4pa3 - Revision history

OCA at 07:13, 27 September 2023

OCA — Wed, 27 Sep 2023 07:13:34 GMT

←Older revision		Revision as of 07:13, 27 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4pa3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Magnetococcus_marinus_MC-1 Magnetococcus marinus MC-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PA3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PA3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4pa3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Magnetococcus_marinus_MC-1 Magnetococcus marinus MC-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PA3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PA3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=12P:DODECAETHYLENE+GLYCOL'>12P</scene>, <scene name='pdbligand=2CV:HEGA-10'>2CV</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.25Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=12P:DODECAETHYLENE+GLYCOL'>12P</scene>, <scene name='pdbligand=2CV:HEGA-10'>2CV</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pa3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pa3 OCA], [https://pdbe.org/4pa3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pa3 RCSB], [https://www.ebi.ac.uk/pdbsum/4pa3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pa3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pa3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pa3 OCA], [https://pdbe.org/4pa3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pa3 RCSB], [https://www.ebi.ac.uk/pdbsum/4pa3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pa3 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 12:49, 1 February 2023

OCA — Wed, 01 Feb 2023 12:49:12 GMT

←Older revision		Revision as of 12:49, 1 February 2023
Line 3:		Line 3:
	<StructureSection load='4pa3' size='340' side='right'caption='[[4pa3]], [[Resolution\|resolution]] 3.25Å' scene=''>		<StructureSection load='4pa3' size='340' side='right'caption='[[4pa3]], [[Resolution\|resolution]] 3.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4pa3]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Magmm Magmm~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PA3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4PA3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4pa3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Magnetococcus_marinus_MC-1 Magnetococcus marinus MC-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PA3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PA3 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=12P:DODECAETHYLENE+GLYCOL'>12P</scene>, <scene name='pdbligand=2CV:HEGA-10'>2CV</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=12P:DODECAETHYLENE+GLYCOL'>12P</scene>, <scene name='pdbligand=2CV:HEGA-10'>2CV</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cbc\|4cbc]], [[4p90\|4p90]], [[4p2z\|4p2z]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pa3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pa3 OCA], [https://pdbe.org/4pa3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pa3 RCSB], [https://www.ebi.ac.uk/pdbsum/4pa3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pa3 ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mmc1_0798 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=156889 MAGMM])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4pa3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pa3 OCA], [~~http~~://pdbe.org/4pa3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4pa3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4pa3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4pa3 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0L5S6_MAGMM A0L5S6_MAGMM]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4pa3" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4pa3" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ion channels 3D structures\|Ion channels 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 23:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Magmm~~]]	+	[[Category: Magnetococcus marinus MC-1]]
-	[[Category: Bagneris, C]]	+	[[Category: Bagneris C]]
-	[[Category: Naylor~~, C E~~]]	+	[[Category: Naylor CE]]
-	[[Category: Wallace~~, B A]]~~	+	[[Category: Wallace BA]]
-	~~[[Category: Channel blocking compound]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Pore]]~~	+
-	~~[[Category: Sodium channel]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 08:40, 1 January 2020

OCA — Wed, 01 Jan 2020 08:40:06 GMT

←Older revision		Revision as of 08:40, 1 January 2020
Line 1:		Line 1:

	==Structure of NavMS in complex with channel blocking compound==		==Structure of NavMS in complex with channel blocking compound==
-	<StructureSection load='4pa3' size='340' side='right' caption='[[4pa3]], [[Resolution\|resolution]] 3.25Å' scene=''>	+	<StructureSection load='4pa3' size='340' side='right'caption='[[4pa3]], [[Resolution\|resolution]] 3.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4pa3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Magmm Magmm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PA3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PA3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4pa3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Magmm Magmm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PA3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PA3 FirstGlance]. <br>
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Magmm]]		[[Category: Magmm]]
	[[Category: Bagneris, C]]		[[Category: Bagneris, C]]

