4p7s - Revision history

OCA at 00:41, 28 December 2023

OCA — Thu, 28 Dec 2023 00:41:03 GMT

←Older revision		Revision as of 00:41, 28 December 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4p7s]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P7S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P7S FirstGlance]. <br>		<table><tr><td colspan='2'>[[4p7s]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P7S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P7S FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2OK:4-(3-METHOXY-5-METHYLPHENOXY)-2-(4-METHOXYPHENYL)-6-METHYLPYRIDINE'>2OK</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.87Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2OK:4-(3-METHOXY-5-METHYLPHENOXY)-2-(4-METHOXYPHENYL)-6-METHYLPYRIDINE'>2OK</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p7s OCA], [https://pdbe.org/4p7s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p7s RCSB], [https://www.ebi.ac.uk/pdbsum/4p7s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p7s ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p7s OCA], [https://pdbe.org/4p7s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p7s RCSB], [https://www.ebi.ac.uk/pdbsum/4p7s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p7s ProSAT]</span></td></tr>
	</table>		</table>

OCA at 12:46, 1 February 2023

OCA — Wed, 01 Feb 2023 12:46:06 GMT

←Older revision		Revision as of 12:46, 1 February 2023
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	<StructureSection load='4p7s' size='340' side='right'caption='[[4p7s]], [[Resolution\|resolution]] 2.87Å' scene=''>		<StructureSection load='4p7s' size='340' side='right'caption='[[4p7s]], [[Resolution\|resolution]] 2.87Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4p7s]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Plafa Plafa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P7S OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4P7S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4p7s]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P7S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P7S FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2OK:4-(3-METHOXY-5-METHYLPHENOXY)-2-(4-METHOXYPHENYL)-6-METHYLPYRIDINE'>2OK</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2OK:4-(3-METHOXY-5-METHYLPHENOXY)-2-(4-METHOXYPHENYL)-6-METHYLPYRIDINE'>2OK</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p7m\|4p7m]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p7s OCA], [https://pdbe.org/4p7s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p7s RCSB], [https://www.ebi.ac.uk/pdbsum/4p7s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p7s ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4p7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p7s OCA], [~~http~~://pdbe.org/4p7s PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4p7s RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4p7s PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4p7s ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q6Q3H7_PLAFA Q6Q3H7_PLAFA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Plafa~~]]	+	[[Category: Plasmodium falciparum]]
-	[[Category: Lolis, E]]	+	[[Category: Lolis E]]
-	[[Category: Pantouris, G]]	+	[[Category: Pantouris G]]
-	~~[[Category: Cytokine-inhibitor complex]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Malaria complex active site~~]]	+

OCA at 07:51, 19 February 2020

OCA — Wed, 19 Feb 2020 07:51:33 GMT

←Older revision		Revision as of 07:51, 19 February 2020
Line 1:		Line 1:

	==Crystal structure of PfMIF in complex with 4-(3-methoxy-5-methylphenoxy)-2-(4-methoxyphenyl)-6-methylpyridine==		==Crystal structure of PfMIF in complex with 4-(3-methoxy-5-methylphenoxy)-2-(4-methoxyphenyl)-6-methylpyridine==
-	<StructureSection load='4p7s' size='340' side='right' caption='[[4p7s]], [[Resolution\|resolution]] 2.87Å' scene=''>	+	<StructureSection load='4p7s' size='340' side='right'caption='[[4p7s]], [[Resolution\|resolution]] 2.87Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4p7s]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P7S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P7S FirstGlance]. <br>		<table><tr><td colspan='2'>[[4p7s]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P7S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P7S FirstGlance]. <br>
Line 17:		Line 17:
	</div>		</div>
	<div class="pdbe-citations 4p7s" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4p7s" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Macrophage inhibitory factor 3D structures\|Macrophage inhibitory factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Plafa]]		[[Category: Plafa]]
	[[Category: Lolis, E]]		[[Category: Lolis, E]]

OCA at 08:35, 22 November 2017

OCA — Wed, 22 Nov 2017 08:35:37 GMT

←Older revision		Revision as of 08:35, 22 November 2017
Line 1:		Line 1:
		+
	==Crystal structure of PfMIF in complex with 4-(3-methoxy-5-methylphenoxy)-2-(4-methoxyphenyl)-6-methylpyridine==		==Crystal structure of PfMIF in complex with 4-(3-methoxy-5-methylphenoxy)-2-(4-methoxyphenyl)-6-methylpyridine==
	<StructureSection load='4p7s' size='340' side='right' caption='[[4p7s]], [[Resolution\|resolution]] 2.87Å' scene=''>		<StructureSection load='4p7s' size='340' side='right' caption='[[4p7s]], [[Resolution\|resolution]] 2.87Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4p7s]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P7S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P7S FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4p7s]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P7S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P7S FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2OK:4-(3-METHOXY-5-METHYLPHENOXY)-2-(4-METHOXYPHENYL)-6-METHYLPYRIDINE'>2OK</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2OK:4-(3-METHOXY-5-METHYLPHENOXY)-2-(4-METHOXYPHENYL)-6-METHYLPYRIDINE'>2OK</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p7m\|4p7m]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p7m\|4p7m]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p7s OCA], [http://pdbe.org/4p7s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p7s RCSB], [http://www.ebi.ac.uk/pdbsum/4p7s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p7s OCA], [http://pdbe.org/4p7s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p7s RCSB], [http://www.ebi.ac.uk/pdbsum/4p7s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p7s ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	</div>		</div>
	<div class="pdbe-citations 4p7s" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4p7s" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Macrophage inhibitory factor\|Macrophage inhibitory factor]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Plafa]]
	[[Category: Lolis, E]]		[[Category: Lolis, E]]
	[[Category: Pantouris, G]]		[[Category: Pantouris, G]]

