4pnb - Revision history

OCA at 07:20, 8 February 2023

OCA — Wed, 08 Feb 2023 07:20:10 GMT

←Older revision		Revision as of 07:20, 8 February 2023
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	<StructureSection load='4pnb' size='340' side='right'caption='[[4pnb]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='4pnb' size='340' side='right'caption='[[4pnb]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4pnb]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PNB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4PNB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4pnb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saltans_group Saltans group]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PNB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PNB FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4pnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pnb OCA], [~~http~~://pdbe.org/4pnb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4pnb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4pnb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4pnb ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pnb OCA], [https://pdbe.org/4pnb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pnb RCSB], [https://www.ebi.ac.uk/pdbsum/4pnb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pnb ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Brady, R L~~]]	+	[[Category: Saltans group]]
-	[[Category: ~~Burton, A J~~]]	+	[[Category: Brady RL]]
-	[[Category: ~~Thomson, A R~~]]	+	[[Category: Burton AJ]]
-	[[Category: ~~Wood, C W~~]]	+	[[Category: Thomson AR]]
-	[[Category: ~~Woolfson, D N~~]]	+	[[Category: Wood CW]]
-	[[Category: ~~Alpha-helical barrel]]~~	+	[[Category: Woolfson DN]]
-	~~[[Category: Artificially designed - often synthetic]]~~	+
-	~~[[Category: Coiled coil]]~~	+
-	~~[[Category: De novo protein]]~~	+
-	~~[[Category: Peptide]]~~	+
-	~~[[Category: Protein design~~]]	+

OCA at 15:38, 11 December 2019

OCA — Wed, 11 Dec 2019 15:38:00 GMT

←Older revision		Revision as of 15:38, 11 December 2019
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-	==A de novo designed hexameric coiled coil CC-Hex3==	+	==A de novo designed hexameric coiled coil CC-Hex3.==
	<StructureSection load='4pnb' size='340' side='right'caption='[[4pnb]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='4pnb' size='340' side='right'caption='[[4pnb]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 07:28, 10 July 2019

OCA — Wed, 10 Jul 2019 07:28:48 GMT

←Older revision		Revision as of 07:28, 10 July 2019
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	==A de novo designed hexameric coiled coil CC-Hex3==		==A de novo designed hexameric coiled coil CC-Hex3==
-	<StructureSection load='4pnb' size='340' side='right' caption='[[4pnb]], [[Resolution\|resolution]] 2.05Å' scene=''>	+	<StructureSection load='4pnb' size='340' side='right'caption='[[4pnb]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4pnb]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PNB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PNB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4pnb]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PNB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PNB FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Brady, R L]]		[[Category: Brady, R L]]
	[[Category: Burton, A J]]		[[Category: Burton, A J]]

OCA at 10:51, 4 August 2016

OCA — Thu, 04 Aug 2016 10:51:47 GMT

←Older revision		Revision as of 10:51, 4 August 2016
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		+
	==A de novo designed hexameric coiled coil CC-Hex3==		==A de novo designed hexameric coiled coil CC-Hex3==
	<StructureSection load='4pnb' size='340' side='right' caption='[[4pnb]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='4pnb' size='340' side='right' caption='[[4pnb]], [[Resolution\|resolution]] 2.05Å' scene=''>
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	<table><tr><td colspan='2'>[[4pnb]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PNB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PNB FirstGlance]. <br>		<table><tr><td colspan='2'>[[4pnb]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PNB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PNB FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pnb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pnb RCSB], [http://www.ebi.ac.uk/pdbsum/4pnb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pnb OCA], [http://pdbe.org/4pnb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pnb RCSB], [http://www.ebi.ac.uk/pdbsum/4pnb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pnb ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4pnb" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:24, 17 December 2014

OCA — Wed, 17 Dec 2014 10:24:01 GMT

←Older revision		Revision as of 10:24, 17 December 2014
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Brady, R L.]]	+	[[Category: Brady, R L]]
-	[[Category: Burton, A J.]]	+	[[Category: Burton, A J]]
-	[[Category: Thomson, A R.]]	+	[[Category: Thomson, A R]]
-	[[Category: Wood, C W.]]	+	[[Category: Wood, C W]]
-	[[Category: Woolfson, D N.]]	+	[[Category: Woolfson, D N]]
	[[Category: Alpha-helical barrel]]		[[Category: Alpha-helical barrel]]
	[[Category: Artificially designed - often synthetic]]		[[Category: Artificially designed - often synthetic]]
	[[Category: Coiled coil]]		[[Category: Coiled coil]]
	[[Category: De novo protein]]		[[Category: De novo protein]]
-	[[Category: Peptide .]]	+	[[Category: Peptide]]
	[[Category: Protein design]]		[[Category: Protein design]]