OCA at 14:47, 15 November 2017

OCA — Wed, 15 Nov 2017 14:47:46 GMT

←Older revision		Revision as of 14:47, 15 November 2017
Line 3:		Line 3:
	<StructureSection load='4pa3' size='340' side='right' caption='[[4pa3]], [[Resolution\|resolution]] 3.25Å' scene=''>		<StructureSection load='4pa3' size='340' side='right' caption='[[4pa3]], [[Resolution\|resolution]] 3.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4pa3]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PA3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PA3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4pa3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Magmm Magmm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PA3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PA3 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=12P:DODECAETHYLENE+GLYCOL'>12P</scene>, <scene name='pdbligand=2CV:HEGA-10'>2CV</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=12P:DODECAETHYLENE+GLYCOL'>12P</scene>, <scene name='pdbligand=2CV:HEGA-10'>2CV</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cbc\|4cbc]], [[4p90\|4p90]], [[4p2z\|4p2z]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cbc\|4cbc]], [[4p90\|4p90]], [[4p2z\|4p2z]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mmc1_0798 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=156889 MAGMM])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pa3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pa3 OCA], [http://pdbe.org/4pa3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pa3 RCSB], [http://www.ebi.ac.uk/pdbsum/4pa3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pa3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pa3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pa3 OCA], [http://pdbe.org/4pa3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pa3 RCSB], [http://www.ebi.ac.uk/pdbsum/4pa3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pa3 ProSAT]</span></td></tr>
	</table>		</table>
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Magmm]]
	[[Category: Bagneris, C]]		[[Category: Bagneris, C]]
	[[Category: Naylor, C E]]		[[Category: Naylor, C E]]

OCA at 10:16, 11 August 2016

OCA — Thu, 11 Aug 2016 10:16:16 GMT

←Older revision		Revision as of 10:16, 11 August 2016
Line 1:		Line 1:
		+
	==Structure of NavMS in complex with channel blocking compound==		==Structure of NavMS in complex with channel blocking compound==
	<StructureSection load='4pa3' size='340' side='right' caption='[[4pa3]], [[Resolution\|resolution]] 3.25Å' scene=''>		<StructureSection load='4pa3' size='340' side='right' caption='[[4pa3]], [[Resolution\|resolution]] 3.25Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=12P:DODECAETHYLENE+GLYCOL'>12P</scene>, <scene name='pdbligand=2CV:HEGA-10'>2CV</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=12P:DODECAETHYLENE+GLYCOL'>12P</scene>, <scene name='pdbligand=2CV:HEGA-10'>2CV</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cbc\|4cbc]], [[4p90\|4p90]], [[4p2z\|4p2z]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cbc\|4cbc]], [[4p90\|4p90]], [[4p2z\|4p2z]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pa3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pa3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pa3 RCSB], [http://www.ebi.ac.uk/pdbsum/4pa3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pa3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pa3 OCA], [http://pdbe.org/4pa3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pa3 RCSB], [http://www.ebi.ac.uk/pdbsum/4pa3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pa3 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4pa3" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 14:36, 5 January 2015

OCA — Mon, 05 Jan 2015 14:36:52 GMT

←Older revision		Revision as of 14:36, 5 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4pa3]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PA3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PA3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4pa3]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PA3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PA3 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=12P:DODECAETHYLENE+GLYCOL'>12P</scene>, <scene name='pdbligand=2CV:HEGA-10'>2CV</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=12P:DODECAETHYLENE+GLYCOL'>12P</scene>, <scene name='pdbligand=2CV:HEGA-10'>2CV</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cbc\|4cbc]], [[4p90\|4p90]], [[4p2z\|4p2z]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cbc\|4cbc]], [[4p90\|4p90]], [[4p2z\|4p2z]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pa3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pa3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pa3 RCSB], [http://www.ebi.ac.uk/pdbsum/4pa3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pa3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pa3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pa3 RCSB], [http://www.ebi.ac.uk/pdbsum/4pa3 PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bagneris, C.]]	+	[[Category: Bagneris, C]]
-	[[Category: Naylor, C E.]]	+	[[Category: Naylor, C E]]
-	[[Category: Wallace, B A.]]	+	[[Category: Wallace, B A]]
	[[Category: Channel blocking compound]]		[[Category: Channel blocking compound]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]

