4p91 - Revision history

OCA at 00:41, 28 December 2023

OCA — Thu, 28 Dec 2023 00:41:33 GMT

←Older revision		Revision as of 00:41, 28 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4p91]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P91 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P91 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4p91]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P91 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P91 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p91 OCA], [https://pdbe.org/4p91 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p91 RCSB], [https://www.ebi.ac.uk/pdbsum/4p91 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p91 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p91 OCA], [https://pdbe.org/4p91 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p91 RCSB], [https://www.ebi.ac.uk/pdbsum/4p91 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p91 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 12:47, 1 February 2023

OCA — Wed, 01 Feb 2023 12:47:47 GMT

←Older revision		Revision as of 12:47, 1 February 2023
Line 1:		Line 1:

	==Crystal structure of the nogo-receptor-2 (27-330)==		==Crystal structure of the nogo-receptor-2 (27-330)==
-	<StructureSection load='4p91' size='340' side='right' caption='[[4p91]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='4p91' size='340' side='right'caption='[[4p91]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4p91]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P91 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4P91 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4p91]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P91 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P91 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p8s\|4p8s]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p91 OCA], [https://pdbe.org/4p91 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p91 RCSB], [https://www.ebi.ac.uk/pdbsum/4p91 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p91 ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rtn4rl2, Ngrh1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4p91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p91 OCA], [~~http~~://pdbe.org/4p91 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4p91 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4p91 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4p91 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/R4RL2_RAT R4RL2_RAT]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Buffalo rat~~]]	+	[[Category: Large Structures]]
-	[[Category: Giger, R]]	+	[[Category: Rattus norvegicus]]
-	[[Category: Goldgur, Y]]	+	[[Category: Giger R]]
-	[[Category: Himanen, J]]	+	[[Category: Goldgur Y]]
-	[[Category: Kolev, M]]	+	[[Category: Himanen J]]
-	[[Category: Nikolov, D]]	+	[[Category: Kolev M]]
-	[[Category: Saha, N]]	+	[[Category: Nikolov D]]
-	[[Category: Semavina, M]]	+	[[Category: Saha N]]
-	~~[[Category: Glycosylation]]~~	+	[[Category: Semavina M]]
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Nogo receptor~~]]	+

OCA at 18:22, 11 August 2016

OCA — Thu, 11 Aug 2016 18:22:04 GMT

←Older revision		Revision as of 18:22, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the nogo-receptor-2 (27-330)==		==Crystal structure of the nogo-receptor-2 (27-330)==
	<StructureSection load='4p91' size='340' side='right' caption='[[4p91]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4p91' size='340' side='right' caption='[[4p91]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p8s\|4p8s]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p8s\|4p8s]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rtn4rl2, Ngrh1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rtn4rl2, Ngrh1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p91 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p91 RCSB], [http://www.ebi.ac.uk/pdbsum/4p91 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p91 OCA], [http://pdbe.org/4p91 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p91 RCSB], [http://www.ebi.ac.uk/pdbsum/4p91 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p91 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4p91" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:01, 5 January 2015

OCA — Mon, 05 Jan 2015 09:01:34 GMT

←Older revision		Revision as of 09:01, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4p91]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P91 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P91 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4p91]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P91 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P91 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p8s\|4p8s]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p8s\|4p8s]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rtn4rl2, Ngrh1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rtn4rl2, Ngrh1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p91 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p91 RCSB], [http://www.ebi.ac.uk/pdbsum/4p91 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p91 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p91 RCSB], [http://www.ebi.ac.uk/pdbsum/4p91 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:
	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
-	[[Category: Giger, R.]]	+	[[Category: Giger, R]]
-	[[Category: Goldgur, Y.]]	+	[[Category: Goldgur, Y]]
-	[[Category: Himanen, J.]]	+	[[Category: Himanen, J]]
-	[[Category: Kolev, M.]]	+	[[Category: Kolev, M]]
-	[[Category: Nikolov, D.]]	+	[[Category: Nikolov, D]]
-	[[Category: Saha, N.]]	+	[[Category: Saha, N]]
-	[[Category: Semavina, M.]]	+	[[Category: Semavina, M]]
	[[Category: Glycosylation]]		[[Category: Glycosylation]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]
	[[Category: Nogo receptor]]		[[Category: Nogo receptor]]

