4osq - Revision history

OCA at 14:59, 8 November 2023

OCA — Wed, 08 Nov 2023 14:59:01 GMT

←Older revision		Revision as of 14:59, 8 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4osq]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Xanthomonas_campestris_pv._armoraciae Xanthomonas campestris pv. armoraciae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OSQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OSQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4osq]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Xanthomonas_campestris_pv._armoraciae Xanthomonas campestris pv. armoraciae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OSQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OSQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.256Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4osq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4osq OCA], [https://pdbe.org/4osq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4osq RCSB], [https://www.ebi.ac.uk/pdbsum/4osq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4osq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4osq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4osq OCA], [https://pdbe.org/4osq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4osq RCSB], [https://www.ebi.ac.uk/pdbsum/4osq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4osq ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:44, 25 January 2023

OCA — Wed, 25 Jan 2023 07:44:03 GMT

←Older revision		Revision as of 07:44, 25 January 2023
Line 3:		Line 3:
	<StructureSection load='4osq' size='340' side='right'caption='[[4osq]], [[Resolution\|resolution]] 2.26Å' scene=''>		<StructureSection load='4osq' size='340' side='right'caption='[[4osq]], [[Resolution\|resolution]] 2.26Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4osq]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Bacterium_campestre_var~~._armoraciae ~~Bacterium campestre var~~. armoraciae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OSQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4OSQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4osq]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Xanthomonas_campestris_pv._armoraciae Xanthomonas campestris pv. armoraciae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OSQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OSQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4osh\|4osh]], [[4osi\|4osi]], [[4osj\|4osj]], [[4osk\|4osk]], [[4osl\|4osl]], [[4osm\|4osm]], [[4osr\|4osr]], [[4oss\|4oss]], [[4ost\|4ost]], [[4osv\|4osv]], [[4osw\|4osw]], [[4osz\|4osz]], [[4ot0\|4ot0]], [[4ot3\|4ot3]], [[4oto\|4oto]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4osq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4osq OCA], [https://pdbe.org/4osq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4osq RCSB], [https://www.ebi.ac.uk/pdbsum/4osq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4osq ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hax3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=329463 Bacterium campestre var. armoraciae])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4osq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4osq OCA], [~~http~~://pdbe.org/4osq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4osq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4osq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4osq ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q3ZD72_XANCA Q3ZD72_XANCA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacterium campestre var. armoraciae]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Deng, D~~]]	+	[[Category: Xanthomonas campestris pv. armoraciae]]
-	[[Category: ~~Pan, X J~~]]	+	[[Category: Deng D]]
-	[[Category: ~~Wu, J P~~]]	+	[[Category: Pan XJ]]
-	[[Category: ~~Yan, C Y~~]]	+	[[Category: Wu JP]]
-	[[Category: Yan~~, N~~]]	+	[[Category: Yan CY]]
-	[[Category: ~~Dna]]~~	+	[[Category: Yan N]]
-	~~[[Category: Dna binding protein]]~~	+
-	~~[[Category: Dna binding protein-dna complex~~]]	+

OCA at 07:36, 17 April 2019

OCA — Wed, 17 Apr 2019 07:36:46 GMT

←Older revision		Revision as of 07:36, 17 April 2019
Line 1:		Line 1:

	==Crystal structure of the S505R mutant of TAL effector dHax3==		==Crystal structure of the S505R mutant of TAL effector dHax3==
-	<StructureSection load='4osq' size='340' side='right' caption='[[4osq]], [[Resolution\|resolution]] 2.26Å' scene=''>	+	<StructureSection load='4osq' size='340' side='right'caption='[[4osq]], [[Resolution\|resolution]] 2.26Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4osq]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OSQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OSQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4osq]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacterium_campestre_var._armoraciae Bacterium campestre var. armoraciae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OSQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OSQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4osh\|4osh]], [[4osi\|4osi]], [[4osj\|4osj]], [[4osk\|4osk]], [[4osl\|4osl]], [[4osm\|4osm]], [[4osr\|4osr]], [[4oss\|4oss]], [[4ost\|4ost]], [[4osv\|4osv]], [[4osw\|4osw]], [[4osz\|4osz]], [[4ot0\|4ot0]], [[4ot3\|4ot3]], [[4oto\|4oto]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4osh\|4osh]], [[4osi\|4osi]], [[4osj\|4osj]], [[4osk\|4osk]], [[4osl\|4osl]], [[4osm\|4osm]], [[4osr\|4osr]], [[4oss\|4oss]], [[4ost\|4ost]], [[4osv\|4osv]], [[4osw\|4osw]], [[4osz\|4osz]], [[4ot0\|4ot0]], [[4ot3\|4ot3]], [[4oto\|4oto]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hax3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=329463 Bacterium campestre var. armoraciae])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4osq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4osq OCA], [http://pdbe.org/4osq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4osq RCSB], [http://www.ebi.ac.uk/pdbsum/4osq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4osq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4osq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4osq OCA], [http://pdbe.org/4osq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4osq RCSB], [http://www.ebi.ac.uk/pdbsum/4osq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4osq ProSAT]</span></td></tr>
	</table>		</table>
Line 17:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4osq" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4osq" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[TAL effector\|TAL effector]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacterium campestre var. armoraciae]]
		+	[[Category: Large Structures]]
	[[Category: Deng, D]]		[[Category: Deng, D]]
	[[Category: Pan, X J]]		[[Category: Pan, X J]]

