4ous - Revision history

OCA at 14:59, 8 November 2023

OCA — Wed, 08 Nov 2023 14:59:54 GMT

←Older revision		Revision as of 14:59, 8 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ous]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OUS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OUS FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ous]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OUS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OUS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.05Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ous FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ous OCA], [https://pdbe.org/4ous PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ous RCSB], [https://www.ebi.ac.uk/pdbsum/4ous PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ous ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ous FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ous OCA], [https://pdbe.org/4ous PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ous RCSB], [https://www.ebi.ac.uk/pdbsum/4ous PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ous ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:47, 25 January 2023

OCA — Wed, 25 Jan 2023 07:47:03 GMT

←Older revision		Revision as of 07:47, 25 January 2023
Line 3:		Line 3:
	<StructureSection load='4ous' size='340' side='right'caption='[[4ous]], [[Resolution\|resolution]] 1.05Å' scene=''>		<StructureSection load='4ous' size='340' side='right'caption='[[4ous]], [[Resolution\|resolution]] 1.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ous]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Brachidanio_rerio Brachidanio~~ rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OUS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4OUS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ous]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OUS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OUS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4oul\|4oul]], [[4oum\|4oum]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ous FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ous OCA], [https://pdbe.org/4ous PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ous RCSB], [https://www.ebi.ac.uk/pdbsum/4ous PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ous ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">caprin2, rng140, si:ch211-11c20.4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ous FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ous OCA], [~~http~~://pdbe.org/4ous PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ous RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ous PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ous ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CAPR2_DANRE CAPR2_DANRE]] May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons. Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation. May be involved in apoptosis (By similarity).	+	[https://www.uniprot.org/uniprot/CAPR2_DANRE CAPR2_DANRE] May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons. Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation. May be involved in apoptosis (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Brachidanio~~ rerio]]	+	[[Category: Danio rerio]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Li, L]]	+	[[Category: Li L]]
-	[[Category: Song, X]]	+	[[Category: Song X]]
-	~~[[Category: C1q domain]]~~	+
-	~~[[Category: Signaling protein]]~~	+
-	~~[[Category: Wnt signaling~~]]	+

OCA at 07:20, 17 April 2019

OCA — Wed, 17 Apr 2019 07:20:47 GMT

←Older revision		Revision as of 07:20, 17 April 2019
Line 1:		Line 1:

	==Crystal structure of zebrafish Caprin-2 C1q domain==		==Crystal structure of zebrafish Caprin-2 C1q domain==
-	<StructureSection load='4ous' size='340' side='right' caption='[[4ous]], [[Resolution\|resolution]] 1.05Å' scene=''>	+	<StructureSection load='4ous' size='340' side='right'caption='[[4ous]], [[Resolution\|resolution]] 1.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ous]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OUS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OUS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ous]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OUS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OUS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4oul\|4oul]], [[4oum\|4oum]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4oul\|4oul]], [[4oum\|4oum]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">caprin2, rng140, si:ch211-11c20.4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ous FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ous OCA], [http://pdbe.org/4ous PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ous RCSB], [http://www.ebi.ac.uk/pdbsum/4ous PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ous ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ous FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ous OCA], [http://pdbe.org/4ous PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ous RCSB], [http://www.ebi.ac.uk/pdbsum/4ous PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ous ProSAT]</span></td></tr>
	</table>		</table>
Line 23:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Brachidanio rerio]]
		+	[[Category: Large Structures]]
	[[Category: Li, L]]		[[Category: Li, L]]
	[[Category: Song, X]]		[[Category: Song, X]]

OCA at 17:18, 18 January 2017

OCA — Wed, 18 Jan 2017 17:18:36 GMT

←Older revision		Revision as of 17:18, 18 January 2017
Line 1:		Line 1:
		+
	==Crystal structure of zebrafish Caprin-2 C1q domain==		==Crystal structure of zebrafish Caprin-2 C1q domain==
	<StructureSection load='4ous' size='340' side='right' caption='[[4ous]], [[Resolution\|resolution]] 1.05Å' scene=''>		<StructureSection load='4ous' size='340' side='right' caption='[[4ous]], [[Resolution\|resolution]] 1.05Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4oul\|4oul]], [[4oum\|4oum]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4oul\|4oul]], [[4oum\|4oum]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ous FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ous OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ous RCSB], [http://www.ebi.ac.uk/pdbsum/4ous PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ous FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ous OCA], [http://pdbe.org/4ous PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ous RCSB], [http://www.ebi.ac.uk/pdbsum/4ous PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ous ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ous" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:29, 8 April 2015

