4pji - Revision history

OCA at 00:44, 28 December 2023

OCA — Thu, 28 Dec 2023 00:44:47 GMT

←Older revision		Revision as of 00:44, 28 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4pji]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PJI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PJI FirstGlance]. <br>		<table><tr><td colspan='2'>[[4pji]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PJI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PJI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=30W:N-(6-FORMYL-4-OXO-3,4-DIHYDROPTERIDIN-2-YL)ACETAMIDE'>30W</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=30W:N-(6-FORMYL-4-OXO-3,4-DIHYDROPTERIDIN-2-YL)ACETAMIDE'>30W</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pji OCA], [https://pdbe.org/4pji PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pji RCSB], [https://www.ebi.ac.uk/pdbsum/4pji PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pji ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pji OCA], [https://pdbe.org/4pji PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pji RCSB], [https://www.ebi.ac.uk/pdbsum/4pji PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pji ProSAT]</span></td></tr>
	</table>		</table>

OCA at 13:08, 1 February 2023

OCA — Wed, 01 Feb 2023 13:08:29 GMT

←Older revision		Revision as of 13:08, 1 February 2023
Line 3:		Line 3:
	<StructureSection load='4pji' size='340' side='right'caption='[[4pji]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='4pji' size='340' side='right'caption='[[4pji]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4pji]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PJI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4PJI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4pji]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PJI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PJI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=30W:N-(6-FORMYL-4-OXO-3,4-DIHYDROPTERIDIN-2-YL)ACETAMIDE'>30W</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=30W:N-(6-FORMYL-4-OXO-3,4-DIHYDROPTERIDIN-2-YL)ACETAMIDE'>30W</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4l4t\|4l4t]], [[4nqc\|4nqc]], [[4pj5\|4pj5]], [[4pj7\|4pj7]], [[4pj8\|4pj8]], [[4pj9\|4pj9]], [[4pja\|4pja]], [[4pjb\|4pjb]], [[4pjc\|4pjc]], [[4pjd\|4pjd]], [[4pje\|4pje]], [[4pjf\|4pjf]], [[4pjg\|4pjg]], [[4pjh\|4pjh]], [[4pjx\|4pjx]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pji OCA], [https://pdbe.org/4pji PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pji RCSB], [https://www.ebi.ac.uk/pdbsum/4pji PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pji ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), B2M, CDABP0092, HDCMA22P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4pji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pji OCA], [~~http~~://pdbe.org/4pji PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4pji RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4pji PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4pji ProSAT]</span></td></tr>	+
	</table>		</table>
-	== Disease ==
-	[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/HMR1_HUMAN HMR1_HUMAN]] Has antigen presentation function. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT cells are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.<ref>PMID:12794138</ref> ~~[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.~~	+	[https://www.uniprot.org/uniprot/HMR1_HUMAN HMR1_HUMAN] Has antigen presentation function. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT cells are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.<ref>PMID:12794138</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 29:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Birkinshaw~~, R W~~]]	+	[[Category: Birkinshaw RW]]
-	[[Category: Rossjohn, J]]	+	[[Category: Rossjohn J]]
-	~~[[Category: Ac-6-fp]]~~	+
-	~~[[Category: Immune complex]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Mr1]]~~	+
-	~~[[Category: Tcr~~]]	+

OCA at 08:20, 17 April 2019

OCA — Wed, 17 Apr 2019 08:20:16 GMT

←Older revision		Revision as of 08:20, 17 April 2019
Line 1:		Line 1:

