4owl - Revision history

OCA at 00:37, 28 December 2023

OCA — Thu, 28 Dec 2023 00:37:15 GMT

←Older revision		Revision as of 00:37, 28 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4owl]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_vulnificus_CMCP6 Vibrio vulnificus CMCP6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OWL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OWL FirstGlance]. <br>		<table><tr><td colspan='2'>[[4owl]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_vulnificus_CMCP6 Vibrio vulnificus CMCP6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OWL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OWL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4owl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4owl OCA], [https://pdbe.org/4owl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4owl RCSB], [https://www.ebi.ac.uk/pdbsum/4owl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4owl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4owl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4owl OCA], [https://pdbe.org/4owl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4owl RCSB], [https://www.ebi.ac.uk/pdbsum/4owl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4owl ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:49, 25 January 2023

OCA — Wed, 25 Jan 2023 07:49:26 GMT

←Older revision		Revision as of 07:49, 25 January 2023
Line 3:		Line 3:
	<StructureSection load='4owl' size='340' side='right'caption='[[4owl]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4owl' size='340' side='right'caption='[[4owl]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4owl]] is a 7 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Vibvu Vibvu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OWL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4OWL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4owl]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_vulnificus_CMCP6 Vibrio vulnificus CMCP6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OWL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OWL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4owj\|4owj]], [[4owk\|4owk]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4owl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4owl OCA], [https://pdbe.org/4owl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4owl RCSB], [https://www.ebi.ac.uk/pdbsum/4owl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4owl ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VV2_0404,vvhA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216895 VIBVU])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4owl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4owl OCA], [~~http~~://pdbe.org/4owl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4owl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4owl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4owl ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/VVHA_VIBVU VVHA_VIBVU]] Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture by mechanisms not clearly defined.	+	[https://www.uniprot.org/uniprot/VVHA_VIBVU VVHA_VIBVU] Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture by mechanisms not clearly defined.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Vibvu~~]]	+	[[Category: Vibrio vulnificus CMCP6]]
-	[[Category: Kaus, K]]	+	[[Category: Kaus K]]
-	[[Category: Olson, R]]	+	[[Category: Olson R]]
-	~~[[Category: Beta-trefoil]]~~	+
-	~~[[Category: Lectin]]~~	+
-	~~[[Category: Pore-forming toxin]]~~	+
-	~~[[Category: R-type lectin]]~~	+
-	~~[[Category: Toxin~~]]	+

OCA at 15:34, 11 December 2019

OCA — Wed, 11 Dec 2019 15:34:55 GMT

←Older revision		Revision as of 15:34, 11 December 2019
Line 1:		Line 1:

	==Crystal Structure of the Vibrio vulnificus Hemolysin/Cytolysin Beta-Trefoil Lectin with N-Acetyl-D-Lactosamine Bound==		==Crystal Structure of the Vibrio vulnificus Hemolysin/Cytolysin Beta-Trefoil Lectin with N-Acetyl-D-Lactosamine Bound==
-	<StructureSection load='4owl' size='340' side='right' caption='[[4owl]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='4owl' size='340' side='right'caption='[[4owl]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4owl]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibvu Vibvu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OWL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OWL FirstGlance]. <br>		<table><tr><td colspan='2'>[[4owl]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibvu Vibvu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OWL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OWL FirstGlance]. <br>
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4owl" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4owl" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cytolysin 3D structures\|Cytolysin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Vibvu]]		[[Category: Vibvu]]
	[[Category: Kaus, K]]		[[Category: Kaus, K]]

OCA at 09:03, 1 November 2017

OCA — Wed, 01 Nov 2017 09:03:18 GMT

←Older revision		Revision as of 09:03, 1 November 2017
Line 1:		Line 1:
		+
	==Crystal Structure of the Vibrio vulnificus Hemolysin/Cytolysin Beta-Trefoil Lectin with N-Acetyl-D-Lactosamine Bound==		==Crystal Structure of the Vibrio vulnificus Hemolysin/Cytolysin Beta-Trefoil Lectin with N-Acetyl-D-Lactosamine Bound==
	<StructureSection load='4owl' size='340' side='right' caption='[[4owl]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4owl' size='340' side='right' caption='[[4owl]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4owl]] is a 7 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OWL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OWL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4owl]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibvu Vibvu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OWL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OWL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4owj\|4owj]], [[4owk\|4owk]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4owj\|4owj]], [[4owk\|4owk]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4owl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4owl OCA], [http://pdbe.org/4owl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4owl RCSB], [http://www.ebi.ac.uk/pdbsum/4owl PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">VV2_0404,vvhA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=216895 VIBVU])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4owl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4owl OCA], [http://pdbe.org/4owl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4owl RCSB], [http://www.ebi.ac.uk/pdbsum/4owl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4owl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 22:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Vibvu]]
	[[Category: Kaus, K]]		[[Category: Kaus, K]]
	[[Category: Olson, R]]		[[Category: Olson, R]]

OCA at 07:42, 7 October 2015

OCA — Wed, 07 Oct 2015 07:42:17 GMT

←Older revision		Revision as of 07:42, 7 October 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4owj\|4owj]], [[4owk\|4owk]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4owj\|4owj]], [[4owk\|4owk]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4owl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4owl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4owl RCSB], [http://www.ebi.ac.uk/pdbsum/4owl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4owl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4owl OCA], [http://pdbe.org/4owl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4owl RCSB], [http://www.ebi.ac.uk/pdbsum/4owl PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4owl" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 28:
	[[Category: Pore-forming toxin]]		[[Category: Pore-forming toxin]]
	[[Category: R-type lectin]]		[[Category: R-type lectin]]
		+	[[Category: Toxin]]

