4plw - Revision history

OCA at 07:17, 27 September 2023

OCA — Wed, 27 Sep 2023 07:17:59 GMT

←Older revision		Revision as of 07:17, 27 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4plw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Apicomplexa Apicomplexa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PLW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PLW FirstGlance]. <br>		<table><tr><td colspan='2'>[[4plw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Apicomplexa Apicomplexa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PLW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PLW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.85Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4plw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4plw OCA], [https://pdbe.org/4plw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4plw RCSB], [https://www.ebi.ac.uk/pdbsum/4plw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4plw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4plw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4plw OCA], [https://pdbe.org/4plw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4plw RCSB], [https://www.ebi.ac.uk/pdbsum/4plw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4plw ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:17, 8 February 2023

OCA — Wed, 08 Feb 2023 07:17:59 GMT

←Older revision		Revision as of 07:17, 8 February 2023
Line 3:		Line 3:
	<StructureSection load='4plw' size='340' side='right'caption='[[4plw]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='4plw' size='340' side='right'caption='[[4plw]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4plw]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~9apic 9apic~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PLW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4PLW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4plw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Apicomplexa Apicomplexa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PLW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PLW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4plc\|4plc]], [[4plf\|4plf]], [[4plg\|4plg]], [[4plh\|4plh]], [[4plt\|4plt]], [[4plv\|4plv]], [[4ply\|4ply]], [[4plz\|4plz]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4plw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4plw OCA], [https://pdbe.org/4plw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4plw RCSB], [https://www.ebi.ac.uk/pdbsum/4plw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4plw ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4plw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4plw OCA], [~~http~~://pdbe.org/4plw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4plw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4plw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4plw ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A075B5H2_9APIC A0A075B5H2_9APIC]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Large Structures]]
-	[[Category: Beckett, B C]]
-	[[Category: Boucher, J I]]
-	[[Category: Classen, S]]
-	[[Category: Jacobowitz, J R]]
-	[[Category: Theobald, D L]]
-	[[Category: Ancestral sequence reconstruction]]
	[[Category: Apicomplexa]]		[[Category: Apicomplexa]]
-	[[Category: ~~Dehydrogenase~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Oxidoreductase~~]]	+	[[Category: Beckett BC]]
-	[[Category: ~~Specificity~~]]	+	[[Category: Boucher JI]]
		+	[[Category: Classen S]]
		+	[[Category: Jacobowitz JR]]
		+	[[Category: Theobald DL]]

OCA at 10:15, 25 December 2019

OCA — Wed, 25 Dec 2019 10:15:05 GMT

←Older revision		Revision as of 10:15, 25 December 2019
Line 19:		Line 19:

	==See Also==		==See Also==
-	*[[Malate ~~dehydrogenase~~\|Malate ~~dehydrogenase~~]]	+	*[[Malate Dehydrogenase 3D structures\|Malate Dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:07, 14 August 2019

OCA — Wed, 14 Aug 2019 18:07:57 GMT

←Older revision		Revision as of 18:07, 14 August 2019
Line 1:		Line 1:

	==Crystal structure of ancestral apicomplexan malate dehydrogenase with lactate.==		==Crystal structure of ancestral apicomplexan malate dehydrogenase with lactate.==
-	<StructureSection load='4plw' size='340' side='right' caption='[[4plw]], [[Resolution\|resolution]] 1.85Å' scene=''>	+	<StructureSection load='4plw' size='340' side='right'caption='[[4plw]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4plw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/9apic 9apic]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PLW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PLW FirstGlance]. <br>		<table><tr><td colspan='2'>[[4plw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/9apic 9apic]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PLW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PLW FirstGlance]. <br>
Line 17:		Line 17:
	</div>		</div>
	<div class="pdbe-citations 4plw" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4plw" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Malate dehydrogenase\|Malate dehydrogenase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Beckett, B C]]		[[Category: Beckett, B C]]
	[[Category: Boucher, J I]]		[[Category: Boucher, J I]]

OCA at 12:02, 6 November 2017

OCA — Mon, 06 Nov 2017 12:02:06 GMT

←Older revision		Revision as of 12:02, 6 November 2017
Line 3:		Line 3:
	<StructureSection load='4plw' size='340' side='right' caption='[[4plw]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='4plw' size='340' side='right' caption='[[4plw]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4plw]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PLW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PLW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4plw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/9apic 9apic]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PLW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PLW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4plc\|4plc]], [[4plf\|4plf]], [[4plg\|4plg]], [[4plh\|4plh]], [[4plt\|4plt]], [[4plv\|4plv]], [[4ply\|4ply]], [[4plz\|4plz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4plc\|4plc]], [[4plf\|4plf]], [[4plg\|4plg]], [[4plh\|4plh]], [[4plt\|4plt]], [[4plv\|4plv]], [[4ply\|4ply]], [[4plz\|4plz]]</td></tr>
Line 17:		Line 17:
	</div>		</div>
	<div class="pdbe-citations 4plw" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4plw" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Malate dehydrogenase\|Malate dehydrogenase]]
	== References ==		== References ==
	<references/>		<references/>
Line 32:		Line 29:
	[[Category: Apicomplexa]]		[[Category: Apicomplexa]]
	[[Category: Dehydrogenase]]		[[Category: Dehydrogenase]]
		+	[[Category: Oxidoreductase]]
	[[Category: Specificity]]		[[Category: Specificity]]

OCA at 17:06, 4 January 2017

OCA — Wed, 04 Jan 2017 17:06:01 GMT

←Older revision		Revision as of 17:06, 4 January 2017
Line 1:		Line 1:
		+
	==Crystal structure of ancestral apicomplexan malate dehydrogenase with lactate.==		==Crystal structure of ancestral apicomplexan malate dehydrogenase with lactate.==
	<StructureSection load='4plw' size='340' side='right' caption='[[4plw]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='4plw' size='340' side='right' caption='[[4plw]], [[Resolution\|resolution]] 1.85Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4plc\|4plc]], [[4plf\|4plf]], [[4plg\|4plg]], [[4plh\|4plh]], [[4plt\|4plt]], [[4plv\|4plv]], [[4ply\|4ply]], [[4plz\|4plz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4plc\|4plc]], [[4plf\|4plf]], [[4plg\|4plg]], [[4plh\|4plh]], [[4plt\|4plt]], [[4plv\|4plv]], [[4ply\|4ply]], [[4plz\|4plz]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4plw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4plw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4plw RCSB], [http://www.ebi.ac.uk/pdbsum/4plw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4plw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4plw OCA], [http://pdbe.org/4plw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4plw RCSB], [http://www.ebi.ac.uk/pdbsum/4plw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4plw ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4plw" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Malate dehydrogenase\|Malate dehydrogenase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:38, 20 January 2015

OCA — Tue, 20 Jan 2015 11:38:27 GMT

←Older revision		Revision as of 11:38, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4plw]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PLW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PLW FirstGlance]. <br>		<table><tr><td colspan='2'>[[4plw]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PLW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PLW FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4plc\|4plc]], [[4plf\|4plf]], [[4plg\|4plg]], [[4plh\|4plh]], [[4plt\|4plt]], [[4plv\|4plv]], [[4ply\|4ply]], [[4plz\|4plz]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4plc\|4plc]], [[4plf\|4plf]], [[4plg\|4plg]], [[4plh\|4plh]], [[4plt\|4plt]], [[4plv\|4plv]], [[4ply\|4ply]], [[4plz\|4plz]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4plw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4plw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4plw RCSB], [http://www.ebi.ac.uk/pdbsum/4plw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4plw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4plw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4plw RCSB], [http://www.ebi.ac.uk/pdbsum/4plw PDBsum]</span></td></tr>
-	<table>	+	</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Beckett, B C.]]	+	[[Category: Beckett, B C]]
-	[[Category: Boucher, J I.]]	+	[[Category: Boucher, J I]]
-	[[Category: Classen, S.]]	+	[[Category: Classen, S]]
-	[[Category: Jacobowitz, J R.]]	+	[[Category: Jacobowitz, J R]]
-	[[Category: Theobald, D L.]]	+	[[Category: Theobald, D L]]
	[[Category: Ancestral sequence reconstruction]]		[[Category: Ancestral sequence reconstruction]]
	[[Category: Apicomplexa]]		[[Category: Apicomplexa]]
	[[Category: Dehydrogenase]]		[[Category: Dehydrogenase]]
	[[Category: Specificity]]		[[Category: Specificity]]

