4pk4 - Revision history

OCA at 12:23, 20 December 2023

OCA — Wed, 20 Dec 2023 12:23:37 GMT

←Older revision		Revision as of 12:23, 20 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4pk4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PK4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PK4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4pk4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PK4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PK4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.78Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pk4 OCA], [https://pdbe.org/4pk4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pk4 RCSB], [https://www.ebi.ac.uk/pdbsum/4pk4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pk4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pk4 OCA], [https://pdbe.org/4pk4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pk4 RCSB], [https://www.ebi.ac.uk/pdbsum/4pk4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pk4 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 13:09, 1 February 2023

OCA — Wed, 01 Feb 2023 13:09:31 GMT

←Older revision		Revision as of 13:09, 1 February 2023
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	<StructureSection load='4pk4' size='340' side='right'caption='[[4pk4]], [[Resolution\|resolution]] 2.78Å' scene=''>		<StructureSection load='4pk4' size='340' side='right'caption='[[4pk4]], [[Resolution\|resolution]] 2.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4pk4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PK4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4PK4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4pk4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PK4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PK4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pfo\|4pfo]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pk4 OCA], [https://pdbe.org/4pk4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pk4 RCSB], [https://www.ebi.ac.uk/pdbsum/4pk4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pk4 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4pk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pk4 OCA], [~~http~~://pdbe.org/4pk4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4pk4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4pk4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4pk4 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/F1RQI7_PIG F1RQI7_PIG]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 20:

	==See Also==		==See Also==
-	*[[Myosin\|Myosin]]	+	*[[Myosin 3D Structures\|Myosin 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 25:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Benisty, H]]	+	[[Category: Sus scrofa]]
-	[[Category: Houdusse, A]]	+	[[Category: Benisty H]]
-	[[Category: Isabet, T]]	+	[[Category: Houdusse A]]
-	[[Category: Llinas, P]]	+	[[Category: Isabet T]]
-	[[Category: Sweeney~~, H L]]~~	+	[[Category: Llinas P]]
-	~~[[Category: Motor domain]]~~	+	[[Category: Sweeney HL]]
-	~~[[Category: Motor protein]]~~	+
-	~~[[Category: Pre powerstroke state~~]]	+

OCA at 23:23, 5 June 2019

OCA — Wed, 05 Jun 2019 23:23:29 GMT

←Older revision		Revision as of 23:23, 5 June 2019
Line 1:		Line 1:

	==Myosin VI motor domain in the PPS state - from a Pi release state crystal, space group P212121 after long soaking with PO4==		==Myosin VI motor domain in the PPS state - from a Pi release state crystal, space group P212121 after long soaking with PO4==
-	<StructureSection load='4pk4' size='340' side='right' caption='[[4pk4]], [[Resolution\|resolution]] 2.78Å' scene=''>	+	<StructureSection load='4pk4' size='340' side='right'caption='[[4pk4]], [[Resolution\|resolution]] 2.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4pk4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PK4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PK4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4pk4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PK4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PK4 FirstGlance]. <br>
Line 24:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Benisty, H]]		[[Category: Benisty, H]]
	[[Category: Houdusse, A]]		[[Category: Houdusse, A]]

OCA at 03:53, 30 August 2017

OCA — Wed, 30 Aug 2017 03:53:26 GMT

←Older revision		Revision as of 03:53, 30 August 2017
Line 6:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pfo\|4pfo]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pfo\|4pfo]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pk4 OCA], [http://pdbe.org/4pk4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pk4 RCSB], [http://www.ebi.ac.uk/pdbsum/4pk4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pk4 OCA], [http://pdbe.org/4pk4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pk4 RCSB], [http://www.ebi.ac.uk/pdbsum/4pk4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pk4 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 17:
	</div>		</div>
	<div class="pdbe-citations 4pk4" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4pk4" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Myosin\|Myosin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:48, 10 May 2016

