4pnq - Revision history

OCA at 00:45, 28 December 2023

OCA — Thu, 28 Dec 2023 00:45:56 GMT

←Older revision		Revision as of 00:45, 28 December 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4pnq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PNQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PNQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[4pnq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PNQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PNQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=32X:5-AMINOISOQUINOLIN-1(4H)-ONE'>32X</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.85Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=32X:5-AMINOISOQUINOLIN-1(4H)-ONE'>32X</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pnq OCA], [https://pdbe.org/4pnq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pnq RCSB], [https://www.ebi.ac.uk/pdbsum/4pnq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pnq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pnq OCA], [https://pdbe.org/4pnq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pnq RCSB], [https://www.ebi.ac.uk/pdbsum/4pnq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pnq ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:20, 8 February 2023

OCA — Wed, 08 Feb 2023 07:20:43 GMT

←Older revision		Revision as of 07:20, 8 February 2023
Line 3:		Line 3:
	<StructureSection load='4pnq' size='340' side='right'caption='[[4pnq]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='4pnq' size='340' side='right'caption='[[4pnq]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4pnq]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PNQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4PNQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4pnq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PNQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PNQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=32X:5-AMINOISOQUINOLIN-1(4H)-ONE'>32X</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=32X:5-AMINOISOQUINOLIN-1(4H)-ONE'>32X</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pml\|4pml]], [[4pnl\|4pnl]], [[4pnm\|4pnm]], [[4pnn\|4pnn]], [[4pnt\|4pnt]], [[4pnr\|4pnr]], [[4pns\|4pns]], [[4tju\|4tju]], [[4tjw\|4tjw]], [[4tjy\|4tjy]], [[4tk0\|4tk0]], [[4tk5\|4tk5]], [[4tkf\|4tkf]], [[4tkg\|4tkg]], [[4tki\|4tki]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pnq OCA], [https://pdbe.org/4pnq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pnq RCSB], [https://www.ebi.ac.uk/pdbsum/4pnq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pnq ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TNKS2, PARP5B, TANK2, TNKL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4pnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pnq OCA], [~~http~~://pdbe.org/4pnq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4pnq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4pnq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4pnq ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>	+	[https://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 20:

	==See Also==		==See Also==
-	*[[Poly (ADP-ribose) polymerase\|Poly (ADP-ribose) polymerase]]	+	*[[Poly(ADP-ribose) polymerase 3D structures\|Poly(ADP-ribose) polymerase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Battaile~~, K P~~]]	+	[[Category: Battaile KP]]
-	[[Category: Beletskaya, I]]	+	[[Category: Beletskaya I]]
-	[[Category: Chirgadze~~, N Y~~]]	+	[[Category: Chirgadze NY]]
-	[[Category: Gebremeskel, S]]	+	[[Category: Gebremeskel S]]
-	[[Category: Gordon, R]]	+	[[Category: Gordon R]]
-	[[Category: Lam, R]]	+	[[Category: Lam R]]
-	[[Category: Pai~~, E F~~]]	+	[[Category: Pai EF]]
-	[[Category: Qiu, W]]	+	[[Category: Qiu W]]
-	[[Category: Romanov, V]]	+	[[Category: Romanov V]]
-	[[Category: Thompson, C]]	+	[[Category: Thompson C]]
-	[[Category: Vodsedalek, J]]	+	[[Category: Vodsedalek J]]
-	~~[[Category: Transferase~~]]	+

OCA at 07:52, 17 April 2019

OCA — Wed, 17 Apr 2019 07:52:43 GMT

←Older revision		Revision as of 07:52, 17 April 2019
Line 1:		Line 1:

	==Crystal Structure of human Tankyrase 2 in complex with 5AIQ.==		==Crystal Structure of human Tankyrase 2 in complex with 5AIQ.==
-	<StructureSection load='4pnq' size='340' side='right' caption='[[4pnq]], [[Resolution\|resolution]] 1.85Å' scene=''>	+	<StructureSection load='4pnq' size='340' side='right'caption='[[4pnq]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4pnq]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PNQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PNQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4pnq]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PNQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PNQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=32X:5-AMINOISOQUINOLIN-1(4H)-ONE'>32X</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=32X:5-AMINOISOQUINOLIN-1(4H)-ONE'>32X</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pml\|4pml]], [[4pnl\|4pnl]], [[4pnm\|4pnm]], [[4pnn\|4pnn]], [[4pnt\|4pnt]], [[4pnr\|4pnr]], [[4pns\|4pns]], [[4tju\|4tju]], [[4tjw\|4tjw]], [[4tjy\|4tjy]], [[4tk0\|4tk0]], [[4tk5\|4tk5]], [[4tkf\|4tkf]], [[4tkg\|4tkg]], [[4tki\|4tki]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pml\|4pml]], [[4pnl\|4pnl]], [[4pnm\|4pnm]], [[4pnn\|4pnn]], [[4pnt\|4pnt]], [[4pnr\|4pnr]], [[4pns\|4pns]], [[4tju\|4tju]], [[4tjw\|4tjw]], [[4tjy\|4tjy]], [[4tk0\|4tk0]], [[4tk5\|4tk5]], [[4tkf\|4tkf]], [[4tkg\|4tkg]], [[4tki\|4tki]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TNKS2, PARP5B, TANK2, TNKL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pnq OCA], [http://pdbe.org/4pnq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pnq RCSB], [http://www.ebi.ac.uk/pdbsum/4pnq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pnq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pnq OCA], [http://pdbe.org/4pnq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pnq RCSB], [http://www.ebi.ac.uk/pdbsum/4pnq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pnq ProSAT]</span></td></tr>
Line 27:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Battaile, K P]]		[[Category: Battaile, K P]]
	[[Category: Beletskaya, I]]		[[Category: Beletskaya, I]]

