4p1t - Revision history

OCA at 00:39, 28 December 2023

OCA — Thu, 28 Dec 2023 00:39:15 GMT

←Older revision		Revision as of 00:39, 28 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4p1t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_FCR-3/Gambia Plasmodium falciparum FCR-3/Gambia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P1T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P1T FirstGlance]. <br>		<table><tr><td colspan='2'>[[4p1t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_FCR-3/Gambia Plasmodium falciparum FCR-3/Gambia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P1T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P1T FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p1t OCA], [https://pdbe.org/4p1t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p1t RCSB], [https://www.ebi.ac.uk/pdbsum/4p1t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p1t ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p1t OCA], [https://pdbe.org/4p1t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p1t RCSB], [https://www.ebi.ac.uk/pdbsum/4p1t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p1t ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 12:37, 1 February 2023

OCA — Wed, 01 Feb 2023 12:37:22 GMT

←Older revision		Revision as of 12:37, 1 February 2023
Line 3:		Line 3:
	<StructureSection load='4p1t' size='340' side='right'caption='[[4p1t]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='4p1t' size='340' side='right'caption='[[4p1t]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4p1t]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Plafg Plafg~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P1T OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4P1T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4p1t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_FCR-3/Gambia Plasmodium falciparum FCR-3/Gambia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P1T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P1T FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wau\|2wau]], [[3cml\|3cml]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p1t OCA], [https://pdbe.org/4p1t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p1t RCSB], [https://www.ebi.ac.uk/pdbsum/4p1t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p1t ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">var2csa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5838 PLAFG])</td></tr>~~	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4p1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p1t OCA], [~~http~~://pdbe.org/4p1t PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4p1t RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4p1t PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4p1t ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q6UDW7_PLAFA Q6UDW7_PLAFA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Plafg~~]]	+	[[Category: Plasmodium falciparum FCR-3/Gambia]]
-	[[Category: Amirat, F]]	+	[[Category: Amirat F]]
-	[[Category: Bentley~~, G A~~]]	+	[[Category: Bentley GA]]
-	[[Category: Dechavanne, S]]	+	[[Category: Dechavanne S]]
-	[[Category: Gamain, B]]	+	[[Category: Gamain B]]
-	[[Category: Gangnard, S]]	+	[[Category: Gangnard S]]
-	[[Category: Lewit-Bentley, A]]	+	[[Category: Lewit-Bentley A]]
-	[[Category: Srivastava, A]]	+	[[Category: Srivastava A]]
-	~~[[Category: Csa]]~~	+
-	~~[[Category: Dbl fold]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Pfemp1~~]]	+

OCA at 07:39, 17 April 2019

OCA — Wed, 17 Apr 2019 07:39:48 GMT

←Older revision		Revision as of 07:39, 17 April 2019
Line 1:		Line 1:
		+
	==Crystal structure of the DBL3X-DBL4epsilon double domain from the extracellular part of VAR2CSA PfEMP1 from Plasmodium falciparum==		==Crystal structure of the DBL3X-DBL4epsilon double domain from the extracellular part of VAR2CSA PfEMP1 from Plasmodium falciparum==
-	<StructureSection load='4p1t' size='340' side='right' caption='[[4p1t]], [[Resolution\|resolution]] 2.90Å' scene=''>	+	<StructureSection load='4p1t' size='340' side='right'caption='[[4p1t]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4p1t]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P1T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P1T FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4p1t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafg Plafg]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P1T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P1T FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wau\|2wau]], [[3cml\|3cml]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wau\|2wau]], [[3cml\|3cml]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p1t OCA], [http://pdbe.org/4p1t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p1t RCSB], [http://www.ebi.ac.uk/pdbsum/4p1t PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">var2csa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5838 PLAFG])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p1t OCA], [http://pdbe.org/4p1t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p1t RCSB], [http://www.ebi.ac.uk/pdbsum/4p1t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p1t ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 19:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Plafg]]
	[[Category: Amirat, F]]		[[Category: Amirat, F]]
	[[Category: Bentley, G A]]		[[Category: Bentley, G A]]

OCA at 19:52, 30 November 2015

OCA — Mon, 30 Nov 2015 19:52:18 GMT

←Older revision		Revision as of 19:52, 30 November 2015
Line 4:		Line 4:
	<table><tr><td colspan='2'>[[4p1t]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P1T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P1T FirstGlance]. <br>		<table><tr><td colspan='2'>[[4p1t]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P1T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P1T FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wau\|2wau]], [[3cml\|3cml]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wau\|2wau]], [[3cml\|3cml]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p1t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p1t RCSB], [http://www.ebi.ac.uk/pdbsum/4p1t PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p1t OCA], [http://pdbe.org/4p1t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p1t RCSB], [http://www.ebi.ac.uk/pdbsum/4p1t PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The human malaria parasite, Plasmodium falciparum, is able to evade spleen-mediated clearing from blood stream by sequestering in peripheral organs. This is due to the adhesive properties conferred by the P. falciparum Erythrocyte Membrane Protein 1 (PfEMP1) family exported by the parasite to the surface of infected erythrocytes. Expression of the VAR2CSA variant of PfEMP1 leads to pregnancy-associated malaria, which occurs when infected erythrocytes massively sequester in the placenta by binding to low-sulfated Chondroitin Sulfate A (CSA) present in the intervillous spaces. VAR2CSA is a 350 kDa protein that carries six Duffy-Binding Like (DBL) domains, one Cysteine-rich Inter-Domain Regions (CIDR) and several inter-domain regions. In the present paper, we report for the first time the crystal structure at 2.9 A of a VAR2CSA double domain, DBL3X-DBL4epsilon, from the FCR3 strain. DBL3X and DBL4epsilon share a large contact interface formed by residues that are invariant or highly conserved in VAR2CSA variants, which suggests that these two central DBL domains (DBL3X-DBL4epsilon) contribute significantly to the structuring of the functional VAR2CSA extracellular region. We have also examined the antigenicity of peptides corresponding to exposed loop regions of the DBL4epsilon structure.
		+
		+	Structure of the DBL3X-DBL4epsilon region of the VAR2CSA placental malaria vaccine candidate: insight into DBL domain interactions.,Gangnard S, Lewit-Bentley A, Dechavanne S, Srivastava A, Amirat F, Bentley GA, Gamain B Sci Rep. 2015 Oct 9;5:14868. doi: 10.1038/srep14868. PMID:26450557<ref>PMID:26450557</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4p1t" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 11:33, 4 March 2015

