4pm7 - Revision history

OCA at 14:29, 29 November 2023

OCA — Wed, 29 Nov 2023 14:29:50 GMT

←Older revision		Revision as of 14:29, 29 November 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4pm7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae_subsp._pneumoniae_HS11286 Klebsiella pneumoniae subsp. pneumoniae HS11286]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PM7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PM7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4pm7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae_subsp._pneumoniae_HS11286 Klebsiella pneumoniae subsp. pneumoniae HS11286]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PM7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PM7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CE3:(6R,7R)-3-(ACETYLOXYMETHYL)-7-[[(2Z)-2-(2-AMINO-1,3-THIAZOL-4-YL)-2-METHOXYIMINO-ETHANOYL]AMINO]-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC+ACID'>CE3</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.29Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CE3:(6R,7R)-3-(ACETYLOXYMETHYL)-7-[[(2Z)-2-(2-AMINO-1,3-THIAZOL-4-YL)-2-METHOXYIMINO-ETHANOYL]AMINO]-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC+ACID'>CE3</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pm7 OCA], [https://pdbe.org/4pm7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pm7 RCSB], [https://www.ebi.ac.uk/pdbsum/4pm7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pm7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pm7 OCA], [https://pdbe.org/4pm7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pm7 RCSB], [https://www.ebi.ac.uk/pdbsum/4pm7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pm7 ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:18, 8 February 2023

OCA — Wed, 08 Feb 2023 07:18:47 GMT

←Older revision		Revision as of 07:18, 8 February 2023
Line 3:		Line 3:
	<StructureSection load='4pm7' size='340' side='right'caption='[[4pm7]], [[Resolution\|resolution]] 1.29Å' scene=''>		<StructureSection load='4pm7' size='340' side='right'caption='[[4pm7]], [[Resolution\|resolution]] 1.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4pm7]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Kleph Kleph~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PM7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4PM7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4pm7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae_subsp._pneumoniae_HS11286 Klebsiella pneumoniae subsp. pneumoniae HS11286]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PM7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PM7 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CE3:(6R,7R)-3-(ACETYLOXYMETHYL)-7-[[(2Z)-2-(2-AMINO-1,3-THIAZOL-4-YL)-2-METHOXYIMINO-ETHANOYL]AMINO]-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC+ACID'>CE3</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CE3:(6R,7R)-3-(ACETYLOXYMETHYL)-7-[[(2Z)-2-(2-AMINO-1,3-THIAZOL-4-YL)-2-METHOXYIMINO-ETHANOYL]AMINO]-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC+ACID'>CE3</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pm5\|4pm5]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pm7 OCA], [https://pdbe.org/4pm7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pm7 RCSB], [https://www.ebi.ac.uk/pdbsum/4pm7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pm7 ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KPHS_p301310 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1125630 KLEPH])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4pm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pm7 OCA], [~~http~~://pdbe.org/4pm7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4pm7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4pm7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4pm7 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A0H3H219_KLEPH A0A0H3H219_KLEPH]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Kleph~~]]	+	[[Category: Klebsiella pneumoniae subsp. pneumoniae HS11286]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Adamski~~, C J~~]]	+	[[Category: Adamski CJ]]
-	[[Category: Cardenas~~, A M~~]]	+	[[Category: Cardenas AM]]
-	[[Category: Palzkill, T]]	+	[[Category: Palzkill T]]
-	[[Category: Sankaran, B]]	+	[[Category: Sankaran B]]
-	~~[[Category: Cefotaxime]]~~	+
-	~~[[Category: Class a beta-lactamase]]~~	+
-	~~[[Category: Hydrolase-antibiotic complex~~]]	+

OCA at 15:37, 11 December 2019

OCA — Wed, 11 Dec 2019 15:37:49 GMT

←Older revision		Revision as of 15:37, 11 December 2019
Line 1:		Line 1:

	==Crystal structure of CTX-M-14 S70G:S237A in complex with cefotaxime at 1.29 Angstroms resolution==		==Crystal structure of CTX-M-14 S70G:S237A in complex with cefotaxime at 1.29 Angstroms resolution==
-	<StructureSection load='4pm7' size='340' side='right' caption='[[4pm7]], [[Resolution\|resolution]] 1.29Å' scene=''>	+	<StructureSection load='4pm7' size='340' side='right'caption='[[4pm7]], [[Resolution\|resolution]] 1.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4pm7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Kleph Kleph]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PM7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PM7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[4pm7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Kleph Kleph]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PM7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PM7 FirstGlance]. <br>
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4pm7" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4pm7" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta-lactamase 3D structures\|Beta-lactamase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 23:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Kleph]]		[[Category: Kleph]]
		+	[[Category: Large Structures]]
	[[Category: Adamski, C J]]		[[Category: Adamski, C J]]
	[[Category: Cardenas, A M]]		[[Category: Cardenas, A M]]

