4pfu - Revision history

OCA at 00:43, 28 December 2023

OCA — Thu, 28 Dec 2023 00:43:22 GMT

←Older revision		Revision as of 00:43, 28 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4pfu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima_MSB8 Thermotoga maritima MSB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PFU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PFU FirstGlance]. <br>		<table><tr><td colspan='2'>[[4pfu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima_MSB8 Thermotoga maritima MSB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PFU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PFU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PRD_900115:4beta-beta-mannobiose'>PRD_900115</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.049Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PRD_900115:4beta-beta-mannobiose'>PRD_900115</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pfu OCA], [https://pdbe.org/4pfu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pfu RCSB], [https://www.ebi.ac.uk/pdbsum/4pfu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pfu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pfu OCA], [https://pdbe.org/4pfu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pfu RCSB], [https://www.ebi.ac.uk/pdbsum/4pfu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pfu ProSAT]</span></td></tr>
	</table>		</table>

OCA at 13:00, 1 February 2023

OCA — Wed, 01 Feb 2023 13:00:23 GMT

←Older revision		Revision as of 13:00, 1 February 2023
Line 3:		Line 3:
	<StructureSection load='4pfu' size='340' side='right'caption='[[4pfu]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='4pfu' size='340' side='right'caption='[[4pfu]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4pfu]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Thema Thema~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PFU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4PFU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4pfu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima_MSB8 Thermotoga maritima MSB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PFU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PFU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~MAB~~:~~MANNOBIOSE~~'>~~MAB~~</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=~~SO4~~:~~SULFATE+ION~~'>~~SO4~~</scene><~~/td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PRD_900115:4beta-beta-mannobiose'>PRD_900115</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat">[[4pft\|4pft]], [[4pfw\|4pfw]], [[4pfy\|4pfy]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pfu OCA], [https://pdbe.org/4pfu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pfu RCSB], [https://www.ebi.ac.uk/pdbsum/4pfu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pfu ProSAT]</span></td></tr>
-	~~<tr id='gene~~'>~~<td class="sblockLbl"><b>[[Gene\|Gene:]]~~</b>~~</td><td class="sblockDat">THEMA_08200, Tmari_1233 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243274 THEMA])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4pfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pfu OCA], [~~http~~://pdbe.org/4pfu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4pfu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4pfu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4pfu ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/G4FEC0_THEMA G4FEC0_THEMA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Thema~~]]	+	[[Category: Thermotoga maritima MSB8]]
-	[[Category: Cuneo~~, M J~~]]	+	[[Category: Cuneo MJ]]
-	[[Category: Ghimire-Rijal, S]]	+	[[Category: Ghimire-Rijal S]]
-	[[Category: Lu, X]]	+	[[Category: Lu X]]
-	~~[[Category: Oligopeptide abc transporter]]~~	+
-	~~[[Category: Periplasmic oligopeptide-binding protein]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 08:34, 4 December 2019

OCA — Wed, 04 Dec 2019 08:34:58 GMT

←Older revision		Revision as of 08:34, 4 December 2019
Line 1:		Line 1:

	==Crystal structure of mannobiose bound oligopeptide ABC transporter, periplasmic oligopeptide-binding protein (TM1226) from THERMOTOGA MARITIMA at 2.05 A resolution==		==Crystal structure of mannobiose bound oligopeptide ABC transporter, periplasmic oligopeptide-binding protein (TM1226) from THERMOTOGA MARITIMA at 2.05 A resolution==
-	<StructureSection load='4pfu' size='340' side='right' caption='[[4pfu]], [[Resolution\|resolution]] 2.05Å' scene=''>	+	<StructureSection load='4pfu' size='340' side='right'caption='[[4pfu]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4pfu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thema Thema]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PFU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PFU FirstGlance]. <br>		<table><tr><td colspan='2'>[[4pfu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thema Thema]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PFU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PFU FirstGlance]. <br>
Line 22:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Thema]]		[[Category: Thema]]
	[[Category: Cuneo, M J]]		[[Category: Cuneo, M J]]