OCA at 20:25, 24 December 2014

OCA — Wed, 24 Dec 2014 20:25:01 GMT

←Older revision		Revision as of 20:25, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4owl]] is a 7 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OWL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OWL FirstGlance]. <br>		<table><tr><td colspan='2'>[[4owl]] is a 7 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OWL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OWL FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4owj\|4owj]], [[4owk\|4owk]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4owj\|4owj]], [[4owk\|4owk]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4owl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4owl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4owl RCSB], [http://www.ebi.ac.uk/pdbsum/4owl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4owl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4owl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4owl RCSB], [http://www.ebi.ac.uk/pdbsum/4owl PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/VVHA_VIBVU VVHA_VIBVU]] Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture by mechanisms not clearly defined.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Kaus, K.]]	+	[[Category: Kaus, K]]
-	[[Category: Olson, R.]]	+	[[Category: Olson, R]]
	[[Category: Beta-trefoil]]		[[Category: Beta-trefoil]]
	[[Category: Lectin]]		[[Category: Lectin]]
	[[Category: Pore-forming toxin]]		[[Category: Pore-forming toxin]]
	[[Category: R-type lectin]]		[[Category: R-type lectin]]

OCA at 06:40, 30 July 2014

OCA — Wed, 30 Jul 2014 06:40:41 GMT

←Older revision		Revision as of 06:40, 30 July 2014
Line 7:		Line 7:
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4owl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4owl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4owl RCSB], [http://www.ebi.ac.uk/pdbsum/4owl PDBsum]</span></td></tr>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4owl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4owl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4owl RCSB], [http://www.ebi.ac.uk/pdbsum/4owl PDBsum]</span></td></tr>
	<table>		<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Pore-forming toxins (PFTs) are a class of pathogen-secreted molecules that oligomerize to form transmembrane channels in cellular membranes. Determining the mechanism for how PFTs bind membranes is important in understanding their role in disease and for developing possible ways to block their action. Vibrio vulnificus, an aquatic pathogen responsible for severe food poisoning and septicemia in humans, secretes a PFT called V. vulnificus hemolysin (VVH), which contains a single C-terminal targeting domain predicted to resemble a beta-trefoil lectin fold. In order to understand the selectivity of the lectin for glycan motifs, we expressed the isolated VVH beta-trefoil domain and used glycan-chip screening to identify that VVH displays a preference for terminal galactosyl groups including N-acetyl-d-galactosamine and N-acetyl-d-lactosamine. The X-ray crystal structure of the VVH lectin domain solved to 2.0A resolution reveals a heptameric ring arrangement similar to the oligomeric form of the related, but inactive, lectin from Vibrio cholerae cytolysin. Structures bound to glycerol, N-acetyl-d-galactosamine, and N-acetyl-d-lactosamine outline a common and versatile mode of recognition allowing VVH to target a wide variety of cell-surface ligands. Sequence analysis in light of our structural and functional data suggests that VVH may represent an earlier step in the evolution of Vibrio PFTs.
		+
		+	Glycan Specificity of the Vibrio vulnificus Hemolysin Lectin Outlines Evolutionary History of Membrane Targeting by a Toxin Family.,Kaus K, Lary JW, Cole JL, Olson R J Mol Biol. 2014 Jul 29;426(15):2800-12. doi: 10.1016/j.jmb.2014.05.021. Epub, 2014 May 24. PMID:24862282<ref>PMID:24862282</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 10:08, 28 May 2014

OCA — Wed, 28 May 2014 10:08:53 GMT

←Older revision		Revision as of 10:08, 28 May 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal Structure of the Vibrio vulnificus Hemolysin/Cytolysin Beta-Trefoil Lectin with N-Acetyl-D-Lactosamine Bound==
-		+	<StructureSection load='4owl' size='340' side='right' caption='[[4owl]], [[Resolution\|resolution]] 2.10Å' scene=''>
-	~~The entry~~ 4owl is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4owl]] is a 7 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OWL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OWL FirstGlance]. <br>
-	~~Authors~~: Kaus, K., Olson, R.	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4owj\|4owj]], [[4owk\|4owk]]</td></tr>
-	~~Description~~: ~~Crystal Structure of the Vibrio vulnificus Hemolysin/Cytolysin~~ Beta-~~Trefoil~~ Lectin ~~with N~~-~~Acetyl~~-~~D-Lactosamine Bound~~	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4owl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4owl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4owl RCSB], [http://www.ebi.ac.uk/pdbsum/4owl PDBsum]</span></td></tr>
		+	<table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Kaus, K.]]
		+	[[Category: Olson, R.]]
		+	[[Category: Beta-trefoil]]
		+	[[Category: Lectin]]
		+	[[Category: Pore-forming toxin]]
		+	[[Category: R-type lectin]]

OCA at 16:24, 19 February 2014

OCA — Wed, 19 Feb 2014 16:24:45 GMT

←Older revision		Revision as of 16:24, 19 February 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4owl is ON HOLD	+	The entry 4owl is ON HOLD until Paper Publication

	Authors: Kaus, K., Olson, R.		Authors: Kaus, K., Olson, R.

	Description: Crystal Structure of the Vibrio vulnificus Hemolysin/Cytolysin Beta-Trefoil Lectin with N-Acetyl-D-Lactosamine Bound		Description: Crystal Structure of the Vibrio vulnificus Hemolysin/Cytolysin Beta-Trefoil Lectin with N-Acetyl-D-Lactosamine Bound

OCA: Protected "4owl" [edit=sysop:move=sysop]

OCA — Thu, 13 Feb 2014 04:52:56 GMT

Protected "4owl" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:52, 13 February 2014