4p00 - Revision history

OCA at 00:38, 28 December 2023

OCA — Thu, 28 Dec 2023 00:38:33 GMT

←Older revision		Revision as of 00:38, 28 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4p00]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Cereibacter_sphaeroides_2.4.1 Cereibacter sphaeroides 2.4.1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P00 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P00 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4p00]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Cereibacter_sphaeroides_2.4.1 Cereibacter sphaeroides 2.4.1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P00 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P00 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PE:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>3PE</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=C2E:9,9-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d 3,2-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)'>C2E</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PLC:DIUNDECYL+PHOSPHATIDYL+CHOLINE'>PLC</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PE:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>3PE</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=C2E:9,9-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d 3,2-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)'>C2E</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PLC:DIUNDECYL+PHOSPHATIDYL+CHOLINE'>PLC</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p00 OCA], [https://pdbe.org/4p00 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p00 RCSB], [https://www.ebi.ac.uk/pdbsum/4p00 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p00 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p00 OCA], [https://pdbe.org/4p00 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p00 RCSB], [https://www.ebi.ac.uk/pdbsum/4p00 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p00 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 12:34, 1 February 2023

OCA — Wed, 01 Feb 2023 12:34:30 GMT

←Older revision		Revision as of 12:34, 1 February 2023
Line 3:		Line 3:
	<StructureSection load='4p00' size='340' side='right'caption='[[4p00]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='4p00' size='340' side='right'caption='[[4p00]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4p00]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Rhos4 Rhos4~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P00 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4P00 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4p00]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Cereibacter_sphaeroides_2.4.1 Cereibacter sphaeroides 2.4.1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P00 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P00 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3PE:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>3PE</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=C2E:9,9-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d 3,2-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)'>C2E</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PLC:DIUNDECYL+PHOSPHATIDYL+CHOLINE'>PLC</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PE:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>3PE</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=C2E:9,9-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d 3,2-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)'>C2E</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PLC:DIUNDECYL+PHOSPHATIDYL+CHOLINE'>PLC</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p00 OCA], [https://pdbe.org/4p00 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p00 RCSB], [https://www.ebi.ac.uk/pdbsum/4p00 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p00 ProSAT]</span></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p02\|4p02]], [[4hg6\|4hg6]]</td></tr>~~	+
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RSP_0333 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272943 RHOS4]), RSP_0332 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272943 RHOS4])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cellulose_synthase_(UDP-forming) Cellulose synthase (UDP-forming)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.12 2.4.1.12] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4p00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p00 OCA], [~~http~~://pdbe.org/4p00 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4p00 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4p00 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4p00 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q3J125_CERS4 Q3J125_CERS4] Catalytic subunit of cellulose synthase. It polymerizes uridine 5'-diphosphate glucose to cellulose.[RuleBase:RU365020]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Cereibacter sphaeroides 2 4.1]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Rhos4]]~~	+	[[Category: McNamara JT]]
-	[[Category: McNamara~~, J T~~]]	+	[[Category: Morgan JLW]]
-	[[Category: Morgan~~, J L.W~~]]	+	[[Category: Zimmer J]]
-	[[Category: Zimmer, J]]	+
-	~~[[Category: Biofilm]]~~	+
-	~~[[Category: Cellulose biosynthesis]]~~	+
-	~~[[Category: Cyclic-di-gmp]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 07:14, 27 November 2019

OCA — Wed, 27 Nov 2019 07:14:20 GMT

←Older revision		Revision as of 07:14, 27 November 2019
Line 1:		Line 1:

	==Bacterial Cellulose Synthase in complex with cyclic-di-GMP and UDP==		==Bacterial Cellulose Synthase in complex with cyclic-di-GMP and UDP==
-	<StructureSection load='4p00' size='340' side='right' caption='[[4p00]], [[Resolution\|resolution]] 3.20Å' scene=''>	+	<StructureSection load='4p00' size='340' side='right'caption='[[4p00]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4p00]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhos4 Rhos4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P00 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P00 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4p00]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhos4 Rhos4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P00 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P00 FirstGlance]. <br>
Line 24:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Rhos4]]		[[Category: Rhos4]]
	[[Category: McNamara, J T]]		[[Category: McNamara, J T]]