	==Structure of human MR1-Ac-6-FP in complex with human MAIT C-C10 TCR==		==Structure of human MR1-Ac-6-FP in complex with human MAIT C-C10 TCR==
-	<StructureSection load='4pji' size='340' side='right' caption='[[4pji]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='4pji' size='340' side='right'caption='[[4pji]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4pji]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PJI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PJI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4pji]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PJI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PJI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=30W:N-(6-FORMYL-4-OXO-3,4-DIHYDROPTERIDIN-2-YL)ACETAMIDE'>30W</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=30W:N-(6-FORMYL-4-OXO-3,4-DIHYDROPTERIDIN-2-YL)ACETAMIDE'>30W</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4l4t\|4l4t]], [[4nqc\|4nqc]], [[4pj5\|4pj5]], [[4pj7\|4pj7]], [[4pj8\|4pj8]], [[4pj9\|4pj9]], [[4pja\|4pja]], [[4pjb\|4pjb]], [[4pjc\|4pjc]], [[4pjd\|4pjd]], [[4pje\|4pje]], [[4pjf\|4pjf]], [[4pjg\|4pjg]], [[4pjh\|4pjh]], [[4pjx\|4pjx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4l4t\|4l4t]], [[4nqc\|4nqc]], [[4pj5\|4pj5]], [[4pj7\|4pj7]], [[4pj8\|4pj8]], [[4pj9\|4pj9]], [[4pja\|4pja]], [[4pjb\|4pjb]], [[4pjc\|4pjc]], [[4pjd\|4pjd]], [[4pje\|4pje]], [[4pjf\|4pjf]], [[4pjg\|4pjg]], [[4pjh\|4pjh]], [[4pjx\|4pjx]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), B2M, CDABP0092, HDCMA22P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pji OCA], [http://pdbe.org/4pji PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pji RCSB], [http://www.ebi.ac.uk/pdbsum/4pji PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pji ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pji OCA], [http://pdbe.org/4pji PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pji RCSB], [http://www.ebi.ac.uk/pdbsum/4pji PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pji ProSAT]</span></td></tr>
	</table>		</table>
Line 21:		Line 22:
	</div>		</div>
	<div class="pdbe-citations 4pji" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4pji" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Birkinshaw, R W]]		[[Category: Birkinshaw, R W]]
	[[Category: Rossjohn, J]]		[[Category: Rossjohn, J]]

OCA at 10:40, 11 August 2016

OCA — Thu, 11 Aug 2016 10:40:09 GMT

←Older revision		Revision as of 10:40, 11 August 2016
Line 1:		Line 1:
		+
	==Structure of human MR1-Ac-6-FP in complex with human MAIT C-C10 TCR==		==Structure of human MR1-Ac-6-FP in complex with human MAIT C-C10 TCR==
	<StructureSection load='4pji' size='340' side='right' caption='[[4pji]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='4pji' size='340' side='right' caption='[[4pji]], [[Resolution\|resolution]] 2.50Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=30W:N-(6-FORMYL-4-OXO-3,4-DIHYDROPTERIDIN-2-YL)ACETAMIDE'>30W</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=30W:N-(6-FORMYL-4-OXO-3,4-DIHYDROPTERIDIN-2-YL)ACETAMIDE'>30W</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4l4t\|4l4t]], [[4nqc\|4nqc]], [[4pj5\|4pj5]], [[4pj7\|4pj7]], [[4pj8\|4pj8]], [[4pj9\|4pj9]], [[4pja\|4pja]], [[4pjb\|4pjb]], [[4pjc\|4pjc]], [[4pjd\|4pjd]], [[4pje\|4pje]], [[4pjf\|4pjf]], [[4pjg\|4pjg]], [[4pjh\|4pjh]], [[4pjx\|4pjx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4l4t\|4l4t]], [[4nqc\|4nqc]], [[4pj5\|4pj5]], [[4pj7\|4pj7]], [[4pj8\|4pj8]], [[4pj9\|4pj9]], [[4pja\|4pja]], [[4pjb\|4pjb]], [[4pjc\|4pjc]], [[4pjd\|4pjd]], [[4pje\|4pje]], [[4pjf\|4pjf]], [[4pjg\|4pjg]], [[4pjh\|4pjh]], [[4pjx\|4pjx]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pji OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pji RCSB], [http://www.ebi.ac.uk/pdbsum/4pji PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pji OCA], [http://pdbe.org/4pji PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pji RCSB], [http://www.ebi.ac.uk/pdbsum/4pji PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pji ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4pji" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:55, 20 January 2015