OCA at 18:56, 11 August 2016

OCA — Thu, 11 Aug 2016 18:56:14 GMT

←Older revision		Revision as of 18:56, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the S505R mutant of TAL effector dHax3==		==Crystal structure of the S505R mutant of TAL effector dHax3==
	<StructureSection load='4osq' size='340' side='right' caption='[[4osq]], [[Resolution\|resolution]] 2.26Å' scene=''>		<StructureSection load='4osq' size='340' side='right' caption='[[4osq]], [[Resolution\|resolution]] 2.26Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4osh\|4osh]], [[4osi\|4osi]], [[4osj\|4osj]], [[4osk\|4osk]], [[4osl\|4osl]], [[4osm\|4osm]], [[4osr\|4osr]], [[4oss\|4oss]], [[4ost\|4ost]], [[4osv\|4osv]], [[4osw\|4osw]], [[4osz\|4osz]], [[4ot0\|4ot0]], [[4ot3\|4ot3]], [[4oto\|4oto]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4osh\|4osh]], [[4osi\|4osi]], [[4osj\|4osj]], [[4osk\|4osk]], [[4osl\|4osl]], [[4osm\|4osm]], [[4osr\|4osr]], [[4oss\|4oss]], [[4ost\|4ost]], [[4osv\|4osv]], [[4osw\|4osw]], [[4osz\|4osz]], [[4ot0\|4ot0]], [[4ot3\|4ot3]], [[4oto\|4oto]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4osq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4osq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4osq RCSB], [http://www.ebi.ac.uk/pdbsum/4osq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4osq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4osq OCA], [http://pdbe.org/4osq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4osq RCSB], [http://www.ebi.ac.uk/pdbsum/4osq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4osq ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4osq" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:25, 5 January 2015

OCA — Mon, 05 Jan 2015 09:25:05 GMT

←Older revision		Revision as of 09:25, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4osq]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OSQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OSQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4osq]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OSQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OSQ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4osh\|4osh]], [[4osi\|4osi]], [[4osj\|4osj]], [[4osk\|4osk]], [[4osl\|4osl]], [[4osm\|4osm]], [[4osr\|4osr]], [[4oss\|4oss]], [[4ost\|4ost]], [[4osv\|4osv]], [[4osw\|4osw]], [[4osz\|4osz]], [[4ot0\|4ot0]], [[4ot3\|4ot3]], [[4oto\|4oto]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4osh\|4osh]], [[4osi\|4osi]], [[4osj\|4osj]], [[4osk\|4osk]], [[4osl\|4osl]], [[4osm\|4osm]], [[4osr\|4osr]], [[4oss\|4oss]], [[4ost\|4ost]], [[4osv\|4osv]], [[4osw\|4osw]], [[4osz\|4osz]], [[4ot0\|4ot0]], [[4ot3\|4ot3]], [[4oto\|4oto]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4osq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4osq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4osq RCSB], [http://www.ebi.ac.uk/pdbsum/4osq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4osq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4osq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4osq RCSB], [http://www.ebi.ac.uk/pdbsum/4osq PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 13:		Line 13:
	Revisiting the TALE repeat.,Deng D, Yan C, Wu J, Pan X, Yan N Protein Cell. 2014 Apr;5(4):297-306. doi: 10.1007/s13238-014-0035-2. Epub 2014, Mar 14. PMID:24622844<ref>PMID:24622844</ref>		Revisiting the TALE repeat.,Deng D, Yan C, Wu J, Pan X, Yan N Protein Cell. 2014 Apr;5(4):297-306. doi: 10.1007/s13238-014-0035-2. Epub 2014, Mar 14. PMID:24622844<ref>PMID:24622844</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Deng, D.]]	+	[[Category: Deng, D]]
-	[[Category: Pan, X J.]]	+	[[Category: Pan, X J]]
-	[[Category: Wu, J P.]]	+	[[Category: Wu, J P]]
-	[[Category: Yan, C Y.]]	+	[[Category: Yan, C Y]]
-	[[Category: Yan, N.]]	+	[[Category: Yan, N]]
	[[Category: Dna]]		[[Category: Dna]]
	[[Category: Dna binding protein]]		[[Category: Dna binding protein]]
	[[Category: Dna binding protein-dna complex]]		[[Category: Dna binding protein-dna complex]]

