4oz0 - Revision history

OCA at 07:07, 27 September 2023

OCA — Wed, 27 Sep 2023 07:07:42 GMT

←Older revision		Revision as of 07:07, 27 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4oz0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OZ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OZ0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4oz0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OZ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OZ0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oz0 OCA], [https://pdbe.org/4oz0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oz0 RCSB], [https://www.ebi.ac.uk/pdbsum/4oz0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oz0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oz0 OCA], [https://pdbe.org/4oz0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oz0 RCSB], [https://www.ebi.ac.uk/pdbsum/4oz0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oz0 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 12:33, 1 February 2023

OCA — Wed, 01 Feb 2023 12:33:03 GMT

←Older revision		Revision as of 12:33, 1 February 2023
Line 3:		Line 3:
	<StructureSection load='4oz0' size='340' side='right'caption='[[4oz0]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='4oz0' size='340' side='right'caption='[[4oz0]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4oz0]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OZ0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4OZ0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4oz0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OZ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OZ0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CAPER, CAPERalpha, FSAP59, HCC1, RBM39, RNPC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oz0 OCA], [https://pdbe.org/4oz0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oz0 RCSB], [https://www.ebi.ac.uk/pdbsum/4oz0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oz0 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4oz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oz0 OCA], [~~http~~://pdbe.org/4oz0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4oz0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4oz0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4oz0 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/RBM39_HUMAN RBM39_HUMAN]] Transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1 (By similarity). May be involved in pre-mRNA splicing process.	+	[https://www.uniprot.org/uniprot/RBM39_HUMAN RBM39_HUMAN] Transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1 (By similarity). May be involved in pre-mRNA splicing process.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kielkopf~~, C L~~]]	+	[[Category: Kielkopf CL]]
-	[[Category: Loerch, S]]	+	[[Category: Loerch S]]
-	~~[[Category: Pre-mrna splicing factor]]~~	+
-	~~[[Category: Protein-peptide complex]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: U2af homology motif]]~~	+
-	~~[[Category: Uhm~~]]	+

OCA at 10:07, 25 December 2019

OCA — Wed, 25 Dec 2019 10:07:06 GMT

←Older revision		Revision as of 10:07, 25 December 2019
Line 1:		Line 1:

	==Crystal structure of human CAPERalpha U2AF homology motif (apo-state)==		==Crystal structure of human CAPERalpha U2AF homology motif (apo-state)==
-	<StructureSection load='4oz0' size='340' side='right' caption='[[4oz0]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='4oz0' size='340' side='right'caption='[[4oz0]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4oz0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OZ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OZ0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4oz0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OZ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OZ0 FirstGlance]. <br>
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Kielkopf, C L]]		[[Category: Kielkopf, C L]]
	[[Category: Loerch, S]]		[[Category: Loerch, S]]

OCA at 14:43, 15 November 2017

OCA — Wed, 15 Nov 2017 14:43:06 GMT

←Older revision		Revision as of 14:43, 15 November 2017
Line 3:		Line 3:
	<StructureSection load='4oz0' size='340' side='right' caption='[[4oz0]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='4oz0' size='340' side='right' caption='[[4oz0]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4oz0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OZ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OZ0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4oz0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OZ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OZ0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CAPER, CAPERalpha, FSAP59, HCC1, RBM39, RNPC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oz0 OCA], [http://pdbe.org/4oz0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4oz0 RCSB], [http://www.ebi.ac.uk/pdbsum/4oz0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4oz0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oz0 OCA], [http://pdbe.org/4oz0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4oz0 RCSB], [http://www.ebi.ac.uk/pdbsum/4oz0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4oz0 ProSAT]</span></td></tr>
	</table>		</table>
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Kielkopf, C L]]		[[Category: Kielkopf, C L]]
	[[Category: Loerch, S]]		[[Category: Loerch, S]]
	[[Category: Pre-mrna splicing factor]]		[[Category: Pre-mrna splicing factor]]
	[[Category: Protein-peptide complex]]		[[Category: Protein-peptide complex]]
		+	[[Category: Transcription]]
	[[Category: U2af homology motif]]		[[Category: U2af homology motif]]
	[[Category: Uhm]]		[[Category: Uhm]]

OCA at 08:00, 5 August 2016

OCA — Fri, 05 Aug 2016 08:00:44 GMT

←Older revision		Revision as of 08:00, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of human CAPERalpha U2AF homology motif (apo-state)==		==Crystal structure of human CAPERalpha U2AF homology motif (apo-state)==
	<StructureSection load='4oz0' size='340' side='right' caption='[[4oz0]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='4oz0' size='340' side='right' caption='[[4oz0]], [[Resolution\|resolution]] 2.20Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4oz0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OZ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OZ0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4oz0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OZ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OZ0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oz0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oz0 RCSB], [http://www.ebi.ac.uk/pdbsum/4oz0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oz0 OCA], [http://pdbe.org/4oz0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4oz0 RCSB], [http://www.ebi.ac.uk/pdbsum/4oz0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4oz0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4oz0" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:06, 25 December 2014

