4p6q - Revision history

OCA at 12:22, 20 December 2023

OCA — Wed, 20 Dec 2023 12:22:49 GMT

←Older revision		Revision as of 12:22, 20 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4p6q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P6Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P6Q FirstGlance]. <br>		<table><tr><td colspan='2'>[[4p6q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P6Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P6Q FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p6q OCA], [https://pdbe.org/4p6q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p6q RCSB], [https://www.ebi.ac.uk/pdbsum/4p6q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p6q ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p6q OCA], [https://pdbe.org/4p6q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p6q RCSB], [https://www.ebi.ac.uk/pdbsum/4p6q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p6q ProSAT]</span></td></tr>
	</table>		</table>

OCA at 12:44, 1 February 2023

OCA — Wed, 01 Feb 2023 12:44:32 GMT

←Older revision		Revision as of 12:44, 1 February 2023
Line 3:		Line 3:
	<StructureSection load='4p6q' size='340' side='right'caption='[[4p6q]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4p6q' size='340' side='right'caption='[[4p6q]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4p6q]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P6Q OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4P6Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4p6q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P6Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P6Q FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPEN, KIAA0929, MINT, SHARP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p6q OCA], [https://pdbe.org/4p6q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p6q RCSB], [https://www.ebi.ac.uk/pdbsum/4p6q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p6q ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4p6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p6q OCA], [~~http~~://pdbe.org/4p6q PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4p6q RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4p6q PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4p6q ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MINT_HUMAN MINT_HUMAN]] May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA.<ref>PMID:11331609</ref> <ref>PMID:12374742</ref>	+	[https://www.uniprot.org/uniprot/MINT_HUMAN MINT_HUMAN] May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA.<ref>PMID:11331609</ref> <ref>PMID:12374742</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arieti, F]]	+	[[Category: Arieti F]]
-	[[Category: Gabus, C]]	+	[[Category: Gabus C]]
-	[[Category: Huet, T]]	+	[[Category: Huet T]]
-	[[Category: Round, A]]	+	[[Category: Round A]]
-	[[Category: Tambalo, M]]	+	[[Category: Tambalo M]]
-	[[Category: Thore, S]]	+	[[Category: Thore S]]
-	~~[[Category: Rna-recognition motif]]~~	+
-	~~[[Category: Spen protein]]~~	+
-	~~[[Category: Steroid rna activator]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcriptional regulation~~]]	+

OCA at 07:18, 17 April 2019

OCA — Wed, 17 Apr 2019 07:18:05 GMT

←Older revision		Revision as of 07:18, 17 April 2019
Line 1:		Line 1:

	==The crystal structure of the Split End protein SHARP adds a new layer of complexity to proteins containing RNA Recognition Motifs==		==The crystal structure of the Split End protein SHARP adds a new layer of complexity to proteins containing RNA Recognition Motifs==
-	<StructureSection load='4p6q' size='340' side='right' caption='[[4p6q]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='4p6q' size='340' side='right'caption='[[4p6q]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4p6q]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P6Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P6Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4p6q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P6Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P6Q FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPEN, KIAA0929, MINT, SHARP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p6q OCA], [http://pdbe.org/4p6q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p6q RCSB], [http://www.ebi.ac.uk/pdbsum/4p6q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p6q ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p6q OCA], [http://pdbe.org/4p6q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p6q RCSB], [http://www.ebi.ac.uk/pdbsum/4p6q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p6q ProSAT]</span></td></tr>
	</table>		</table>
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Arieti, F]]		[[Category: Arieti, F]]
	[[Category: Gabus, C]]		[[Category: Gabus, C]]