OCA at 08:42, 22 November 2017

OCA — Wed, 22 Nov 2017 08:42:39 GMT

←Older revision		Revision as of 08:42, 22 November 2017
Line 3:		Line 3:
	<StructureSection load='4pm7' size='340' side='right' caption='[[4pm7]], [[Resolution\|resolution]] 1.29Å' scene=''>		<StructureSection load='4pm7' size='340' side='right' caption='[[4pm7]], [[Resolution\|resolution]] 1.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4pm7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PM7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PM7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4pm7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Kleph Kleph]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PM7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PM7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CE3:(6R,7R)-3-(ACETYLOXYMETHYL)-7-[[(2Z)-2-(2-AMINO-1,3-THIAZOL-4-YL)-2-METHOXYIMINO-ETHANOYL]AMINO]-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC+ACID'>CE3</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CE3:(6R,7R)-3-(ACETYLOXYMETHYL)-7-[[(2Z)-2-(2-AMINO-1,3-THIAZOL-4-YL)-2-METHOXYIMINO-ETHANOYL]AMINO]-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC+ACID'>CE3</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pm5\|4pm5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pm5\|4pm5]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KPHS_p301310 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1125630 KLEPH])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pm7 OCA], [http://pdbe.org/4pm7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pm7 RCSB], [http://www.ebi.ac.uk/pdbsum/4pm7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pm7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pm7 OCA], [http://pdbe.org/4pm7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pm7 RCSB], [http://www.ebi.ac.uk/pdbsum/4pm7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pm7 ProSAT]</span></td></tr>
	</table>		</table>
Line 17:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 4pm7" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 4pm7" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Beta-lactamase\|Beta-lactamase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Kleph]]
	[[Category: Adamski, C J]]		[[Category: Adamski, C J]]
	[[Category: Cardenas, A M]]		[[Category: Cardenas, A M]]

OCA at 17:00, 4 January 2017

OCA — Wed, 04 Jan 2017 17:00:49 GMT

←Older revision		Revision as of 17:00, 4 January 2017
Line 1:		Line 1:
		+
	==Crystal structure of CTX-M-14 S70G:S237A in complex with cefotaxime at 1.29 Angstroms resolution==		==Crystal structure of CTX-M-14 S70G:S237A in complex with cefotaxime at 1.29 Angstroms resolution==
	<StructureSection load='4pm7' size='340' side='right' caption='[[4pm7]], [[Resolution\|resolution]] 1.29Å' scene=''>		<StructureSection load='4pm7' size='340' side='right' caption='[[4pm7]], [[Resolution\|resolution]] 1.29Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CE3:(6R,7R)-3-(ACETYLOXYMETHYL)-7-[[(2Z)-2-(2-AMINO-1,3-THIAZOL-4-YL)-2-METHOXYIMINO-ETHANOYL]AMINO]-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC+ACID'>CE3</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CE3:(6R,7R)-3-(ACETYLOXYMETHYL)-7-[[(2Z)-2-(2-AMINO-1,3-THIAZOL-4-YL)-2-METHOXYIMINO-ETHANOYL]AMINO]-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC+ACID'>CE3</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pm5\|4pm5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pm5\|4pm5]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pm7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pm7 RCSB], [http://www.ebi.ac.uk/pdbsum/4pm7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pm7 OCA], [http://pdbe.org/4pm7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pm7 RCSB], [http://www.ebi.ac.uk/pdbsum/4pm7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pm7 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4pm7" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 05:43, 11 March 2015

OCA — Wed, 11 Mar 2015 05:43:31 GMT

←Older revision		Revision as of 05:43, 11 March 2015
Line 15:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+
		+	==See Also==
		+	*[[Beta-lactamase\|Beta-lactamase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:22, 4 March 2015