OCA — Thu, 25 Dec 2014 17:06:26 GMT

←Older revision		Revision as of 17:06, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4oz0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OZ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OZ0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4oz0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OZ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OZ0 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oz0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oz0 RCSB], [http://www.ebi.ac.uk/pdbsum/4oz0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oz0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oz0 RCSB], [http://www.ebi.ac.uk/pdbsum/4oz0 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RBM39_HUMAN RBM39_HUMAN]] Transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1 (By similarity). May be involved in pre-mRNA splicing process.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Kielkopf, C L.]]	+	[[Category: Kielkopf, C L]]
-	[[Category: Loerch, S.]]	+	[[Category: Loerch, S]]
	[[Category: Pre-mrna splicing factor]]		[[Category: Pre-mrna splicing factor]]
	[[Category: Protein-peptide complex]]		[[Category: Protein-peptide complex]]
	[[Category: U2af homology motif]]		[[Category: U2af homology motif]]
	[[Category: Uhm]]		[[Category: Uhm]]

OCA at 06:29, 11 June 2014

OCA — Wed, 11 Jun 2014 06:29:06 GMT

←Older revision		Revision as of 06:29, 11 June 2014
Line 2:		Line 2:
	<StructureSection load='4oz0' size='340' side='right' caption='[[4oz0]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='4oz0' size='340' side='right' caption='[[4oz0]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4oz0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OZ0 OCA]. <br>	+	<table><tr><td colspan='2'>[[4oz0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OZ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OZ0 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene><br>		</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene><br>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oz0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oz0 RCSB], [http://www.ebi.ac.uk/pdbsum/4oz0 PDBsum]</span></td></tr>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oz0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oz0 RCSB], [http://www.ebi.ac.uk/pdbsum/4oz0 PDBsum]</span></td></tr>
	<table>		<table>
Line 13:		Line 12:
	Cancer-Relevant Splicing Factor CAPERalpha Engages the Essential Splicing Factor SF3b155 in a Specific Ternary Complex.,Loerch S, Maucuer A, Manceau V, Green MR, Kielkopf CL J Biol Chem. 2014 May 2. PMID:24795046<ref>PMID:24795046</ref>		Cancer-Relevant Splicing Factor CAPERalpha Engages the Essential Splicing Factor SF3b155 in a Specific Ternary Complex.,Loerch S, Maucuer A, Manceau V, Green MR, Kielkopf CL J Biol Chem. 2014 May 2. PMID:24795046<ref>PMID:24795046</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==

OCA at 07:17, 14 May 2014

OCA — Wed, 14 May 2014 07:17:25 GMT

←Older revision		Revision as of 07:17, 14 May 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of human CAPERalpha U2AF homology motif (apo-state)==
		+	<StructureSection load='4oz0' size='340' side='right' caption='[[4oz0]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4oz0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OZ0 OCA]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oz0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oz0 RCSB], [http://www.ebi.ac.uk/pdbsum/4oz0 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	U2AF Homology Motifs (UHMs) mediate protein-protein interactions with U2AF Ligand Motifs (ULMs) of pre-mRNA splicing factors. The UHM-containing alternative splicing factor CAPERalpha regulates splicing of tumor-promoting VEGF isoforms, yet the molecular target of the CAPERalpha UHM is unknown. Here, we present structures of the CAPERalpha UHM bound to a representative SF3b155 ULM at 1.7 A resolution, and for comparison, in the absence of ligand at 2.2 A resolution. The prototypical UHM/ULM interactions authenticate CAPERalpha as a bona fide member of the UHM-family of proteins. We identify SF3b155 as the relevant ULM-containing partner of full-length CAPERalpha in human cell extracts. Isothermal titration calorimetry comparisons of the purified CAPERalpha UHM binding known ULM-containing proteins demonstrate that high affinity interactions depend on the presence of an intact, intrinsically-unstructured SF3b155 domain containing seven ULM-like motifs. The interplay among bound CAPERalpha molecules gives rise to the appearance of two high affinity sites in the SF3b155 ULM-containing domain. In conjunction with the previously-identified, UHM/ULM-mediated complexes of U2AF65 and SPF45 with SF3b155, this work demonstrates the capacity of SF3b155 to offer a platform for coordinated recruitment of UHM-containing splicing factors.

-	~~The entry 4oz0 is ON HOLD until Paper Publication~~	+	Cancer-Relevant Splicing Factor CAPERalpha Engages the Essential Splicing Factor SF3b155 in a Specific Ternary Complex.,Loerch S, Maucuer A, Manceau V, Green MR, Kielkopf CL J Biol Chem. 2014 May 2. PMID:24795046<ref>PMID:24795046</ref>

-	~~Authors: Loerch~~, S., Kielkopf, C.L.	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal structure of human CAPERalpha U2AF~~ homology motif ~~(apo-state)~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Kielkopf, C L.]]
		+	[[Category: Loerch, S.]]
		+	[[Category: Pre-mrna splicing factor]]
		+	[[Category: Protein-peptide complex]]
		+	[[Category: U2af homology motif]]
		+	[[Category: Uhm]]

OCA at 12:24, 12 March 2014

OCA — Wed, 12 Mar 2014 12:24:55 GMT

←Older revision		Revision as of 12:24, 12 March 2014
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-	The entry 4oz0 is ON HOLD	+	The entry 4oz0 is ON HOLD until Paper Publication

	Authors: Loerch, S., Kielkopf, C.L.		Authors: Loerch, S., Kielkopf, C.L.

	Description: Crystal structure of human CAPERalpha U2AF homology motif (apo-state)		Description: Crystal structure of human CAPERalpha U2AF homology motif (apo-state)

OCA: Protected "4oz0" [edit=sysop:move=sysop]

OCA — Wed, 19 Feb 2014 16:27:02 GMT

Protected "4oz0" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:27, 19 February 2014