4plk - Revision history

OCA at 07:17, 8 February 2023

OCA — Wed, 08 Feb 2023 07:17:31 GMT

←Older revision		Revision as of 07:17, 8 February 2023
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	<StructureSection load='4plk' size='340' side='right'caption='[[4plk]], [[Resolution\|resolution]] 4.00Å' scene=''>		<StructureSection load='4plk' size='340' side='right'caption='[[4plk]], [[Resolution\|resolution]] 4.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4plk]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Hev Hev~~] and [~~http~~://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PLK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4PLK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4plk]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Orthohepevirus_A Orthohepevirus A]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PLK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PLK FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4plj\|4plj]]</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4plk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4plk OCA], [https://pdbe.org/4plk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4plk RCSB], [https://www.ebi.ac.uk/pdbsum/4plk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4plk ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4plk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4plk OCA], [~~http~~://pdbe.org/4plk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4plk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4plk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4plk ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/L0L7P5_HEV L0L7P5_HEV]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Hev]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: ~~Li, S W~~]]	+	[[Category: Orthohepevirus A]]
-	[[Category: ~~Sivaraman, J~~]]	+	[[Category: Li SW]]
-	[[Category: ~~Tang, X H~~]]	+	[[Category: Sivaraman J]]
-	[[Category: ~~Complex]]~~	+	[[Category: Tang XH]]
-	~~[[Category: Neutralizing antibody]]~~	+
-	~~[[Category: Viral protein-immune system complex~~]]	+

OCA at 08:17, 17 April 2019

OCA — Wed, 17 Apr 2019 08:17:36 GMT

←Older revision		Revision as of 08:17, 17 April 2019
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	==Hepatitis E Virus E2s domain (Genotype I) in complex with a neutralizing antibody 8G12==		==Hepatitis E Virus E2s domain (Genotype I) in complex with a neutralizing antibody 8G12==
-	<StructureSection load='4plk' size='340' side='right' caption='[[4plk]], [[Resolution\|resolution]] 4.00Å' scene=''>	+	<StructureSection load='4plk' size='340' side='right'caption='[[4plk]], [[Resolution\|resolution]] 4.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4plk]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PLK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PLK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4plk]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Hev Hev] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PLK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PLK FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4plj\|4plj]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4plj\|4plj]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4plk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4plk OCA], [http://pdbe.org/4plk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4plk RCSB], [http://www.ebi.ac.uk/pdbsum/4plk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4plk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4plk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4plk OCA], [http://pdbe.org/4plk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4plk RCSB], [http://www.ebi.ac.uk/pdbsum/4plk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4plk ProSAT]</span></td></tr>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Hev]]
		+	[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Li, S W]]		[[Category: Li, S W]]

OCA at 17:36, 9 March 2017

OCA — Thu, 09 Mar 2017 17:36:31 GMT

←Older revision		Revision as of 17:36, 9 March 2017
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		+
	==Hepatitis E Virus E2s domain (Genotype I) in complex with a neutralizing antibody 8G12==		==Hepatitis E Virus E2s domain (Genotype I) in complex with a neutralizing antibody 8G12==
	<StructureSection load='4plk' size='340' side='right' caption='[[4plk]], [[Resolution\|resolution]] 4.00Å' scene=''>		<StructureSection load='4plk' size='340' side='right' caption='[[4plk]], [[Resolution\|resolution]] 4.00Å' scene=''>
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	<table><tr><td colspan='2'>[[4plk]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PLK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PLK FirstGlance]. <br>		<table><tr><td colspan='2'>[[4plk]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PLK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PLK FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4plj\|4plj]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4plj\|4plj]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4plk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4plk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4plk RCSB], [http://www.ebi.ac.uk/pdbsum/4plk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4plk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4plk OCA], [http://pdbe.org/4plk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4plk RCSB], [http://www.ebi.ac.uk/pdbsum/4plk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4plk ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4plk" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:07, 8 April 2015