OCA at 08:00, 4 August 2016

OCA — Thu, 04 Aug 2016 08:00:24 GMT

←Older revision		Revision as of 08:00, 4 August 2016
Line 1:		Line 1:
		+
	==Bacterial Cellulose Synthase in complex with cyclic-di-GMP and UDP==		==Bacterial Cellulose Synthase in complex with cyclic-di-GMP and UDP==
	<StructureSection load='4p00' size='340' side='right' caption='[[4p00]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='4p00' size='340' side='right' caption='[[4p00]], [[Resolution\|resolution]] 3.20Å' scene=''>
Line 8:		Line 9:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RSP_0333 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272943 RHOS4]), RSP_0332 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272943 RHOS4])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RSP_0333 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272943 RHOS4]), RSP_0332 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272943 RHOS4])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cellulose_synthase_(UDP-forming) Cellulose synthase (UDP-forming)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.12 2.4.1.12] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cellulose_synthase_(UDP-forming) Cellulose synthase (UDP-forming)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.12 2.4.1.12] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p00 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p00 RCSB], [http://www.ebi.ac.uk/pdbsum/4p00 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p00 OCA], [http://pdbe.org/4p00 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p00 RCSB], [http://www.ebi.ac.uk/pdbsum/4p00 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p00 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4p00" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:26, 24 December 2014

OCA — Wed, 24 Dec 2014 11:26:16 GMT

←Older revision		Revision as of 11:26, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4p00]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhos4 Rhos4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P00 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P00 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4p00]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhos4 Rhos4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P00 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P00 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3PE:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>3PE</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=C2E:9,9-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d 3,2-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)'>C2E</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PLC:DIUNDECYL+PHOSPHATIDYL+CHOLINE'>PLC</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3PE:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>3PE</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=C2E:9,9-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d 3,2-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)'>C2E</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PLC:DIUNDECYL+PHOSPHATIDYL+CHOLINE'>PLC</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p02\|4p02]], [[4hg6\|4hg6]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p02\|4p02]], [[4hg6\|4hg6]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RSP_0333 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272943 RHOS4]), RSP_0332 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272943 RHOS4])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RSP_0333 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272943 RHOS4]), RSP_0332 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272943 RHOS4])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cellulose_synthase_(UDP-forming) Cellulose synthase (UDP-forming)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.12 2.4.1.12] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cellulose_synthase_(UDP-forming) Cellulose synthase (UDP-forming)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.12 2.4.1.12] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p00 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p00 RCSB], [http://www.ebi.ac.uk/pdbsum/4p00 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p00 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p00 RCSB], [http://www.ebi.ac.uk/pdbsum/4p00 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Rhos4]]		[[Category: Rhos4]]
-	[[Category: McNamara, J T.]]	+	[[Category: McNamara, J T]]
-	[[Category: Morgan, J L.W.]]	+	[[Category: Morgan, J L.W]]
-	[[Category: Zimmer, J.]]	+	[[Category: Zimmer, J]]
	[[Category: Biofilm]]		[[Category: Biofilm]]
	[[Category: Cellulose biosynthesis]]		[[Category: Cellulose biosynthesis]]

OCA at 06:35, 11 June 2014

OCA — Wed, 11 Jun 2014 06:35:36 GMT

←Older revision		Revision as of 06:35, 11 June 2014
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-	~~{{STRUCTURE_4p00\| PDB=4p00 \| SCENE= }}~~	+	==Bacterial Cellulose Synthase in complex with cyclic-di-GMP and UDP==
-	===Bacterial Cellulose Synthase in complex with cyclic-di-GMP and UDP===	+	<StructureSection load='4p00' size='340' side='right' caption='[[4p00]], [[Resolution\|resolution]] 3.20Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24704788}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4p00]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhos4 Rhos4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P00 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P00 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3PE:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>3PE</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=C2E:9,9-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d 3,2-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)'>C2E</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PLC:DIUNDECYL+PHOSPHATIDYL+CHOLINE'>PLC</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p02\|4p02]], [[4hg6\|4hg6]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RSP_0333 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272943 RHOS4]), RSP_0332 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272943 RHOS4])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cellulose_synthase_(UDP-forming) Cellulose synthase (UDP-forming)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.12 2.4.1.12] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p00 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p00 RCSB], [http://www.ebi.ac.uk/pdbsum/4p00 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The bacterial signaling molecule cyclic di-GMP (c-di-GMP) stimulates the synthesis of bacterial cellulose, which is frequently found in biofilms. Bacterial cellulose is synthesized and translocated across the inner membrane by a complex of cellulose synthase BcsA and BcsB subunits. Here we present crystal structures of the c-di-GMP-activated BcsA-BcsB complex. The structures reveal that c-di-GMP releases an autoinhibited state of the enzyme by breaking a salt bridge that otherwise tethers a conserved gating loop that controls access to and substrate coordination at the active site. Disrupting the salt bridge by mutagenesis generates a constitutively active cellulose synthase. Additionally, the c-di-GMP-activated BcsA-BcsB complex contains a nascent cellulose polymer whose terminal glucose unit rests at a new location above BcsA's active site and is positioned for catalysis. Our mechanistic insights indicate how c-di-GMP allosterically modulates enzymatic functions.

-	~~==About this Structure==~~	+	Mechanism of activation of bacterial cellulose synthase by cyclic di-GMP.,Morgan JL, McNamara JT, Zimmer J Nat Struct Mol Biol. 2014 Apr 6. doi: 10.1038/nsmb.2803. PMID:24704788<ref>PMID:24704788</ref>
-	~~[[4p00]] is a 3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rhos4 Rhos4]~~. ~~Full crystallographic information is available from [http~~:/~~/oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=4P00 OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024704788</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Rhos4]]		[[Category: Rhos4]]
	[[Category: McNamara, J T.]]		[[Category: McNamara, J T.]]

OCA at 06:35, 23 April 2014

OCA — Wed, 23 Apr 2014 06:35:24 GMT

←Older revision		Revision as of 06:35, 23 April 2014
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	{{STRUCTURE_4p00\| PDB=4p00 \| SCENE= }}		{{STRUCTURE_4p00\| PDB=4p00 \| SCENE= }}
	===Bacterial Cellulose Synthase in complex with cyclic-di-GMP and UDP===		===Bacterial Cellulose Synthase in complex with cyclic-di-GMP and UDP===
		+	{{ABSTRACT_PUBMED_24704788}}

	==About this Structure==		==About this Structure==
-	[[4p00]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P00 OCA].	+	[[4p00]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhos4 Rhos4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P00 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:024704788</ref><references group="xtra"/><references/>
		+	[[Category: Rhos4]]
	[[Category: McNamara, J T.]]		[[Category: McNamara, J T.]]
	[[Category: Morgan, J L.W.]]		[[Category: Morgan, J L.W.]]

OCA at 06:46, 9 April 2014

OCA — Wed, 09 Apr 2014 06:46:59 GMT

←Older revision		Revision as of 06:46, 9 April 2014
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-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4p00\| PDB=4p00 \| SCENE= }}
		+	===Bacterial Cellulose Synthase in complex with cyclic-di-GMP and UDP===

-	~~The entry~~ 4p00 is ~~ON HOLD~~	+	==About this Structure==
-		+	[[4p00]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P00 OCA].
-	~~Authors~~: ~~Morgan, J~~.L.W., McNamara, J.T., Zimmer, J.	+	[[Category: McNamara, J T.]]
-		+	[[Category: Morgan, J L.W.]]
-	~~Description~~: ~~Bacterial~~ Cellulose ~~Synthase in complex with cyclic~~-di-~~GMP and UDP~~	+	[[Category: Zimmer, J.]]
		+	[[Category: Biofilm]]
		+	[[Category: Cellulose biosynthesis]]
		+	[[Category: Cyclic-di-gmp]]
		+	[[Category: Membrane protein]]
		+	[[Category: Transferase]]

OCA at 12:26, 12 March 2014

OCA — Wed, 12 Mar 2014 12:26:06 GMT

←Older revision		Revision as of 12:26, 12 March 2014
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	The entry 4p00 is ON HOLD		The entry 4p00 is ON HOLD

-	Authors: Morgan, ~~JLW~~, McNamara, JT, Zimmer, J	+	Authors: Morgan, J.L.W., McNamara, J.T., Zimmer, J.

	Description: Bacterial Cellulose Synthase in complex with cyclic-di-GMP and UDP		Description: Bacterial Cellulose Synthase in complex with cyclic-di-GMP and UDP

OCA: Protected "4p00" [edit=sysop:move=sysop]

OCA — Mon, 03 Mar 2014 16:57:26 GMT

Protected "4p00" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:57, 3 March 2014