OCA — Tue, 10 May 2016 15:48:30 GMT

←Older revision		Revision as of 15:48, 10 May 2016
Line 1:		Line 1:
		+
	==Myosin VI motor domain in the PPS state - from a Pi release state crystal, space group P212121 after long soaking with PO4==		==Myosin VI motor domain in the PPS state - from a Pi release state crystal, space group P212121 after long soaking with PO4==
	<StructureSection load='4pk4' size='340' side='right' caption='[[4pk4]], [[Resolution\|resolution]] 2.78Å' scene=''>		<StructureSection load='4pk4' size='340' side='right' caption='[[4pk4]], [[Resolution\|resolution]] 2.78Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pfo\|4pfo]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pfo\|4pfo]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pk4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pk4 RCSB], [http://www.ebi.ac.uk/pdbsum/4pk4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pk4 OCA], [http://pdbe.org/4pk4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pk4 RCSB], [http://www.ebi.ac.uk/pdbsum/4pk4 PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Fundamental to cellular processes are directional movements driven by molecular motors. A common theme for these and other molecular machines driven by ATP is that controlled release of hydrolysis products is essential for using the chemical energy efficiently. Mechanochemical transduction by myosin motors on actin is coupled to unknown structural changes that result in the sequential release of inorganic phosphate (Pi) and MgADP. We present here a myosin structure possessing an actin-binding interface and a tunnel (back door) that creates an escape route for Pi with a minimal rotation of the myosin lever arm that drives movements. We propose that this state represents the beginning of the powerstroke on actin and that Pi translocation from the nucleotide pocket triggered by actin binding initiates myosin force generation. This elucidates how actin initiates force generation and movement and may represent a strategy common to many molecular machines.
		+
		+	How actin initiates the motor activity of Myosin.,Llinas P, Isabet T, Song L, Ropars V, Zong B, Benisty H, Sirigu S, Morris C, Kikuti C, Safer D, Sweeney HL, Houdusse A Dev Cell. 2015 May 26;33(4):401-12. doi: 10.1016/j.devcel.2015.03.025. Epub 2015 , Apr 30. PMID:25936506<ref>PMID:25936506</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 4pk4" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 11:33, 30 April 2015

OCA — Thu, 30 Apr 2015 11:33:20 GMT

←Older revision		Revision as of 11:33, 30 April 2015
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	==Myosin VI motor domain in the PPS state - from a Pi release state crystal, space group P212121 after long soaking with PO4==
-		+	<StructureSection load='4pk4' size='340' side='right' caption='[[4pk4]], [[Resolution\|resolution]] 2.78Å' scene=''>
-	~~The entry 4pk4 is ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4pk4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PK4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PK4 FirstGlance]. <br>
-	~~Authors: Isabet, T., Benisty, H., Llinas, P., Sweeney, H.L., Houdusse, A.~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pfo\|4pfo]]</td></tr>
-	~~Description:~~ Myosin VI motor domain in the PPS state -from a Pi release state crystal, space group P212121 after long soaking with PO4	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pk4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pk4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pk4 RCSB], [http://www.ebi.ac.uk/pdbsum/4pk4 PDBsum]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[Category: ~~Llinas~~, P]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Benisty, H]]
	[[Category: Houdusse, A]]		[[Category: Houdusse, A]]
-	[[Category: Sweeney, H.L]]
	[[Category: Isabet, T]]		[[Category: Isabet, T]]
-	[[Category: ~~Benisty~~, H]]	+	[[Category: Llinas, P]]
		+	[[Category: Sweeney, H L]]
		+	[[Category: Motor domain]]
		+	[[Category: Motor protein]]
		+	[[Category: Pre powerstroke state]]

OCA at 15:05, 24 December 2014

OCA — Wed, 24 Dec 2014 15:05:53 GMT

←Older revision		Revision as of 15:05, 24 December 2014
Line 6:		Line 6:

	Description: Myosin VI motor domain in the PPS state -from a Pi release state crystal, space group P212121 after long soaking with PO4		Description: Myosin VI motor domain in the PPS state -from a Pi release state crystal, space group P212121 after long soaking with PO4
		+	[[Category: Unreleased Structures]]
		+	[[Category: Llinas, P]]
		+	[[Category: Houdusse, A]]
		+	[[Category: Sweeney, H.L]]
		+	[[Category: Isabet, T]]
		+	[[Category: Benisty, H]]

OCA: Protected "4pk4" [edit=sysop:move=sysop]

OCA — Wed, 21 May 2014 08:07:12 GMT

Protected "4pk4" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:07, 21 May 2014

OCA: New page: '''Unreleased structure''' The entry 4pk4 is ON HOLD until Paper Publication Authors: Isabet, T., Benisty, H., Llinas, P., Sweeney, H.L., Houdusse, A. Description: Myosin VI motor doma...

OCA — Wed, 21 May 2014 08:07:10 GMT

New page: '''Unreleased structure''' The entry 4pk4 is ON HOLD until Paper Publication Authors: Isabet, T., Benisty, H., Llinas, P., Sweeney, H.L., Houdusse, A. Description: Myosin VI motor doma...

New page

'''Unreleased structure'''

The entry 4pk4 is ON HOLD until Paper Publication

Authors: Isabet, T., Benisty, H., Llinas, P., Sweeney, H.L., Houdusse, A.

Description: Myosin VI motor domain in the PPS state -from a Pi release state crystal, space group P212121 after long soaking with PO4