4p9m - Revision history

OCA at 07:13, 27 September 2023

OCA — Wed, 27 Sep 2023 07:13:26 GMT

←Older revision		Revision as of 07:13, 27 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4p9m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P9M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P9M FirstGlance]. <br>		<table><tr><td colspan='2'>[[4p9m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P9M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P9M FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.13Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p9m OCA], [https://pdbe.org/4p9m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p9m RCSB], [https://www.ebi.ac.uk/pdbsum/4p9m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p9m ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p9m OCA], [https://pdbe.org/4p9m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p9m RCSB], [https://www.ebi.ac.uk/pdbsum/4p9m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p9m ProSAT]</span></td></tr>
	</table>		</table>

OCA at 12:48, 1 February 2023

OCA — Wed, 01 Feb 2023 12:48:32 GMT

←Older revision		Revision as of 12:48, 1 February 2023
Line 3:		Line 3:
	<StructureSection load='4p9m' size='340' side='right'caption='[[4p9m]], [[Resolution\|resolution]] 2.13Å' scene=''>		<StructureSection load='4p9m' size='340' side='right'caption='[[4p9m]], [[Resolution\|resolution]] 2.13Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4p9m]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P9M OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4P9M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4p9m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P9M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4P9M FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p9h\|4p9h]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4p9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p9m OCA], [https://pdbe.org/4p9m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4p9m RCSB], [https://www.ebi.ac.uk/pdbsum/4p9m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4p9m ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4p9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p9m OCA], [~~http~~://pdbe.org/4p9m PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4p9m RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4p9m PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4p9m ProSAT]</span></td></tr>	+
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 21:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bjorkman~~, P J~~]]	+	[[Category: Bjorkman PJ]]
-	[[Category: Scharf, L]]	+	[[Category: Scharf L]]
-	~~[[Category: Anti hiv]]~~	+
-	~~[[Category: Antibody]]~~	+
-	~~[[Category: Ig fold]]~~	+
-	~~[[Category: Immune system~~]]	+

OCA at 08:09, 19 February 2020

OCA — Wed, 19 Feb 2020 08:09:42 GMT

←Older revision		Revision as of 08:09, 19 February 2020
Line 1:		Line 1:

	==Crystal structure of 8ANC195 Fab==		==Crystal structure of 8ANC195 Fab==
-	<StructureSection load='4p9m' size='340' side='right' caption='[[4p9m]], [[Resolution\|resolution]] 2.13Å' scene=''>	+	<StructureSection load='4p9m' size='340' side='right'caption='[[4p9m]], [[Resolution\|resolution]] 2.13Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4p9m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P9M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P9M FirstGlance]. <br>		<table><tr><td colspan='2'>[[4p9m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P9M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P9M FirstGlance]. <br>
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Bjorkman, P J]]		[[Category: Bjorkman, P J]]
	[[Category: Scharf, L]]		[[Category: Scharf, L]]

OCA at 08:36, 22 November 2017

OCA — Wed, 22 Nov 2017 08:36:49 GMT

←Older revision		Revision as of 08:36, 22 November 2017
Line 3:		Line 3:
	<StructureSection load='4p9m' size='340' side='right' caption='[[4p9m]], [[Resolution\|resolution]] 2.13Å' scene=''>		<StructureSection load='4p9m' size='340' side='right' caption='[[4p9m]], [[Resolution\|resolution]] 2.13Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4p9m]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P9M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P9M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4p9m]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P9M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P9M FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p9h\|4p9h]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p9h\|4p9h]]</td></tr>
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Bjorkman, P J]]		[[Category: Bjorkman, P J]]
	[[Category: Scharf, L]]		[[Category: Scharf, L]]

OCA at 05:59, 5 August 2016

OCA — Fri, 05 Aug 2016 05:59:03 GMT

←Older revision		Revision as of 05:59, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of 8ANC195 Fab==		==Crystal structure of 8ANC195 Fab==
	<StructureSection load='4p9m' size='340' side='right' caption='[[4p9m]], [[Resolution\|resolution]] 2.13Å' scene=''>		<StructureSection load='4p9m' size='340' side='right' caption='[[4p9m]], [[Resolution\|resolution]] 2.13Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p9h\|4p9h]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p9h\|4p9h]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p9m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p9m RCSB], [http://www.ebi.ac.uk/pdbsum/4p9m PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p9m OCA], [http://pdbe.org/4p9m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p9m RCSB], [http://www.ebi.ac.uk/pdbsum/4p9m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p9m ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4p9m" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:26, 24 December 2014