OCA at 07:07, 5 November 2014

OCA — Wed, 05 Nov 2014 07:07:28 GMT

←Older revision		Revision as of 07:07, 5 November 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pnb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pnb RCSB], [http://www.ebi.ac.uk/pdbsum/4pnb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pnb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pnb RCSB], [http://www.ebi.ac.uk/pdbsum/4pnb PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The design of protein sequences that fold into prescribed de novo structures is challenging. General solutions to this problem require geometric descriptions of protein folds and methods to fit sequences to these. The alpha-helical coiled coils present a promising class of protein for this and offer considerable scope for exploring hitherto unseen structures. For alpha-helical barrels, which have more than four helices and accessible central channels, many of the possible structures remain unobserved. Here, we combine geometrical considerations, knowledge-based scoring, and atomistic modeling to facilitate the design of new channel-containing alpha-helical barrels. X-ray crystal structures of the resulting designs match predicted in silico models. Furthermore, the observed channels are chemically defined and have diameters related to oligomer state, which present routes to design protein function.
		+
		+	Computational design of water-soluble alpha-helical barrels.,Thomson AR, Wood CW, Burton AJ, Bartlett GJ, Sessions RB, Brady RL, Woolfson DN Science. 2014 Oct 24;346(6208):485-8. doi: 10.1126/science.1257452. PMID:25342807<ref>PMID:25342807</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 11:42, 22 October 2014

OCA — Wed, 22 Oct 2014 11:42:27 GMT

←Older revision		Revision as of 11:42, 22 October 2014
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-	'''~~Unreleased structure~~'''	+	==A de novo designed hexameric coiled coil CC-Hex3==
-		+	<StructureSection load='4pnb' size='340' side='right' caption='[[4pnb]], [[Resolution\|resolution]] 2.05Å' scene=''>
-	~~The entry~~ 4pnb is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4pnb]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PNB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PNB FirstGlance]. <br>
-	~~Authors~~: ~~Wood~~, C.W., Burton, A.J., Thomson, A.R., ~~Brady, R~~.~~L.,~~ Woolfson, D.N.	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
-		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pnb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pnb RCSB], [http://www.ebi.ac.uk/pdbsum/4pnb PDBsum]</span></td></tr>
-	~~Description~~: ~~A de novo~~ designed ~~hexameric coiled coil CC~~-~~Hex3~~	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Brady, R L.]]
		+	[[Category: Burton, A J.]]
		+	[[Category: Thomson, A R.]]
		+	[[Category: Wood, C W.]]
		+	[[Category: Woolfson, D N.]]
		+	[[Category: Alpha-helical barrel]]
		+	[[Category: Artificially designed - often synthetic]]
		+	[[Category: Coiled coil]]
		+	[[Category: De novo protein]]
		+	[[Category: Peptide .]]
		+	[[Category: Protein design]]

OCA: Protected "4pnb" [edit=sysop:move=sysop]

OCA — Wed, 04 Jun 2014 04:56:13 GMT

Protected "4pnb" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:56, 4 June 2014

OCA: New page: '''Unreleased structure''' The entry 4pnb is ON HOLD until Paper Publication Authors: Wood, C.W., Burton, A.J., Thomson, A.R., Brady, R.L., Woolfson, D.N. Description: A de novo design...

OCA — Wed, 04 Jun 2014 04:56:12 GMT

New page: '''Unreleased structure''' The entry 4pnb is ON HOLD until Paper Publication Authors: Wood, C.W., Burton, A.J., Thomson, A.R., Brady, R.L., Woolfson, D.N. Description: A de novo design...

New page

'''Unreleased structure'''

The entry 4pnb is ON HOLD until Paper Publication

Authors: Wood, C.W., Burton, A.J., Thomson, A.R., Brady, R.L., Woolfson, D.N.

Description: A de novo designed hexameric coiled coil CC-Hex3