OCA — Wed, 08 Apr 2015 05:29:17 GMT

←Older revision		Revision as of 05:29, 8 April 2015
Line 9:		Line 9:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/CAPR2_DANRE CAPR2_DANRE]] May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons. Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation. May be involved in apoptosis (By similarity).		[[http://www.uniprot.org/uniprot/CAPR2_DANRE CAPR2_DANRE]] May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons. Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation. May be involved in apoptosis (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Previously, we have identified Caprin-2 as a new regulator in canonical Wnt signaling through a mechanism of facilitating LRP5/6 phosphorylation; moreover, we found that its C-terminal C1q-related domain (Cap2_CRD) is required for this process. Here, we determined the crystal structures of Cap2_CRD from human and zebrafish, which both associate as a homotrimer with calcium located at the symmetric center. Surprisingly, the calcium binding-deficient mutant exists as a more stable trimer than its wild-type counterpart. Further studies showed that this Caprin-2 mutant disabled in binding calcium maintains the activity of promoting LRP5/6 phosphorylation, whereas the mutations disrupting Cap2_CRD homotrimer did impair such activity. Together, our findings suggested that the C-terminal CRD domain of Caprin-2 forms a flexible homotrimer mediated by calcium and that such trimeric assembly is required for Caprin-2 to regulate canonical Wnt signaling.
		+
		+	Structural insights into the C1q domain of Caprin-2 in canonical Wnt signaling.,Miao H, Jia Y, Xie S, Wang X, Zhao J, Chu Y, Zhou Z, Shi Z, Song X, Li L J Biol Chem. 2014 Dec 5;289(49):34104-13. doi: 10.1074/jbc.M114.591636. Epub 2014, Oct 20. PMID:25331957<ref>PMID:25331957</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 17:16, 24 December 2014

OCA — Wed, 24 Dec 2014 17:16:26 GMT

←Older revision		Revision as of 17:16, 24 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ous FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ous OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ous RCSB], [http://www.ebi.ac.uk/pdbsum/4ous PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ous FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ous OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ous RCSB], [http://www.ebi.ac.uk/pdbsum/4ous PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CAPR2_DANRE CAPR2_DANRE]] May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons. Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation. May be involved in apoptosis (By similarity).
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Li, L.]]	+	[[Category: Li, L]]
-	[[Category: Song, X.]]	+	[[Category: Song, X]]
	[[Category: C1q domain]]		[[Category: C1q domain]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]
	[[Category: Wnt signaling]]		[[Category: Wnt signaling]]

OCA at 11:28, 29 October 2014

OCA — Wed, 29 Oct 2014 11:28:04 GMT

←Older revision		Revision as of 11:28, 29 October 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of zebrafish Caprin-2 C1q domain==
-		+	<StructureSection load='4ous' size='340' side='right' caption='[[4ous]], [[Resolution\|resolution]] 1.05Å' scene=''>
-	~~The entry~~ 4ous is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4ous]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OUS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OUS FirstGlance]. <br>
-	~~Authors~~: ~~Song~~, X., Li, L.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4oul\|4oul]], [[4oum\|4oum]]</td></tr>
-	~~Description~~: ~~Crystal structure of zebrafish Caprin-2~~ C1q domain	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ous FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ous OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ous RCSB], [http://www.ebi.ac.uk/pdbsum/4ous PDBsum]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Li, L.]]
		+	[[Category: Song, X.]]
		+	[[Category: C1q domain]]
		+	[[Category: Signaling protein]]
		+	[[Category: Wnt signaling]]

OCA at 12:22, 12 March 2014

OCA — Wed, 12 Mar 2014 12:22:13 GMT

←Older revision		Revision as of 12:22, 12 March 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4ous is ON HOLD	+	The entry 4ous is ON HOLD until Paper Publication

	Authors: Song, X., Li, L.		Authors: Song, X., Li, L.

	Description: Crystal structure of zebrafish Caprin-2 C1q domain		Description: Crystal structure of zebrafish Caprin-2 C1q domain

OCA: Protected "4ous" [edit=sysop:move=sysop]

OCA — Mon, 03 Mar 2014 16:53:17 GMT

Protected "4ous" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:53, 3 March 2014

OCA: New page: '''Unreleased structure''' The entry 4ous is ON HOLD Authors: Song, X., Li, L. Description: Crystal structure of zebrafish Caprin-2 C1q domain

OCA — Mon, 03 Mar 2014 16:53:15 GMT

New page: '''Unreleased structure''' The entry 4ous is ON HOLD Authors: Song, X., Li, L. Description: Crystal structure of zebrafish Caprin-2 C1q domain

New page

'''Unreleased structure'''

The entry 4ous is ON HOLD

Authors: Song, X., Li, L.

Description: Crystal structure of zebrafish Caprin-2 C1q domain