OCA — Wed, 04 Mar 2015 11:22:41 GMT

←Older revision		Revision as of 11:22, 4 March 2015
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pm7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pm7 RCSB], [http://www.ebi.ac.uk/pdbsum/4pm7 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pm7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pm7 RCSB], [http://www.ebi.ac.uk/pdbsum/4pm7 PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Extended-spectrum beta-lactamases (ESBLs) pose a threat to public health because of their ability to confer resistance to extended-spectrum cephalosporins such as cefotaxime. The CTX-M beta-lactamases are the most widespread ESBL enzymes among antibiotic resistant bacteria. Many of the active site residues are conserved between the CTX-M family and non-ESBL beta-lactamases such as TEM-1, but the residues Ser237 and Arg276 are specific to the CTX-M family, suggesting that they may help to define the increased specificity for cefotaxime hydrolysis. To test this hypothesis, site-directed mutagenesis of these positions was performed in the CTX-M-14 beta-lactamase. Substitutions of Ser237 and Arg276 with their TEM-1 counterparts, Ala237 and Asn276, had a modest effect on cefotaxime hydrolysis, as did removal of the Arg276 side chain in an R276A mutant. The S237A:R276N and S237A:R276A double mutants, however, exhibited 29- and 14-fold losses in catalytic efficiency for cefotaxime hydrolysis, respectively, while the catalytic efficiency for benzylpenicillin hydrolysis was unchanged. Therefore, together, the Ser237 and Arg276 residues are important contributors to the cefotaximase substrate profile of the enzyme. High-resolution crystal structures of the CTX-M-14 S70G, S70G:S237A, and S70G:S237A:R276A variants alone and in complex with cefotaxime show that residues Ser237 and Arg276 in the wild-type enzyme promote the expansion of the active site to accommodate cefotaxime and favor a conformation of cefotaxime that allows optimal contacts between the enzyme and substrate. The conservation of these residues, linked to their effects on structure and catalysis, imply that their coevolution is an important specificity determinant in the CTX-M family.
		+
		+	Molecular Basis for the Catalytic Specificity of the CTX-M Extended-Spectrum beta-Lactamases.,Adamski CJ, Cardenas AM, Brown NG, Horton LB, Sankaran B, Prasad BV, Gilbert HF, Palzkill T Biochemistry. 2015 Jan 20;54(2):447-57. doi: 10.1021/bi501195g. Epub 2014 Dec 24. PMID:25489790<ref>PMID:25489790</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 14:51, 31 December 2014

OCA — Wed, 31 Dec 2014 14:51:56 GMT

←Older revision		Revision as of 14:51, 31 December 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of CTX-M-14 S70G:S237A in complex with cefotaxime at 1.29 Angstroms resolution==
-		+	<StructureSection load='4pm7' size='340' side='right' caption='[[4pm7]], [[Resolution\|resolution]] 1.29Å' scene=''>
-	~~The entry~~ 4pm7 is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4pm7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PM7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PM7 FirstGlance]. <br>
-	~~Authors~~: ~~Adamski, C~~.J.~~, Cardenas, A~~.M.~~, Sankaran, B~~., ~~Palzkill~~, T.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CE3:(6R,7R)-3-(ACETYLOXYMETHYL)-7-[[(2Z)-2-(2-AMINO-1,3-THIAZOL-4-YL)-2-METHOXYIMINO-ETHANOYL]AMINO]-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC+ACID'>CE3</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pm5\|4pm5]]</td></tr>
-	~~Description~~: ~~Crystal structure of CTX~~-M-~~14 S70G~~:~~S237A in complex with cefotaxime at 1~~.~~29 Angstroms resolution~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pm7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pm7 RCSB], [http://www.ebi.ac.uk/pdbsum/4pm7 PDBsum]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Adamski, C J]]
		+	[[Category: Cardenas, A M]]
	[[Category: Palzkill, T]]		[[Category: Palzkill, T]]
-	[[Category: Cardenas, A.M]]
	[[Category: Sankaran, B]]		[[Category: Sankaran, B]]
-	[[Category: ~~Adamski, C.J~~]]	+	[[Category: Cefotaxime]]
		+	[[Category: Class a beta-lactamase]]
		+	[[Category: Hydrolase-antibiotic complex]]

OCA at 15:07, 24 December 2014

OCA — Wed, 24 Dec 2014 15:07:37 GMT

←Older revision		Revision as of 15:07, 24 December 2014
Line 6:		Line 6:

	Description: Crystal structure of CTX-M-14 S70G:S237A in complex with cefotaxime at 1.29 Angstroms resolution		Description: Crystal structure of CTX-M-14 S70G:S237A in complex with cefotaxime at 1.29 Angstroms resolution
		+	[[Category: Unreleased Structures]]
		+	[[Category: Palzkill, T]]
		+	[[Category: Cardenas, A.M]]
		+	[[Category: Sankaran, B]]
		+	[[Category: Adamski, C.J]]

OCA at 07:04, 23 July 2014

OCA — Wed, 23 Jul 2014 07:04:11 GMT

←Older revision		Revision as of 07:04, 23 July 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4pm7 is ON HOLD	+	The entry 4pm7 is ON HOLD until Paper Publication

	Authors: Adamski, C.J., Cardenas, A.M., Sankaran, B., Palzkill, T.		Authors: Adamski, C.J., Cardenas, A.M., Sankaran, B., Palzkill, T.

	Description: Crystal structure of CTX-M-14 S70G:S237A in complex with cefotaxime at 1.29 Angstroms resolution		Description: Crystal structure of CTX-M-14 S70G:S237A in complex with cefotaxime at 1.29 Angstroms resolution