OCA at 11:59, 6 November 2017

OCA — Mon, 06 Nov 2017 11:59:38 GMT

←Older revision		Revision as of 11:59, 6 November 2017
Line 3:		Line 3:
	<StructureSection load='4pfu' size='340' side='right' caption='[[4pfu]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='4pfu' size='340' side='right' caption='[[4pfu]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4pfu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PFU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PFU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4pfu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thema Thema]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PFU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PFU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAB:MANNOBIOSE'>MAB</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAB:MANNOBIOSE'>MAB</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pft\|4pft]], [[4pfw\|4pfw]], [[4pfy\|4pfy]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pft\|4pft]], [[4pfw\|4pfw]], [[4pfy\|4pfy]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">THEMA_08200, Tmari_1233 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243274 THEMA])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pfu OCA], [http://pdbe.org/4pfu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pfu RCSB], [http://www.ebi.ac.uk/pdbsum/4pfu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pfu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pfu OCA], [http://pdbe.org/4pfu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pfu RCSB], [http://www.ebi.ac.uk/pdbsum/4pfu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pfu ProSAT]</span></td></tr>
	</table>		</table>
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Thema]]
	[[Category: Cuneo, M J]]		[[Category: Cuneo, M J]]
	[[Category: Ghimire-Rijal, S]]		[[Category: Ghimire-Rijal, S]]

OCA at 17:00, 4 January 2017

OCA — Wed, 04 Jan 2017 17:00:13 GMT

←Older revision		Revision as of 17:00, 4 January 2017
Line 1:		Line 1:
		+
	==Crystal structure of mannobiose bound oligopeptide ABC transporter, periplasmic oligopeptide-binding protein (TM1226) from THERMOTOGA MARITIMA at 2.05 A resolution==		==Crystal structure of mannobiose bound oligopeptide ABC transporter, periplasmic oligopeptide-binding protein (TM1226) from THERMOTOGA MARITIMA at 2.05 A resolution==
	<StructureSection load='4pfu' size='340' side='right' caption='[[4pfu]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='4pfu' size='340' side='right' caption='[[4pfu]], [[Resolution\|resolution]] 2.05Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAB:MANNOBIOSE'>MAB</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAB:MANNOBIOSE'>MAB</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pft\|4pft]], [[4pfw\|4pfw]], [[4pfy\|4pfy]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pft\|4pft]], [[4pfw\|4pfw]], [[4pfy\|4pfy]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pfu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pfu RCSB], [http://www.ebi.ac.uk/pdbsum/4pfu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pfu OCA], [http://pdbe.org/4pfu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pfu RCSB], [http://www.ebi.ac.uk/pdbsum/4pfu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pfu ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4pfu" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:30, 25 January 2015

OCA — Sun, 25 Jan 2015 10:30:29 GMT

←Older revision		Revision as of 10:30, 25 January 2015
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Cuneo, M J.]]	+	[[Category: Cuneo, M J]]
-	[[Category: Ghimire-Rijal, S.]]	+	[[Category: Ghimire-Rijal, S]]
-	[[Category: Lu, X.]]	+	[[Category: Lu, X]]
	[[Category: Oligopeptide abc transporter]]		[[Category: Oligopeptide abc transporter]]
	[[Category: Periplasmic oligopeptide-binding protein]]		[[Category: Periplasmic oligopeptide-binding protein]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA at 06:43, 5 November 2014

OCA — Wed, 05 Nov 2014 06:43:37 GMT

←Older revision		Revision as of 06:43, 5 November 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4pfu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PFU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PFU FirstGlance]. <br>		<table><tr><td colspan='2'>[[4pfu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PFU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PFU FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAB:MANNOBIOSE'>MAB</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAB:MANNOBIOSE'>MAB</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pft\|4pft]], [[4pfw\|4pfw]], [[4pfy\|4pfy]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pft\|4pft]], [[4pfw\|4pfw]], [[4pfy\|4pfy]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pfu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pfu RCSB], [http://www.ebi.ac.uk/pdbsum/4pfu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pfu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pfu RCSB], [http://www.ebi.ac.uk/pdbsum/4pfu PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 06:27, 24 September 2014

