4pof - Revision history

OCA at 17:19, 20 September 2023

OCA — Wed, 20 Sep 2023 17:19:38 GMT

←Older revision		Revision as of 17:19, 20 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[4pof]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus_DSM_3638 Pyrococcus furiosus DSM 3638]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4POF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4POF FirstGlance]. <br>		<table><tr><td colspan='2'>[[4pof]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus_DSM_3638 Pyrococcus furiosus DSM 3638]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4POF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4POF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.648Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pof OCA], [https://pdbe.org/4pof PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pof RCSB], [https://www.ebi.ac.uk/pdbsum/4pof PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pof ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pof OCA], [https://pdbe.org/4pof PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pof RCSB], [https://www.ebi.ac.uk/pdbsum/4pof PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pof ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:21, 8 February 2023

OCA — Wed, 08 Feb 2023 07:21:43 GMT

←Older revision		Revision as of 07:21, 8 February 2023
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	==PfMCM N-terminal domain without DNA==		==PfMCM N-terminal domain without DNA==
-	<StructureSection load='4pof' size='340' side='right' caption='[[4pof]], [[Resolution\|resolution]] 2.65Å' scene=''>	+	<StructureSection load='4pof' size='340' side='right'caption='[[4pof]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[4pof]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Pyrfu Pyrfu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4POF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4POF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[4pof]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus_DSM_3638 Pyrococcus furiosus DSM 3638]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4POF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4POF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pog\|4pog]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pof OCA], [https://pdbe.org/4pof PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pof RCSB], [https://www.ebi.ac.uk/pdbsum/4pof PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pof ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cdc21, PF0482 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=186497 PYRFU])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=4pof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pof OCA], [~~http~~://pdbe.org/4pof PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=4pof RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/4pof PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=4pof ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8U3I4_PYRFU Q8U3I4_PYRFU]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Pyrfu~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Bell, S P~~]]	+	[[Category: Pyrococcus furiosus DSM 3638]]
-	[[Category: ~~Enemark, E J~~]]	+	[[Category: Bell SP]]
-	[[Category: ~~Epling, L B~~]]	+	[[Category: Enemark EJ]]
-	[[Category: ~~Froelich, C A~~]]	+	[[Category: Epling LB]]
-	[[Category: ~~Kang, S~~]]	+	[[Category: Froelich CA]]
-	[[Category: ~~Dna binding protein]]~~	+	[[Category: Kang S]]
-	~~[[Category: Dna replication]]~~	+
-	~~[[Category: Ob-fold]]~~	+
-	~~[[Category: Replication~~]]	+

OCA at 01:02, 5 August 2016

OCA — Fri, 05 Aug 2016 01:02:42 GMT

←Older revision		Revision as of 01:02, 5 August 2016
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		+
	==PfMCM N-terminal domain without DNA==		==PfMCM N-terminal domain without DNA==
	<StructureSection load='4pof' size='340' side='right' caption='[[4pof]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='4pof' size='340' side='right' caption='[[4pof]], [[Resolution\|resolution]] 2.65Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pog\|4pog]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pog\|4pog]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cdc21, PF0482 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=186497 PYRFU])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cdc21, PF0482 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=186497 PYRFU])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pof OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pof RCSB], [http://www.ebi.ac.uk/pdbsum/4pof PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pof OCA], [http://pdbe.org/4pof PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pof RCSB], [http://www.ebi.ac.uk/pdbsum/4pof PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pof ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 4pof" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 10:56, 24 December 2014

OCA — Wed, 24 Dec 2014 10:56:44 GMT

←Older revision		Revision as of 10:56, 24 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_4pof~~\| ~~PDB~~=4pof \| ~~SCENE~~= }}	+	==PfMCM N-terminal domain without DNA==
-	===~~PfMCM N~~-~~terminal domain without DNA~~===	+	<StructureSection load='4pof' size='340' side='right' caption='[[4pof]], [[Resolution\|resolution]] 2.65Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[4pof]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrfu Pyrfu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4POF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4POF FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4pog\|4pog]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cdc21, PF0482 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=186497 PYRFU])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pof OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pof RCSB], [http://www.ebi.ac.uk/pdbsum/4pof PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The ring-shaped MCM helicase is essential to all phases of DNA replication. The complex loads at replication origins as an inactive double-hexamer encircling duplex DNA. Helicase activation converts this species to two active single hexamers that encircle single-stranded DNA (ssDNA). The molecular details of MCM DNA interactions during these events are unknown. We determined the crystal structure of the Pyrococcus furiosus MCM N-terminal domain hexamer bound to ssDNA and define a conserved MCM-ssDNA binding motif (MSSB). Intriguingly, ssDNA binds the MCM ring interior perpendicular to the central channel with defined polarity. In eukaryotes, the MSSB is conserved in several Mcm2-7 subunits, and MSSB mutant combinations in S. cerevisiae Mcm2-7 are not viable. Mutant Mcm2-7 complexes assemble and are recruited to replication origins, but are defective in helicase loading and activation. Our findings identify an important MCM-ssDNA interaction and suggest it functions during helicase activation to select the strand for translocation. DOI: http://dx.doi.org/10.7554/eLife.01993.001.