OCA — Wed, 04 Mar 2015 11:33:56 GMT

←Older revision		Revision as of 11:33, 4 March 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of the DBL3X-DBL4epsilon double domain from the extracellular part of VAR2CSA PfEMP1 from Plasmodium falciparum==
-		+	<StructureSection load='4p1t' size='340' side='right' caption='[[4p1t]], [[Resolution\|resolution]] 2.90Å' scene=''>
-	~~The entry~~ 4p1t is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4p1t]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P1T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P1T FirstGlance]. <br>
-	~~Authors~~: ~~Gangnard~~, S.~~, Dechavanne, S~~.~~, Srivastava, A~~.~~, Amirat, F~~., ~~Gamain, B~~.~~, Lewit~~-~~Bentley~~, A., ~~Bentley, G~~.A.	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2wau\|2wau]], [[3cml\|3cml]]</td></tr>
-		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p1t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p1t RCSB], [http://www.ebi.ac.uk/pdbsum/4p1t PDBsum]</span></td></tr>
-	~~Description~~: ~~Crystal structure of the DBL3X-DBL4epsilon double domain from the extracellular part of VAR2CSA PfEMP1 from Plasmodium falciparum~~	+	</table>
-	[[Category: ~~Unreleased Structures~~]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Amirat, F]]
		+	[[Category: Bentley, G A]]
		+	[[Category: Dechavanne, S]]
	[[Category: Gamain, B]]		[[Category: Gamain, B]]
		+	[[Category: Gangnard, S]]
	[[Category: Lewit-Bentley, A]]		[[Category: Lewit-Bentley, A]]
	[[Category: Srivastava, A]]		[[Category: Srivastava, A]]
-	[[Category: ~~Bentley, G.A~~]]	+	[[Category: Csa]]
-	[[Category: ~~Gangnard, S~~]]	+	[[Category: Dbl fold]]
-	[[Category: ~~Dechavanne, S~~]]	+	[[Category: Membrane protein]]
-	[[Category: ~~Amirat, F~~]]	+	[[Category: Pfemp1]]

OCA at 14:43, 24 December 2014

OCA — Wed, 24 Dec 2014 14:43:27 GMT

←Older revision		Revision as of 14:43, 24 December 2014
Line 6:		Line 6:

	Description: Crystal structure of the DBL3X-DBL4epsilon double domain from the extracellular part of VAR2CSA PfEMP1 from Plasmodium falciparum		Description: Crystal structure of the DBL3X-DBL4epsilon double domain from the extracellular part of VAR2CSA PfEMP1 from Plasmodium falciparum
		+	[[Category: Unreleased Structures]]
		+	[[Category: Gamain, B]]
		+	[[Category: Lewit-Bentley, A]]
		+	[[Category: Srivastava, A]]
		+	[[Category: Bentley, G.A]]
		+	[[Category: Gangnard, S]]
		+	[[Category: Dechavanne, S]]
		+	[[Category: Amirat, F]]

OCA at 08:47, 26 March 2014

OCA — Wed, 26 Mar 2014 08:47:30 GMT

←Older revision		Revision as of 08:47, 26 March 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4p1t is ON HOLD	+	The entry 4p1t is ON HOLD until Paper Publication

	Authors: Gangnard, S., Dechavanne, S., Srivastava, A., Amirat, F., Gamain, B., Lewit-Bentley, A., Bentley, G.A.		Authors: Gangnard, S., Dechavanne, S., Srivastava, A., Amirat, F., Gamain, B., Lewit-Bentley, A., Bentley, G.A.

	Description: Crystal structure of the DBL3X-DBL4epsilon double domain from the extracellular part of VAR2CSA PfEMP1 from Plasmodium falciparum		Description: Crystal structure of the DBL3X-DBL4epsilon double domain from the extracellular part of VAR2CSA PfEMP1 from Plasmodium falciparum

OCA: Protected "4p1t" [edit=sysop:move=sysop]

OCA — Wed, 12 Mar 2014 12:28:50 GMT

Protected "4p1t" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:28, 12 March 2014

OCA: New page: '''Unreleased structure''' The entry 4p1t is ON HOLD Authors: Gangnard, S., Dechavanne, S., Srivastava, A., Amirat, F., Gamain, B., Lewit-Bentley, A., Bentley, G.A. Description: Crysta...

OCA — Wed, 12 Mar 2014 12:28:49 GMT

New page: '''Unreleased structure''' The entry 4p1t is ON HOLD Authors: Gangnard, S., Dechavanne, S., Srivastava, A., Amirat, F., Gamain, B., Lewit-Bentley, A., Bentley, G.A. Description: Crysta...

New page

'''Unreleased structure'''

The entry 4p1t is ON HOLD

Authors: Gangnard, S., Dechavanne, S., Srivastava, A., Amirat, F., Gamain, B., Lewit-Bentley, A., Bentley, G.A.

Description: Crystal structure of the DBL3X-DBL4epsilon double domain from the extracellular part of VAR2CSA PfEMP1 from Plasmodium falciparum