4oyx - Revision history

OCA at 00:38, 28 December 2023

OCA — Thu, 28 Dec 2023 00:38:07 GMT

←Older revision		Revision as of 00:38, 28 December 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4oyx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OYX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OYX FirstGlance]. <br>		<table><tr><td colspan='2'>[[4oyx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OYX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OYX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=APC:DIPHOSPHOMETHYLPHOSPHONIC+ACID+ADENOSYL+ESTER'>APC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.89Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=APC:DIPHOSPHOMETHYLPHOSPHONIC+ACID+ADENOSYL+ESTER'>APC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oyx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oyx OCA], [https://pdbe.org/4oyx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oyx RCSB], [https://www.ebi.ac.uk/pdbsum/4oyx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oyx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oyx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oyx OCA], [https://pdbe.org/4oyx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oyx RCSB], [https://www.ebi.ac.uk/pdbsum/4oyx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oyx ProSAT]</span></td></tr>
	</table>		</table>

OCA at 12:32, 1 February 2023

OCA — Wed, 01 Feb 2023 12:32:53 GMT

←Older revision		Revision as of 12:32, 1 February 2023
Line 1:		Line 1:

	==Human solAC Complexed with AMPCPP==		==Human solAC Complexed with AMPCPP==
-	<StructureSection load='4oyx' size='340' side='right' caption='[[4oyx]], [[Resolution\|resolution]] 1.89Å' scene=''>	+	<StructureSection load='4oyx' size='340' side='right'caption='[[4oyx]], [[Resolution\|resolution]] 1.89Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4oyx]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OYX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4OYX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4oyx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OYX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OYX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=APC:DIPHOSPHOMETHYLPHOSPHONIC+ACID+ADENOSYL+ESTER'>APC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL~~</scene></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=APC:DIPHOSPHOMETHYLPHOSPHONIC+ACID+ADENOSYL+ESTER'>APC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE~~</scene>, <scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene~~></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oyx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oyx OCA], [https://pdbe.org/4oyx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oyx RCSB], [https://www.ebi.ac.uk/pdbsum/4oyx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oyx ProSAT]</span></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4oya\|4oya]], [[4oyb\|4oyb]], [[4oyi\|4oyi]], [[4oym\|4oym]], [[4oyo\|4oyo]], [[4oyp\|4oyp]], [[4oyw\|4oyw]], [[4oyz\|4oyz]], [[4oz2\|4oz2]], [[4oz3\|4oz3]]</td></tr>	+
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADCY10, SAC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4oyx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oyx OCA], [~~http~~://pdbe.org/4oyx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4oyx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4oyx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4oyx ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/ADCYA_HUMAN ADCYA_HUMAN]] Idiopathic hypercalciuria. Disease susceptibility is associated with variations affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/ADCYA_HUMAN ADCYA_HUMAN] Idiopathic hypercalciuria. Disease susceptibility is associated with variations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ADCYA_HUMAN ADCYA_HUMAN]] Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. Involved in ciliary beat regulation.<ref>PMID:15659711</ref> <ref>PMID:17591988</ref>	+	[https://www.uniprot.org/uniprot/ADCYA_HUMAN ADCYA_HUMAN] Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. Involved in ciliary beat regulation.<ref>PMID:15659711</ref> <ref>PMID:17591988</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 22:

	==See Also==		==See Also==
-	*[[Adenylyl cyclase\|Adenylyl cyclase]]	+	*[[3D Adenylyl cyclase 3D structures\|3D Adenylyl cyclase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Adenylate cyclase~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Human~~]]	+	[[Category: Large Structures]]
-	[[Category: Vinkovic, M]]	+	[[Category: Vinkovic M]]
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Protein-substrate analogue complex~~]]	+

OCA at 17:14, 11 August 2016

OCA — Thu, 11 Aug 2016 17:14:01 GMT

←Older revision		Revision as of 17:14, 11 August 2016
Line 1:		Line 1:
		+
	==Human solAC Complexed with AMPCPP==		==Human solAC Complexed with AMPCPP==
	<StructureSection load='4oyx' size='340' side='right' caption='[[4oyx]], [[Resolution\|resolution]] 1.89Å' scene=''>		<StructureSection load='4oyx' size='340' side='right' caption='[[4oyx]], [[Resolution\|resolution]] 1.89Å' scene=''>
Line 8:		Line 9:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADCY10, SAC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADCY10, SAC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oyx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oyx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oyx RCSB], [http://www.ebi.ac.uk/pdbsum/4oyx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oyx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oyx OCA], [http://pdbe.org/4oyx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4oyx RCSB], [http://www.ebi.ac.uk/pdbsum/4oyx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4oyx ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 22:		Line 23:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4oyx" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Adenylyl cyclase\|Adenylyl cyclase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:31, 20 January 2015

