4ph9 - Revision history

OCA at 07:17, 27 September 2023

OCA — Wed, 27 Sep 2023 07:17:03 GMT

←Older revision		Revision as of 07:17, 27 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ph9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PH9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PH9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ph9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PH9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PH9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKR:ACRYLIC+ACID'>AKR</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=IBP:IBUPROFEN'>IBP</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.81Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKR:ACRYLIC+ACID'>AKR</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=IBP:IBUPROFEN'>IBP</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ph9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ph9 OCA], [https://pdbe.org/4ph9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ph9 RCSB], [https://www.ebi.ac.uk/pdbsum/4ph9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ph9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ph9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ph9 OCA], [https://pdbe.org/4ph9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ph9 RCSB], [https://www.ebi.ac.uk/pdbsum/4ph9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ph9 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 13:02, 1 February 2023

OCA — Wed, 01 Feb 2023 13:02:31 GMT

←Older revision		Revision as of 13:02, 1 February 2023
Line 3:		Line 3:
	<StructureSection load='4ph9' size='340' side='right'caption='[[4ph9]], [[Resolution\|resolution]] 1.81Å' scene=''>		<StructureSection load='4ph9' size='340' side='right'caption='[[4ph9]], [[Resolution\|resolution]] 1.81Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ph9]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PH9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4PH9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ph9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PH9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PH9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AKR:ACRYLIC+ACID'>AKR</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=IBP:IBUPROFEN'>IBP</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKR:ACRYLIC+ACID'>AKR</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=IBP:IBUPROFEN'>IBP</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qmo\|3qmo]], [[1eqg\|1eqg]], [[3hs5\|3hs5]], [[3nt1\|3nt1]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ph9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ph9 OCA], [https://pdbe.org/4ph9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ph9 RCSB], [https://www.ebi.ac.uk/pdbsum/4ph9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ph9 ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ptgs2, Cox-2, Cox2, Pghs-b, Tis10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4ph9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ph9 OCA], [~~http~~://pdbe.org/4ph9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4ph9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4ph9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4ph9 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PGH2_MOUSE PGH2_MOUSE]] Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.<ref>PMID:12925531</ref> <ref>PMID:20463020</ref> <ref>PMID:20810665</ref> <ref>PMID:21489986</ref>	+	[https://www.uniprot.org/uniprot/PGH2_MOUSE PGH2_MOUSE] Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.<ref>PMID:12925531</ref> <ref>PMID:20463020</ref> <ref>PMID:20810665</ref> <ref>PMID:21489986</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice]]~~	+	[[Category: Mus musculus]]
-	~~[[Category: Prostaglandin-endoperoxide synthase~~]]	+	[[Category: Lucido MJ]]
-	[[Category: Lucido~~, M J~~]]	+	[[Category: Malkowski MG]]
-	[[Category: Malkowski~~, M G~~]]	+	[[Category: Orlando BJ]]
-	[[Category: Orlando~~, B J]]~~	+
-	~~[[Category: Cox]]~~	+
-	~~[[Category: Cox-2]]~~	+
-	~~[[Category: Cyclooxygenase]]~~	+
-	~~[[Category: Ibuprofen]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Monotopic]]~~	+
-	~~[[Category: Nsaid]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Prostaglandin~~]]	+

OCA at 10:13, 25 December 2019

OCA — Wed, 25 Dec 2019 10:13:25 GMT

←Older revision		Revision as of 10:13, 25 December 2019
Line 1:		Line 1:

	==The structure of Ibuprofen bound to cyclooxygenase-2==		==The structure of Ibuprofen bound to cyclooxygenase-2==
-	<StructureSection load='4ph9' size='340' side='right' caption='[[4ph9]], [[Resolution\|resolution]] 1.81Å' scene=''>	+	<StructureSection load='4ph9' size='340' side='right'caption='[[4ph9]], [[Resolution\|resolution]] 1.81Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4ph9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PH9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PH9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4ph9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PH9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PH9 FirstGlance]. <br>
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 4ph9" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4ph9" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cyclooxygenase 3D structures\|Cyclooxygenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Prostaglandin-endoperoxide synthase]]		[[Category: Prostaglandin-endoperoxide synthase]]

