4p23 - Revision history

OCA at 12:22, 20 December 2023

OCA — Wed, 20 Dec 2023 12:22:30 GMT

←Older revision		Revision as of 12:22, 20 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4p23]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P23 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P23 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4p23]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P23 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P23 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p23 OCA], [https://pdbe.org/4p23 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p23 RCSB], [https://www.ebi.ac.uk/pdbsum/4p23 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p23 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.25Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p23 OCA], [https://pdbe.org/4p23 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p23 RCSB], [https://www.ebi.ac.uk/pdbsum/4p23 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p23 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 12:37, 1 February 2023

OCA — Wed, 01 Feb 2023 12:37:44 GMT

←Older revision		Revision as of 12:37, 1 February 2023
Line 3:		Line 3:
	<StructureSection load='4p23' size='340' side='right'caption='[[4p23]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='4p23' size='340' side='right'caption='[[4p23]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4p23]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P23 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4P23 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4p23]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P23 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P23 FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3rdt\|3rdt]], [[4p46\|4p46]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p23 OCA], [https://pdbe.org/4p23 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p23 RCSB], [https://www.ebi.ac.uk/pdbsum/4p23 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p23 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">H2-Aa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4p23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p23 OCA], [~~http~~://pdbe.org/4p23 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4p23 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4p23 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4p23 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/HA2B_MOUSE HA2B_MOUSE]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Huseby~~, E S~~]]	+	[[Category: Huseby ES]]
-	[[Category: Stadinski~~, B D~~]]	+	[[Category: Stadinski BD]]
-	[[Category: Stern, L]]	+	[[Category: Stern L]]
-	[[Category: Trenh, P]]	+	[[Category: Trenh P]]
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Tcr mhc peptide~~]]	+

OCA at 08:21, 17 April 2019

OCA — Wed, 17 Apr 2019 08:21:28 GMT

←Older revision		Revision as of 08:21, 17 April 2019
Line 1:		Line 1:

	==J809.B5 TCR bound to IAb/3K==		==J809.B5 TCR bound to IAb/3K==
-	<StructureSection load='4p23' size='340' side='right' caption='[[4p23]], [[Resolution\|resolution]] 2.25Å' scene=''>	+	<StructureSection load='4p23' size='340' side='right'caption='[[4p23]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4p23]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P23 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P23 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4p23]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P23 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P23 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3rdt\|3rdt]], [[4p46\|4p46]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3rdt\|3rdt]], [[4p46\|4p46]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">H2-Aa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p23 OCA], [http://pdbe.org/4p23 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p23 RCSB], [http://www.ebi.ac.uk/pdbsum/4p23 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p23 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p23 OCA], [http://pdbe.org/4p23 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p23 RCSB], [http://www.ebi.ac.uk/pdbsum/4p23 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p23 ProSAT]</span></td></tr>
	</table>		</table>
Line 20:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Huseby, E S]]		[[Category: Huseby, E S]]
	[[Category: Stadinski, B D]]		[[Category: Stadinski, B D]]

OCA at 20:27, 11 August 2016

OCA — Thu, 11 Aug 2016 20:27:35 GMT

←Older revision		Revision as of 20:27, 11 August 2016
Line 1:		Line 1:
		+
	==J809.B5 TCR bound to IAb/3K==		==J809.B5 TCR bound to IAb/3K==
	<StructureSection load='4p23' size='340' side='right' caption='[[4p23]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='4p23' size='340' side='right' caption='[[4p23]], [[Resolution\|resolution]] 2.25Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4p23]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P23 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P23 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4p23]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P23 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P23 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3rdt\|3rdt]], [[4p46\|4p46]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3rdt\|3rdt]], [[4p46\|4p46]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p23 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p23 RCSB], [http://www.ebi.ac.uk/pdbsum/4p23 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p23 OCA], [http://pdbe.org/4p23 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p23 RCSB], [http://www.ebi.ac.uk/pdbsum/4p23 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p23 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4p23" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:51, 22 January 2015

OCA — Thu, 22 Jan 2015 06:51:51 GMT

←Older revision		Revision as of 06:51, 22 January 2015
Line 18:		Line 18:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Huseby, E S.]]	+	[[Category: Huseby, E S]]
-	[[Category: Stadinski, B D.]]	+	[[Category: Stadinski, B D]]
-	[[Category: Stern, L.]]	+	[[Category: Stern, L]]
-	[[Category: Trenh, P.]]	+	[[Category: Trenh, P]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Tcr mhc peptide]]		[[Category: Tcr mhc peptide]]

