4plu - Revision history

OCA at 00:45, 28 December 2023

OCA — Thu, 28 Dec 2023 00:45:27 GMT

←Older revision		Revision as of 00:45, 28 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4plu]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PLU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PLU FirstGlance]. <br>		<table><tr><td colspan='2'>[[4plu]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PLU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PLU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HBX:BENZALDEHYDE'>HBX</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.63Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HBX:BENZALDEHYDE'>HBX</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4plu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4plu OCA], [https://pdbe.org/4plu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4plu RCSB], [https://www.ebi.ac.uk/pdbsum/4plu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4plu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4plu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4plu OCA], [https://pdbe.org/4plu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4plu RCSB], [https://www.ebi.ac.uk/pdbsum/4plu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4plu ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:17, 8 February 2023

OCA — Wed, 08 Feb 2023 07:17:50 GMT

←Older revision		Revision as of 07:17, 8 February 2023
Line 1:		Line 1:

	==Crystal structure of Macrophage Migration Inhibitory Factor in complex with benzaldehyde==		==Crystal structure of Macrophage Migration Inhibitory Factor in complex with benzaldehyde==
-	<StructureSection load='4plu' size='340' side='right' caption='[[4plu]], [[Resolution\|resolution]] 1.63Å' scene=''>	+	<StructureSection load='4plu' size='340' side='right'caption='[[4plu]], [[Resolution\|resolution]] 1.63Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4plu]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PLU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4PLU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4plu]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PLU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PLU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HBX:BENZALDEHYDE'>HBX</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HBX:BENZALDEHYDE'>HBX</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MIF, GLIF, MMIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4plu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4plu OCA], [https://pdbe.org/4plu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4plu RCSB], [https://www.ebi.ac.uk/pdbsum/4plu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4plu ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4plu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4plu OCA], [~~http~~://pdbe.org/4plu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4plu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4plu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4plu ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[~~http~~://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.	+	[https://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[https://omim.org/entry/604302 604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>	+	[https://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 4plu" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4plu" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Macrophage inhibitory factor 3D structures\|Macrophage inhibitory factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Lolis, E~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Pantouris, G~~]]	+	[[Category: Lolis E]]
-	[[Category: ~~Active site]]~~	+	[[Category: Pantouris G]]
-	~~[[Category: Covalent inhibitor]]~~	+
-	~~[[Category: Isomerase]]~~	+
-	~~[[Category: Isomerase-isomerase inhibitor complex~~]]	+

OCA at 08:42, 22 November 2017

OCA — Wed, 22 Nov 2017 08:42:37 GMT

←Older revision		Revision as of 08:42, 22 November 2017
Line 1:		Line 1:
		+
	==Crystal structure of Macrophage Migration Inhibitory Factor in complex with benzaldehyde==		==Crystal structure of Macrophage Migration Inhibitory Factor in complex with benzaldehyde==
	<StructureSection load='4plu' size='340' side='right' caption='[[4plu]], [[Resolution\|resolution]] 1.63Å' scene=''>		<StructureSection load='4plu' size='340' side='right' caption='[[4plu]], [[Resolution\|resolution]] 1.63Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4plu]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PLU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PLU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4plu]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PLU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PLU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HBX:BENZALDEHYDE'>HBX</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HBX:BENZALDEHYDE'>HBX</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4plu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4plu OCA], [http://pdbe.org/4plu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4plu RCSB], [http://www.ebi.ac.uk/pdbsum/4plu PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MIF, GLIF, MMIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4plu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4plu OCA], [http://pdbe.org/4plu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4plu RCSB], [http://www.ebi.ac.uk/pdbsum/4plu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4plu ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 23:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Lolis, E]]		[[Category: Lolis, E]]
	[[Category: Pantouris, G]]		[[Category: Pantouris, G]]

OCA at 14:33, 30 September 2015

OCA — Wed, 30 Sep 2015 14:33:58 GMT

←Older revision		Revision as of 14:33, 30 September 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of Macrophage Migration Inhibitory Factor in complex with benzaldehyde==
		+	<StructureSection load='4plu' size='340' side='right' caption='[[4plu]], [[Resolution\|resolution]] 1.63Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4plu]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PLU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PLU FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HBX:BENZALDEHYDE'>HBX</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4plu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4plu OCA], [http://pdbe.org/4plu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4plu RCSB], [http://www.ebi.ac.uk/pdbsum/4plu PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[http://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	For more than 15 years, the tautomerase active site of macrophage migration inhibitory factor (MIF) and its catalytic residue Pro1 have been being targeted for the development of therapeutics that block activation of its cell surface receptor, CD74. Neither the biological role of the MIF catalytic site nor the mechanistic details of CD74 activation are well understood. The inherently unstable structure of CD74 remains the biggest obstacle in structural studies with MIF for understanding the basis of CD74 activation. Using a novel approach, we elucidate the mechanistic details that control activation of CD74 by MIF surface residues and identify structural parameters of inhibitors that reduce CD74 biological activation. We also find that N-terminal mutants located deep in the catalytic site affect surface residues immediately outside the catalytic site, which are responsible for reduction of CD74 activation.

