4oyu - Revision history

OCA at 00:38, 28 December 2023

OCA — Thu, 28 Dec 2023 00:38:03 GMT

←Older revision		Revision as of 00:38, 28 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4oyu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OYU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OYU FirstGlance]. <br>		<table><tr><td colspan='2'>[[4oyu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OYU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OYU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oyu OCA], [https://pdbe.org/4oyu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oyu RCSB], [https://www.ebi.ac.uk/pdbsum/4oyu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oyu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oyu OCA], [https://pdbe.org/4oyu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oyu RCSB], [https://www.ebi.ac.uk/pdbsum/4oyu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oyu ProSAT]</span></td></tr>
	</table>		</table>

OCA at 12:32, 1 February 2023

OCA — Wed, 01 Feb 2023 12:32:51 GMT

←Older revision		Revision as of 12:32, 1 February 2023
Line 3:		Line 3:
	<StructureSection load='4oyu' size='340' side='right'caption='[[4oyu]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='4oyu' size='340' side='right'caption='[[4oyu]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4oyu]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OYU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4OYU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4oyu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OYU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OYU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mkln1, Msk ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oyu OCA], [https://pdbe.org/4oyu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oyu RCSB], [https://www.ebi.ac.uk/pdbsum/4oyu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oyu ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4oyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oyu OCA], [~~http~~://pdbe.org/4oyu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4oyu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4oyu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4oyu ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/MKLN1_RAT MKLN1_RAT]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Delto, C~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: ~~Kuper, J~~]]	+	[[Category: Delto C]]
-	[[Category: ~~Schindelin, H~~]]	+	[[Category: Kuper J]]
-	[[Category: ~~Dimer]]~~	+	[[Category: Schindelin H]]
-	~~[[Category: Discoidin domain]]~~	+
-	~~[[Category: Lish motif]]~~	+
-	~~[[Category: Protein binding~~]]	+

OCA at 07:16, 17 April 2019

OCA — Wed, 17 Apr 2019 07:16:40 GMT

←Older revision		Revision as of 07:16, 17 April 2019
Line 1:		Line 1:

	==Crystal structure of the N-terminal domains of muskelin==		==Crystal structure of the N-terminal domains of muskelin==
-	<StructureSection load='4oyu' size='340' side='right' caption='[[4oyu]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='4oyu' size='340' side='right'caption='[[4oyu]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4oyu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OYU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OYU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4oyu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OYU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OYU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mkln1, Msk ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oyu OCA], [http://pdbe.org/4oyu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4oyu RCSB], [http://www.ebi.ac.uk/pdbsum/4oyu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4oyu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oyu OCA], [http://pdbe.org/4oyu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4oyu RCSB], [http://www.ebi.ac.uk/pdbsum/4oyu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4oyu ProSAT]</span></td></tr>
	</table>		</table>
Line 20:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Delto, C]]		[[Category: Delto, C]]
	[[Category: Kuper, J]]		[[Category: Kuper, J]]

OCA at 16:49, 2 January 2017

OCA — Mon, 02 Jan 2017 16:49:30 GMT

←Older revision

Revision as of 16:49, 2 January 2017

OCA at 11:45, 12 February 2015

OCA — Thu, 12 Feb 2015 11:45:53 GMT

←Older revision		Revision as of 11:45, 12 February 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of the N-terminal domains of muskelin==
		+	<StructureSection load='4oyu' size='340' side='right' caption='[[4oyu]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4oyu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OYU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OYU FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oyu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oyu RCSB], [http://www.ebi.ac.uk/pdbsum/4oyu PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Neurons regulate the number of surface receptors by balancing the transport to and from the plasma membrane to adjust their signaling properties. The protein muskelin was recently identified as a key factor guiding the transport of alpha1 subunit-containing GABAA receptors. Here we present the crystal structure of muskelin, comprising its N-terminal discoidin domain and Lis1-homology (LisH) motif. The molecule crystallized as a dimer with the LisH motif exclusively mediating oligomerization. Our subsequent biochemical analyses confirmed that the LisH motif acts as a dimerization element in muskelin. Together with an intermolecular head-to-tail interaction, the LisH-dependent dimerization is required to assemble a muskelin tetramer. Intriguingly, our cellular studies revealed that the loss of this dimerization results in a complete redistribution of muskelin from the cytoplasm to the nucleus and impairs muskelin's function in GABAA receptor transport. These studies demonstrate that the LisH-dependent dimerization is a crucial factor for muskelin function.

-	The ~~entry 4oyu is ON HOLD until Paper Publication~~	+	The LisH Motif of Muskelin Is Crucial for Oligomerization and Governs Intracellular Localization.,Delto CF, Heisler FF, Kuper J, Sander B, Kneussel M, Schindelin H Structure. 2015 Feb 3;23(2):364-73. doi: 10.1016/j.str.2014.11.016. Epub 2015 Jan, 8. PMID:25579817<ref>PMID:25579817</ref>

-	~~Authors: Delto~~, C.~~, Kuper, J~~.~~, Schindelin, H~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: Crystal structure of the N-terminal domains of muskelin~~	+	== References ==
-	~~[[Category: Unreleased Structures]]~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Delto, C]]		[[Category: Delto, C]]
		+	[[Category: Kuper, J]]
	[[Category: Schindelin, H]]		[[Category: Schindelin, H]]
-	[[Category: ~~Kuper, J~~]]	+	[[Category: Dimer]]
		+	[[Category: Discoidin domain]]
		+	[[Category: Lish motif]]
		+	[[Category: Protein binding]]

OCA at 11:38, 7 February 2015

OCA — Sat, 07 Feb 2015 11:38:28 GMT

←Older revision		Revision as of 11:38, 7 February 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4oyu is ON HOLD	+	The entry 4oyu is ON HOLD until Paper Publication

	Authors: Delto, C., Kuper, J., Schindelin, H.		Authors: Delto, C., Kuper, J., Schindelin, H.

OCA at 14:40, 24 December 2014

OCA — Wed, 24 Dec 2014 14:40:31 GMT

←Older revision		Revision as of 14:40, 24 December 2014
Line 6:		Line 6:

	Description: Crystal structure of the N-terminal domains of muskelin		Description: Crystal structure of the N-terminal domains of muskelin
		+	[[Category: Unreleased Structures]]
		+	[[Category: Delto, C]]
		+	[[Category: Schindelin, H]]
		+	[[Category: Kuper, J]]

OCA at 13:05, 10 December 2014

OCA — Wed, 10 Dec 2014 13:05:43 GMT

←Older revision		Revision as of 13:05, 10 December 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4oyu is ON HOLD ~~until Paper Publication~~	+	The entry 4oyu is ON HOLD

	Authors: Delto, C., Kuper, J., Schindelin, H.		Authors: Delto, C., Kuper, J., Schindelin, H.

	Description: Crystal structure of the N-terminal domains of muskelin		Description: Crystal structure of the N-terminal domains of muskelin

OCA at 08:46, 26 March 2014

OCA — Wed, 26 Mar 2014 08:46:50 GMT

←Older revision		Revision as of 08:46, 26 March 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4oyu is ON HOLD	+	The entry 4oyu is ON HOLD until Paper Publication

	Authors: Delto, C., Kuper, J., Schindelin, H.		Authors: Delto, C., Kuper, J., Schindelin, H.

	Description: Crystal structure of the N-terminal domains of muskelin		Description: Crystal structure of the N-terminal domains of muskelin

OCA: Protected "4oyu" [edit=sysop:move=sysop]

OCA — Wed, 19 Feb 2014 16:26:47 GMT

Protected "4oyu" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:26, 19 February 2014