OCA at 13:21, 4 August 2016

OCA — Thu, 04 Aug 2016 13:21:39 GMT

←Older revision		Revision as of 13:21, 4 August 2016
Line 1:		Line 1:
		+
	==The crystal structure of the Split End protein SHARP adds a new layer of complexity to proteins containing RNA Recognition Motifs==		==The crystal structure of the Split End protein SHARP adds a new layer of complexity to proteins containing RNA Recognition Motifs==
	<StructureSection load='4p6q' size='340' side='right' caption='[[4p6q]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4p6q' size='340' side='right' caption='[[4p6q]], [[Resolution\|resolution]] 2.00Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[4p6q]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P6Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P6Q FirstGlance]. <br>		<table><tr><td colspan='2'>[[4p6q]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P6Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P6Q FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p6q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p6q RCSB], [http://www.ebi.ac.uk/pdbsum/4p6q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p6q OCA], [http://pdbe.org/4p6q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p6q RCSB], [http://www.ebi.ac.uk/pdbsum/4p6q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p6q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4p6q" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:59, 24 December 2014

OCA — Wed, 24 Dec 2014 14:59:54 GMT

←Older revision		Revision as of 14:59, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4p6q]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P6Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P6Q FirstGlance]. <br>		<table><tr><td colspan='2'>[[4p6q]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P6Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P6Q FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p6q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p6q RCSB], [http://www.ebi.ac.uk/pdbsum/4p6q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p6q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p6q RCSB], [http://www.ebi.ac.uk/pdbsum/4p6q PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MINT_HUMAN MINT_HUMAN]] May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA.<ref>PMID:11331609</ref> <ref>PMID:12374742</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Arieti, F.]]	+	[[Category: Arieti, F]]
-	[[Category: Gabus, C.]]	+	[[Category: Gabus, C]]
-	[[Category: Huet, T.]]	+	[[Category: Huet, T]]
-	[[Category: Round, A.]]	+	[[Category: Round, A]]
-	[[Category: Tambalo, M.]]	+	[[Category: Tambalo, M]]
-	[[Category: Thore, S.]]	+	[[Category: Thore, S]]
	[[Category: Rna-recognition motif]]		[[Category: Rna-recognition motif]]
	[[Category: Spen protein]]		[[Category: Spen protein]]

OCA at 06:22, 11 June 2014

OCA — Wed, 11 Jun 2014 06:22:16 GMT

←Older revision		Revision as of 06:22, 11 June 2014
Line 2:		Line 2:
	<StructureSection load='4p6q' size='340' side='right' caption='[[4p6q]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='4p6q' size='340' side='right' caption='[[4p6q]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4p6q]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P6Q OCA]. <br>	+	<table><tr><td colspan='2'>[[4p6q]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P6Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P6Q FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>		</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p6q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p6q RCSB], [http://www.ebi.ac.uk/pdbsum/4p6q PDBsum]</span></td></tr>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p6q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p6q RCSB], [http://www.ebi.ac.uk/pdbsum/4p6q PDBsum]</span></td></tr>
	<table>		<table>
Line 13:		Line 12:
	The crystal structure of the Split End protein SHARP adds a new layer of complexity to proteins containing RNA recognition motifs.,Arieti F, Gabus C, Tambalo M, Huet T, Round A, Thore S Nucleic Acids Res. 2014 Apr 19. PMID:24748666<ref>PMID:24748666</ref>		The crystal structure of the Split End protein SHARP adds a new layer of complexity to proteins containing RNA recognition motifs.,Arieti F, Gabus C, Tambalo M, Huet T, Round A, Thore S Nucleic Acids Res. 2014 Apr 19. PMID:24748666<ref>PMID:24748666</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==