OCA — Wed, 24 Dec 2014 11:26:58 GMT

←Older revision		Revision as of 11:26, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4p9m]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P9M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P9M FirstGlance]. <br>		<table><tr><td colspan='2'>[[4p9m]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P9M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P9M FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p9h\|4p9h]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p9h\|4p9h]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p9m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p9m RCSB], [http://www.ebi.ac.uk/pdbsum/4p9m PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p9m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p9m RCSB], [http://www.ebi.ac.uk/pdbsum/4p9m PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bjorkman, P J.]]	+	[[Category: Bjorkman, P J]]
-	[[Category: Scharf, L.]]	+	[[Category: Scharf, L]]
	[[Category: Anti hiv]]		[[Category: Anti hiv]]
	[[Category: Antibody]]		[[Category: Antibody]]
	[[Category: Ig fold]]		[[Category: Ig fold]]
	[[Category: Immune system]]		[[Category: Immune system]]

OCA at 06:27, 11 June 2014

OCA — Wed, 11 Jun 2014 06:27:58 GMT

←Older revision		Revision as of 06:27, 11 June 2014
Line 13:		Line 13:
	Antibody 8ANC195 Reveals a Site of Broad Vulnerability on the HIV-1 Envelope Spike.,Scharf L, Scheid JF, Lee JH, West AP Jr, Chen C, Gao H, Gnanapragasam PN, Mares R, Seaman MS, Ward AB, Nussenzweig MC, Bjorkman PJ Cell Rep. 2014 May 8;7(3):785-95. doi: 10.1016/j.celrep.2014.04.001. Epub 2014, Apr 24. PMID:24767986<ref>PMID:24767986</ref>		Antibody 8ANC195 Reveals a Site of Broad Vulnerability on the HIV-1 Envelope Spike.,Scharf L, Scheid JF, Lee JH, West AP Jr, Chen C, Gao H, Gnanapragasam PN, Mares R, Seaman MS, Ward AB, Nussenzweig MC, Bjorkman PJ Cell Rep. 2014 May 8;7(3):785-95. doi: 10.1016/j.celrep.2014.04.001. Epub 2014, Apr 24. PMID:24767986<ref>PMID:24767986</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==

OCA at 09:01, 21 May 2014

OCA — Wed, 21 May 2014 09:01:06 GMT

←Older revision		Revision as of 09:01, 21 May 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of 8ANC195 Fab==
		+	<StructureSection load='4p9m' size='340' side='right' caption='[[4p9m]], [[Resolution\|resolution]] 2.13Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4p9m]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P9M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P9M FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4p9h\|4p9h]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p9m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p9m RCSB], [http://www.ebi.ac.uk/pdbsum/4p9m PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Broadly neutralizing antibodies (bNAbs) to HIV-1 envelope glycoprotein (Env) can prevent infection in animal models. Characterized bNAb targets, although key to vaccine and therapeutic strategies, are currently limited. We defined a new site of vulnerability by solving structures of bNAb 8ANC195 complexed with monomeric gp120 by X-ray crystallography and trimeric Env by electron microscopy. The site includes portions of gp41 and N-linked glycans adjacent to the CD4-binding site on gp120, making 8ANC195 the first donor-derived anti-HIV-1 bNAb with an epitope spanning both Env subunits. Rather than penetrating the glycan shield by using a single variable-region CDR loop, 8ANC195 inserted its entire heavy-chain variable domain into a gap to form a large interface with gp120 glycans and regions of the gp120 inner domain not contacted by other bNAbs. By isolating additional 8ANC195 clonal variants, we identified a more potent variant, which may be valuable for therapeutic approaches using bNAb combinations with nonoverlapping epitopes.

-	~~The entry 4p9m is ON HOLD~~	+	Antibody 8ANC195 Reveals a Site of Broad Vulnerability on the HIV-1 Envelope Spike.,Scharf L, Scheid JF, Lee JH, West AP Jr, Chen C, Gao H, Gnanapragasam PN, Mares R, Seaman MS, Ward AB, Nussenzweig MC, Bjorkman PJ Cell Rep. 2014 May 8;7(3):785-95. doi: 10.1016/j.celrep.2014.04.001. Epub 2014, Apr 24. PMID:24767986<ref>PMID:24767986</ref>

-	~~Authors: Scharf~~, L., Bjorkman, P.J.	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal structure of 8ANC195 Fab~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Bjorkman, P J.]]
		+	[[Category: Scharf, L.]]
		+	[[Category: Anti hiv]]
		+	[[Category: Antibody]]
		+	[[Category: Ig fold]]
		+	[[Category: Immune system]]

OCA: Protected "4p9m" [edit=sysop:move=sysop]

OCA — Wed, 09 Apr 2014 05:55:11 GMT

Protected "4p9m" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:55, 9 April 2014

OCA: New page: '''Unreleased structure''' The entry 4p9m is ON HOLD Authors: Scharf, L., Bjorkman, P.J. Description: Crystal structure of 8ANC195 Fab

OCA — Wed, 09 Apr 2014 05:55:10 GMT

New page: '''Unreleased structure''' The entry 4p9m is ON HOLD Authors: Scharf, L., Bjorkman, P.J. Description: Crystal structure of 8ANC195 Fab

New page

'''Unreleased structure'''

The entry 4p9m is ON HOLD

Authors: Scharf, L., Bjorkman, P.J.

Description: Crystal structure of 8ANC195 Fab