OCA — Wed, 24 Sep 2014 06:27:38 GMT

←Older revision		Revision as of 06:27, 24 September 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of mannobiose bound oligopeptide ABC transporter, periplasmic oligopeptide-binding protein (TM1226) from THERMOTOGA MARITIMA at 2.05 A resolution==
		+	<StructureSection load='4pfu' size='340' side='right' caption='[[4pfu]], [[Resolution\|resolution]] 2.05Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4pfu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PFU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PFU FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAB:MANNOBIOSE'>MAB</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pft\|4pft]], [[4pfw\|4pfw]], [[4pfy\|4pfy]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pfu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pfu RCSB], [http://www.ebi.ac.uk/pdbsum/4pfu PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Many bacteria exist in a state of feast or famine where high nutrient availability leads to periods of growth followed by nutrient scarcity and growth stagnation. To adapt to the constantly changing nutrient flux, metabolite acquisition systems must be able to function over a broad range. This however creates difficulties as nutrient concentrations vary over many orders of magnitude, requiring metabolite acquisition systems to simultaneously balance ligand specificity and the dynamic range in which a response to a metabolite is elicited. Here we present how a gene duplication of a periplasmic binding protein (PBP) in a mannose ABC transport system potentially resolves this dilemma through gene functionalization. Determination of ligand binding affinities and specificities of the gene duplicates with fluorescence and circular dichroism demonstrate that although the binding specificity is maintained the Kd values for the same ligand differ over three orders of magnitude. These results suggest this metabolite acquisition system can transport ligand at both low and high environmental concentrations while preventing saturation with related and less preferentially metabolized compounds. The X-ray crystal structures of the beta mannose bound proteins help clarify the structural basis of gene functionalization and reveal that affinity and specificity are potentially encoded in different regions of the binding site. These studies suggest a possible functional role and adaptive advantage for the presence of two PBPs in ABC transport systems and a way bacteria can adapt to varying nutrient flux through functionalization of gene duplicates.

-	~~The entry 4pfu is ON HOLD~~	+	Duplication of genes in an ATP binding cassette transport system increases dynamic range while maintaining ligand specificity.,Ghimire-Rijal S, Lu X, Myles DA, Cuneo MJ J Biol Chem. 2014 Sep 10. pii: jbc.M114.590992. PMID:25210043<ref>PMID:25210043</ref>

-	~~Authors: Lu~~, X., Ghimire-Rijal, S., ~~Cuneo, M.J~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal structure of mannobiose bound oligopeptide ABC transporter, periplasmic~~ oligopeptide-binding protein ~~(TM1226) from THERMOTOGA MARITIMA at 2.05 A resolution~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Cuneo, M J.]]
		+	[[Category: Ghimire-Rijal, S.]]
		+	[[Category: Lu, X.]]
		+	[[Category: Oligopeptide abc transporter]]
		+	[[Category: Periplasmic oligopeptide-binding protein]]
		+	[[Category: Transport protein]]

OCA: Protected "4pfu" [edit=sysop:move=sysop]

OCA — Wed, 07 May 2014 07:44:45 GMT

Protected "4pfu" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:44, 7 May 2014

OCA: New page: '''Unreleased structure''' The entry 4pfu is ON HOLD Authors: Lu, X., Ghimire-Rijal, S., Cuneo, M.J. Description: Crystal structure of mannobiose bound oligopeptide ABC transporter, pe...

OCA — Wed, 07 May 2014 07:44:44 GMT

New page: '''Unreleased structure''' The entry 4pfu is ON HOLD Authors: Lu, X., Ghimire-Rijal, S., Cuneo, M.J. Description: Crystal structure of mannobiose bound oligopeptide ABC transporter, pe...

New page

'''Unreleased structure'''

The entry 4pfu is ON HOLD

Authors: Lu, X., Ghimire-Rijal, S., Cuneo, M.J.

Description: Crystal structure of mannobiose bound oligopeptide ABC transporter, periplasmic oligopeptide-binding protein (TM1226) from THERMOTOGA MARITIMA at 2.05 A resolution