OCA at 06:54, 11 June 2014

OCA — Wed, 11 Jun 2014 06:54:12 GMT

←Older revision		Revision as of 06:54, 11 June 2014
Line 2:		Line 2:
	<StructureSection load='4p91' size='340' side='right' caption='[[4p91]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4p91' size='340' side='right' caption='[[4p91]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4p91]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P91 OCA]. <br>	+	<table><tr><td colspan='2'>[[4p91]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P91 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P91 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>		</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p8s\|4p8s]]</td></tr>		<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p8s\|4p8s]]</td></tr>
-	<tr><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat">~~<span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase]~~, ~~with EC number~~ [http://www.~~brenda-enzymes~~.~~info~~/~~php~~/~~result_flat~~.~~php4~~?~~ecno~~=~~2.7.1.2 2.7.1.2~~] ~~</span>~~</td></tr>	+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rtn4rl2, Ngrh1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p91 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p91 RCSB], [http://www.ebi.ac.uk/pdbsum/4p91 PDBsum]</span></td></tr>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p91 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p91 RCSB], [http://www.ebi.ac.uk/pdbsum/4p91 PDBsum]</span></td></tr>
	<table>		<table>
Line 14:		Line 14:
	Crystal structure of the Nogo-receptor-2.,Semavina M, Saha N, Kolev MV, Goldgur Y, Giger RJ, Himanen JP, Nikolov DB Protein Sci. 2011 Apr;20(4):684-9. doi: 10.1002/pro.597. PMID:21308849<ref>PMID:21308849</ref>		Crystal structure of the Nogo-receptor-2.,Semavina M, Saha N, Kolev MV, Goldgur Y, Giger RJ, Himanen JP, Nikolov DB Protein Sci. 2011 Apr;20(4):684-9. doi: 10.1002/pro.597. PMID:21308849<ref>PMID:21308849</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Buffalo rat]]
	[[Category: Giger, R.]]		[[Category: Giger, R.]]
	[[Category: Goldgur, Y.]]		[[Category: Goldgur, Y.]]

OCA at 09:30, 1 May 2014

OCA — Thu, 01 May 2014 09:30:53 GMT

←Older revision		Revision as of 09:30, 1 May 2014
Line 2:		Line 2:
	<StructureSection load='4p91' size='340' side='right' caption='[[4p91]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='4p91' size='340' side='right' caption='[[4p91]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	[[4p91]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P91 OCA]. <br>	+	<table><tr><td colspan='2'>[[4p91]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P91 OCA]. <br>
-	<b>[[Ligand\|Ligands:]]</b> <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
-	<b>[[Related_structure\|Related:]]</b> [[4p8s\|4p8s]]<br>	+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p8s\|4p8s]]</td></tr>
-	<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>	+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
-	<b>Resources:</b> <span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p91 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p91 RCSB], [http://www.ebi.ac.uk/pdbsum/4p91 PDBsum]</span><br>	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p91 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p91 RCSB], [http://www.ebi.ac.uk/pdbsum/4p91 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
	The inhibition of axon regeneration upon mechanical injury is dependent on interactions between Nogo receptors (NgRs) and their myelin-derived ligands. NgRs are composed of a leucine-rich repeat (LRR) region, thought to be structurally similar among the different isoforms of the receptor, and a divergent "stalk" region. It has been shown by others that the LRR and stalk regions of NgR1 and NgR2 have distinct roles in conferring binding affinity to the myelin associated glycoprotein (MAG) in vivo. Here, we show that purified recombinant full length NgR1 and NgR2 maintain significantly higher binding affinity for purified MAG as compared to the isolated LRR region of either NgR1 or NgR2. We also present the crystal structure of the LRR and part of the stalk regions of NgR2 and compare it to the previously reported NgR1 structure with respect to the distinct signaling properties of the two receptor isoforms.		The inhibition of axon regeneration upon mechanical injury is dependent on interactions between Nogo receptors (NgRs) and their myelin-derived ligands. NgRs are composed of a leucine-rich repeat (LRR) region, thought to be structurally similar among the different isoforms of the receptor, and a divergent "stalk" region. It has been shown by others that the LRR and stalk regions of NgR1 and NgR2 have distinct roles in conferring binding affinity to the myelin associated glycoprotein (MAG) in vivo. Here, we show that purified recombinant full length NgR1 and NgR2 maintain significantly higher binding affinity for purified MAG as compared to the isolated LRR region of either NgR1 or NgR2. We also present the crystal structure of the LRR and part of the stalk regions of NgR2 and compare it to the previously reported NgR1 structure with respect to the distinct signaling properties of the two receptor isoforms.
Line 13:		Line 15:

	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>		From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:05, 30 April 2014