OCA at 06:48, 24 September 2014

OCA — Wed, 24 Sep 2014 06:48:28 GMT

←Older revision		Revision as of 06:48, 24 September 2014
Line 23:		Line 23:
	[[Category: Classen, S.]]		[[Category: Classen, S.]]
	[[Category: Jacobowitz, J R.]]		[[Category: Jacobowitz, J R.]]
-	[[Category: Theobald, D L]]	+	[[Category: Theobald, D L.]]
	[[Category: Ancestral sequence reconstruction]]		[[Category: Ancestral sequence reconstruction]]
	[[Category: Apicomplexa]]		[[Category: Apicomplexa]]
	[[Category: Dehydrogenase]]		[[Category: Dehydrogenase]]
	[[Category: Specificity]]		[[Category: Specificity]]

OCA at 09:18, 16 July 2014

OCA — Wed, 16 Jul 2014 09:18:29 GMT

←Older revision		Revision as of 09:18, 16 July 2014
Line 7:		Line 7:
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4plw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4plw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4plw RCSB], [http://www.ebi.ac.uk/pdbsum/4plw PDBsum]</span></td></tr>		<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4plw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4plw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4plw RCSB], [http://www.ebi.ac.uk/pdbsum/4plw PDBsum]</span></td></tr>
	<table>		<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Malate and lactate dehydrogenases (MDH and LDH) are homologous, core metabolic enzymes that share a fold and catalytic mechanism yet possess strict specificity for their substrates. In the Apicomplexa, convergent evolution of an unusual LDH from MDH resulted in a difference in substrate preference exceeding 12 orders of magnitude. The molecular and evolutionary mechanisms responsible for this extraordinary functional shift are currently unknown. Using ancestral sequence reconstruction, we find that the evolution of pyruvate specificity in apicomplexan LDHs arose through a classic neofunctionalization mechanism characterized by long-range epistasis, a promiscuous intermediate, and relatively few gain-of-function mutations of large effect. Residues far from the active site determine specificity, as shown by the crystal structures of three ancestral proteins that bracket the key gene duplication event. This work provides an unprecedented atomic-resolution view of evolutionary trajectories resulting in the de novo creation of a nascent enzymatic function.
		+
		+	An atomic-resolution view of neofunctionalization in the evolution of apicomplexan lactate dehydrogenases.,Boucher JI, Jacobowitz JR, Beckett BC, Classen S, Theobald DL Elife. 2014 Jun 25:e02304. doi: 10.7554/eLife.02304. PMID:24966208<ref>PMID:24966208</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:52, 2 July 2014

OCA — Wed, 02 Jul 2014 08:52:06 GMT

←Older revision		Revision as of 08:52, 2 July 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of ancestral apicomplexan malate dehydrogenase with lactate.==
-		+	<StructureSection load='4plw' size='340' side='right' caption='[[4plw]], [[Resolution\|resolution]] 1.85Å' scene=''>
-	~~The entry~~ 4plw is ~~ON HOLD~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4plw]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PLW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PLW FirstGlance]. <br>
-	~~Authors~~: ~~Boucher~~, J.I., ~~Jacobowitz~~, J.R., Beckett, B.C., Classen, S., Theobald, D.L	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4plc\|4plc]], [[4plf\|4plf]], [[4plg\|4plg]], [[4plh\|4plh]], [[4plt\|4plt]], [[4plv\|4plv]], [[4ply\|4ply]], [[4plz\|4plz]]</td></tr>
-	~~Description~~: ~~Crystal structure of ancestral apicomplexan malate dehydrogenase with lactate.~~	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4plw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4plw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4plw RCSB], [http://www.ebi.ac.uk/pdbsum/4plw PDBsum]</span></td></tr>
		+	<table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Beckett, B C.]]
		+	[[Category: Boucher, J I.]]
		+	[[Category: Classen, S.]]
		+	[[Category: Jacobowitz, J R.]]
		+	[[Category: Theobald, D L]]
		+	[[Category: Ancestral sequence reconstruction]]
		+	[[Category: Apicomplexa]]
		+	[[Category: Dehydrogenase]]
		+	[[Category: Specificity]]