OCA — Tue, 20 Jan 2015 11:31:16 GMT

←Older revision		Revision as of 11:31, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4oyx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OYX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OYX FirstGlance]. <br>		<table><tr><td colspan='2'>[[4oyx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OYX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OYX FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=APC:DIPHOSPHOMETHYLPHOSPHONIC+ACID+ADENOSYL+ESTER'>APC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=APC:DIPHOSPHOMETHYLPHOSPHONIC+ACID+ADENOSYL+ESTER'>APC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4oya\|4oya]], [[4oyb\|4oyb]], [[4oyi\|4oyi]], [[4oym\|4oym]], [[4oyo\|4oyo]], [[4oyp\|4oyp]], [[4oyw\|4oyw]], [[4oyz\|4oyz]], [[4oz2\|4oz2]], [[4oz3\|4oz3]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4oya\|4oya]], [[4oyb\|4oyb]], [[4oyi\|4oyi]], [[4oym\|4oym]], [[4oyo\|4oyo]], [[4oyp\|4oyp]], [[4oyw\|4oyw]], [[4oyz\|4oyz]], [[4oz2\|4oz2]], [[4oz3\|4oz3]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADCY10, SAC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADCY10, SAC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oyx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oyx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oyx RCSB], [http://www.ebi.ac.uk/pdbsum/4oyx PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oyx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oyx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oyx RCSB], [http://www.ebi.ac.uk/pdbsum/4oyx PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/ADCYA_HUMAN ADCYA_HUMAN]] Idiopathic hypercalciuria. Disease susceptibility is associated with variations affecting the gene represented in this entry.		[[http://www.uniprot.org/uniprot/ADCYA_HUMAN ADCYA_HUMAN]] Idiopathic hypercalciuria. Disease susceptibility is associated with variations affecting the gene represented in this entry.
Line 28:		Line 28:
	[[Category: Adenylate cyclase]]		[[Category: Adenylate cyclase]]
	[[Category: Human]]		[[Category: Human]]
-	[[Category: Vinkovic, M.]]	+	[[Category: Vinkovic, M]]
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Protein-substrate analogue complex]]		[[Category: Protein-substrate analogue complex]]

OCA at 06:22, 11 June 2014

OCA — Wed, 11 Jun 2014 06:22:37 GMT

←Older revision		Revision as of 06:22, 11 June 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4oyx\| PDB~~=4oyx \| ~~SCENE~~= }}	+	==Human solAC Complexed with AMPCPP==
-	===~~Human solAC Complexed~~ with ~~AMPCPP~~===	+	<StructureSection load='4oyx' size='340' side='right' caption='[[4oyx]], [[Resolution\|resolution]] 1.89Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24616449}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4oyx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OYX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OYX FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=APC:DIPHOSPHOMETHYLPHOSPHONIC+ACID+ADENOSYL+ESTER'>APC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4oya\|4oya]], [[4oyb\|4oyb]], [[4oyi\|4oyi]], [[4oym\|4oym]], [[4oyo\|4oyo]], [[4oyp\|4oyp]], [[4oyw\|4oyw]], [[4oyz\|4oyz]], [[4oz2\|4oz2]], [[4oz3\|4oz3]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ADCY10, SAC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oyx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oyx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oyx RCSB], [http://www.ebi.ac.uk/pdbsum/4oyx PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/ADCYA_HUMAN ADCYA_HUMAN]] Idiopathic hypercalciuria. Disease susceptibility is associated with variations affecting the gene represented in this entry.		[[http://www.uniprot.org/uniprot/ADCYA_HUMAN ADCYA_HUMAN]] Idiopathic hypercalciuria. Disease susceptibility is associated with variations affecting the gene represented in this entry.
-		+	== Function ==
-	==Function==	+
	[[http://www.uniprot.org/uniprot/ADCYA_HUMAN ADCYA_HUMAN]] Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. Involved in ciliary beat regulation.<ref>PMID:15659711</ref> <ref>PMID:17591988</ref>		[[http://www.uniprot.org/uniprot/ADCYA_HUMAN ADCYA_HUMAN]] Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. Involved in ciliary beat regulation.<ref>PMID:15659711</ref> <ref>PMID:17591988</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Soluble adenylate cyclases catalyse the synthesis of the second messenger cAMP through the cyclisation of ATP and are the only known enzymes to be directly activated by bicarbonate. Here, we report the first crystal structure of the human enzyme that reveals a pseudosymmetrical arrangement of two catalytic domains to produce a single competent active site and a novel discrete bicarbonate binding pocket. Crystal structures of the apo protein, the protein in complex with alpha,beta-methylene adenosine 5'-triphosphate (AMPCPP) and calcium, with the allosteric activator bicarbonate, and also with a number of inhibitors identified using fragment screening, all show a flexible active site that undergoes significant conformational changes on binding of ligands. The resulting nanomolar-potent inhibitors that were developed bind at both the substrate binding pocket and the allosteric site, and can be used as chemical probes to further elucidate the function of this protein.