-	~~The entry 4plu is ON HOLD until Paper Publication~~	+	An Analysis of MIF Structural Features that Control Functional Activation of CD74.,Pantouris G, Syed MA, Fan C, Rajasekaran D, Cho TY, Rosenberg EM Jr, Bucala R, Bhandari V, Lolis EJ Chem Biol. 2015 Sep 17;22(9):1197-205. doi: 10.1016/j.chembiol.2015.08.006. Epub , 2015 Sep 10. PMID:26364929<ref>PMID:26364929</ref>

-	~~Authors: Pantouris~~, G.~~, Lolis, E~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal structure of Macrophage Migration Inhibitory Factor in complex with benzaldehyde~~	+	<div class="pdbe-citations 4plu" style="background-color:#fffaf0;"></div>
-	~~[[Category: Unreleased Structures]]~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Lolis, E]]		[[Category: Lolis, E]]
	[[Category: Pantouris, G]]		[[Category: Pantouris, G]]
		+	[[Category: Active site]]
		+	[[Category: Covalent inhibitor]]
		+	[[Category: Isomerase]]
		+	[[Category: Isomerase-isomerase inhibitor complex]]

OCA at 15:07, 24 December 2014

OCA — Wed, 24 Dec 2014 15:07:20 GMT

←Older revision		Revision as of 15:07, 24 December 2014
Line 6:		Line 6:

	Description: Crystal structure of Macrophage Migration Inhibitory Factor in complex with benzaldehyde		Description: Crystal structure of Macrophage Migration Inhibitory Factor in complex with benzaldehyde
		+	[[Category: Unreleased Structures]]
		+	[[Category: Lolis, E]]
		+	[[Category: Pantouris, G]]

OCA at 07:11, 2 July 2014

OCA — Wed, 02 Jul 2014 07:11:15 GMT

←Older revision		Revision as of 07:11, 2 July 2014
Line 5:		Line 5:
	Authors: Pantouris, G., Lolis, E.		Authors: Pantouris, G., Lolis, E.

-	Description: Crystal structure of Macrophage Migration Inhibitory Factor in complex with ~~a covalent inhibitor~~	+	Description: Crystal structure of Macrophage Migration Inhibitory Factor in complex with benzaldehyde

OCA at 05:47, 25 June 2014

OCA — Wed, 25 Jun 2014 05:47:52 GMT

←Older revision		Revision as of 05:47, 25 June 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4plu is ON HOLD	+	The entry 4plu is ON HOLD until Paper Publication

	Authors: Pantouris, G., Lolis, E.		Authors: Pantouris, G., Lolis, E.

	Description: Crystal structure of Macrophage Migration Inhibitory Factor in complex with a covalent inhibitor		Description: Crystal structure of Macrophage Migration Inhibitory Factor in complex with a covalent inhibitor

OCA at 06:26, 18 June 2014

OCA — Wed, 18 Jun 2014 06:26:43 GMT

←Older revision		Revision as of 06:26, 18 June 2014
Line 3:		Line 3:
	The entry 4plu is ON HOLD		The entry 4plu is ON HOLD

-	Authors: Pantouris G., Lolis E.	+	Authors: Pantouris, G., Lolis, E.

	Description: Crystal structure of Macrophage Migration Inhibitory Factor in complex with a covalent inhibitor		Description: Crystal structure of Macrophage Migration Inhibitory Factor in complex with a covalent inhibitor

OCA: Protected "4plu" [edit=sysop:move=sysop]

OCA — Wed, 28 May 2014 08:16:25 GMT

Protected "4plu" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:16, 28 May 2014

OCA: New page: '''Unreleased structure''' The entry 4plu is ON HOLD Authors: Pantouris G., Lolis E. Description: Crystal structure of Macrophage Migration Inhibitory Factor in complex with a covalent...

OCA — Wed, 28 May 2014 08:16:23 GMT

New page: '''Unreleased structure''' The entry 4plu is ON HOLD Authors: Pantouris G., Lolis E. Description: Crystal structure of Macrophage Migration Inhibitory Factor in complex with a covalent...

New page

'''Unreleased structure'''

The entry 4plu is ON HOLD

Authors: Pantouris G., Lolis E.

Description: Crystal structure of Macrophage Migration Inhibitory Factor in complex with a covalent inhibitor