OCA at 09:40, 28 May 2014

OCA — Wed, 28 May 2014 09:40:51 GMT

←Older revision		Revision as of 09:40, 28 May 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of the S505R mutant of TAL effector dHax3==
		+	<StructureSection load='4osq' size='340' side='right' caption='[[4osq]], [[Resolution\|resolution]] 2.26Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4osq]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OSQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OSQ FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4osh\|4osh]], [[4osi\|4osi]], [[4osj\|4osj]], [[4osk\|4osk]], [[4osl\|4osl]], [[4osm\|4osm]], [[4osr\|4osr]], [[4oss\|4oss]], [[4ost\|4ost]], [[4osv\|4osv]], [[4osw\|4osw]], [[4osz\|4osz]], [[4ot0\|4ot0]], [[4ot3\|4ot3]], [[4oto\|4oto]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4osq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4osq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4osq RCSB], [http://www.ebi.ac.uk/pdbsum/4osq PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Transcription activator-like (TAL) effectors specifically bind to double stranded (ds) DNA through a central domain of tandem repeats. Each TAL effector (TALE) repeat comprises 33-35 amino acids and recognizes one specific DNA base through a highly variable residue at a fixed position in the repeat. Structural studies have revealed the molecular basis of DNA recognition by TALE repeats. Examination of the overall structure reveals that the basic building block of TALE protein, namely a helical hairpin, is one-helix shifted from the previously defined TALE motif. Here we wish to suggest a structure-based re-demarcation of the TALE repeat which starts with the residues that bind to the DNA backbone phosphate and concludes with the base-recognition hyper-variable residue. This new numbering system is consistent with the alpha-solenoid superfamily to which TALE belongs, and reflects the structural integrity of TAL effectors. In addition, it confers integral number of TALE repeats that matches the number of bound DNA bases. We then present fifteen crystal structures of engineered dHax3 variants in complex with target DNA molecules, which elucidate the structural basis for the recognition of bases adenine (A) and guanine (G) by reported or uncharacterized TALE codes. Finally, we analyzed the sequence-structure correlation of the amino acid residues within a TALE repeat. The structural analyses reported here may advance the mechanistic understanding of TALE proteins and facilitate the design of TALEN with improved affinity and specificity.

-	~~The entry 4osq is ON HOLD~~	+	Revisiting the TALE repeat.,Deng D, Yan C, Wu J, Pan X, Yan N Protein Cell. 2014 Apr;5(4):297-306. doi: 10.1007/s13238-014-0035-2. Epub 2014, Mar 14. PMID:24622844<ref>PMID:24622844</ref>

-	~~Authors~~: Deng, D., Wu, J.P., Yan, C.Y.~~, Pan, X.J.,~~ Yan, N.	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal structure of the S505R mutant of TAL effector dHax3~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Deng, D.]]
		+	[[Category: Pan, X J.]]
		+	[[Category: Wu, J P.]]
		+	[[Category: Yan, C Y.]]
		+	[[Category: Yan, N.]]
		+	[[Category: Dna]]
		+	[[Category: Dna binding protein]]
		+	[[Category: Dna binding protein-dna complex]]

OCA: Protected "4osq" [edit=sysop:move=sysop]

OCA — Wed, 19 Feb 2014 16:22:54 GMT

Protected "4osq" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:22, 19 February 2014

OCA: New page: '''Unreleased structure''' The entry 4osq is ON HOLD Authors: Deng, D., Wu, J.P., Yan, C.Y., Pan, X.J., Yan, N. Description: Crystal structure of the S505R mutant of TAL effector dHax3

OCA — Wed, 19 Feb 2014 16:22:53 GMT

New page: '''Unreleased structure''' The entry 4osq is ON HOLD Authors: Deng, D., Wu, J.P., Yan, C.Y., Pan, X.J., Yan, N. Description: Crystal structure of the S505R mutant of TAL effector dHax3

New page

'''Unreleased structure'''

The entry 4osq is ON HOLD

Authors: Deng, D., Wu, J.P., Yan, C.Y., Pan, X.J., Yan, N.

Description: Crystal structure of the S505R mutant of TAL effector dHax3