-	~~==About this Structure==~~	+	A conserved MCM single-stranded DNA binding element is essential for replication initiation.,Froelich CA, Kang S, Epling LB, Bell SP, Enemark EJ Elife. 2014 Apr 1;3:e01993. doi: 10.7554/eLife.01993. PMID:24692448<ref>PMID:24692448</ref>
-	~~[[4pof]]~~ is ~~a 6 chain structure~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id~~=~~4POF OCA~~].	+
-	[[Category: Bell, S P.]]	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: Enemark, E J.]]	+	</div>
-	[[Category: Epling, L B.]]	+	== References ==
-	[[Category: Froelich, C A.]]	+	<references/>
-	[[Category: Kang, S.]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Pyrfu]]
		+	[[Category: Bell, S P]]
		+	[[Category: Enemark, E J]]
		+	[[Category: Epling, L B]]
		+	[[Category: Froelich, C A]]
		+	[[Category: Kang, S]]
	[[Category: Dna binding protein]]		[[Category: Dna binding protein]]
	[[Category: Dna replication]]		[[Category: Dna replication]]
	[[Category: Ob-fold]]		[[Category: Ob-fold]]
	[[Category: Replication]]		[[Category: Replication]]

OCA at 06:48, 9 April 2014

OCA — Wed, 09 Apr 2014 06:48:11 GMT

←Older revision		Revision as of 06:48, 9 April 2014
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-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_4pof\| PDB=4pof \| SCENE= }}
		+	===PfMCM N-terminal domain without DNA===

-	~~The entry~~ 4pof is ~~ON HOLD until Paper Publication~~	+	==About this Structure==
-		+	[[4pof]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4POF OCA].
-	~~Authors~~: ~~Froelich, C~~.A.~~, Kang~~, S., Epling, L.B., ~~Bell~~, S.~~P., Enemark, E.J.~~	+	[[Category: Bell, S P.]]
-		+	[[Category: Enemark, E J.]]
-	~~Description~~: ~~PfMCM N~~-~~terminal domain without DNA~~	+	[[Category: Epling, L B.]]
		+	[[Category: Froelich, C A.]]
		+	[[Category: Kang, S.]]
		+	[[Category: Dna binding protein]]
		+	[[Category: Dna replication]]
		+	[[Category: Ob-fold]]
		+	[[Category: Replication]]

OCA at 07:36, 19 March 2014

OCA — Wed, 19 Mar 2014 07:36:33 GMT

←Older revision		Revision as of 07:36, 19 March 2014
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 4pof is ON HOLD	+	The entry 4pof is ON HOLD until Paper Publication

	Authors: Froelich, C.A., Kang, S., Epling, L.B., Bell, S.P., Enemark, E.J.		Authors: Froelich, C.A., Kang, S., Epling, L.B., Bell, S.P., Enemark, E.J.

	Description: PfMCM N-terminal domain without DNA		Description: PfMCM N-terminal domain without DNA

OCA: Protected "4pof" [edit=sysop:move=sysop]

OCA — Wed, 12 Mar 2014 12:32:07 GMT

Protected "4pof" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:32, 12 March 2014

OCA: New page: '''Unreleased structure''' The entry 4pof is ON HOLD Authors: Froelich, C.A., Kang, S., Epling, L.B., Bell, S.P., Enemark, E.J. Description: PfMCM N-terminal domain without DNA

OCA — Wed, 12 Mar 2014 12:32:05 GMT

New page: '''Unreleased structure''' The entry 4pof is ON HOLD Authors: Froelich, C.A., Kang, S., Epling, L.B., Bell, S.P., Enemark, E.J. Description: PfMCM N-terminal domain without DNA

New page

'''Unreleased structure'''

The entry 4pof is ON HOLD

Authors: Froelich, C.A., Kang, S., Epling, L.B., Bell, S.P., Enemark, E.J.

Description: PfMCM N-terminal domain without DNA