4p4p - Revision history

OCA at 07:11, 27 September 2023

OCA — Wed, 27 Sep 2023 07:11:20 GMT

←Older revision		Revision as of 07:11, 27 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4p4p]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_infantum Leishmania infantum] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P4P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P4P FirstGlance]. <br>		<table><tr><td colspan='2'>[[4p4p]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_infantum Leishmania infantum] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P4P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P4P FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2973Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p4p OCA], [https://pdbe.org/4p4p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p4p RCSB], [https://www.ebi.ac.uk/pdbsum/4p4p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p4p ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p4p OCA], [https://pdbe.org/4p4p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p4p RCSB], [https://www.ebi.ac.uk/pdbsum/4p4p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p4p ProSAT]</span></td></tr>
	</table>		</table>
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 4p4p" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4p4p" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[DNA polymerase 3D structures\|DNA polymerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:41, 1 February 2023

OCA — Wed, 01 Feb 2023 12:41:44 GMT

←Older revision		Revision as of 12:41, 1 February 2023
Line 3:		Line 3:
	<StructureSection load='4p4p' size='340' side='right'caption='[[4p4p]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4p4p' size='340' side='right'caption='[[4p4p]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4p4p]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Leiin Leiin~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P4P OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4P4P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4p4p]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_infantum Leishmania infantum] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P4P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P4P FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4p4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p4p OCA], [~~http~~://pdbe.org/4p4p PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4p4p RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4p4p PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4p4p ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p4p OCA], [https://pdbe.org/4p4p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p4p RCSB], [https://www.ebi.ac.uk/pdbsum/4p4p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p4p ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9U6N3_LEIIN Q9U6N3_LEIIN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 16:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4p4p" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4p4p" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[DNA polymerase 3D structures\|DNA polymerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 24:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Leiin~~]]	+	[[Category: Leishmania infantum]]
-	[[Category: Alonso, A]]	+	[[Category: Synthetic construct]]
-	[[Category: Bebenek, K]]	+	[[Category: Alonso A]]
-	[[Category: Burak, M]]	+	[[Category: Bebenek K]]
-	[[Category: Garcia-Diaz, M]]	+	[[Category: Burak M]]
-	[[Category: Kunkel, T]]	+	[[Category: Garcia-Diaz M]]
-	[[Category: Larraga, V]]	+	[[Category: Kunkel T]]
-	[[Category: Mejia, E]]	+	[[Category: Larraga V]]
-	~~[[Category: Dna polymerase]]~~	+	[[Category: Mejia E]]
-	~~[[Category: Transferase-dna complex~~]]	+

OCA at 10:08, 25 December 2019

OCA — Wed, 25 Dec 2019 10:08:46 GMT

←Older revision		Revision as of 10:08, 25 December 2019
Line 18:		Line 18:

	==See Also==		==See Also==
-	*[[DNA polymerase\|DNA polymerase]]	+	*[[DNA polymerase 3D structures\|DNA polymerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:52, 17 April 2019

OCA — Wed, 17 Apr 2019 07:52:40 GMT

←Older revision		Revision as of 07:52, 17 April 2019
Line 1:		Line 1:

	==Crystal structure of Leishmania infantum polymerase beta: Nick complex==		==Crystal structure of Leishmania infantum polymerase beta: Nick complex==
-	<StructureSection load='4p4p' size='340' side='right' caption='[[4p4p]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='4p4p' size='340' side='right'caption='[[4p4p]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4p4p]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P4P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P4P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4p4p]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Leiin Leiin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P4P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P4P FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p4p OCA], [http://pdbe.org/4p4p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p4p RCSB], [http://www.ebi.ac.uk/pdbsum/4p4p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p4p ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p4p OCA], [http://pdbe.org/4p4p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p4p RCSB], [http://www.ebi.ac.uk/pdbsum/4p4p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p4p ProSAT]</span></td></tr>
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Leiin]]
	[[Category: Alonso, A]]		[[Category: Alonso, A]]
	[[Category: Bebenek, K]]		[[Category: Bebenek, K]]

OCA at 18:10, 11 August 2016

OCA — Thu, 11 Aug 2016 18:10:35 GMT

←Older revision		Revision as of 18:10, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of Leishmania infantum polymerase beta: Nick complex==		==Crystal structure of Leishmania infantum polymerase beta: Nick complex==
	<StructureSection load='4p4p' size='340' side='right' caption='[[4p4p]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='4p4p' size='340' side='right' caption='[[4p4p]], [[Resolution\|resolution]] 2.30Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4p4p]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P4P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P4P FirstGlance]. <br>		<table><tr><td colspan='2'>[[4p4p]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P4P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P4P FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p4p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p4p RCSB], [http://www.ebi.ac.uk/pdbsum/4p4p PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p4p OCA], [http://pdbe.org/4p4p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p4p RCSB], [http://www.ebi.ac.uk/pdbsum/4p4p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p4p ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4p4p" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[DNA polymerase\|DNA polymerase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:42, 5 January 2015

OCA — Mon, 05 Jan 2015 14:42:17 GMT

←Older revision		Revision as of 14:42, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4p4p]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P4P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P4P FirstGlance]. <br>		<table><tr><td colspan='2'>[[4p4p]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P4P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P4P FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p4p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p4p RCSB], [http://www.ebi.ac.uk/pdbsum/4p4p PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p4p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p4p RCSB], [http://www.ebi.ac.uk/pdbsum/4p4p PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 18:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Alonso, A.]]	+	[[Category: Alonso, A]]
-	[[Category: Bebenek, K.]]	+	[[Category: Bebenek, K]]
-	[[Category: Burak, M.]]	+	[[Category: Burak, M]]
-	[[Category: Garcia-Diaz, M.]]	+	[[Category: Garcia-Diaz, M]]
-	[[Category: Kunkel, T.]]	+	[[Category: Kunkel, T]]
-	[[Category: Larraga, V.]]	+	[[Category: Larraga, V]]
-	[[Category: Mejia, E.]]	+	[[Category: Mejia, E]]
	[[Category: Dna polymerase]]		[[Category: Dna polymerase]]
	[[Category: Transferase-dna complex]]		[[Category: Transferase-dna complex]]

OCA at 02:24, 7 August 2014

OCA — Thu, 07 Aug 2014 02:24:36 GMT

←Older revision		Revision as of 02:24, 7 August 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of Leishmania infantum polymerase beta: Nick complex==
		+	<StructureSection load='4p4p' size='340' side='right' caption='[[4p4p]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4p4p]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P4P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P4P FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p4p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p4p RCSB], [http://www.ebi.ac.uk/pdbsum/4p4p PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Protozoans of the genus Leishmania, the pathogenic agent causing leishmaniasis, encode the family X DNA polymerase Li Pol beta. Here, we report the first crystal structures of Li Pol beta. Our pre- and post-catalytic structures show that the polymerase adopts the common family X DNA polymerase fold. However, in contrast to other family X DNA polymerases, the dNTP-induced conformational changes in Li Pol beta are much more subtle. Moreover, pre- and post-catalytic structures reveal that Li Pol beta interacts with the template strand through a nonconserved, variable region known as loop3. Li Pol beta Deltaloop3 mutants display a higher catalytic rate, catalytic efficiency and overall error rates with respect to WT Li Pol beta. These results further demonstrate the subtle structural variability that exists within this family of enzymes and provides insight into how this variability underlies the substantial functional differences among their members.

-	~~The entry 4p4p is ON HOLD~~	+	Structures of the Leishmania infantum polymerase beta.,Mejia E, Burak M, Alonso A, Larraga V, Kunkel TA, Bebenek K, Garcia-Diaz M DNA Repair (Amst). 2014 Jun;18:1-9. doi: 10.1016/j.dnarep.2014.03.001. Epub 2014 , Mar 22. PMID:24666693<ref>PMID:24666693</ref>

-	~~Authors: Mejia~~, E.~~, Burak, M~~., Alonso, A.~~, Larraga, V., Kunkel, T.,~~ Bebenek, K., Garcia-Diaz, M.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal structure of Leishmania infantum~~ polymerase ~~beta~~: ~~Nick~~ complex	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Alonso, A.]]
		+	[[Category: Bebenek, K.]]
		+	[[Category: Burak, M.]]
		+	[[Category: Garcia-Diaz, M.]]
		+	[[Category: Kunkel, T.]]
		+	[[Category: Larraga, V.]]
		+	[[Category: Mejia, E.]]
		+	[[Category: Dna polymerase]]
		+	[[Category: Transferase-dna complex]]

OCA: Protected "4p4p" [edit=sysop:move=sysop]

OCA — Wed, 19 Mar 2014 07:35:06 GMT

Protected "4p4p" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:35, 19 March 2014

OCA: New page: '''Unreleased structure''' The entry 4p4p is ON HOLD Authors: Mejia, E., Burak, M., Alonso, A., Larraga, V., Kunkel, T., Bebenek, K., Garcia-Diaz, M. Description: Crystal structure of ...

OCA — Wed, 19 Mar 2014 07:35:05 GMT

New page: '''Unreleased structure''' The entry 4p4p is ON HOLD Authors: Mejia, E., Burak, M., Alonso, A., Larraga, V., Kunkel, T., Bebenek, K., Garcia-Diaz, M. Description: Crystal structure of ...

New page

'''Unreleased structure'''

The entry 4p4p is ON HOLD

Authors: Mejia, E., Burak, M., Alonso, A., Larraga, V., Kunkel, T., Bebenek, K., Garcia-Diaz, M.

Description: Crystal structure of Leishmania infantum polymerase beta: Nick complex