OCA — Tue, 20 Jan 2015 11:55:01 GMT

←Older revision		Revision as of 11:55, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4pji]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PJI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PJI FirstGlance]. <br>		<table><tr><td colspan='2'>[[4pji]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PJI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PJI FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=30W:N-(6-FORMYL-4-OXO-3,4-DIHYDROPTERIDIN-2-YL)ACETAMIDE'>30W</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=30W:N-(6-FORMYL-4-OXO-3,4-DIHYDROPTERIDIN-2-YL)ACETAMIDE'>30W</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4l4t\|4l4t]], [[4nqc\|4nqc]], [[4pj5\|4pj5]], [[4pj7\|4pj7]], [[4pj8\|4pj8]], [[4pj9\|4pj9]], [[4pja\|4pja]], [[4pjb\|4pjb]], [[4pjc\|4pjc]], [[4pjd\|4pjd]], [[4pje\|4pje]], [[4pjf\|4pjf]], [[4pjg\|4pjg]], [[4pjh\|4pjh]], [[4pjx\|4pjx]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4l4t\|4l4t]], [[4nqc\|4nqc]], [[4pj5\|4pj5]], [[4pj7\|4pj7]], [[4pj8\|4pj8]], [[4pj9\|4pj9]], [[4pja\|4pja]], [[4pjb\|4pjb]], [[4pjc\|4pjc]], [[4pjd\|4pjd]], [[4pje\|4pje]], [[4pjf\|4pjf]], [[4pjg\|4pjg]], [[4pjh\|4pjh]], [[4pjx\|4pjx]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pji OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pji RCSB], [http://www.ebi.ac.uk/pdbsum/4pji PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pji OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pji RCSB], [http://www.ebi.ac.uk/pdbsum/4pji PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>		[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Birkinshaw, R W.]]	+	[[Category: Birkinshaw, R W]]
-	[[Category: Rossjohn, J.]]	+	[[Category: Rossjohn, J]]
	[[Category: Ac-6-fp]]		[[Category: Ac-6-fp]]
	[[Category: Immune complex]]		[[Category: Immune complex]]

OCA at 02:32, 7 August 2014

OCA — Thu, 07 Aug 2014 02:32:48 GMT

←Older revision		Revision as of 02:32, 7 August 2014
Line 11:		Line 11:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/HMR1_HUMAN HMR1_HUMAN]] Has antigen presentation function. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT cells are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.<ref>PMID:12794138</ref> [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.		[[http://www.uniprot.org/uniprot/HMR1_HUMAN HMR1_HUMAN]] Has antigen presentation function. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT cells are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.<ref>PMID:12794138</ref> [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mucosal-associated invariant T (MAIT) cells express an invariant T cell receptor (TCR) alpha-chain (TRAV1-2 joined to TRAJ33, TRAJ20, or TRAJ12 in humans), which pairs with an array of TCR beta-chains. MAIT TCRs can bind folate- and riboflavin-based metabolites restricted by the major histocompatibility complex (MHC)-related class I-like molecule, MR1. However, the impact of MAIT TCR and MR1-ligand heterogeneity on MAIT cell biology is unclear. We show how a previously uncharacterized MR1 ligand, acetyl-6-formylpterin (Ac-6-FP), markedly stabilized MR1, potently up-regulated MR1 cell surface expression, and inhibited MAIT cell activation. These enhanced properties of Ac-6-FP were attributable to structural alterations in MR1 that subsequently affected MAIT TCR recognition via conformational changes within the complementarity-determining region (CDR) 3beta loop. Analysis of seven TRBV6-1(+) MAIT TCRs demonstrated how CDR3beta hypervariability impacted on MAIT TCR recognition by altering TCR flexibility and contacts with MR1 and the Ag itself. Ternary structures of TRBV6-1, TRBV6-4, and TRBV20(+) MAIT TCRs in complex with MR1 bound to a potent riboflavin-based antigen (Ag) showed how variations in TRBV gene usage exclusively impacted on MR1 contacts within a consensus MAIT TCR-MR1 footprint. Moreover, differential TRAJ gene usage was readily accommodated within a conserved MAIT TCR-MR1-Ag docking mode. Collectively, MAIT TCR heterogeneity can fine-tune MR1 recognition in an Ag-dependent manner, thereby modulating MAIT cell recognition.
		+
		+	A molecular basis underpinning the T cell receptor heterogeneity of mucosal-associated invariant T cells.,Eckle SB, Birkinshaw RW, Kostenko L, Corbett AJ, McWilliam HE, Reantragoon R, Chen Z, Gherardin NA, Beddoe T, Liu L, Patel O, Meehan B, Fairlie DP, Villadangos JA, Godfrey DI, Kjer-Nielsen L, McCluskey J, Rossjohn J J Exp Med. 2014 Jul 28;211(8):1585-600. doi: 10.1084/jem.20140484. Epub 2014 Jul , 21. PMID:25049336<ref>PMID:25049336</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:50, 2 July 2014