OCA at 08:40, 22 November 2017

OCA — Wed, 22 Nov 2017 08:40:44 GMT

←Older revision		Revision as of 08:40, 22 November 2017
Line 3:		Line 3:
	<StructureSection load='4ph9' size='340' side='right' caption='[[4ph9]], [[Resolution\|resolution]] 1.81Å' scene=''>		<StructureSection load='4ph9' size='340' side='right' caption='[[4ph9]], [[Resolution\|resolution]] 1.81Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4ph9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PH9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PH9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4ph9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PH9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PH9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AKR:ACRYLIC+ACID'>AKR</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=IBP:IBUPROFEN'>IBP</scene>, <scene name='pdbligand=~~NAG~~:~~N-ACETYL~~-D-~~GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=~~MAN~~:~~ALPHA~~-D-~~MANNOSE~~'>~~MAN~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AKR:ACRYLIC+ACID'>AKR</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=IBP:IBUPROFEN'>IBP</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qmo\|3qmo]], [[1eqg\|1eqg]], [[3hs5\|3hs5]], [[3nt1\|3nt1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qmo\|3qmo]], [[1eqg\|1eqg]], [[3hs5\|3hs5]], [[3nt1\|3nt1]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ptgs2, Cox-2, Cox2, Pghs-b, Tis10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ph9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ph9 OCA], [http://pdbe.org/4ph9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ph9 RCSB], [http://www.ebi.ac.uk/pdbsum/4ph9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ph9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ph9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ph9 OCA], [http://pdbe.org/4ph9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ph9 RCSB], [http://www.ebi.ac.uk/pdbsum/4ph9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ph9 ProSAT]</span></td></tr>
Line 24:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Prostaglandin-endoperoxide synthase]]		[[Category: Prostaglandin-endoperoxide synthase]]
	[[Category: Lucido, M J]]		[[Category: Lucido, M J]]

OCA at 17:14, 4 January 2017

OCA — Wed, 04 Jan 2017 17:14:15 GMT

←Older revision		Revision as of 17:14, 4 January 2017
Line 1:		Line 1:
		+
	==The structure of Ibuprofen bound to cyclooxygenase-2==		==The structure of Ibuprofen bound to cyclooxygenase-2==
	<StructureSection load='4ph9' size='340' side='right' caption='[[4ph9]], [[Resolution\|resolution]] 1.81Å' scene=''>		<StructureSection load='4ph9' size='340' side='right' caption='[[4ph9]], [[Resolution\|resolution]] 1.81Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qmo\|3qmo]], [[1eqg\|1eqg]], [[3hs5\|3hs5]], [[3nt1\|3nt1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qmo\|3qmo]], [[1eqg\|1eqg]], [[3hs5\|3hs5]], [[3nt1\|3nt1]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ph9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ph9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ph9 RCSB], [http://www.ebi.ac.uk/pdbsum/4ph9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ph9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ph9 OCA], [http://pdbe.org/4ph9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ph9 RCSB], [http://www.ebi.ac.uk/pdbsum/4ph9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ph9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4ph9" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:48, 25 December 2014

OCA — Thu, 25 Dec 2014 15:48:11 GMT

←Older revision		Revision as of 15:48, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ph9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ph9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ph9 RCSB], [http://www.ebi.ac.uk/pdbsum/4ph9 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ph9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ph9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ph9 RCSB], [http://www.ebi.ac.uk/pdbsum/4ph9 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PGH2_MOUSE PGH2_MOUSE]] Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.<ref>PMID:12925531</ref> <ref>PMID:20463020</ref> <ref>PMID:20810665</ref> <ref>PMID:21489986</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 10:13, 17 December 2014