OCA at 15:31, 11 August 2016

OCA — Thu, 11 Aug 2016 15:31:46 GMT

←Older revision		Revision as of 15:31, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of human Tankyrase 2 in complex with 5AIQ.==		==Crystal Structure of human Tankyrase 2 in complex with 5AIQ.==
	<StructureSection load='4pnq' size='340' side='right' caption='[[4pnq]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='4pnq' size='340' side='right' caption='[[4pnq]], [[Resolution\|resolution]] 1.85Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pml\|4pml]], [[4pnl\|4pnl]], [[4pnm\|4pnm]], [[4pnn\|4pnn]], [[4pnt\|4pnt]], [[4pnr\|4pnr]], [[4pns\|4pns]], [[4tju\|4tju]], [[4tjw\|4tjw]], [[4tjy\|4tjy]], [[4tk0\|4tk0]], [[4tk5\|4tk5]], [[4tkf\|4tkf]], [[4tkg\|4tkg]], [[4tki\|4tki]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pml\|4pml]], [[4pnl\|4pnl]], [[4pnm\|4pnm]], [[4pnn\|4pnn]], [[4pnt\|4pnt]], [[4pnr\|4pnr]], [[4pns\|4pns]], [[4tju\|4tju]], [[4tjw\|4tjw]], [[4tjy\|4tjy]], [[4tk0\|4tk0]], [[4tk5\|4tk5]], [[4tkf\|4tkf]], [[4tkg\|4tkg]], [[4tki\|4tki]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pnq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pnq RCSB], [http://www.ebi.ac.uk/pdbsum/4pnq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pnq OCA], [http://pdbe.org/4pnq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pnq RCSB], [http://www.ebi.ac.uk/pdbsum/4pnq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pnq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4pnq" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Poly (ADP-ribose) polymerase\|Poly (ADP-ribose) polymerase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:14, 7 January 2015

OCA — Wed, 07 Jan 2015 11:14:16 GMT

←Older revision		Revision as of 11:14, 7 January 2015
Line 10:		Line 10:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>		[[http://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The poly(ADP-ribose) polymerase (PARP) family represents a new class of therapeutic targets with diverse potential disease indications. PARP1 and PARP2 inhibitors have been developed for breast and ovarian tumors manifesting double-stranded DNA-repair defects, whereas tankyrase 1 and 2 (TNKS1 and TNKS2, also known as PARP5a and PARP5b, respectively) inhibitors have been developed for tumors with elevated beta-catenin activity. As the clinical relevance of PARP inhibitors continues to be actively explored, there is heightened interest in the design of selective inhibitors based on the detailed structural features of how small-molecule inhibitors bind to each of the PARP family members. Here, the high-resolution crystal structures of the human TNKS2 PARP domain in complex with 16 various PARP inhibitors are reported, including the compounds BSI-201, AZD-2281 and ABT-888, which are currently in Phase 2 or 3 clinical trials. These structures provide insight into the inhibitor-binding modes for the tankyrase PARP domain and valuable information to guide the rational design of future tankyrase-specific inhibitors.
		+
		+	Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2.,Qiu W, Lam R, Voytyuk O, Romanov V, Gordon R, Gebremeskel S, Vodsedalek J, Thompson C, Beletskaya I, Battaile KP, Pai EF, Rottapel R, Chirgadze NY Acta Crystallogr D Biol Crystallogr. 2014 Oct;70(Pt 10):2740-53. doi:, 10.1107/S1399004714017660. Epub 2014 Sep 27. PMID:25286857<ref>PMID:25286857</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:57, 25 December 2014