OCA at 08:54, 20 October 2014

OCA — Mon, 20 Oct 2014 08:54:54 GMT

←Older revision		Revision as of 08:54, 20 October 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4p23]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P23 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P23 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4p23]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P23 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P23 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3rdt\|3rdt]], [[4p46\|4p46]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3rdt\|3rdt]], [[4p46\|4p46]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p23 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p23 RCSB], [http://www.ebi.ac.uk/pdbsum/4p23 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p23 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p23 RCSB], [http://www.ebi.ac.uk/pdbsum/4p23 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:19, 11 June 2014

OCA — Wed, 11 Jun 2014 07:19:49 GMT

←Older revision		Revision as of 07:19, 11 June 2014
Line 12:		Line 12:
	Effect of CDR3 Sequences and Distal V Gene Residues in Regulating TCR-MHC Contacts and Ligand Specificity.,Stadinski BD, Trenh P, Duke B, Huseby PG, Li G, Stern LJ, Huseby ES J Immunol. 2014 May 9. PMID:24813203<ref>PMID:24813203</ref>		Effect of CDR3 Sequences and Distal V Gene Residues in Regulating TCR-MHC Contacts and Ligand Specificity.,Stadinski BD, Trenh P, Duke B, Huseby PG, Li G, Stern LJ, Huseby ES J Immunol. 2014 May 9. PMID:24813203<ref>PMID:24813203</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==

OCA at 09:50, 28 May 2014

OCA — Wed, 28 May 2014 09:50:09 GMT

←Older revision		Revision as of 09:50, 28 May 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==J809.B5 TCR bound to IAb/3K==
		+	<StructureSection load='4p23' size='340' side='right' caption='[[4p23]], [[Resolution\|resolution]] 2.25Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4p23]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P23 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P23 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3rdt\|3rdt]], [[4p46\|4p46]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p23 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p23 RCSB], [http://www.ebi.ac.uk/pdbsum/4p23 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The mature T cell repertoire has the ability to orchestrate immunity to a wide range of potential pathogen challenges. This ability stems from thymic development producing individual T cell clonotypes that express TCRs with unique patterns of Ag reactivity. The Ag specificity of TCRs is created from the combinatorial pairing of one of a set of germline encoded TCR Valpha and Vbeta gene segments with randomly created CDR3 sequences. How the amalgamation of germline encoded and randomly created TCR sequences results in Ag receptors with unique patterns of ligand specificity is not fully understood. Using cellular, biophysical, and structural analyses, we show that CDR3alpha residues can modulate the geometry in which TCRs bind peptide-MHC (pMHC), governing whether and how germline encoded TCR Valpha and Vbeta residues interact with MHC. In addition, a CDR1alpha residue that is positioned distal to the TCR-pMHC binding interface is shown to contribute to the peptide specificity of T cells. These findings demonstrate that the specificity of individual T cell clonotypes arises not only from TCR residues that create direct contacts with the pMHC, but also from a collection of indirect effects that modulate how TCR residues are used to bind pMHC.

-	~~The entry 4p23 is ON HOLD~~	+	Effect of CDR3 Sequences and Distal V Gene Residues in Regulating TCR-MHC Contacts and Ligand Specificity.,Stadinski BD, Trenh P, Duke B, Huseby PG, Li G, Stern LJ, Huseby ES J Immunol. 2014 May 9. PMID:24813203<ref>PMID:24813203</ref>

-	~~Authors: Stadinski~~, B.D., Huseby, E.S., ~~Trenh, P~~., Stern, L.	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~J809~~.~~B5 TCR bound to IAb/3K~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Huseby, E S.]]
		+	[[Category: Stadinski, B D.]]
		+	[[Category: Stern, L.]]
		+	[[Category: Trenh, P.]]
		+	[[Category: Immune system]]
		+	[[Category: Tcr mhc peptide]]

OCA at 07:58, 21 May 2014

OCA — Wed, 21 May 2014 07:58:10 GMT

←Older revision		Revision as of 07:58, 21 May 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4p23 is ON HOLD ~~until sometime in the future~~	+	The entry 4p23 is ON HOLD

-	Authors: Stadinski, B.D.; Huseby, E.S.; Trenh, P; Stern, L	+	Authors: Stadinski, B.D., Huseby, E.S., Trenh, P., Stern, L.

	Description: J809.B5 TCR bound to IAb/3K		Description: J809.B5 TCR bound to IAb/3K

OCA at 07:31, 19 March 2014

OCA — Wed, 19 Mar 2014 07:31:17 GMT

←Older revision		Revision as of 07:31, 19 March 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4p23 is ON HOLD	+	The entry 4p23 is ON HOLD until sometime in the future

	Authors: Stadinski, B.D.; Huseby, E.S.; Trenh, P; Stern, L		Authors: Stadinski, B.D.; Huseby, E.S.; Trenh, P; Stern, L

	Description: J809.B5 TCR bound to IAb/3K		Description: J809.B5 TCR bound to IAb/3K