-	~~==About this~~ Structure==	+	Crystal Structure of Human Soluble Adenylate Cyclase Reveals a Distinct, Highly Flexible Allosteric Bicarbonate Binding Pocket.,Saalau-Bethell SM, Berdini V, Cleasby A, Congreve M, Coyle JE, Lock V, Murray CW, O'Brien MA, Rich SJ, Sambrook T, Vinkovic M, Yon JR, Jhoti H ChemMedChem. 2014 Feb 24. doi: 10.1002/cmdc.201300480. PMID:24616449<ref>PMID:24616449</ref>
-	~~[[4oyx]] is~~ a ~~1 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=4OYX OCA]~~.	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024616449</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Adenylate cyclase]]		[[Category: Adenylate cyclase]]
		+	[[Category: Human]]
	[[Category: Vinkovic, M.]]		[[Category: Vinkovic, M.]]
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Protein-substrate analogue complex]]		[[Category: Protein-substrate analogue complex]]

OCA at 09:02, 2 April 2014

OCA — Wed, 02 Apr 2014 09:02:09 GMT

←Older revision		Revision as of 09:02, 2 April 2014
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4oyx\| PDB=4oyx \| SCENE= }}
		+	===Human solAC Complexed with AMPCPP===
		+	{{ABSTRACT_PUBMED_24616449}}

-	~~The entry 4oyx~~ is ~~ON HOLD until Paper Publication~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/ADCYA_HUMAN ADCYA_HUMAN]] Idiopathic hypercalciuria. Disease susceptibility is associated with variations affecting the gene represented in this entry.

-	~~Authors~~: ~~Vinkovic~~, M.	+	==Function==
		+	[[http://www.uniprot.org/uniprot/ADCYA_HUMAN ADCYA_HUMAN]] Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. Involved in ciliary beat regulation.<ref>PMID:15659711</ref> <ref>PMID:17591988</ref>

-	~~Description~~: ~~Human solAC Complexed with AMPCPP~~	+	==About this Structure==
		+	[[4oyx]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OYX OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:024616449</ref><references group="xtra"/><references/>
		+	[[Category: Adenylate cyclase]]
		+	[[Category: Vinkovic, M.]]
		+	[[Category: Lyase]]
		+	[[Category: Protein-substrate analogue complex]]

OCA at 07:29, 19 March 2014

OCA — Wed, 19 Mar 2014 07:29:54 GMT

←Older revision		Revision as of 07:29, 19 March 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4oyx is ON HOLD	+	The entry 4oyx is ON HOLD until Paper Publication

	Authors: Vinkovic, M.		Authors: Vinkovic, M.

	Description: Human solAC Complexed with AMPCPP		Description: Human solAC Complexed with AMPCPP

OCA at 12:24, 12 March 2014

OCA — Wed, 12 Mar 2014 12:24:47 GMT

←Older revision		Revision as of 12:24, 12 March 2014
Line 5:		Line 5:
	Authors: Vinkovic, M.		Authors: Vinkovic, M.

-	Description: ~~Crystal Structure Analysis of the~~ solAC	+	Description: Human solAC Complexed with AMPCPP

OCA: Protected "4oyx" [edit=sysop:move=sysop]

OCA — Wed, 19 Feb 2014 16:26:54 GMT

Protected "4oyx" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:26, 19 February 2014

OCA: New page: '''Unreleased structure''' The entry 4oyx is ON HOLD Authors: Vinkovic, M. Description: Crystal Structure Analysis of the solAC

OCA — Wed, 19 Feb 2014 16:26:53 GMT

New page: '''Unreleased structure''' The entry 4oyx is ON HOLD Authors: Vinkovic, M. Description: Crystal Structure Analysis of the solAC

New page

'''Unreleased structure'''

The entry 4oyx is ON HOLD

Authors: Vinkovic, M.

Description: Crystal Structure Analysis of the solAC