OCA — Thu, 25 Dec 2014 11:57:02 GMT

←Older revision		Revision as of 11:57, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pnq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pnq RCSB], [http://www.ebi.ac.uk/pdbsum/4pnq PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pnq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pnq RCSB], [http://www.ebi.ac.uk/pdbsum/4pnq PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Battaile, K P.]]	+	[[Category: Battaile, K P]]
-	[[Category: Beletskaya, I.]]	+	[[Category: Beletskaya, I]]
-	[[Category: Chirgadze, N Y.]]	+	[[Category: Chirgadze, N Y]]
-	[[Category: Gebremeskel, S.]]	+	[[Category: Gebremeskel, S]]
-	[[Category: Gordon, R.]]	+	[[Category: Gordon, R]]
-	[[Category: Lam, R.]]	+	[[Category: Lam, R]]
-	[[Category: Pai, E F.]]	+	[[Category: Pai, E F]]
-	[[Category: Qiu, W.]]	+	[[Category: Qiu, W]]
-	[[Category: Romanov, V.]]	+	[[Category: Romanov, V]]
-	[[Category: Thompson, C.]]	+	[[Category: Thompson, C]]
-	[[Category: Vodsedalek, J.]]	+	[[Category: Vodsedalek, J]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 10:54, 20 October 2014

OCA — Mon, 20 Oct 2014 10:54:32 GMT

←Older revision		Revision as of 10:54, 20 October 2014
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal Structure of human Tankyrase 2 in complex with 5AIQ.==
-		+	<StructureSection load='4pnq' size='340' side='right' caption='[[4pnq]], [[Resolution\|resolution]] 1.85Å' scene=''>
-	~~The entry~~ 4pnq is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[4pnq]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PNQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PNQ FirstGlance]. <br>
-	~~Authors~~: ~~Qiu~~, W., ~~Lam~~, R., ~~Romanov~~, V., ~~Gordon~~, R., ~~Gebremeskel~~, S., ~~Vodsedalek~~, J., ~~Thompson~~, C., Beletskaya, I., ~~Battaile~~, K.P., Pai, E.F., ~~Chirgadze~~, ~~N.Y~~.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=32X:5-AMINOISOQUINOLIN-1(4H)-ONE'>32X</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pml\|4pml]], [[4pnl\|4pnl]], [[4pnm\|4pnm]], [[4pnn\|4pnn]], [[4pnt\|4pnt]], [[4pnr\|4pnr]], [[4pns\|4pns]], [[4tju\|4tju]], [[4tjw\|4tjw]], [[4tjy\|4tjy]], [[4tk0\|4tk0]], [[4tk5\|4tk5]], [[4tkf\|4tkf]], [[4tkg\|4tkg]], [[4tki\|4tki]]</td></tr>
-	~~Description~~: ~~Crystal Structure of human Tankyrase 2 in complex with 5AIQ~~.	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pnq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pnq RCSB], [http://www.ebi.ac.uk/pdbsum/4pnq PDBsum]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Battaile, K P.]]
		+	[[Category: Beletskaya, I.]]
		+	[[Category: Chirgadze, N Y.]]
		+	[[Category: Gebremeskel, S.]]
		+	[[Category: Gordon, R.]]
		+	[[Category: Lam, R.]]
		+	[[Category: Pai, E F.]]
		+	[[Category: Qiu, W.]]
		+	[[Category: Romanov, V.]]
		+	[[Category: Thompson, C.]]
		+	[[Category: Vodsedalek, J.]]
		+	[[Category: Transferase]]

OCA at 07:28, 13 August 2014

OCA — Wed, 13 Aug 2014 07:28:38 GMT

←Older revision		Revision as of 07:28, 13 August 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4pnq is ON HOLD	+	The entry 4pnq is ON HOLD until Paper Publication

	Authors: Qiu, W., Lam, R., Romanov, V., Gordon, R., Gebremeskel, S., Vodsedalek, J., Thompson, C., Beletskaya, I., Battaile, K.P., Pai, E.F., Chirgadze, N.Y.		Authors: Qiu, W., Lam, R., Romanov, V., Gordon, R., Gebremeskel, S., Vodsedalek, J., Thompson, C., Beletskaya, I., Battaile, K.P., Pai, E.F., Chirgadze, N.Y.

	Description: Crystal Structure of human Tankyrase 2 in complex with 5AIQ.		Description: Crystal Structure of human Tankyrase 2 in complex with 5AIQ.

OCA: Protected "4pnq" [edit=sysop:move=sysop]

OCA — Wed, 04 Jun 2014 04:56:26 GMT

Protected "4pnq" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:56, 4 June 2014

OCA: New page: '''Unreleased structure''' The entry 4pnq is ON HOLD Authors: Qiu, W., Lam, R., Romanov, V., Gordon, R., Gebremeskel, S., Vodsedalek, J., Thompson, C., Beletskaya, I., Battaile, K.P., P...

OCA — Wed, 04 Jun 2014 04:56:25 GMT

New page: '''Unreleased structure''' The entry 4pnq is ON HOLD Authors: Qiu, W., Lam, R., Romanov, V., Gordon, R., Gebremeskel, S., Vodsedalek, J., Thompson, C., Beletskaya, I., Battaile, K.P., P...

New page

'''Unreleased structure'''

The entry 4pnq is ON HOLD

Authors: Qiu, W., Lam, R., Romanov, V., Gordon, R., Gebremeskel, S., Vodsedalek, J., Thompson, C., Beletskaya, I., Battaile, K.P., Pai, E.F., Chirgadze, N.Y.

Description: Crystal Structure of human Tankyrase 2 in complex with 5AIQ.