OCA at 07:18, 11 June 2014

OCA — Wed, 11 Jun 2014 07:18:43 GMT

←Older revision		Revision as of 07:18, 11 June 2014
Line 13:		Line 13:
	Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism.,Bagneris C, DeCaen PG, Naylor CE, Pryde DC, Nobeli I, Clapham DE, Wallace BA Proc Natl Acad Sci U S A. 2014 May 21. pii: 201406855. PMID:24850863<ref>PMID:24850863</ref>		Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism.,Bagneris C, DeCaen PG, Naylor CE, Pryde DC, Nobeli I, Clapham DE, Wallace BA Proc Natl Acad Sci U S A. 2014 May 21. pii: 201406855. PMID:24850863<ref>PMID:24850863</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==

OCA at 05:09, 4 June 2014

OCA — Wed, 04 Jun 2014 05:09:14 GMT

←Older revision		Revision as of 05:09, 4 June 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Structure of NavMS in complex with channel blocking compound==
		+	<StructureSection load='4pa3' size='340' side='right' caption='[[4pa3]], [[Resolution\|resolution]] 3.25Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4pa3]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PA3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PA3 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=12P:DODECAETHYLENE+GLYCOL'>12P</scene>, <scene name='pdbligand=2CV:HEGA-10'>2CV</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4cbc\|4cbc]], [[4p90\|4p90]], [[4p2z\|4p2z]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pa3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pa3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pa3 RCSB], [http://www.ebi.ac.uk/pdbsum/4pa3 PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Voltage-gated sodium channels are important targets for the development of pharmaceutical drugs, because mutations in different human sodium channel isoforms have causal relationships with a range of neurological and cardiovascular diseases. In this study, functional electrophysiological studies show that the prokaryotic sodium channel from Magnetococcus marinus (NavMs) binds and is inhibited by eukaryotic sodium channel blockers in a manner similar to the human Nav1.1 channel, despite millions of years of divergent evolution between the two types of channels. Crystal complexes of the NavMs pore with several brominated blocker compounds depict a common antagonist binding site in the cavity, adjacent to lipid-facing fenestrations proposed to be the portals for drug entry. In silico docking studies indicate the full extent of the blocker binding site, and electrophysiology studies of NavMs channels with mutations at adjacent residues validate the location. These results suggest that the NavMs channel can be a valuable tool for screening and rational design of human drugs.

-	~~The entry 4pa3 is ON HOLD until Paper Publication~~	+	Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism.,Bagneris C, DeCaen PG, Naylor CE, Pryde DC, Nobeli I, Clapham DE, Wallace BA Proc Natl Acad Sci U S A. 2014 May 21. pii: 201406855. PMID:24850863<ref>PMID:24850863</ref>

-	~~Authors: Naylor~~, C.E., Bagneris, C., Wallace, B.A.	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Structure of NavMS in complex with channel~~ blocking compound	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Bagneris, C.]]
		+	[[Category: Naylor, C E.]]
		+	[[Category: Wallace, B A.]]
		+	[[Category: Channel blocking compound]]
		+	[[Category: Membrane protein]]
		+	[[Category: Pore]]
		+	[[Category: Sodium channel]]
		+	[[Category: Transport protein]]

OCA: Protected "4pa3" [edit=sysop:move=sysop]

OCA — Wed, 16 Apr 2014 09:04:44 GMT

Protected "4pa3" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:04, 16 April 2014

OCA: New page: '''Unreleased structure''' The entry 4pa3 is ON HOLD until Paper Publication Authors: Naylor, C.E., Bagneris, C., Wallace, B.A. Description: Structure of NavMS in complex with channel ...

OCA — Wed, 16 Apr 2014 09:04:43 GMT

New page: '''Unreleased structure''' The entry 4pa3 is ON HOLD until Paper Publication Authors: Naylor, C.E., Bagneris, C., Wallace, B.A. Description: Structure of NavMS in complex with channel ...

New page

'''Unreleased structure'''

The entry 4pa3 is ON HOLD until Paper Publication

Authors: Naylor, C.E., Bagneris, C., Wallace, B.A.

Description: Structure of NavMS in complex with channel blocking compound