4p2l - Revision history

OCA at 07:09, 27 September 2023

OCA — Wed, 27 Sep 2023 07:09:34 GMT

←Older revision		Revision as of 07:09, 27 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4p2l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P2L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P2L FirstGlance]. <br>		<table><tr><td colspan='2'>[[4p2l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P2L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P2L FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p2l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p2l OCA], [https://pdbe.org/4p2l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p2l RCSB], [https://www.ebi.ac.uk/pdbsum/4p2l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p2l ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p2l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p2l OCA], [https://pdbe.org/4p2l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p2l RCSB], [https://www.ebi.ac.uk/pdbsum/4p2l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p2l ProSAT]</span></td></tr>
	</table>		</table>

OCA at 12:38, 1 February 2023

OCA — Wed, 01 Feb 2023 12:38:33 GMT

←Older revision		Revision as of 12:38, 1 February 2023
Line 3:		Line 3:
	<StructureSection load='4p2l' size='340' side='right'caption='[[4p2l]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='4p2l' size='340' side='right'caption='[[4p2l]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4p2l]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P2L OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4P2L FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4p2l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P2L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P2L FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3t58\|3t58]], [[3q6o\|3q6o]], [[3llk\|3llk]], [[3qcp\|3qcp]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p2l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p2l OCA], [https://pdbe.org/4p2l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p2l RCSB], [https://www.ebi.ac.uk/pdbsum/4p2l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p2l ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Qsox1, Qscn6, Sox2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thiol_oxidase Thiol oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.3.2 1.8.3.2] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4p2l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p2l OCA], [~~http~~://pdbe.org/4p2l PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4p2l RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4p2l PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4p2l ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/QSOX1_RAT QSOX1_RAT]] Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins.<ref>PMID:16806532</ref>	+	[https://www.uniprot.org/uniprot/QSOX1_RAT QSOX1_RAT] Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins.<ref>PMID:16806532</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 20:

	==See Also==		==See Also==
-	*[[Sulfhydryl oxidase\|Sulfhydryl oxidase]]	+	*[[Sulfhydryl oxidase 3D structures\|Sulfhydryl oxidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Thiol oxidase~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: Fass, D]]	+	[[Category: Fass D]]
-	[[Category: Gat, Y]]	+	[[Category: Gat Y]]
-	~~[[Category: Disulfide formation]]~~	+
-	~~[[Category: Enzyme intermediate]]~~	+
-	~~[[Category: Erv fold]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Thioredoxin fold~~]]	+

OCA at 12:13, 17 July 2019

OCA — Wed, 17 Jul 2019 12:13:33 GMT

←Older revision		Revision as of 12:13, 17 July 2019
Line 1:		Line 1:

	==Quiescin Sulfhydryl Oxidase from Rattus norvegicus==		==Quiescin Sulfhydryl Oxidase from Rattus norvegicus==
-	<StructureSection load='4p2l' size='340' side='right' caption='[[4p2l]], [[Resolution\|resolution]] 2.90Å' scene=''>	+	<StructureSection load='4p2l' size='340' side='right'caption='[[4p2l]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4p2l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P2L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P2L FirstGlance]. <br>		<table><tr><td colspan='2'>[[4p2l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P2L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P2L FirstGlance]. <br>
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Thiol oxidase]]		[[Category: Thiol oxidase]]
	[[Category: Fass, D]]		[[Category: Fass, D]]

OCA at 07:49, 21 March 2018

OCA — Wed, 21 Mar 2018 07:49:50 GMT

←Older revision		Revision as of 07:49, 21 March 2018
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 4p2l" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4p2l" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Sulfhydryl oxidase\|Sulfhydryl oxidase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:33, 22 November 2017

OCA — Wed, 22 Nov 2017 08:33:01 GMT

←Older revision		Revision as of 08:33, 22 November 2017
Line 3:		Line 3:
	<StructureSection load='4p2l' size='340' side='right' caption='[[4p2l]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='4p2l' size='340' side='right' caption='[[4p2l]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4p2l]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P2L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P2L FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4p2l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P2L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P2L FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3t58\|3t58]], [[3q6o\|3q6o]], [[3llk\|3llk]], [[3qcp\|3qcp]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3t58\|3t58]], [[3q6o\|3q6o]], [[3llk\|3llk]], [[3qcp\|3qcp]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Qsox1, Qscn6, Sox2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thiol_oxidase Thiol oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.3.2 1.8.3.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thiol_oxidase Thiol oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.3.2 1.8.3.2] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p2l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p2l OCA], [http://pdbe.org/4p2l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p2l RCSB], [http://www.ebi.ac.uk/pdbsum/4p2l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p2l ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p2l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p2l OCA], [http://pdbe.org/4p2l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p2l RCSB], [http://www.ebi.ac.uk/pdbsum/4p2l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p2l ProSAT]</span></td></tr>
Line 20:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 4p2l" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4p2l" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Sulfhydryl oxidase\|Sulfhydryl oxidase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Buffalo rat]]
	[[Category: Thiol oxidase]]		[[Category: Thiol oxidase]]
	[[Category: Fass, D]]		[[Category: Fass, D]]