OCA at 07:16, 14 May 2014

OCA — Wed, 14 May 2014 07:16:08 GMT

←Older revision		Revision as of 07:16, 14 May 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==The crystal structure of the Split End protein SHARP adds a new layer of complexity to proteins containing RNA Recognition Motifs==
		+	<StructureSection load='4p6q' size='340' side='right' caption='[[4p6q]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4p6q]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P6Q OCA]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p6q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p6q RCSB], [http://www.ebi.ac.uk/pdbsum/4p6q PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Split Ends (SPEN) protein was originally discovered in Drosophila in the late 1990s. Since then, homologous proteins have been identified in eukaryotic species ranging from plants to humans. Every family member contains three predicted RNA recognition motifs (RRMs) in the N-terminal region of the protein. We have determined the crystal structure of the region of the human SPEN homolog that contains these RRMs-the SMRT/HDAC1 Associated Repressor Protein (SHARP), at 2.0 A resolution. SHARP is a co-regulator of the nuclear receptors. We demonstrate that two of the three RRMs, namely RRM3 and RRM4, interact via a highly conserved interface. Furthermore, we show that the RRM3-RRM4 block is the main platform mediating the stable association with the H12-H13 substructure found in the steroid receptor RNA activator (SRA), a long, non-coding RNA previously shown to play a crucial role in nuclear receptor transcriptional regulation. We determine that SHARP association with SRA relies on both single- and double-stranded RNA sequences. The crystal structure of the SHARP-RRM fragment, together with the associated RNA-binding studies, extend the repertoire of nucleic acid binding properties of RRM domains suggesting a new hypothesis for a better understanding of SPEN protein functions.

-	The ~~entry 4p6q is ON HOLD until Paper Publication~~	+	The crystal structure of the Split End protein SHARP adds a new layer of complexity to proteins containing RNA recognition motifs.,Arieti F, Gabus C, Tambalo M, Huet T, Round A, Thore S Nucleic Acids Res. 2014 Apr 19. PMID:24748666<ref>PMID:24748666</ref>

-	~~Authors~~: Arieti, F., Gabus, C.~~, Tambalo, M.,~~ Huet, T., Round, A., Thore, S.	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~The crystal structure of the Split End~~ protein ~~SHARP adds a new layer of complexity to proteins containing RNA Recognition Motifs~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Arieti, F.]]
		+	[[Category: Gabus, C.]]
		+	[[Category: Huet, T.]]
		+	[[Category: Round, A.]]
		+	[[Category: Tambalo, M.]]
		+	[[Category: Thore, S.]]
		+	[[Category: Rna-recognition motif]]
		+	[[Category: Spen protein]]
		+	[[Category: Steroid rna activator]]
		+	[[Category: Transcription]]
		+	[[Category: Transcriptional regulation]]

OCA at 05:52, 9 April 2014

OCA — Wed, 09 Apr 2014 05:52:47 GMT

←Older revision		Revision as of 05:52, 9 April 2014
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4p6q is ON HOLD	+	The entry 4p6q is ON HOLD until Paper Publication

	Authors: Arieti, F., Gabus, C., Tambalo, M., Huet, T., Round, A., Thore, S.		Authors: Arieti, F., Gabus, C., Tambalo, M., Huet, T., Round, A., Thore, S.

	Description: The crystal structure of the Split End protein SHARP adds a new layer of complexity to proteins containing RNA Recognition Motifs		Description: The crystal structure of the Split End protein SHARP adds a new layer of complexity to proteins containing RNA Recognition Motifs

OCA: Protected "4p6q" [edit=sysop:move=sysop]

OCA — Wed, 02 Apr 2014 08:30:31 GMT

Protected "4p6q" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:30, 2 April 2014

OCA: New page: '''Unreleased structure''' The entry 4p6q is ON HOLD Authors: Arieti, F., Gabus, C., Tambalo, M., Huet, T., Round, A., Thore, S. Description: The crystal structure of the Split End pro...

OCA — Wed, 02 Apr 2014 08:30:30 GMT

New page: '''Unreleased structure''' The entry 4p6q is ON HOLD Authors: Arieti, F., Gabus, C., Tambalo, M., Huet, T., Round, A., Thore, S. Description: The crystal structure of the Split End pro...

New page

'''Unreleased structure'''

The entry 4p6q is ON HOLD

Authors: Arieti, F., Gabus, C., Tambalo, M., Huet, T., Round, A., Thore, S.

Description: The crystal structure of the Split End protein SHARP adds a new layer of complexity to proteins containing RNA Recognition Motifs