4pcz - Revision history

OCA at 07:15, 27 September 2023

OCA — Wed, 27 Sep 2023 07:15:16 GMT

←Older revision		Revision as of 07:15, 27 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4pcz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactococcus_cremoris Lactococcus cremoris] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PCZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PCZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4pcz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactococcus_cremoris Lactococcus cremoris] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PCZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PCZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3DR:1,2-DIDEOXYRIBOFURANOSE-5-PHOSPHATE'>3DR</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3DR:1,2-DIDEOXYRIBOFURANOSE-5-PHOSPHATE'>3DR</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pcz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pcz OCA], [https://pdbe.org/4pcz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pcz RCSB], [https://www.ebi.ac.uk/pdbsum/4pcz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pcz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pcz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pcz OCA], [https://pdbe.org/4pcz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pcz RCSB], [https://www.ebi.ac.uk/pdbsum/4pcz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pcz ProSAT]</span></td></tr>
	</table>		</table>

OCA at 12:52, 1 February 2023

OCA — Wed, 01 Feb 2023 12:52:55 GMT

←Older revision		Revision as of 12:52, 1 February 2023
Line 3:		Line 3:
	<StructureSection load='4pcz' size='340' side='right'caption='[[4pcz]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='4pcz' size='340' side='right'caption='[[4pcz]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4pcz]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"streptococcus_hollandicus"_scholl_1891 "streptococcus hollandicus" scholl 1891~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PCZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4PCZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4pcz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactococcus_cremoris Lactococcus cremoris] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PCZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PCZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3DR:1,2-DIDEOXYRIBOFURANOSE-5-PHOSPHATE'>3DR</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr~~ id~~='NonStdRes'><td class~~="~~sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat~~"><scene name='pdbligand=3DR:1,2-DIDEOXYRIBOFURANOSE-5-PHOSPHATE'>3DR</scene><~~/td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pcz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pcz OCA], [https://pdbe.org/4pcz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pcz RCSB], [https://www.ebi.ac.uk/pdbsum/4pcz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pcz ProSAT]</span></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat">[[4pd2\|4pd2]], [[4pdg\|4pdg]], [[4pdi\|4pdi]]</td></tr>~~	+
-	~~<tr id='gene~~'>~~<td class="sblockLbl"><b>[[Gene\|Gene:]]~~</~~b></td><td class="sblockDat"~~>~~mutM~~, ~~fpg ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1359 "Streptococcus hollandicus" Scholl 1891])~~<~~/td></tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[http://en.wikipedia.org/wiki/DNA-formamidopyrimidine_glycosylase DNA-formamidopyrimidine glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.23 3.2.2.23]~~ </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4pcz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pcz OCA], [~~http~~://pdbe.org/4pcz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4pcz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4pcz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4pcz ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/FPG_LACLC FPG_LACLC]] Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.<ref>PMID:7704272</ref>	+	[https://www.uniprot.org/uniprot/FPG_LACLC FPG_LACLC] Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.<ref>PMID:7704272</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 20:

	==See Also==		==See Also==
-	*[[DNA glycosylase\|DNA glycosylase]]	+	*[[DNA glycosylase 3D structures\|DNA glycosylase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Streptococcus hollandicus scholl 1891]]~~	+	[[Category: Lactococcus cremoris]]
-	~~[[Category: DNA-formamidopyrimidine glycosylase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Castaing, B~~]]	+	[[Category: Synthetic construct]]
-	[[Category: ~~Coste, F~~]]	+	[[Category: Castaing B]]
-	[[Category: ~~Dna glycosylase]]~~	+	[[Category: Coste F]]
-	~~[[Category: Hydrolase-dna complex]]~~	+
-	~~[[Category: Thf~~]]	+

OCA at 08:03, 17 April 2019

OCA — Wed, 17 Apr 2019 08:03:36 GMT

←Older revision		Revision as of 08:03, 17 April 2019
Line 1:		Line 1:

	==Crystal structure of a complex between R247G LlFPG mutant and a THF containing DNA==		==Crystal structure of a complex between R247G LlFPG mutant and a THF containing DNA==
-	<StructureSection load='4pcz' size='340' side='right' caption='[[4pcz]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='4pcz' size='340' side='right'caption='[[4pcz]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4pcz]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PCZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PCZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4pcz]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"streptococcus_hollandicus"_scholl_1891 "streptococcus hollandicus" scholl 1891]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PCZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PCZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=3DR:1,2-DIDEOXYRIBOFURANOSE-5-PHOSPHATE'>3DR</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=3DR:1,2-DIDEOXYRIBOFURANOSE-5-PHOSPHATE'>3DR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pd2\|4pd2]], [[4pdg\|4pdg]], [[4pdi\|4pdi]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pd2\|4pd2]], [[4pdg\|4pdg]], [[4pdi\|4pdi]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">mutM, fpg ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1359 "Streptococcus hollandicus" Scholl 1891])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-formamidopyrimidine_glycosylase DNA-formamidopyrimidine glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.23 3.2.2.23] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-formamidopyrimidine_glycosylase DNA-formamidopyrimidine glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.23 3.2.2.23] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pcz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pcz OCA], [http://pdbe.org/4pcz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pcz RCSB], [http://www.ebi.ac.uk/pdbsum/4pcz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pcz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pcz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pcz OCA], [http://pdbe.org/4pcz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pcz RCSB], [http://www.ebi.ac.uk/pdbsum/4pcz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pcz ProSAT]</span></td></tr>
Line 21:		Line 22:
	</div>		</div>
	<div class="pdbe-citations 4pcz" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4pcz" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[DNA glycosylase\|DNA glycosylase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Streptococcus hollandicus scholl 1891]]
	[[Category: DNA-formamidopyrimidine glycosylase]]		[[Category: DNA-formamidopyrimidine glycosylase]]
		+	[[Category: Large Structures]]
	[[Category: Castaing, B]]		[[Category: Castaing, B]]
	[[Category: Coste, F]]		[[Category: Coste, F]]

OCA at 17:08, 4 January 2017

OCA — Wed, 04 Jan 2017 17:08:18 GMT

←Older revision		Revision as of 17:08, 4 January 2017
Line 1:		Line 1:
		+
	==Crystal structure of a complex between R247G LlFPG mutant and a THF containing DNA==		==Crystal structure of a complex between R247G LlFPG mutant and a THF containing DNA==
	<StructureSection load='4pcz' size='340' side='right' caption='[[4pcz]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='4pcz' size='340' side='right' caption='[[4pcz]], [[Resolution\|resolution]] 1.70Å' scene=''>
Line 7:		Line 8:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pd2\|4pd2]], [[4pdg\|4pdg]], [[4pdi\|4pdi]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pd2\|4pd2]], [[4pdg\|4pdg]], [[4pdi\|4pdi]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-formamidopyrimidine_glycosylase DNA-formamidopyrimidine glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.23 3.2.2.23] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-formamidopyrimidine_glycosylase DNA-formamidopyrimidine glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.23 3.2.2.23] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pcz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pcz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pcz RCSB], [http://www.ebi.ac.uk/pdbsum/4pcz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pcz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pcz OCA], [http://pdbe.org/4pcz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pcz RCSB], [http://www.ebi.ac.uk/pdbsum/4pcz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pcz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4pcz" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:08, 1 April 2015

OCA — Wed, 01 Apr 2015 13:08:15 GMT

←Older revision		Revision as of 13:08, 1 April 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of a complex between R247G LlFPG mutant and a THF containing DNA==
		+	<StructureSection load='4pcz' size='340' side='right' caption='[[4pcz]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4pcz]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PCZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PCZ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=3DR:1,2-DIDEOXYRIBOFURANOSE-5-PHOSPHATE'>3DR</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pd2\|4pd2]], [[4pdg\|4pdg]], [[4pdi\|4pdi]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-formamidopyrimidine_glycosylase DNA-formamidopyrimidine glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.23 3.2.2.23] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pcz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pcz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pcz RCSB], [http://www.ebi.ac.uk/pdbsum/4pcz PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FPG_LACLC FPG_LACLC]] Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.<ref>PMID:7704272</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	DNA glycosylases from the Fpg/Nei structural superfamily are base excision repair enzymes involved in the removal of a wide variety of mutagen and potentially lethal oxidized purines and pyrimidines. Although involved in genome stability, the recent discovery of synthetic lethal relationships between DNA glycosylases and other pathways highlights the potential of DNA glycosylase inhibitors for future medicinal chemistry development in cancer therapy. By combining biochemical and structural approaches, the physical target of 2-thioxanthine (2TX), an uncompetitive inhibitor of Fpg, was identified. 2TX interacts with the zinc finger (ZnF) DNA binding domain of the enzyme. This explains why the zincless hNEIL1 enzyme is resistant to 2TX. Crystal structures of the enzyme bound to DNA in the presence of 2TX demonstrate that the inhibitor chemically reacts with cysteine thiolates of ZnF and induces the loss of zinc. The molecular mechanism by which 2TX inhibits Fpg may be generalized to all prokaryote and eukaryote ZnF-containing Fpg/Nei-DNA glycosylases. Cell experiments show that 2TX can operate in cellulo on the human Fpg/Nei DNA glycosylases. The atomic elucidation of the determinants for the interaction of 2TX to Fpg provides the foundation for the future design and synthesis of new inhibitors with high efficiency and selectivity.

-	~~The entry 4pcz is ON HOLD until Paper Publication~~	+	Zinc finger oxidation of Fpg/Nei DNA glycosylases by 2-thioxanthine: biochemical and X-ray structural characterization.,Biela A, Coste F, Culard F, Guerin M, Goffinont S, Gasteiger K, Ciesla J, Winczura A, Kazimierczuk Z, Gasparutto D, Carell T, Tudek B, Castaing B Nucleic Acids Res. 2014;42(16):10748-61. doi: 10.1093/nar/gku613. Epub 2014 Aug, 20. PMID:25143530<ref>PMID:25143530</ref>

-	~~Authors: Coste~~, F.~~, Castaing, B~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: Crystal structure of a complex between R247G LlFPG mutant and a THF containing DNA~~	+	== References ==
-	[[Category: ~~Unreleased Structures~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: DNA-formamidopyrimidine glycosylase]]
	[[Category: Castaing, B]]		[[Category: Castaing, B]]
	[[Category: Coste, F]]		[[Category: Coste, F]]
		+	[[Category: Dna glycosylase]]
		+	[[Category: Hydrolase-dna complex]]
		+	[[Category: Thf]]

OCA at 14:56, 24 December 2014

OCA — Wed, 24 Dec 2014 14:56:44 GMT

←Older revision		Revision as of 14:56, 24 December 2014
Line 6:		Line 6:

	Description: Crystal structure of a complex between R247G LlFPG mutant and a THF containing DNA		Description: Crystal structure of a complex between R247G LlFPG mutant and a THF containing DNA
		+	[[Category: Unreleased Structures]]
		+	[[Category: Castaing, B]]
		+	[[Category: Coste, F]]

OCA at 06:29, 30 April 2014

OCA — Wed, 30 Apr 2014 06:29:18 GMT

←Older revision		Revision as of 06:29, 30 April 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4pcz is ON HOLD	+	The entry 4pcz is ON HOLD until Paper Publication

	Authors: Coste, F., Castaing, B.		Authors: Coste, F., Castaing, B.

	Description: Crystal structure of a complex between R247G LlFPG mutant and a THF containing DNA		Description: Crystal structure of a complex between R247G LlFPG mutant and a THF containing DNA

OCA: Protected "4pcz" [edit=sysop:move=sysop]

OCA — Wed, 23 Apr 2014 07:26:24 GMT

Protected "4pcz" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:26, 23 April 2014

OCA: New page: '''Unreleased structure''' The entry 4pcz is ON HOLD Authors: Coste, F., Castaing, B. Description: Crystal structure of a complex between R247G LlFPG mutant and a THF containing DNA

OCA — Wed, 23 Apr 2014 07:26:23 GMT

New page: '''Unreleased structure''' The entry 4pcz is ON HOLD Authors: Coste, F., Castaing, B. Description: Crystal structure of a complex between R247G LlFPG mutant and a THF containing DNA

New page

'''Unreleased structure'''

The entry 4pcz is ON HOLD

Authors: Coste, F., Castaing, B.

Description: Crystal structure of a complex between R247G LlFPG mutant and a THF containing DNA