OCA at 02:27, 5 August 2016

OCA — Fri, 05 Aug 2016 02:27:39 GMT

←Older revision		Revision as of 02:27, 5 August 2016
Line 1:		Line 1:
		+
	==Quiescin Sulfhydryl Oxidase from Rattus norvegicus==		==Quiescin Sulfhydryl Oxidase from Rattus norvegicus==
	<StructureSection load='4p2l' size='340' side='right' caption='[[4p2l]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='4p2l' size='340' side='right' caption='[[4p2l]], [[Resolution\|resolution]] 2.90Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3t58\|3t58]], [[3q6o\|3q6o]], [[3llk\|3llk]], [[3qcp\|3qcp]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3t58\|3t58]], [[3q6o\|3q6o]], [[3llk\|3llk]], [[3qcp\|3qcp]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thiol_oxidase Thiol oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.3.2 1.8.3.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thiol_oxidase Thiol oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.3.2 1.8.3.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p2l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p2l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p2l RCSB], [http://www.ebi.ac.uk/pdbsum/4p2l PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p2l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p2l OCA], [http://pdbe.org/4p2l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p2l RCSB], [http://www.ebi.ac.uk/pdbsum/4p2l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p2l ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4p2l" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Sulfhydryl oxidase\|Sulfhydryl oxidase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 22:01, 24 December 2014

OCA — Wed, 24 Dec 2014 22:01:50 GMT

←Older revision		Revision as of 22:01, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4p2l]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P2L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P2L FirstGlance]. <br>		<table><tr><td colspan='2'>[[4p2l]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P2L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P2L FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3t58\|3t58]], [[3q6o\|3q6o]], [[3llk\|3llk]], [[3qcp\|3qcp]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3t58\|3t58]], [[3q6o\|3q6o]], [[3llk\|3llk]], [[3qcp\|3qcp]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thiol_oxidase Thiol oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.3.2 1.8.3.2] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thiol_oxidase Thiol oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.3.2 1.8.3.2] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p2l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p2l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p2l RCSB], [http://www.ebi.ac.uk/pdbsum/4p2l PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p2l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p2l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p2l RCSB], [http://www.ebi.ac.uk/pdbsum/4p2l PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/QSOX1_RAT QSOX1_RAT]] Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins.<ref>PMID:16806532</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Thiol oxidase]]		[[Category: Thiol oxidase]]
-	[[Category: Fass, D.]]	+	[[Category: Fass, D]]
-	[[Category: Gat, Y.]]	+	[[Category: Gat, Y]]
	[[Category: Disulfide formation]]		[[Category: Disulfide formation]]
	[[Category: Enzyme intermediate]]		[[Category: Enzyme intermediate]]

OCA at 06:27, 25 June 2014

OCA — Wed, 25 Jun 2014 06:27:34 GMT

←Older revision		Revision as of 06:27, 25 June 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Quiescin Sulfhydryl Oxidase from Rattus norvegicus==
		+	<StructureSection load='4p2l' size='340' side='right' caption='[[4p2l]], [[Resolution\|resolution]] 2.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4p2l]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P2L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P2L FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3t58\|3t58]], [[3q6o\|3q6o]], [[3llk\|3llk]], [[3qcp\|3qcp]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thiol_oxidase Thiol oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.3.2 1.8.3.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p2l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p2l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p2l RCSB], [http://www.ebi.ac.uk/pdbsum/4p2l PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Thioredoxin superfamily proteins introduce disulfide bonds into substrates, catalyze the removal of disulfides, and operate in electron relays. These functions rely on one or more dithiol/disulfide exchange reactions. The flavoenzyme quiescin sulfhydryl oxidase (QSOX), a catalyst of disulfide bond formation with an interdomain electron transfer step in its catalytic cycle, provides a unique opportunity for exploring the structural environment of enzymatic dithiol/disulfide exchange. Wild-type Rattus norvegicus QSOX1 (RnQSOX1) was crystallized in a conformation that juxtaposes the two redox-active di-cysteine motifs in the enzyme, presenting the entire electron-transfer pathway and proton-transfer participants in their native configurations. As such a state cannot generally be enriched and stabilized for analysis, RnQSOX1 gives unprecedented insight into the functional group environments of the four cysteines involved in dithiol/disulfide exchange and provides the framework for analysis of the energetics of electron transfer in the presence of the bound flavin adenine dinucleotide cofactor. Hybrid quantum mechanics/molecular mechanics (QM/MM) free energy simulations based on the X-ray crystal structure suggest that formation of the interdomain disulfide intermediate is highly favorable and secures the flexible enzyme in a state from which further electron transfer via the flavin can occur.

-	~~The entry 4p2l is ON HOLD until Paper Publication~~	+	Enzyme structure captures four cysteines aligned for disulfide relay.,Gat Y, Vardi-Kilshtain A, Grossman I, Major DT, Fass D Protein Sci. 2014 Jun 3. doi: 10.1002/pro.2496. PMID:24888638<ref>PMID:24888638</ref>

-	~~Authors: Gat~~, Y., Fass, D.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Quiescin Sulfhydryl Oxidase from Rattus norvegicus~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Thiol oxidase]]
		+	[[Category: Fass, D.]]
		+	[[Category: Gat, Y.]]
		+	[[Category: Disulfide formation]]
		+	[[Category: Enzyme intermediate]]
		+	[[Category: Erv fold]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Thioredoxin fold]]

OCA at 06:23, 30 April 2014

OCA — Wed, 30 Apr 2014 06:23:51 GMT

←Older revision		Revision as of 06:23, 30 April 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4p2l is ON HOLD	+	The entry 4p2l is ON HOLD until Paper Publication

	Authors: Gat, Y., Fass, D.		Authors: Gat, Y., Fass, D.

	Description: Quiescin Sulfhydryl Oxidase from Rattus norvegicus		Description: Quiescin Sulfhydryl Oxidase from Rattus norvegicus

OCA: Protected "4p2l" [edit=sysop:move=sysop]

OCA — Wed, 12 Mar 2014 12:30:08 GMT

Protected "4p2l" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:30, 12 March 2014