OCA — Wed, 17 Dec 2014 10:13:34 GMT

←Older revision		Revision as of 10:13, 17 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ph9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ph9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ph9 RCSB], [http://www.ebi.ac.uk/pdbsum/4ph9 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ph9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ph9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ph9 RCSB], [http://www.ebi.ac.uk/pdbsum/4ph9 PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The cyclooxygenases (COX-1 and COX-2) catalyze the rate-limiting step in the biosynthesis of prostaglandins, and are the pharmacological targets of non-steroidal anti-inflammatory drugs (NSAIDs) and COX-2 selective inhibitors (coxibs). Ibuprofen (IBP) is one of the most commonly available over-the-counter pharmaceuticals in the world. The anti-inflammatory and analgesic properties of IBP are thought to arise from inhibition of COX-2 rather than COX-1. While an X-ray crystal structure of IBP bound to COX-1 has been solved, no such structure exists for the cognate isoform COX-2. We have determined the crystal structure of muCOX-2 with a racemic mixture of (R/S)-IBP. Our structure reveals that only the S-isomer of IBP was bound, indicating that the S-isomer possesses higher affinity for COX-2 than the R-isomer. Mutational analysis of Arg-120 and Tyr-355 at the entrance of the cyclooxygenase channel confirmed their role in binding and inhibition of COX-2 by IBP. Our results provide the first atomic level detail of the interaction between IBP and COX-2.
		+
		+	The structure of ibuprofen bound to cyclooxygenase-2.,Orlando BJ, Lucido MJ, Malkowski MG J Struct Biol. 2014 Nov 25. pii: S1047-8477(14)00243-3. doi:, 10.1016/j.jsb.2014.11.005. PMID:25463020<ref>PMID:25463020</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:12, 26 November 2014

OCA — Wed, 26 Nov 2014 08:12:26 GMT

←Older revision		Revision as of 08:12, 26 November 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==The structure of Ibuprofen bound to cyclooxygenase-2==
-		+	<StructureSection load='4ph9' size='340' side='right' caption='[[4ph9]], [[Resolution\|resolution]] 1.81Å' scene=''>
-	~~The entry~~ 4ph9 is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4ph9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PH9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PH9 FirstGlance]. <br>
-	~~Authors~~: ~~Orlando~~, B.J., ~~Lucido~~, M.J., Malkowski, M.G.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AKR:ACRYLIC+ACID'>AKR</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=IBP:IBUPROFEN'>IBP</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3qmo\|3qmo]], [[1eqg\|1eqg]], [[3hs5\|3hs5]], [[3nt1\|3nt1]]</td></tr>
-	~~Description~~:	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ph9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ph9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ph9 RCSB], [http://www.ebi.ac.uk/pdbsum/4ph9 PDBsum]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Prostaglandin-endoperoxide synthase]]
		+	[[Category: Lucido, M J]]
		+	[[Category: Malkowski, M G]]
		+	[[Category: Orlando, B J]]
		+	[[Category: Cox]]
		+	[[Category: Cox-2]]
		+	[[Category: Cyclooxygenase]]
		+	[[Category: Ibuprofen]]
		+	[[Category: Membrane protein]]
		+	[[Category: Monotopic]]
		+	[[Category: Nsaid]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Prostaglandin]]

OCA at 09:23, 22 October 2014

OCA — Wed, 22 Oct 2014 09:23:29 GMT

←Older revision		Revision as of 09:23, 22 October 2014
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4ph9 is ON HOLD	+	The entry 4ph9 is ON HOLD until Paper Publication

	Authors: Orlando, B.J., Lucido, M.J., Malkowski, M.G.		Authors: Orlando, B.J., Lucido, M.J., Malkowski, M.G.

	Description:		Description:

OCA: Protected "4ph9" [edit=sysop:move=sysop]

OCA — Wed, 14 May 2014 07:08:11 GMT

Protected "4ph9" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:08, 14 May 2014