OCA — Wed, 08 Apr 2015 11:07:44 GMT

←Older revision		Revision as of 11:07, 8 April 2015
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-	'''~~Unreleased~~ structure'''	+	==Hepatitis E Virus E2s domain (Genotype I) in complex with a neutralizing antibody 8G12==
		+	<StructureSection load='4plk' size='340' side='right' caption='[[4plk]], [[Resolution\|resolution]] 4.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4plk]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PLK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PLK FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4plj\|4plj]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4plk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4plk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4plk RCSB], [http://www.ebi.ac.uk/pdbsum/4plk PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Hepatitis E virus (HEV), a non-enveloped, positive-sense, single-stranded RNA virus, is a major cause of enteric hepatitis. Classified into the family Hepeviridae, HEV comprises four genotypes (genotypes 1-4), which belong to a single serotype. We describe a monoclonal antibody (mAb), 8G12, which equally recognizes all four genotypes of HEV, with approximately 2.53-3.45 nM binding affinity. The mAb 8G12 has a protective, neutralizing capacity, which can significantly block virus infection in host cells. Animal studies with genotypes 1, 3 and 4 confirmed the cross-genotype neutralizing capacity of 8G12 and its effective prevention of hepatitis E disease. The complex crystal structures of 8G12 with the HEV E2s domain (the most protruded region of the virus capsid) of the abundant genotypes 1 and 4 were determined at 4.0 and 2.3 A resolution, respectively. These structures revealed that 8G12 recognizes both genotypes through the epitopes in the E2s dimerization region. Structure-based mutagenesis and cell-model assays with virus-like particles identified several conserved residues (Glu549, Lys554 and Gly591) that are essential for 8G12 neutralization. Moreover, the epitope of 8G12 is identified as a key epitope involved in virus-host interactions. These findings will help develop a common strategy for the prevention of the most abundant form of HEV infection.Cell Research advance online publication 20 March 2015; doi:10.1038/cr.2015.34.

-	~~The entry 4plk is ON HOLD until Paper Publication~~	+	Structural basis for the neutralization of hepatitis E virus by a cross-genotype antibody.,Gu Y, Tang X, Zhang X, Song C, Zheng M, Wang K, Zhang J, Ng MH, Hew CL, Li S, Xia N, Sivaraman J Cell Res. 2015 Mar 20. doi: 10.1038/cr.2015.34. PMID:25793314<ref>PMID:25793314</ref>

-	~~Authors: Tang~~, X.~~H., Li,~~ S.~~W., Sivaraman, J~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: Hepatitis E Virus E2s domain (Genotype I) in complex with a neutralizing antibody 8G12~~	+	== References ==
-	[[Category: ~~Unreleased Structures~~]]	+	<references/>
-	[[Category: ~~Tang~~, ~~X.H~~]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Mus musculus]]
		+	[[Category: Li, S W]]
	[[Category: Sivaraman, J]]		[[Category: Sivaraman, J]]
-	[[Category: Li, ~~S.W~~]]	+	[[Category: Tang, X H]]
		+	[[Category: Complex]]
		+	[[Category: Neutralizing antibody]]
		+	[[Category: Viral protein-immune system complex]]

OCA at 08:25, 1 April 2015

OCA — Wed, 01 Apr 2015 08:25:27 GMT

←Older revision		Revision as of 08:25, 1 April 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4plk is ON HOLD	+	The entry 4plk is ON HOLD until Paper Publication

	Authors: Tang, X.H., Li, S.W., Sivaraman, J.		Authors: Tang, X.H., Li, S.W., Sivaraman, J.

OCA at 15:07, 24 December 2014

OCA — Wed, 24 Dec 2014 15:07:10 GMT

←Older revision		Revision as of 15:07, 24 December 2014
Line 6:		Line 6:

	Description: Hepatitis E Virus E2s domain (Genotype I) in complex with a neutralizing antibody 8G12		Description: Hepatitis E Virus E2s domain (Genotype I) in complex with a neutralizing antibody 8G12
		+	[[Category: Unreleased Structures]]
		+	[[Category: Tang, X.H]]
		+	[[Category: Sivaraman, J]]
		+	[[Category: Li, S.W]]

OCA at 06:26, 18 June 2014

OCA — Wed, 18 Jun 2014 06:26:35 GMT

←Older revision		Revision as of 06:26, 18 June 2014
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	Authors: Tang, X.H., Li, S.W., Sivaraman, J.		Authors: Tang, X.H., Li, S.W., Sivaraman, J.

-	Description: Hepatitis E Virus E2s domain (Genotype IV) in complex with a neutralizing antibody 8G12	+	Description: Hepatitis E Virus E2s domain (Genotype I) in complex with a neutralizing antibody 8G12

OCA: Protected "4plk" [edit=sysop:move=sysop]

OCA — Wed, 28 May 2014 08:15:48 GMT

Protected "4plk" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:15, 28 May 2014

OCA: New page: '''Unreleased structure''' The entry 4plk is ON HOLD Authors: Tang, X.H., Li, S.W., Sivaraman, J. Description: Hepatitis E Virus E2s domain (Genotype IV) in complex with a neutralizing...

OCA — Wed, 28 May 2014 08:15:46 GMT

New page: '''Unreleased structure''' The entry 4plk is ON HOLD Authors: Tang, X.H., Li, S.W., Sivaraman, J. Description: Hepatitis E Virus E2s domain (Genotype IV) in complex with a neutralizing...

New page

'''Unreleased structure'''

The entry 4plk is ON HOLD

Authors: Tang, X.H., Li, S.W., Sivaraman, J.

Description: Hepatitis E Virus E2s domain (Genotype IV) in complex with a neutralizing antibody 8G12