ZX]]
-	[[Category: Wang~~, Z X~~]]	+	[[Category: Wu JW]]
-	[[Category: Wu~~, J W]]~~	+
-	~~[[Category: Calmodulin-binding]]~~	+
-	~~[[Category: Hydrolase-metal binding protein complex~~]]	+

OCA at 08:16, 17 April 2019

OCA — Wed, 17 Apr 2019 08:16:32 GMT

←Older revision		Revision as of 08:16, 17 April 2019
Line 1:		Line 1:

	==Crystal structure of mammalian calcineurin==		==Crystal structure of mammalian calcineurin==
-	<StructureSection load='4orc' size='340' side='right' caption='[[4orc]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='4orc' size='340' side='right'caption='[[4orc]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4orc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ORC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ORC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4orc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ORC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ORC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ora\|4ora]], [[4orb\|4orb]], [[4or9\|4or9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ora\|4ora]], [[4orb\|4orb]], [[4or9\|4or9]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CALNA2, CALNB, CNA2, PPP3CB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), CNA2, CNB, PPP3R1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4orc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4orc OCA], [http://pdbe.org/4orc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4orc RCSB], [http://www.ebi.ac.uk/pdbsum/4orc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4orc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4orc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4orc OCA], [http://pdbe.org/4orc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4orc RCSB], [http://www.ebi.ac.uk/pdbsum/4orc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4orc ProSAT]</span></td></tr>
Line 11:		Line 12:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/PP2BB_HUMAN PP2BB_HUMAN]] Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. [[http://www.uniprot.org/uniprot/CANB1_HUMAN CANB1_HUMAN]] Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.		[[http://www.uniprot.org/uniprot/PP2BB_HUMAN PP2BB_HUMAN]] Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. [[http://www.uniprot.org/uniprot/CANB1_HUMAN CANB1_HUMAN]] Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.
		+
		+	==See Also==
		+	*[[Calcineurin\|Calcineurin]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Phosphoprotein phosphatase]]		[[Category: Phosphoprotein phosphatase]]
	[[Category: Li, S J]]		[[Category: Li, S J]]

OCA at 14:54, 22 December 2016

OCA — Thu, 22 Dec 2016 14:54:45 GMT

←Older revision		Revision as of 14:54, 22 December 2016
Line 1:		Line 1:
-	==~~Crytal~~ structure of mammalian calcineurin==	+
		+	==Crystal structure of mammalian calcineurin==
	<StructureSection load='4orc' size='340' side='right' caption='[[4orc]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='4orc' size='340' side='right' caption='[[4orc]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ora\|4ora]], [[4orb\|4orb]], [[4or9\|4or9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ora\|4ora]], [[4orb\|4orb]], [[4or9\|4or9]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4orc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4orc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4orc RCSB], [http://www.ebi.ac.uk/pdbsum/4orc PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4orc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4orc OCA], [http://pdbe.org/4orc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4orc RCSB], [http://www.ebi.ac.uk/pdbsum/4orc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4orc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 12:15, 20 May 2015

OCA — Wed, 20 May 2015 12:15:28 GMT

←Older revision		Revision as of 12:15, 20 May 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crytal structure of mammalian calcineurin==
-		+	<StructureSection load='4orc' size='340' side='right' caption='[[4orc]], [[Resolution\|resolution]] 2.70Å' scene=''>
-	~~The entry~~ 4orc is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4orc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ORC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ORC FirstGlance]. <br>
-	~~Authors~~: Ma, L., Li, S.J., ~~Wang, J~~., ~~Wu, J~~.W., ~~Wang, Z~~.X.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4ora\|4ora]], [[4orb\|4orb]], [[4or9\|4or9]]</td></tr>
-	~~Description: Crytal structure of mammalian calcineurin~~	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4orc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4orc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4orc RCSB], [http://www.ebi.ac.uk/pdbsum/4orc PDBsum]</span></td></tr>
-	[[~~Category~~: ~~Wang, Z~~.X]]	+	</table>
-	[[Category: ~~Wu, J.W~~]]	+	== Function ==
-	[[Category: Li, S.J]]	+	[[http://www.uniprot.org/uniprot/PP2BB_HUMAN PP2BB_HUMAN]] Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. [[http://www.uniprot.org/uniprot/CANB1_HUMAN CANB1_HUMAN]] Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Phosphoprotein phosphatase]]
		+	[[Category: Li, S J]]
	[[Category: Ma, L]]		[[Category: Ma, L]]
	[[Category: Wang, J]]		[[Category: Wang, J]]
		+	[[Category: Wang, Z X]]
		+	[[Category: Wu, J W]]
		+	[[Category: Calmodulin-binding]]
		+	[[Category: Hydrolase-metal binding protein complex]]

OCA at 14:32, 24 December 2014

OCA — Wed, 24 Dec 2014 14:32:39 GMT

←Older revision		Revision as of 14:32, 24 December 2014
Line 6:		Line 6:

	Description: Crytal structure of mammalian calcineurin		Description: Crytal structure of mammalian calcineurin
		+	[[Category: Unreleased Structures]]
		+	[[Category: Wang, Z.X]]
		+	[[Category: Wu, J.W]]
		+	[[Category: Li, S.J]]
		+	[[Category: Ma, L]]
		+	[[Category: Wang, J]]

OCA at 12:19, 12 March 2014

OCA — Wed, 12 Mar 2014 12:19:49 GMT

←Older revision		Revision as of 12:19, 12 March 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4orc is ON HOLD	+	The entry 4orc is ON HOLD until Paper Publication

	Authors: Ma, L., Li, S.J., Wang, J., Wu, J.W., Wang, Z.X.		Authors: Ma, L., Li, S.J., Wang, J., Wu, J.W., Wang, Z.X.

-	Description: ~~crytal~~ structure of mammalian calcineurin	+	Description: Crytal structure of mammalian calcineurin

OCA: Protected "4orc" [edit=sysop:move=sysop]

OCA — Wed, 19 Feb 2014 16:20:41 GMT

Protected "4orc" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:20, 19 February 2014

OCA: New page: '''Unreleased structure''' The entry 4orc is ON HOLD Authors: Ma, L., Li, S.J., Wang, J., Wu, J.W., Wang, Z.X. Description: crytal structure of mammalian calcineurin

OCA — Wed, 19 Feb 2014 16:20:40 GMT

New page: '''Unreleased structure''' The entry 4orc is ON HOLD Authors: Ma, L., Li, S.J., Wang, J., Wu, J.W., Wang, Z.X. Description: crytal structure of mammalian calcineurin

New page

'''Unreleased structure'''

The entry 4orc is ON HOLD

Authors: Ma, L., Li, S.J., Wang, J., Wu, J.W., Wang, Z.X.

Description: crytal structure of mammalian calcineurin