OCA at 21:15, 15 October 2015

OCA — Thu, 15 Oct 2015 21:15:58 GMT

←Older revision		Revision as of 21:15, 15 October 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2OK:4-(3-METHOXY-5-METHYLPHENOXY)-2-(4-METHOXYPHENYL)-6-METHYLPYRIDINE'>2OK</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2OK:4-(3-METHOXY-5-METHYLPHENOXY)-2-(4-METHOXYPHENYL)-6-METHYLPYRIDINE'>2OK</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p7m\|4p7m]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p7m\|4p7m]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p7s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p7s RCSB], [http://www.ebi.ac.uk/pdbsum/4p7s PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p7s OCA], [http://pdbe.org/4p7s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p7s RCSB], [http://www.ebi.ac.uk/pdbsum/4p7s PDBsum]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4p7s" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Macrophage inhibitory factor\|Macrophage inhibitory factor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:50, 25 January 2015

OCA — Sun, 25 Jan 2015 08:50:59 GMT

←Older revision		Revision as of 08:50, 25 January 2015
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Lolis, E.]]	+	[[Category: Lolis, E]]
-	[[Category: Pantouris, G.]]	+	[[Category: Pantouris, G]]
	[[Category: Cytokine-inhibitor complex]]		[[Category: Cytokine-inhibitor complex]]
	[[Category: Inhibitor]]		[[Category: Inhibitor]]
	[[Category: Malaria complex active site]]		[[Category: Malaria complex active site]]

OCA at 10:36, 20 October 2014

OCA — Mon, 20 Oct 2014 10:36:05 GMT

←Older revision		Revision as of 10:36, 20 October 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of PfMIF in complex with 4-(3-methoxy-5-methylphenoxy)-2-(4-methoxyphenyl)-6-methylpyridine==
		+	<StructureSection load='4p7s' size='340' side='right' caption='[[4p7s]], [[Resolution\|resolution]] 2.87Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4p7s]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P7S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P7S FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2OK:4-(3-METHOXY-5-METHYLPHENOXY)-2-(4-METHOXYPHENYL)-6-METHYLPYRIDINE'>2OK</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p7m\|4p7m]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p7s OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p7s RCSB], [http://www.ebi.ac.uk/pdbsum/4p7s PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We report the crystal structures of two inhibitors of Plasmodium falciparum macrophage migration inhibitory factor (PfMIF) with nanomolar Ki's, analyze their interactions with the active site of PfMIF, and provide explanations regarding their selectivity of PfMIF versus human MIF. These inhibitors were also found to selectively inhibit interactions between PfMIF and the human MIF receptor CD74. The results of this study provide the framework for the development of new therapeutics that target PfMIF.

-	~~The entry 4p7s is ON HOLD until Paper Publication~~	+	Crystallographic and Receptor Binding Characterization of Plasmodium falciparum Macrophage Migration Inhibitory Factor Complexed to Two Potent Inhibitors.,Pantouris G, Rajasekaran D, Garcia AB, Ruiz VG, Leng L, Jorgensen WL, Bucala R, Lolis EJ J Med Chem. 2014 Oct 8. PMID:25268646<ref>PMID:25268646</ref>

-	~~Authors: Pantouris~~, G., Lolis, E.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal structure of PfMIF in complex with 4~~-~~(3-methoxy-5-methylphenoxy)-2-(4-methoxyphenyl)-6-methylpyridine~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Lolis, E.]]
		+	[[Category: Pantouris, G.]]
		+	[[Category: Cytokine-inhibitor complex]]
		+	[[Category: Inhibitor]]
		+	[[Category: Malaria complex active site]]

OCA at 07:40, 7 May 2014

OCA — Wed, 07 May 2014 07:40:55 GMT

←Older revision		Revision as of 07:40, 7 May 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4p7s is ON HOLD	+	The entry 4p7s is ON HOLD until Paper Publication

	Authors: Pantouris, G., Lolis, E.		Authors: Pantouris, G., Lolis, E.

-	Description: Crystal structure of PfMIF in complex with ~~competitive inhibitor~~	+	Description: Crystal structure of PfMIF in complex with 4-(3-methoxy-5-methylphenoxy)-2-(4-methoxyphenyl)-6-methylpyridine

OCA at 06:26, 30 April 2014

OCA — Wed, 30 Apr 2014 06:26:00 GMT

←Older revision		Revision as of 06:26, 30 April 2014
Line 3:		Line 3:
	The entry 4p7s is ON HOLD		The entry 4p7s is ON HOLD

-	Authors: Pantouris G., Lolis E.	+	Authors: Pantouris, G., Lolis, E.

	Description: Crystal structure of PfMIF in complex with competitive inhibitor		Description: Crystal structure of PfMIF in complex with competitive inhibitor

OCA: Protected "4p7s" [edit=sysop:move=sysop]

OCA — Wed, 02 Apr 2014 08:31:42 GMT

Protected "4p7s" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:31, 2 April 2014