OCA — Wed, 30 Apr 2014 10:05:49 GMT

←Older revision		Revision as of 10:05, 30 April 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	[[4p91]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P91 OCA]. <br>		[[4p91]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P91 OCA]. <br>
-	<b>Related:</b> [[4p8s\|4p8s]]<br>	+	<b>[[Ligand\|Ligands:]]</b> <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
		+	<b>[[Related_structure\|Related:]]</b> [[4p8s\|4p8s]]<br>
	<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>		<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
		+	<b>Resources:</b> <span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p91 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p91 RCSB], [http://www.ebi.ac.uk/pdbsum/4p91 PDBsum]</span><br>
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
	The inhibition of axon regeneration upon mechanical injury is dependent on interactions between Nogo receptors (NgRs) and their myelin-derived ligands. NgRs are composed of a leucine-rich repeat (LRR) region, thought to be structurally similar among the different isoforms of the receptor, and a divergent "stalk" region. It has been shown by others that the LRR and stalk regions of NgR1 and NgR2 have distinct roles in conferring binding affinity to the myelin associated glycoprotein (MAG) in vivo. Here, we show that purified recombinant full length NgR1 and NgR2 maintain significantly higher binding affinity for purified MAG as compared to the isolated LRR region of either NgR1 or NgR2. We also present the crystal structure of the LRR and part of the stalk regions of NgR2 and compare it to the previously reported NgR1 structure with respect to the distinct signaling properties of the two receptor isoforms.		The inhibition of axon regeneration upon mechanical injury is dependent on interactions between Nogo receptors (NgRs) and their myelin-derived ligands. NgRs are composed of a leucine-rich repeat (LRR) region, thought to be structurally similar among the different isoforms of the receptor, and a divergent "stalk" region. It has been shown by others that the LRR and stalk regions of NgR1 and NgR2 have distinct roles in conferring binding affinity to the myelin associated glycoprotein (MAG) in vivo. Here, we show that purified recombinant full length NgR1 and NgR2 maintain significantly higher binding affinity for purified MAG as compared to the isolated LRR region of either NgR1 or NgR2. We also present the crystal structure of the LRR and part of the stalk regions of NgR2 and compare it to the previously reported NgR1 structure with respect to the distinct signaling properties of the two receptor isoforms.

OCA at 07:40, 30 April 2014

OCA — Wed, 30 Apr 2014 07:40:37 GMT

←Older revision		Revision as of 07:40, 30 April 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of the nogo-receptor-2 (27-330)==
		+	<StructureSection load='4p91' size='340' side='right' caption='[[4p91]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	[[4p91]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P91 OCA]. <br>
		+	<b>Related:</b> [[4p8s\|4p8s]]<br>
		+	<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
		+	== Publication Abstract from PubMed ==
		+	The inhibition of axon regeneration upon mechanical injury is dependent on interactions between Nogo receptors (NgRs) and their myelin-derived ligands. NgRs are composed of a leucine-rich repeat (LRR) region, thought to be structurally similar among the different isoforms of the receptor, and a divergent "stalk" region. It has been shown by others that the LRR and stalk regions of NgR1 and NgR2 have distinct roles in conferring binding affinity to the myelin associated glycoprotein (MAG) in vivo. Here, we show that purified recombinant full length NgR1 and NgR2 maintain significantly higher binding affinity for purified MAG as compared to the isolated LRR region of either NgR1 or NgR2. We also present the crystal structure of the LRR and part of the stalk regions of NgR2 and compare it to the previously reported NgR1 structure with respect to the distinct signaling properties of the two receptor isoforms.

-	~~The entry 4p91 is ON HOLD~~	+	Crystal structure of the Nogo-receptor-2.,Semavina M, Saha N, Kolev MV, Goldgur Y, Giger RJ, Himanen JP, Nikolov DB Protein Sci. 2011 Apr;20(4):684-9. doi: 10.1002/pro.597. PMID:21308849<ref>PMID:21308849</ref>

-	~~Authors: Semavina~~, M.~~, Saha, N~~.~~, Kolev, M~~.~~, Goldgur, Y.,~~ Giger, R., Himanen, J., Nikolov, D.	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	== References ==
-	~~Description~~: ~~Crystal structure of the nogo-~~receptor~~-2 (27-330)~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Giger, R.]]
		+	[[Category: Goldgur, Y.]]
		+	[[Category: Himanen, J.]]
		+	[[Category: Kolev, M.]]
		+	[[Category: Nikolov, D.]]
		+	[[Category: Saha, N.]]
		+	[[Category: Semavina, M.]]
		+	[[Category: Glycosylation]]
		+	[[Category: Membrane protein]]
		+	[[Category: Nogo receptor]]

OCA: Protected "4p91" [edit=sysop:move=sysop]

OCA — Wed, 09 Apr 2014 05:54:31 GMT

Protected "4p91" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:54, 9 April 2014

OCA: New page: '''Unreleased structure''' The entry 4p91 is ON HOLD Authors: Semavina, M., Saha, N., Kolev, M., Goldgur, Y., Giger, R., Himanen, J., Nikolov, D. Description: Crystal structure of the ...

OCA — Wed, 09 Apr 2014 05:54:30 GMT

New page: '''Unreleased structure''' The entry 4p91 is ON HOLD Authors: Semavina, M., Saha, N., Kolev, M., Goldgur, Y., Giger, R., Himanen, J., Nikolov, D. Description: Crystal structure of the ...

New page

'''Unreleased structure'''

The entry 4p91 is ON HOLD

Authors: Semavina, M., Saha, N., Kolev, M., Goldgur, Y., Giger, R., Himanen, J., Nikolov, D.

Description: Crystal structure of the nogo-receptor-2 (27-330)