OCA — Wed, 02 Jul 2014 08:50:54 GMT

←Older revision		Revision as of 08:50, 2 July 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Structure of human MR1-Ac-6-FP in complex with human MAIT C-C10 TCR==
-		+	<StructureSection load='4pji' size='340' side='right' caption='[[4pji]], [[Resolution\|resolution]] 2.50Å' scene=''>
-	~~The entry~~ 4pji is ~~ON HOLD~~ ~~until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4pji]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PJI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PJI FirstGlance]. <br>
-	~~Authors~~: Birkinshaw, R.W., Rossjohn, J.	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=30W:N-(6-FORMYL-4-OXO-3,4-DIHYDROPTERIDIN-2-YL)ACETAMIDE'>30W</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4l4t\|4l4t]], [[4nqc\|4nqc]], [[4pj5\|4pj5]], [[4pj7\|4pj7]], [[4pj8\|4pj8]], [[4pj9\|4pj9]], [[4pja\|4pja]], [[4pjb\|4pjb]], [[4pjc\|4pjc]], [[4pjd\|4pjd]], [[4pje\|4pje]], [[4pjf\|4pjf]], [[4pjg\|4pjg]], [[4pjh\|4pjh]], [[4pjx\|4pjx]]</td></tr>
-	~~Description~~:	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pji OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pji RCSB], [http://www.ebi.ac.uk/pdbsum/4pji PDBsum]</span></td></tr>
		+	<table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HMR1_HUMAN HMR1_HUMAN]] Has antigen presentation function. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT cells are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent.<ref>PMID:12794138</ref> [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Birkinshaw, R W.]]
		+	[[Category: Rossjohn, J.]]
		+	[[Category: Ac-6-fp]]
		+	[[Category: Immune complex]]
		+	[[Category: Immune system]]
		+	[[Category: Mr1]]
		+	[[Category: Tcr]]

OCA at 04:55, 4 June 2014

OCA — Wed, 04 Jun 2014 04:55:27 GMT

←Older revision		Revision as of 04:55, 4 June 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4pji is ON HOLD	+	The entry 4pji is ON HOLD until Paper Publication

-	Authors: Birkinshaw, R.W., Rossjohn, R.	+	Authors: Birkinshaw, R.W., Rossjohn, J.

	Description:		Description:

OCA: Protected "4pji" [edit=sysop:move=sysop]

OCA — Wed, 21 May 2014 08:06:13 GMT

Protected "4pji" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:06, 21 May 2014

OCA: New page: '''Unreleased structure''' The entry 4pji is ON HOLD Authors: Birkinshaw, R.W., Rossjohn, R. Description:

OCA — Wed, 21 May 2014 08:06:12 GMT

New page: '''Unreleased structure''' The entry 4pji is ON HOLD Authors: Birkinshaw, R.W., Rossjohn, R. Description:

New page

'''Unreleased structure'''

The entry 4pji is ON HOLD

Authors: Birkinshaw, R.W., Rossjohn, R.

Description: