4p01 - Revision history

OCA at 00:38, 28 December 2023

OCA — Thu, 28 Dec 2023 00:38:34 GMT

←Older revision		Revision as of 00:38, 28 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4p01]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P01 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P01 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4p01]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P01 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P01 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1ZW:N-[(4-CYANOPHENYL)METHYL]METHANETHIOAMIDE'>1ZW</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.07Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1ZW:N-[(4-CYANOPHENYL)METHYL]METHANETHIOAMIDE'>1ZW</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p01 OCA], [https://pdbe.org/4p01 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p01 RCSB], [https://www.ebi.ac.uk/pdbsum/4p01 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p01 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p01 OCA], [https://pdbe.org/4p01 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p01 RCSB], [https://www.ebi.ac.uk/pdbsum/4p01 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p01 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 12:34, 1 February 2023

OCA — Wed, 01 Feb 2023 12:34:39 GMT

←Older revision		Revision as of 12:34, 1 February 2023
Line 1:		Line 1:

	==Crystal Structure Analysis of Macrophage Migration Inhibitory Factor in complex with N-[(4-cyanophenyl)methyl]methanethioamide==		==Crystal Structure Analysis of Macrophage Migration Inhibitory Factor in complex with N-[(4-cyanophenyl)methyl]methanethioamide==
-	<StructureSection load='4p01' size='340' side='right' caption='[[4p01]], [[Resolution\|resolution]] 2.07Å' scene=''>	+	<StructureSection load='4p01' size='340' side='right'caption='[[4p01]], [[Resolution\|resolution]] 2.07Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4p01]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P01 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4P01 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4p01]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P01 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P01 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1ZW:N-[(4-CYANOPHENYL)METHYL]METHANETHIOAMIDE'>1ZW</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1ZW:N-[(4-CYANOPHENYL)METHYL]METHANETHIOAMIDE'>1ZW</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p0h\|4p0h]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p01 OCA], [https://pdbe.org/4p01 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p01 RCSB], [https://www.ebi.ac.uk/pdbsum/4p01 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p01 ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MIF, GLIF, MMIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4p01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p01 OCA], [~~http~~://pdbe.org/4p01 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4p01 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4p01 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4p01 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[~~http~~://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.	+	[https://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[https://omim.org/entry/604302 604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>	+	[https://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4p01" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4p01" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Macrophage inhibitory factor 3D structures\|Macrophage inhibitory factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Lolis, E~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Pantouris, G~~]]	+	[[Category: Lolis E]]
-	[[Category: ~~Active site]]~~	+	[[Category: Pantouris G]]
-	~~[[Category: Complex]]~~	+
-	~~[[Category: Covalent modification]]~~	+
-	~~[[Category: Isomerase-isomerase inhibitor complex]]~~	+
-	~~[[Category: Trimer~~]]	+

OCA at 08:32, 22 November 2017

OCA — Wed, 22 Nov 2017 08:32:12 GMT

←Older revision		Revision as of 08:32, 22 November 2017
Line 1:		Line 1:
		+
	==Crystal Structure Analysis of Macrophage Migration Inhibitory Factor in complex with N-[(4-cyanophenyl)methyl]methanethioamide==		==Crystal Structure Analysis of Macrophage Migration Inhibitory Factor in complex with N-[(4-cyanophenyl)methyl]methanethioamide==
	<StructureSection load='4p01' size='340' side='right' caption='[[4p01]], [[Resolution\|resolution]] 2.07Å' scene=''>		<StructureSection load='4p01' size='340' side='right' caption='[[4p01]], [[Resolution\|resolution]] 2.07Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p0h\|4p0h]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p0h\|4p0h]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MIF, GLIF, MMIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MIF, GLIF, MMIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p01 OCA], [http://pdbe.org/4p01 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p01 RCSB], [http://www.ebi.ac.uk/pdbsum/4p01 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p01 OCA], [http://pdbe.org/4p01 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p01 RCSB], [http://www.ebi.ac.uk/pdbsum/4p01 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p01 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 21:		Line 22:
	</div>		</div>
	<div class="pdbe-citations 4p01" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4p01" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Macrophage inhibitory factor\|Macrophage inhibitory factor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:09, 30 September 2015

OCA — Wed, 30 Sep 2015 06:09:20 GMT

←Older revision		Revision as of 06:09, 30 September 2015
Line 6:		Line 6:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p0h\|4p0h]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p0h\|4p0h]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MIF, GLIF, MMIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MIF, GLIF, MMIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p01 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p01 RCSB], [http://www.ebi.ac.uk/pdbsum/4p01 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p01 OCA], [http://pdbe.org/4p01 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p01 RCSB], [http://www.ebi.ac.uk/pdbsum/4p01 PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 12:		Line 12:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>		[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	For more than 15 years, the tautomerase active site of macrophage migration inhibitory factor (MIF) and its catalytic residue Pro1 have been being targeted for the development of therapeutics that block activation of its cell surface receptor, CD74. Neither the biological role of the MIF catalytic site nor the mechanistic details of CD74 activation are well understood. The inherently unstable structure of CD74 remains the biggest obstacle in structural studies with MIF for understanding the basis of CD74 activation. Using a novel approach, we elucidate the mechanistic details that control activation of CD74 by MIF surface residues and identify structural parameters of inhibitors that reduce CD74 biological activation. We also find that N-terminal mutants located deep in the catalytic site affect surface residues immediately outside the catalytic site, which are responsible for reduction of CD74 activation.
		+
		+	An Analysis of MIF Structural Features that Control Functional Activation of CD74.,Pantouris G, Syed MA, Fan C, Rajasekaran D, Cho TY, Rosenberg EM Jr, Bucala R, Bhandari V, Lolis EJ Chem Biol. 2015 Sep 17;22(9):1197-205. doi: 10.1016/j.chembiol.2015.08.006. Epub , 2015 Sep 10. PMID:26364929<ref>PMID:26364929</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4p01" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 34:
	[[Category: Complex]]		[[Category: Complex]]
	[[Category: Covalent modification]]		[[Category: Covalent modification]]
		+	[[Category: Isomerase-isomerase inhibitor complex]]
	[[Category: Trimer]]		[[Category: Trimer]]

OCA at 09:11, 5 January 2015

OCA — Mon, 05 Jan 2015 09:11:11 GMT

←Older revision		Revision as of 09:11, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4p01]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P01 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P01 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4p01]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P01 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P01 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1ZW:N-[(4-CYANOPHENYL)METHYL]METHANETHIOAMIDE'>1ZW</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1ZW:N-[(4-CYANOPHENYL)METHYL]METHANETHIOAMIDE'>1ZW</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p0h\|4p0h]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p0h\|4p0h]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MIF, GLIF, MMIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MIF, GLIF, MMIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p01 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p01 RCSB], [http://www.ebi.ac.uk/pdbsum/4p01 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p01 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p01 RCSB], [http://www.ebi.ac.uk/pdbsum/4p01 PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[http://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.		[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[http://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
Line 20:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
-	[[Category: Lolis, E.]]	+	[[Category: Lolis, E]]
-	[[Category: Pantouris, G.]]	+	[[Category: Pantouris, G]]
	[[Category: Active site]]		[[Category: Active site]]
	[[Category: Complex]]		[[Category: Complex]]
	[[Category: Covalent modification]]		[[Category: Covalent modification]]
	[[Category: Trimer]]		[[Category: Trimer]]

OCA at 06:24, 11 June 2014

OCA — Wed, 11 Jun 2014 06:24:46 GMT

←Older revision		Revision as of 06:24, 11 June 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4p01\| PDB=4p01 \| SCENE= }}~~	+	==Crystal Structure Analysis of Macrophage Migration Inhibitory Factor in complex with N-[(4-cyanophenyl)methyl]methanethioamide==
-	===Crystal Structure Analysis of Macrophage Migration Inhibitory Factor in complex with N-[(4-cyanophenyl)methyl]methanethioamide===	+	<StructureSection load='4p01' size='340' side='right' caption='[[4p01]], [[Resolution\|resolution]] 2.07Å' scene=''>
-		+	== Structural highlights ==
-	==Disease==	+	<table><tr><td colspan='2'>[[4p01]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P01 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P01 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1ZW:N-[(4-CYANOPHENYL)METHYL]METHANETHIOAMIDE'>1ZW</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p0h\|4p0h]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MIF, GLIF, MMIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p01 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p01 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p01 RCSB], [http://www.ebi.ac.uk/pdbsum/4p01 PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[http://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.		[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[http://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
-		+	== Function ==
-	==Function==	+
	[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>		[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>

-	==~~About this Structure~~==	+	==See Also==
-	[[~~4p01~~]] ~~is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P01 OCA].~~	+	*[[Macrophage inhibitory factor\|Macrophage inhibitory factor]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
		+	[[Category: Human]]
	[[Category: Lolis, E.]]		[[Category: Lolis, E.]]
	[[Category: Pantouris, G.]]		[[Category: Pantouris, G.]]

OCA at 09:44, 19 March 2014

OCA — Wed, 19 Mar 2014 09:44:23 GMT

←Older revision		Revision as of 09:44, 19 March 2014
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4p01\| PDB=4p01 \| SCENE= }}
		+	===Crystal Structure Analysis of Macrophage Migration Inhibitory Factor in complex with N-[(4-cyanophenyl)methyl]methanethioamide===

-	~~The~~ entry ~~4p01 is ON HOLD~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[http://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.

-	~~Authors~~: ~~Pantouris~~, G., ~~Lolis, E~~.	+	==Function==
		+	[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>

-	~~Description: Crystal~~ Structure ~~Analysis of Macrophage Migration Inhibitory Factor with 4-~~[~~(4-oxo-2-thioxo-1,~~3-~~thiazolan-3-yl)methyl~~]~~benzonitrile~~	+	==About this Structure==
		+	[[4p01]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P01 OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
		+	[[Category: Lolis, E.]]
		+	[[Category: Pantouris, G.]]
		+	[[Category: Active site]]
		+	[[Category: Complex]]
		+	[[Category: Covalent modification]]
		+	[[Category: Trimer]]

OCA at 12:26, 12 March 2014

OCA — Wed, 12 Mar 2014 12:26:09 GMT

←Older revision		Revision as of 12:26, 12 March 2014
Line 3:		Line 3:
	The entry 4p01 is ON HOLD		The entry 4p01 is ON HOLD

-	Authors: Pantouris, G, Lolis, E	+	Authors: Pantouris, G., Lolis, E.

	Description: Crystal Structure Analysis of Macrophage Migration Inhibitory Factor with 4-[(4-oxo-2-thioxo-1,3-thiazolan-3-yl)methyl]benzonitrile		Description: Crystal Structure Analysis of Macrophage Migration Inhibitory Factor with 4-[(4-oxo-2-thioxo-1,3-thiazolan-3-yl)methyl]benzonitrile

OCA: Protected "4p01" [edit=sysop:move=sysop]

OCA — Mon, 03 Mar 2014 16:57:28 GMT

Protected "4p01" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:57, 3 March 2014

OCA: New page: '''Unreleased structure''' The entry 4p01 is ON HOLD Authors: Pantouris, G, Lolis, E Description: Crystal Structure Analysis of Macrophage Migration Inhibitory Factor with 4-[(4-oxo-2-...

OCA — Mon, 03 Mar 2014 16:57:27 GMT

New page: '''Unreleased structure''' The entry 4p01 is ON HOLD Authors: Pantouris, G, Lolis, E Description: Crystal Structure Analysis of Macrophage Migration Inhibitory Factor with 4-[(4-oxo-2-...

New page

'''Unreleased structure'''

The entry 4p01 is ON HOLD

Authors: Pantouris, G, Lolis, E

Description: Crystal Structure Analysis of Macrophage Migration Inhibitory Factor with 4-[(4-oxo-2-thioxo-1,3-thiazolan-3-yl)methyl]benzonitrile